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Protein

Agglutinin isolectin 1

Gene
N/A
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin.

Miscellaneous

The 4 sites proposed for binding to carbohydrates (N-acetyl-D-glucosamine) of receptor molecules are on the surface of the agglutinin molecule.

GO - Molecular functioni

Keywordsi

LigandChitin-binding, Lectin

Protein family/group databases

CAZyiCBM18 Carbohydrate-Binding Module Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Agglutinin isolectin 1
Alternative name(s):
Isolectin A
WGA1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Pathology & Biotechi

Protein family/group databases

Allergomei3501 Tri a 18.0101
650 Tri a 18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000525527 – 197Agglutinin isolectin 1Add BLAST171
PropeptideiPRO_0000005256198 – 212Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi29 ↔ 44
Disulfide bondi38 ↔ 50
Disulfide bondi43 ↔ 57
Disulfide bondi61 ↔ 66
Disulfide bondi72 ↔ 87
Disulfide bondi81 ↔ 93
Disulfide bondi86 ↔ 100
Disulfide bondi104 ↔ 109
Disulfide bondi115 ↔ 130
Disulfide bondi124 ↔ 136
Disulfide bondi129 ↔ 143
Disulfide bondi147 ↔ 152
Disulfide bondi158 ↔ 173
Disulfide bondi167 ↔ 179
Disulfide bondi172 ↔ 186
Disulfide bondi190 ↔ 195

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP10968

Expressioni

Gene expression databases

ExpressionAtlasiP10968 baseline

Interactioni

Subunit structurei

Homodimer, u-shaped.1 Publication

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Helixi39 – 41Combined sources3
Beta strandi48 – 53Combined sources6
Helixi54 – 57Combined sources4
Beta strandi63 – 65Combined sources3
Helixi73 – 76Combined sources4
Helixi82 – 84Combined sources3
Beta strandi91 – 96Combined sources6
Helixi97 – 100Combined sources4
Beta strandi106 – 108Combined sources3
Helixi116 – 119Combined sources4
Helixi125 – 127Combined sources3
Beta strandi134 – 139Combined sources6
Helixi140 – 143Combined sources4
Beta strandi144 – 146Combined sources3
Beta strandi149 – 151Combined sources3
Turni160 – 164Combined sources5
Helixi168 – 170Combined sources3
Beta strandi179 – 182Combined sources4
Helixi183 – 186Combined sources4
Beta strandi192 – 194Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGCX-ray2.20A/B28-197[»]
2CWGX-ray2.00A/B28-197[»]
2UVOX-ray1.40A/B/E/F28-197[»]
2X3TX-ray2.75A/B/C/D28-197[»]
4AMLX-ray1.60A/B28-197[»]
7WGAX-ray2.00A/B28-197[»]
ProteinModelPortaliP10968
SMRiP10968
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10968

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 68Chitin-binding type-1 1PROSITE-ProRule annotationAdd BLAST42
Domaini69 – 111Chitin-binding type-1 2PROSITE-ProRule annotationAdd BLAST43
Domaini112 – 154Chitin-binding type-1 3PROSITE-ProRule annotationAdd BLAST43
Domaini155 – 197Chitin-binding type-1 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 38Substrate binding3
Regioni88 – 99Substrate bindingAdd BLAST12
Regioni140 – 141Substrate binding2

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

OrthoDBiEOG09360PEG

Family and domain databases

Gene3Di3.30.60.10, 4 hits
InterProiView protein in InterPro
IPR001002 Chitin-bd_1
IPR018371 Chitin-binding_1_CS
IPR036861 Endochitinase-like_sf
PfamiView protein in Pfam
PF00187 Chitin_bind_1, 4 hits
PRINTSiPR00451 CHITINBINDNG
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000609 Chitin_bd_1, 3 hits
SMARTiView protein in SMART
SM00270 ChtBD1, 4 hits
SUPFAMiSSF57016 SSF57016, 4 hits
PROSITEiView protein in PROSITE
PS00026 CHIT_BIND_I_1, 4 hits
PS50941 CHIT_BIND_I_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMMSTRALA LGAAAVLAFA AATAQAQRCG EQGSNMECPN NLCCSQYGYC
60 70 80 90 100
GMGGDYCGKG CQNGACWTSK RCGSQAGGAT CTNNQCCSQY GYCGFGAEYC
110 120 130 140 150
GAGCQGGPCR ADIKCGSQAG GKLCPNNLCC SQWGFCGLGS EFCGGGCQSG
160 170 180 190 200
ACSTDKPCGK DAGGRVCTNN YCCSKWGSCG IGPGYCGAGC QSGGCDGVFA
210
EAITANSTLL QE
Length:212
Mass (Da):21,239
Last modified:November 1, 1990 - v2
Checksum:iEC7B6F007DDC15EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63N → D AA sequence (PubMed:2499688).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25536 mRNA Translation: AAA34256.1
PIRiS09623
UniGeneiTa.12645

Similar proteinsi

Entry informationi

Entry nameiAGI1_WHEAT
AccessioniPrimary (citable) accession number: P10968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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