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P10962

- MAK16_YEAST

UniProt

P10962 - MAK16_YEAST

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Protein

Protein MAK16

Gene

MAK16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.1 Publication

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  4. ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-28836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16
Alternative name(s):
Maintenance of killer protein 16
Gene namesi
Name:MAK16
Ordered Locus Names:YAL025C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL025c.
SGDiS000000023. MAK16.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Protein MAK16PRO_0000203793Add
BLAST

Proteomic databases

MaxQBiP10962.
PaxDbiP10962.
PeptideAtlasiP10962.

Expressioni

Gene expression databases

GenevestigatoriP10962.

Interactioni

Protein-protein interaction databases

BioGridi31741. 60 interactions.
DIPiDIP-6521N.
IntActiP10962. 3 interactions.
MINTiMINT-485081.
STRINGi4932.YAL025C.

Structurei

3D structure databases

ProteinModelPortaliP10962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati213 – 22081
Repeati222 – 22982

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 229172 X 8 AA repeatsAdd
BLAST
Regioni251 – 264147 X 2 AA repeats of S-[DE]Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1446Nuclear localization signalSequence Analysis
Motifi282 – 2876Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 23541Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5129.
GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
InParanoidiP10962.
KOiK14831.
OMAiSPAHMWE.
OrthoDBiEOG7QZGNM.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view]
PfamiPF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
PIRSFiPIRSF003352. MAK16. 1 hit.

Sequencei

Sequence statusi: Complete.

P10962-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDEIVWQVI NQSFCSHRIK APNGQNFCRN EYNVTGLCTR QSCPLANSKY
60 70 80 90 100
ATVKCDNGKL YLYMKTPERA HTPAKLWERI KLSKNYTKAL QQIDEHLLHW
110 120 130 140 150
SKFFRHKCKQ RFTKLTQVMI TERRLALREE ERHYVGVAPK VKRREQNRER
160 170 180 190 200
KALVAAKIEK AIEKELMDRL KSGAYGDKPL NVDEKVWKKI MGQMEEENSQ
210 220 230 240 250
DEEEDWDEEE ESDDGEVEYV ADDGEGEYVD VDDLEKWLAD SDREASSASE
260 270 280 290 300
SESDSESESD SDSDEENKNS AKRRKKGTSA KTKRPKVEIE YEEEHEVQNA

EQEVAQ
Length:306
Mass (Da):35,696
Last modified:July 27, 2011 - v2
Checksum:i309ED6897EA24F73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501E → Q in AAA34752. (PubMed:3045810)Curated
Sequence conflicti250 – 2501E → Q in AAC05007. (PubMed:7731988)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03852 Genomic DNA. Translation: AAA34752.1.
U12980 Genomic DNA. Translation: AAC05007.1.
BK006935 Genomic DNA. Translation: DAA06963.2.
PIRiA35588. BVBYK6.
RefSeqiNP_009377.2. NM_001178170.2.

Genome annotation databases

EnsemblFungiiYAL025C; YAL025C; YAL025C.
GeneIDi851208.
KEGGisce:YAL025C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03852 Genomic DNA. Translation: AAA34752.1 .
U12980 Genomic DNA. Translation: AAC05007.1 .
BK006935 Genomic DNA. Translation: DAA06963.2 .
PIRi A35588. BVBYK6.
RefSeqi NP_009377.2. NM_001178170.2.

3D structure databases

ProteinModelPortali P10962.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31741. 60 interactions.
DIPi DIP-6521N.
IntActi P10962. 3 interactions.
MINTi MINT-485081.
STRINGi 4932.YAL025C.

Proteomic databases

MaxQBi P10962.
PaxDbi P10962.
PeptideAtlasi P10962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL025C ; YAL025C ; YAL025C .
GeneIDi 851208.
KEGGi sce:YAL025C.

Organism-specific databases

CYGDi YAL025c.
SGDi S000000023. MAK16.

Phylogenomic databases

eggNOGi COG5129.
GeneTreei ENSGT00390000012859.
HOGENOMi HOG000201538.
InParanoidi P10962.
KOi K14831.
OMAi SPAHMWE.
OrthoDBi EOG7QZGNM.

Enzyme and pathway databases

BioCyci YEAST:G3O-28836-MONOMER.

Miscellaneous databases

NextBioi 968079.
PROi P10962.

Gene expression databases

Genevestigatori P10962.

Family and domain databases

InterProi IPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view ]
Pfami PF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view ]
PIRSFi PIRSF003352. MAK16. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae."
    Wickner R.B.
    Proc. Natl. Acad. Sci. U.S.A. 85:6007-6011(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 250.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiMAK16_YEAST
AccessioniPrimary (citable) accession number: P10962
Secondary accession number(s): D6VPJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3