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P10962

- MAK16_YEAST

UniProt

P10962 - MAK16_YEAST

Protein

Protein MAK16

Gene

MAK16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.1 Publication

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    4. ribosomal large subunit biogenesis Source: SGD

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28836-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MAK16
    Alternative name(s):
    Maintenance of killer protein 16
    Gene namesi
    Name:MAK16
    Ordered Locus Names:YAL025C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL025c.
    SGDiS000000023. MAK16.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. preribosome, large subunit precursor Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Protein MAK16PRO_0000203793Add
    BLAST

    Proteomic databases

    MaxQBiP10962.
    PaxDbiP10962.
    PeptideAtlasiP10962.

    Expressioni

    Gene expression databases

    GenevestigatoriP10962.

    Interactioni

    Protein-protein interaction databases

    BioGridi31741. 60 interactions.
    DIPiDIP-6521N.
    IntActiP10962. 3 interactions.
    MINTiMINT-485081.
    STRINGi4932.YAL025C.

    Structurei

    3D structure databases

    ProteinModelPortaliP10962.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati213 – 22081
    Repeati222 – 22982

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni213 – 229172 X 8 AA repeatsAdd
    BLAST
    Regioni251 – 264147 X 2 AA repeats of S-[DE]Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi139 – 1446Nuclear localization signalSequence Analysis
    Motifi282 – 2876Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi195 – 23541Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the MAK16 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5129.
    GeneTreeiENSGT00390000012859.
    HOGENOMiHOG000201538.
    KOiK14831.
    OMAiSPAHMWE.
    OrthoDBiEOG7QZGNM.

    Family and domain databases

    InterProiIPR029004. L28e/Mak16.
    IPR006958. Mak16.
    [Graphical view]
    PfamiPF04874. Mak16. 1 hit.
    PF01778. Ribosomal_L28e. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003352. MAK16. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P10962-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDEIVWQVI NQSFCSHRIK APNGQNFCRN EYNVTGLCTR QSCPLANSKY    50
    ATVKCDNGKL YLYMKTPERA HTPAKLWERI KLSKNYTKAL QQIDEHLLHW 100
    SKFFRHKCKQ RFTKLTQVMI TERRLALREE ERHYVGVAPK VKRREQNRER 150
    KALVAAKIEK AIEKELMDRL KSGAYGDKPL NVDEKVWKKI MGQMEEENSQ 200
    DEEEDWDEEE ESDDGEVEYV ADDGEGEYVD VDDLEKWLAD SDREASSASE 250
    SESDSESESD SDSDEENKNS AKRRKKGTSA KTKRPKVEIE YEEEHEVQNA 300
    EQEVAQ 306
    Length:306
    Mass (Da):35,696
    Last modified:July 27, 2011 - v2
    Checksum:i309ED6897EA24F73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501E → Q in AAA34752. (PubMed:3045810)Curated
    Sequence conflicti250 – 2501E → Q in AAC05007. (PubMed:7731988)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03852 Genomic DNA. Translation: AAA34752.1.
    U12980 Genomic DNA. Translation: AAC05007.1.
    BK006935 Genomic DNA. Translation: DAA06963.2.
    PIRiA35588. BVBYK6.
    RefSeqiNP_009377.2. NM_001178170.2.

    Genome annotation databases

    EnsemblFungiiYAL025C; YAL025C; YAL025C.
    GeneIDi851208.
    KEGGisce:YAL025C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03852 Genomic DNA. Translation: AAA34752.1 .
    U12980 Genomic DNA. Translation: AAC05007.1 .
    BK006935 Genomic DNA. Translation: DAA06963.2 .
    PIRi A35588. BVBYK6.
    RefSeqi NP_009377.2. NM_001178170.2.

    3D structure databases

    ProteinModelPortali P10962.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31741. 60 interactions.
    DIPi DIP-6521N.
    IntActi P10962. 3 interactions.
    MINTi MINT-485081.
    STRINGi 4932.YAL025C.

    Proteomic databases

    MaxQBi P10962.
    PaxDbi P10962.
    PeptideAtlasi P10962.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL025C ; YAL025C ; YAL025C .
    GeneIDi 851208.
    KEGGi sce:YAL025C.

    Organism-specific databases

    CYGDi YAL025c.
    SGDi S000000023. MAK16.

    Phylogenomic databases

    eggNOGi COG5129.
    GeneTreei ENSGT00390000012859.
    HOGENOMi HOG000201538.
    KOi K14831.
    OMAi SPAHMWE.
    OrthoDBi EOG7QZGNM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28836-MONOMER.

    Miscellaneous databases

    NextBioi 968079.
    PROi P10962.

    Gene expression databases

    Genevestigatori P10962.

    Family and domain databases

    InterProi IPR029004. L28e/Mak16.
    IPR006958. Mak16.
    [Graphical view ]
    Pfami PF04874. Mak16. 1 hit.
    PF01778. Ribosomal_L28e. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003352. MAK16. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae."
      Wickner R.B.
      Proc. Natl. Acad. Sci. U.S.A. 85:6007-6011(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 250.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiMAK16_YEAST
    AccessioniPrimary (citable) accession number: P10962
    Secondary accession number(s): D6VPJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3