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Protein

Protein MAK16

Gene

MAK16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-28836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16
Alternative name(s):
Maintenance of killer protein 16
Gene namesi
Name:MAK16
Ordered Locus Names:YAL025C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL025C.
SGDiS000000023. MAK16.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037931 – 306Protein MAK16Add BLAST306

Proteomic databases

MaxQBiP10962.
PRIDEiP10962.

PTM databases

iPTMnetiP10962.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DBP9Q062184EBI-10937,EBI-5640
NOC2P397443EBI-10937,EBI-29259
RPF1P388053EBI-10937,EBI-24614
URB1P342413EBI-10937,EBI-26595

Protein-protein interaction databases

BioGridi31741. 68 interactors.
DIPiDIP-6521N.
IntActiP10962. 11 interactors.
MINTiMINT-485081.

Structurei

3D structure databases

ProteinModelPortaliP10962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati213 – 22018
Repeati222 – 22928

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni213 – 2292 X 8 AA repeatsAdd BLAST17
Regioni251 – 2647 X 2 AA repeats of S-[DE]Add BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 144Nuclear localization signalSequence analysis6
Motifi282 – 287Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 235Asp/Glu-rich (acidic)Add BLAST41

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
InParanoidiP10962.
KOiK14831.
OMAiWGEREFV.
OrthoDBiEOG092C4P58.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view]
PfamiPF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
PIRSFiPIRSF003352. MAK16. 1 hit.

Sequencei

Sequence statusi: Complete.

P10962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEIVWQVI NQSFCSHRIK APNGQNFCRN EYNVTGLCTR QSCPLANSKY
60 70 80 90 100
ATVKCDNGKL YLYMKTPERA HTPAKLWERI KLSKNYTKAL QQIDEHLLHW
110 120 130 140 150
SKFFRHKCKQ RFTKLTQVMI TERRLALREE ERHYVGVAPK VKRREQNRER
160 170 180 190 200
KALVAAKIEK AIEKELMDRL KSGAYGDKPL NVDEKVWKKI MGQMEEENSQ
210 220 230 240 250
DEEEDWDEEE ESDDGEVEYV ADDGEGEYVD VDDLEKWLAD SDREASSASE
260 270 280 290 300
SESDSESESD SDSDEENKNS AKRRKKGTSA KTKRPKVEIE YEEEHEVQNA

EQEVAQ
Length:306
Mass (Da):35,696
Last modified:July 27, 2011 - v2
Checksum:i309ED6897EA24F73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250E → Q in AAA34752 (PubMed:3045810).Curated1
Sequence conflicti250E → Q in AAC05007 (PubMed:7731988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03852 Genomic DNA. Translation: AAA34752.1.
U12980 Genomic DNA. Translation: AAC05007.1.
BK006935 Genomic DNA. Translation: DAA06963.2.
PIRiA35588. BVBYK6.
RefSeqiNP_009377.2. NM_001178170.2.

Genome annotation databases

EnsemblFungiiYAL025C; YAL025C; YAL025C.
GeneIDi851208.
KEGGisce:YAL025C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03852 Genomic DNA. Translation: AAA34752.1.
U12980 Genomic DNA. Translation: AAC05007.1.
BK006935 Genomic DNA. Translation: DAA06963.2.
PIRiA35588. BVBYK6.
RefSeqiNP_009377.2. NM_001178170.2.

3D structure databases

ProteinModelPortaliP10962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31741. 68 interactors.
DIPiDIP-6521N.
IntActiP10962. 11 interactors.
MINTiMINT-485081.

PTM databases

iPTMnetiP10962.

Proteomic databases

MaxQBiP10962.
PRIDEiP10962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL025C; YAL025C; YAL025C.
GeneIDi851208.
KEGGisce:YAL025C.

Organism-specific databases

EuPathDBiFungiDB:YAL025C.
SGDiS000000023. MAK16.

Phylogenomic databases

GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
InParanoidiP10962.
KOiK14831.
OMAiWGEREFV.
OrthoDBiEOG092C4P58.

Enzyme and pathway databases

BioCyciYEAST:G3O-28836-MONOMER.

Miscellaneous databases

PROiP10962.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view]
PfamiPF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
PIRSFiPIRSF003352. MAK16. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAK16_YEAST
AccessioniPrimary (citable) accession number: P10962
Secondary accession number(s): D6VPJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.