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P10962 (MAK16_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MAK16
Alternative name(s):
Maintenance of killer protein 16
Gene names
Name:MAK16
Ordered Locus Names:YAL025C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle. Ref.1

Subcellular location

Nucleus.

Sequence similarities

Belongs to the MAK16 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Protein MAK16
PRO_0000203793

Regions

Repeat213 – 22081
Repeat222 – 22982
Region213 – 229172 X 8 AA repeats
Region251 – 264147 X 2 AA repeats of S-[DE]
Motif139 – 1446Nuclear localization signal Potential
Motif282 – 2876Nuclear localization signal Potential
Compositional bias195 – 23541Asp/Glu-rich (acidic)

Experimental info

Sequence conflict2501E → Q in AAA34752. Ref.1
Sequence conflict2501E → Q in AAC05007. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P10962 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 309ED6897EA24F73

FASTA30635,696
        10         20         30         40         50         60 
MSDEIVWQVI NQSFCSHRIK APNGQNFCRN EYNVTGLCTR QSCPLANSKY ATVKCDNGKL 

        70         80         90        100        110        120 
YLYMKTPERA HTPAKLWERI KLSKNYTKAL QQIDEHLLHW SKFFRHKCKQ RFTKLTQVMI 

       130        140        150        160        170        180 
TERRLALREE ERHYVGVAPK VKRREQNRER KALVAAKIEK AIEKELMDRL KSGAYGDKPL 

       190        200        210        220        230        240 
NVDEKVWKKI MGQMEEENSQ DEEEDWDEEE ESDDGEVEYV ADDGEGEYVD VDDLEKWLAD 

       250        260        270        280        290        300 
SDREASSASE SESDSESESD SDSDEENKNS AKRRKKGTSA KTKRPKVEIE YEEEHEVQNA 


EQEVAQ 

« Hide

References

« Hide 'large scale' references
[1]"Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae."
Wickner R.B.
Proc. Natl. Acad. Sci. U.S.A. 85:6007-6011(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 250.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03852 Genomic DNA. Translation: AAA34752.1.
U12980 Genomic DNA. Translation: AAC05007.1.
BK006935 Genomic DNA. Translation: DAA06963.2.
PIRBVBYK6. A35588.
RefSeqNP_009377.2. NM_001178170.2.

3D structure databases

ProteinModelPortalP10962.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31741. 60 interactions.
DIPDIP-6521N.
IntActP10962. 3 interactions.
MINTMINT-485081.
STRING4932.YAL025C.

Proteomic databases

PaxDbP10962.
PeptideAtlasP10962.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL025C; YAL025C; YAL025C.
GeneID851208.
KEGGsce:YAL025C.

Organism-specific databases

CYGDYAL025c.
SGDS000000023. MAK16.

Phylogenomic databases

eggNOGCOG5129.
GeneTreeENSGT00390000012859.
HOGENOMHOG000201538.
KOK14831.
OMAVEIEYEE.
OrthoDBEOG7QZGNM.

Enzyme and pathway databases

BioCycYEAST:G3O-28836-MONOMER.

Gene expression databases

GenevestigatorP10962.

Family and domain databases

InterProIPR006958. Mak16.
[Graphical view]
PANTHERPTHR23405:SF4. PTHR23405:SF4. 1 hit.
PfamPF04874. Mak16. 1 hit.
[Graphical view]
PIRSFPIRSF003352. MAK16. 1 hit.
ProtoNetSearch...

Other

NextBio968079.
PROP10962.

Entry information

Entry nameMAK16_YEAST
AccessionPrimary (citable) accession number: P10962
Secondary accession number(s): D6VPJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families