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P10960

- SAP_RAT

UniProt

P10960 - SAP_RAT

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Protein

Sulfated glycoprotein 1

Gene
Psap, Sgp1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. glycolipid transport Source: RGD
  2. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfated glycoprotein 1
Short name:
SGP-1
Alternative name(s):
Prosaposin
Gene namesi
Name:Psap
Synonyms:Sgp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3423. Psap.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. lysosome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 554538Sulfated glycoprotein 1PRO_0000031629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 138 By similarity
Disulfide bondi66 ↔ 132 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 106 By similarity
Disulfide bondi197 ↔ 270 By similarity
Disulfide bondi200 ↔ 264 By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi229 ↔ 240 By similarity
Disulfide bondi314 ↔ 387 By similarity
Disulfide bondi317 ↔ 381 By similarity
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi345 ↔ 356 By similarity
Disulfide bondi439 ↔ 512 By similarity
Disulfide bondi442 ↔ 506 By similarity
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi470 ↔ 481 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10960.
PRIDEiP10960.

PTM databases

PhosphoSiteiP10960.

Expressioni

Gene expression databases

GenevestigatoriP10960.

Structurei

3D structure databases

ProteinModelPortaliP10960.
SMRiP10960. Positions 60-140, 195-271, 435-514.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5841Saposin A-type 1Add
BLAST
Domaini59 – 14284Saposin B-type 1Add
BLAST
Domaini193 – 27482Saposin B-type 2Add
BLAST
Domaini310 – 39182Saposin B-type 3Add
BLAST
Domaini435 – 51682Saposin B-type 4Add
BLAST
Domaini518 – 55437Saposin A-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG244726.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiP10960.
KOiK12382.
PhylomeDBiP10960.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10960-1 [UniParc]FASTAAdd to Basket

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MYALALLASL LVTALTSPVQ DPKICSGGSA VVCRDVKTAV DCRAVKHCQQ    50
MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATEEEILHYL EKTCAWIHDS 100
SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ 150
RQLESNKIPE VDLARVVAPF MSNIPLLLYP QDRPRSQPQP KANEDVCQDC 200
MKLVTDIQTA VRTNSSFVQG LVDHVKEDCD RLGPGVSDIC KNYVDQYSEV 250
AVQMMMHMQP KEICVMVGFC DEVKRVPMRT LVPATEAIKN ILPALELTDP 300
YEQDVIQAQN VIFCQVCQLV MRKLSELIIN NATEELLIKG LSKACSLLPA 350
PASTKCQEVL VTFGPSLLDV LMHEVNPNFL CGVISLCSAN PNLVGTLEQP 400
AAAIVSALPK EPAPPKQPEE PKQSALRAHV PPQKNGGFCE VCKKLVIYLE 450
HNLEKNSTKE EILAALEKGC SFLPDPYQKQ CDEFVAEYEP LLLEILVEVM 500
DPSFVCSKIG VCPSAYKLLL GTEKCVWGPG YWCQNSETAA RCNAVDHCKR 550
HVWN 554
Length:554
Mass (Da):61,124
Last modified:July 1, 1989 - v1
Checksum:iDFE3F3A3A0520C6B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151P → L1 Publication
Sequence conflicti115 – 1151P → L1 Publication
Sequence conflicti299 – 2991D → E in AAB36042. 1 Publication
Sequence conflicti462 – 4621I → V in AAB36233. 1 Publication
Sequence conflicti527 – 5271W → R in AAB36233. 1 Publication
Sequence conflicti536 – 5361S → M in AAB36233. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19936 mRNA. Translation: AAA42136.1.
S81353 mRNA. Translation: AAB36042.2.
S81373 mRNA. Translation: AAB36233.2.
PIRiA28716.
RefSeqiNP_001177165.1. NM_001190236.1.
NP_037145.2. NM_013013.2.
UniGeneiRn.97173.

Genome annotation databases

GeneIDi25524.
KEGGirno:25524.
UCSCiRGD:3423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19936 mRNA. Translation: AAA42136.1 .
S81353 mRNA. Translation: AAB36042.2 .
S81373 mRNA. Translation: AAB36233.2 .
PIRi A28716.
RefSeqi NP_001177165.1. NM_001190236.1.
NP_037145.2. NM_013013.2.
UniGenei Rn.97173.

3D structure databases

ProteinModelPortali P10960.
SMRi P10960. Positions 60-140, 195-271, 435-514.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P10960.

Proteomic databases

PaxDbi P10960.
PRIDEi P10960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25524.
KEGGi rno:25524.
UCSCi RGD:3423. rat.

Organism-specific databases

CTDi 5660.
RGDi 3423. Psap.

Phylogenomic databases

eggNOGi NOG244726.
HOGENOMi HOG000049216.
HOVERGENi HBG002617.
InParanoidi P10960.
KOi K12382.
PhylomeDBi P10960.

Miscellaneous databases

NextBioi 606999.

Gene expression databases

Genevestigatori P10960.

Family and domain databases

Gene3Di 1.10.225.10. 4 hits.
InterProi IPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view ]
PIRSFi PIRSF002431. Saposin. 1 hit.
PRINTSi PR01797. SAPOSIN.
SMARTi SM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 3 hits.
PROSITEi PS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biosynthesis and molecular cloning of sulfated glycoprotein 1 secreted by rat Sertoli cells: sequence similarity with the 70-kilodalton precursor to sulfatide/GM1 activator."
    Collard M.W., Sylvester S.R., Tsuruta J.K., Griswold M.D.
    Biochemistry 27:4557-4564(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Sertoli cell.
  2. "Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells."
    Morales C.R., El-Alfy M., Zhao Q., Igdoura S.A.
    Histol. Histopathol. 10:1023-1034(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Expression and tissue distribution of rat sulfated glycoprotein-1 (prosaposin)."
    Morales C.R., El-Alfy M., Zhao Q., Igdoura S.A.
    J. Histochem. Cytochem. 44:327-337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 68-78; 108-122; 192-212; 323-343; 444-445 AND 460-479, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSAP_RAT
AccessioniPrimary (citable) accession number: P10960
Secondary accession number(s): Q62841, Q64190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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