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P10960

- SAP_RAT

UniProt

P10960 - SAP_RAT

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Protein

Sulfated glycoprotein 1

Gene

Psap

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. glycolipid transport Source: RGD
  2. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfated glycoprotein 1
Short name:
SGP-1
Alternative name(s):
Prosaposin
Gene namesi
Name:Psap
Synonyms:Sgp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3423. Psap.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. lysosome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 554538Sulfated glycoprotein 1PRO_0000031629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 138PROSITE-ProRule annotation
Disulfide bondi66 ↔ 132PROSITE-ProRule annotation
Glycosylationi80 – 801N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi94 ↔ 106PROSITE-ProRule annotation
Disulfide bondi197 ↔ 270PROSITE-ProRule annotation
Disulfide bondi200 ↔ 264PROSITE-ProRule annotation
Glycosylationi214 – 2141N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi314 ↔ 387PROSITE-ProRule annotation
Disulfide bondi317 ↔ 381PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi345 ↔ 356PROSITE-ProRule annotation
Disulfide bondi439 ↔ 512PROSITE-ProRule annotation
Disulfide bondi442 ↔ 506PROSITE-ProRule annotation
Glycosylationi456 – 4561N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi470 ↔ 481PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10960.
PRIDEiP10960.

PTM databases

PhosphoSiteiP10960.

Expressioni

Gene expression databases

GenevestigatoriP10960.

Interactioni

Protein-protein interaction databases

BioGridi247556. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP10960.
SMRiP10960. Positions 60-140, 195-271, 435-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5841Saposin A-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini59 – 14284Saposin B-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini193 – 27482Saposin B-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini310 – 39182Saposin B-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini435 – 51682Saposin B-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 55437Saposin A-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 saposin A-type domains.PROSITE-ProRule annotation
Contains 4 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG244726.
HOGENOMiHOG000049216.
HOVERGENiHBG002617.
InParanoidiP10960.
KOiK12382.
PhylomeDBiP10960.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view]
PfamiPF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view]
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10960 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYALALLASL LVTALTSPVQ DPKICSGGSA VVCRDVKTAV DCRAVKHCQQ
60 70 80 90 100
MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATEEEILHYL EKTCAWIHDS
110 120 130 140 150
SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ
160 170 180 190 200
RQLESNKIPE VDLARVVAPF MSNIPLLLYP QDRPRSQPQP KANEDVCQDC
210 220 230 240 250
MKLVTDIQTA VRTNSSFVQG LVDHVKEDCD RLGPGVSDIC KNYVDQYSEV
260 270 280 290 300
AVQMMMHMQP KEICVMVGFC DEVKRVPMRT LVPATEAIKN ILPALELTDP
310 320 330 340 350
YEQDVIQAQN VIFCQVCQLV MRKLSELIIN NATEELLIKG LSKACSLLPA
360 370 380 390 400
PASTKCQEVL VTFGPSLLDV LMHEVNPNFL CGVISLCSAN PNLVGTLEQP
410 420 430 440 450
AAAIVSALPK EPAPPKQPEE PKQSALRAHV PPQKNGGFCE VCKKLVIYLE
460 470 480 490 500
HNLEKNSTKE EILAALEKGC SFLPDPYQKQ CDEFVAEYEP LLLEILVEVM
510 520 530 540 550
DPSFVCSKIG VCPSAYKLLL GTEKCVWGPG YWCQNSETAA RCNAVDHCKR

HVWN
Length:554
Mass (Da):61,124
Last modified:July 1, 1989 - v1
Checksum:iDFE3F3A3A0520C6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151P → L(PubMed:8573994)Curated
Sequence conflicti115 – 1151P → L(PubMed:8601692)Curated
Sequence conflicti299 – 2991D → E in AAB36042. (PubMed:8573994)Curated
Sequence conflicti462 – 4621I → V in AAB36233. (PubMed:8601692)Curated
Sequence conflicti527 – 5271W → R in AAB36233. (PubMed:8601692)Curated
Sequence conflicti536 – 5361S → M in AAB36233. (PubMed:8601692)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19936 mRNA. Translation: AAA42136.1.
S81353 mRNA. Translation: AAB36042.2.
S81373 mRNA. Translation: AAB36233.2.
PIRiA28716.
RefSeqiNP_001177165.1. NM_001190236.1.
NP_037145.2. NM_013013.2.
UniGeneiRn.97173.

Genome annotation databases

GeneIDi25524.
KEGGirno:25524.
UCSCiRGD:3423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19936 mRNA. Translation: AAA42136.1 .
S81353 mRNA. Translation: AAB36042.2 .
S81373 mRNA. Translation: AAB36233.2 .
PIRi A28716.
RefSeqi NP_001177165.1. NM_001190236.1.
NP_037145.2. NM_013013.2.
UniGenei Rn.97173.

3D structure databases

ProteinModelPortali P10960.
SMRi P10960. Positions 60-140, 195-271, 435-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247556. 1 interaction.

PTM databases

PhosphoSitei P10960.

Proteomic databases

PaxDbi P10960.
PRIDEi P10960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25524.
KEGGi rno:25524.
UCSCi RGD:3423. rat.

Organism-specific databases

CTDi 5660.
RGDi 3423. Psap.

Phylogenomic databases

eggNOGi NOG244726.
HOGENOMi HOG000049216.
HOVERGENi HBG002617.
InParanoidi P10960.
KOi K12382.
PhylomeDBi P10960.

Miscellaneous databases

NextBioi 606999.

Gene expression databases

Genevestigatori P10960.

Family and domain databases

Gene3Di 1.10.225.10. 4 hits.
InterProi IPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
[Graphical view ]
PIRSFi PIRSF002431. Saposin. 1 hit.
PRINTSi PR01797. SAPOSIN.
SMARTi SM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 3 hits.
PROSITEi PS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biosynthesis and molecular cloning of sulfated glycoprotein 1 secreted by rat Sertoli cells: sequence similarity with the 70-kilodalton precursor to sulfatide/GM1 activator."
    Collard M.W., Sylvester S.R., Tsuruta J.K., Griswold M.D.
    Biochemistry 27:4557-4564(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Sertoli cell.
  2. "Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells."
    Morales C.R., El-Alfy M., Zhao Q., Igdoura S.A.
    Histol. Histopathol. 10:1023-1034(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Expression and tissue distribution of rat sulfated glycoprotein-1 (prosaposin)."
    Morales C.R., El-Alfy M., Zhao Q., Igdoura S.A.
    J. Histochem. Cytochem. 44:327-337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 68-78; 108-122; 192-212; 323-343; 444-445 AND 460-479, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSAP_RAT
AccessioniPrimary (citable) accession number: P10960
Secondary accession number(s): Q62841, Q64190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3