ID FIB12_BPT4 Reviewed; 527 AA. AC P10930; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 05-MAY-2009, sequence version 3. DT 08-NOV-2023, entry version 130. DE RecName: Full=Short tail fiber protein gp12; DE AltName: Full=Gene product 12; DE Short=gp12; GN Name=12; OS Enterobacteria phage T4 (Bacteriophage T4). OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; OC Straboviridae; Tevenvirinae; Tequatrovirus. OX NCBI_TaxID=10665; OH NCBI_TaxID=562; Escherichia coli. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=D; RX PubMed=3357780; DOI=10.1093/nar/16.5.2334; RA Selivanov N.A., Prilipov A.G., Mesyanzhinov V.V.; RT "Nucleotide and deduced amino acid sequence of bacteriophage T4 gene 12."; RL Nucleic Acids Res. 16:2334-2334(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003; RA Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.; RT "Bacteriophage T4 genome."; RL Microbiol. Mol. Biol. Rev. 67:86-156(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57. RC STRAIN=D; RX PubMed=2548819; DOI=10.1089/dna.1.1989.8.287; RA Barrett B.K., Berget P.B.; RT "Using transposon Tn5 insertions to sequence bacteriophage T4 gene 11."; RL DNA 8:287-295(1989). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4. RC STRAIN=D; RX PubMed=2726468; DOI=10.1093/nar/17.8.3303; RA Prilipov A.G., Selivanov N.A., Efimov V.P., Marusich E.I., RA Mesyanzhinov V.V.; RT "Nucleotide sequences of bacteriophage T4 genes 9, 10 and 11."; RL Nucleic Acids Res. 17:3303-3303(1989). RN [5] RP FUNCTION. RX PubMed=12837775; DOI=10.1128/jb.185.14.4022-4030.2003; RA Weigele P.R., Scanlon E., King J.; RT "Homotrimeric, beta-stranded viral adhesins and tail proteins."; RL J. Bacteriol. 185:4022-4030(2003). RN [6] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 250-527, AND SUBUNIT. RX PubMed=11743729; DOI=10.1006/jmbi.2000.5204; RA van Raaij M.J., Schoehn G., Burda M.R., Miller S.; RT "Crystal structure of a heat and protease-stable part of the bacteriophage RT T4 short tail fibre."; RL J. Mol. Biol. 314:1137-1146(2001). RN [7] RP STRUCTURE BY ELECTRON MICROSCOPY (4.11 ANGSTROMS), SUBUNIT, SUBCELLULAR RP LOCATION, AND FUNCTION. RX PubMed=27193680; DOI=10.1038/nature17971; RA Taylor N.M., Prokhorov N.S., Guerrero-Ferreira R.C., Shneider M.M., RA Browning C., Goldie K.N., Stahlberg H., Leiman P.G.; RT "Structure of the T4 baseplate and its function in triggering sheath RT contraction."; RL Nature 533:346-352(2016). CC -!- FUNCTION: Structural component of the short tail fiber. Adhesion CC protein that binds irreversibly to the lipopolysaccharides component CC (LPS) on the cell surface of Escherichia coli B strains during virus CC attachment. After at least three long tail fibers have bound, short CC tail fibers extend and bind irreversibly to the core region of the host CC cell LPS. {ECO:0000269|PubMed:12837775, ECO:0000269|PubMed:27193680}. CC -!- SUBUNIT: Homotrimer. {ECO:0000269|PubMed:11743729, CC ECO:0000269|PubMed:27193680}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:27193680}. CC -!- SIMILARITY: Belongs to the tevenvirinae short tail fiber protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X06792; CAA29951.1; -; Genomic_DNA. DR EMBL; AF158101; AAD42417.1; -; Genomic_DNA. DR EMBL; M26253; AAA32495.1; -; Genomic_DNA. DR EMBL; X14192; CAA32398.1; -; Genomic_DNA. DR PIR; C32479; C32479. DR PIR; S01889; GIBPT4. DR RefSeq; NP_049770.1; NC_000866.4. DR PDB; 1OCY; X-ray; 1.50 A; A=332-527. DR PDB; 1PDI; EM; 12.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=250-527. DR PDB; 5IV5; EM; 4.11 A; AI/AJ/BA/DB/DC/DD/FE/FF/FG/HH/HI/HJ/O/P/Q/l/m/n=1-527. DR PDB; 5LYE; X-ray; 1.90 A; A=85-396, B=518-527. DR PDBsum; 1OCY; -. DR PDBsum; 1PDI; -. DR PDBsum; 5IV5; -. DR PDBsum; 5LYE; -. DR SMR; P10930; -. DR DrugBank; DB04272; Citric acid. DR TCDB; 1.K.1.1.1; the gp27/5 t4-baseplate (t4-bp) family. DR GeneID; 1258789; -. DR KEGG; vg:1258789; -. DR OrthoDB; 3474at10239; -. DR EvolutionaryTrace; P10930; -. DR Proteomes; UP000009087; Segment. DR GO; GO:0098025; C:virus tail, baseplate; IDA:UniProtKB. DR GO; GO:0098024; C:virus tail, fiber; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR Gene3D; 2.10.280.10; heat- and protease-stable fragment of the bacteriophage t4 short fibre, domain 1; 1. DR Gene3D; 2.160.30.10; heat- and protease-stable fragment of the bacteriophage t4 short fibre, domain 2; 1. DR Gene3D; 3.90.1340.10; Phage tail collar domain; 1. DR Gene3D; 4.10.1070.10; receptor-binding domain of the bacteriophage t4 short tail fibre, domain 2; 1. DR InterPro; IPR015173; Phage_T4_Gp12. DR InterPro; IPR011083; Phage_tail_collar_dom. DR InterPro; IPR037053; Phage_tail_collar_dom_sf. DR InterPro; IPR027448; Short_tail_fibre_C. DR InterPro; IPR044916; Short_tail_fibre_C_sf. DR Pfam; PF07484; Collar; 1. DR Pfam; PF09089; gp12-short_mid; 1. DR Pfam; PF14928; S_tail_recep_bd; 1. DR SUPFAM; SSF69349; Phage fibre proteins; 1. DR SUPFAM; SSF88874; Receptor-binding domain of short tail fibre protein gp12; 1. PE 1: Evidence at protein level; KW 3D-structure; Host-virus interaction; Late protein; Reference proteome; KW Viral attachment to host cell; Viral attachment to host entry receptor; KW Viral tail fiber protein; Viral tail protein; Virion; KW Virus entry into host cell. FT CHAIN 1..527 FT /note="Short tail fiber protein gp12" FT /id="PRO_0000165002" FT CONFLICT 33 FT /note="Q -> H (in Ref. 1; CAA29951 and 2; AAD42417)" FT /evidence="ECO:0000305" FT HELIX 335..340 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 346..353 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 359..364 FT /evidence="ECO:0007829|PDB:1OCY" FT TURN 369..371 FT /evidence="ECO:0007829|PDB:1OCY" FT HELIX 373..378 FT /evidence="ECO:0007829|PDB:1OCY" FT TURN 379..383 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 387..391 FT /evidence="ECO:0007829|PDB:1OCY" FT HELIX 407..410 FT /evidence="ECO:0007829|PDB:1OCY" FT HELIX 412..414 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 415..417 FT /evidence="ECO:0007829|PDB:1OCY" FT TURN 425..428 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 454..456 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 465..467 FT /evidence="ECO:0007829|PDB:1OCY" FT HELIX 493..495 FT /evidence="ECO:0007829|PDB:1OCY" FT HELIX 498..500 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 508..510 FT /evidence="ECO:0007829|PDB:1OCY" FT STRAND 520..524 FT /evidence="ECO:0007829|PDB:1OCY" SQ SEQUENCE 527 AA; 56205 MW; F86C7E65205486CC CRC64; MSNNTYQHVS NESRYVKFDP TDTNFPPEIT DVQAAIAAIS PAGVNGVPDA SSTTKGILFI PTEQEVIDGT NNTKAVTPAT LATRLSYPNA TETVYGLTRY STNDEAIAGV NNESSITPAK FTVALNNAFE TRVSTESSNG VIKISSLPQA LAGADDTTAM TPLKTQQLAI KLIAQIAPSE TTATESDQGV VQLATVAQVR QGTLREGYAI SPYTFMNSSS TEEYKGVIKL GTQSEVNSNN ASVAVTGATL NGRGSTTSMR GVVKLTTTAG SQSGGDASSA LAWNADVIQQ RGGQIIYGTL RIEDTFTIAN GGANITGTVR MTGGYIQGNR IVTQNEIDRT IPVGAIMMWA ADSLPSDAWR FCHGGTVSAS DCPLYASRIG TRYGGNPSNP GLPDMRGLFV RGSGRGSHLT NPNVNGNDQF GKPRLGVGCT GGYVGEVQIQ QMSYHKHAGG FGEHDDLGAF GNTRRSNFVG TRKGLDWDNR SYFTNDGYEI DPESQRNSKY TLNRPELIGN ETRPWNISLN YIIKVKE //