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Protein

Histone H1.0

Gene

H1f0

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

GO - Molecular functioni

  • AT DNA binding Source: CAFA
  • chromatin DNA binding Source: MGI
  • double-stranded DNA binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-211227 Activation of DNA fragmentation factor
R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1'
Histone H1(0)
MyD196
Cleaved into the following chain:
Gene namesi
Name:H1f0
Synonyms:H1fv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95893 H1f0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001959131 – 194Histone H1.0Add BLAST194
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004232082 – 194Histone H1.0, N-terminally processedAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Histone H1.0, N-terminally processedBy similarity1
Modified residuei42CitrullineBy similarity1
Modified residuei104ADP-ribosylserineBy similarity1

Post-translational modificationi

ADP-ribosylated on Ser-104 in response to DNA damage.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination

Proteomic databases

EPDiP10922
MaxQBiP10922
PaxDbiP10922
PeptideAtlasiP10922
PRIDEiP10922
TopDownProteomicsiP10922

PTM databases

iPTMnetiP10922
PhosphoSitePlusiP10922

Expressioni

Gene expression databases

BgeeiENSMUSG00000096210
CleanExiMM_H1F0
GenevisibleiP10922 MM

Interactioni

Protein-protein interaction databases

BioGridi200145, 7 interactors
IntActiP10922, 3 interactors
MINTiP10922
STRINGi10090.ENSMUSP00000137309

Structurei

3D structure databases

DisProtiDP00097
ProteinModelPortaliP10922
SMRiP10922
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00810000125570
HOVERGENiHBG069502
InParanoidiP10922
KOiK11275
OMAiFEQPKGP
OrthoDBiEOG091G0LIU
PhylomeDBiP10922
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKGDE
110 120 130 140 150
PKRSVAFKKT KKEVKKVATP KKAAKPKKAA SKAPSKKPKA TPVKKAKKKP
160 170 180 190
AATPKKAKKP KVVKVKPVKA SKPKKAKTVK PKAKSSAKRA SKKK
Length:194
Mass (Da):20,861
Last modified:January 23, 2007 - v4
Checksum:i41EF06627E2AC81C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65D → N in CAA31569 (PubMed:2846273).Curated1
Sequence conflicti190A → G in CAA31569 (PubMed:2846273).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13171 mRNA Translation: CAA31569.1
U18295 Genomic DNA Translation: AAA69911.1
AK051213 mRNA Translation: BAC34559.1
AK077473 mRNA Translation: BAC36817.1
AK145675 mRNA Translation: BAE26583.1
AK146077 mRNA Translation: BAE26881.1
BC003830 mRNA Translation: AAH03830.1
BC011493 mRNA Translation: AAH11493.1
BC110361 mRNA Translation: AAI10362.1
CCDSiCCDS56990.1
PIRiI49150
RefSeqiNP_032223.2, NM_008197.3
UniGeneiMm.24350

Genome annotation databases

EnsembliENSMUST00000180086; ENSMUSP00000137309; ENSMUSG00000096210
GeneIDi14958
KEGGimmu:14958
UCSCiuc007wsd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiH10_MOUSE
AccessioniPrimary (citable) accession number: P10922
Secondary accession number(s): Q3UKC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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