Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10915

- HPLN1_HUMAN

UniProt

P10915 - HPLN1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hyaluronan and proteoglycan link protein 1

Gene

HAPLN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

ReactomeiREACT_163906. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 1
Alternative name(s):
Cartilage-linking protein 1
Short name:
Cartilage-link protein
Proteoglycan link protein
Gene namesi
Name:HAPLN1
Synonyms:CRTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:2380. HAPLN1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1515PRO_0000013177Add
BLAST
Chaini16 – 354339Hyaluronan and proteoglycan link protein 1PRO_0000013178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi61 ↔ 139By similarity
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi205 ↔ 226By similarity
Disulfide bondi279 ↔ 349By similarity
Disulfide bondi304 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP10915.
PaxDbiP10915.
PRIDEiP10915.

PTM databases

PhosphoSiteiP10915.

Miscellaneous databases

PMAP-CutDBP10915.

Expressioni

Tissue specificityi

Widely expressed. Weakly expressed in the brain.2 Publications

Gene expression databases

BgeeiP10915.
CleanExiHS_HAPLN1.
ExpressionAtlasiP10915. baseline and differential.
GenevestigatoriP10915.

Organism-specific databases

HPAiHPA019105.
HPA019482.

Interactioni

Protein-protein interaction databases

BioGridi107794. 3 interactions.
STRINGi9606.ENSP00000274341.

Structurei

3D structure databases

ProteinModelPortaliP10915.
SMRiP10915. Positions 42-145, 166-253, 269-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 152115Ig-like V-typeAdd
BLAST
Domaini159 – 25496Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini259 – 35193Link 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG145467.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiP10915.
KOiK06848.
OMAiWRSGLDW.
PhylomeDBiP10915.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10915-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF
60 70 80 90 100
SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY
110 120 130 140 150
HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV
160 170 180 190 200
VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG
210 220 230 240 250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV
260 270 280 290 300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG
310 320 330 340 350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF

RAYN
Length:354
Mass (Da):40,166
Last modified:April 1, 1990 - v2
Checksum:i315C96EC3AC2626A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti274 – 2741E → V in AAH57808. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811N → S.
Corresponds to variant rs6864342 [ dbSNP | Ensembl ].
VAR_049316
Natural varianti333 – 3331R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036168

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17405 mRNA. Translation: CAA35462.1.
U43328 mRNA. Translation: AAA85216.1.
AK313713 mRNA. Translation: BAG36456.1.
CH471084 Genomic DNA. Translation: EAW95912.1.
BC057808 mRNA. Translation: AAH57808.1.
CCDSiCCDS4061.1.
PIRiS14914. LKHU.
RefSeqiNP_001875.1. NM_001884.3.
UniGeneiHs.2799.

Genome annotation databases

EnsembliENST00000274341; ENSP00000274341; ENSG00000145681.
GeneIDi1404.
KEGGihsa:1404.
UCSCiuc003kim.3. human.

Polymorphism databases

DMDMi130310.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17405 mRNA. Translation: CAA35462.1 .
U43328 mRNA. Translation: AAA85216.1 .
AK313713 mRNA. Translation: BAG36456.1 .
CH471084 Genomic DNA. Translation: EAW95912.1 .
BC057808 mRNA. Translation: AAH57808.1 .
CCDSi CCDS4061.1.
PIRi S14914. LKHU.
RefSeqi NP_001875.1. NM_001884.3.
UniGenei Hs.2799.

3D structure databases

ProteinModelPortali P10915.
SMRi P10915. Positions 42-145, 166-253, 269-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107794. 3 interactions.
STRINGi 9606.ENSP00000274341.

Chemistry

DrugBanki DB08818. Hyaluronan.

PTM databases

PhosphoSitei P10915.

Polymorphism databases

DMDMi 130310.

Proteomic databases

MaxQBi P10915.
PaxDbi P10915.
PRIDEi P10915.

Protocols and materials databases

DNASUi 1404.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274341 ; ENSP00000274341 ; ENSG00000145681 .
GeneIDi 1404.
KEGGi hsa:1404.
UCSCi uc003kim.3. human.

Organism-specific databases

CTDi 1404.
GeneCardsi GC05M082933.
HGNCi HGNC:2380. HAPLN1.
HPAi HPA019105.
HPA019482.
MIMi 115435. gene.
neXtProti NX_P10915.
PharmGKBi PA26901.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145467.
GeneTreei ENSGT00760000119025.
HOGENOMi HOG000234353.
HOVERGENi HBG051922.
InParanoidi P10915.
KOi K06848.
OMAi WRSGLDW.
PhylomeDBi P10915.
TreeFami TF332134.

Enzyme and pathway databases

Reactomei REACT_163906. ECM proteoglycans.

Miscellaneous databases

GeneWikii HAPLN1.
GenomeRNAii 1404.
NextBioi 5743.
PMAP-CutDB P10915.
PROi P10915.
SOURCEi Search...

Gene expression databases

Bgeei P10915.
CleanExi HS_HAPLN1.
ExpressionAtlasi P10915. baseline and differential.
Genevestigatori P10915.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 2 hits.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of human cartilage link protein."
    Dudhia J., Hardingham T.E.
    Nucleic Acids Res. 18:1292-1292(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Articular chondrocyte.
  2. "Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene."
    Osborne-Lawrence S.L., Sinclair A.K., Hicks R.C., Lacey S.W., Eddy R.L. Jr., Byers M.G., Shows T.B., Duby A.D.
    Genomics 8:562-567(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterization of the promoter for the rat and human link protein gene."
    Rhodes C., Savagner P., Line S., Sasaki M., Chirigos M., Doege K., Yamada Y.
    Nucleic Acids Res. 19:1933-1939(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  7. "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain."
    Hirakawa S., Oohashi T., Su W.-D., Yoshioka H., Murakami T., Arata J., Ninomiya Y.
    Biochem. Biophys. Res. Commun. 276:982-989(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-333.

Entry informationi

Entry nameiHPLN1_HUMAN
AccessioniPrimary (citable) accession number: P10915
Secondary accession number(s): B2R9A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3