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Protein

Glycerophosphodiester phosphodiesterase, cytoplasmic

Gene

ugpQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.

Miscellaneous

There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli: a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ).

Catalytic activityi

A glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.1 Publication

Cofactori

Mg2+1 Publication, Co2+1 Publication, Mn2+1 Publication

Kineticsi

  1. KM=0.22 mM for glycerophosphoethanolamine1 Publication
  2. KM=0.66 mM for glycerophosphoserine1 Publication
  3. KM=0.62 mM for glycerophosphoglycerol1 Publication
  4. KM=0.39 mM for glycerophosphoinositol1 Publication
  5. KM=2.0 mM for glycerophosphocholine1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    GO - Molecular functioni

    • glycerophosphocholine phosphodiesterase activity Source: EcoCyc
    • glycerophosphodiester phosphodiesterase activity Source: EcoCyc
    • glycerophosphoinositol glycerophosphodiesterase activity Source: EcoCyc
    • magnesium ion binding Source: EcoCyc

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase
    Biological processGlycerol metabolism
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:GLYCPDIESTER-CYTO-MONOMER
    MetaCyc:GLYCPDIESTER-CYTO-MONOMER
    BRENDAi3.1.4.46 2026

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerophosphodiester phosphodiesterase, cytoplasmic (EC:3.1.4.46)
    Short name:
    Glycerophosphoryl diester phosphodiesterase, cytoplasmic
    Gene namesi
    Name:ugpQ
    Ordered Locus Names:b3449, JW3414
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    Proteomesi
    • UP000000318 Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    EcoGeneiEG11050 ugpQ

    Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002005741 – 247Glycerophosphodiester phosphodiesterase, cytoplasmicAdd BLAST247

    Proteomic databases

    PaxDbiP10908
    PRIDEiP10908

    Expressioni

    Inductioni

    Up-regulated by low levels of phosphate in the medium.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi4261665, 14 interactors
    IntActiP10908, 10 interactors
    STRINGi316385.ECDH10B_3623

    Structurei

    3D structure databases

    ProteinModelPortaliP10908
    SMRiP10908
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini7 – 244GP-PDEAdd BLAST238

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiENOG4107T6V Bacteria
    COG0584 LUCA
    HOGENOMiHOG000004697
    InParanoidiP10908
    KOiK01126
    OMAiVAGELPW
    PhylomeDBiP10908

    Family and domain databases

    Gene3Di3.20.20.190, 1 hit
    InterProiView protein in InterPro
    IPR004129 GlyceroP-diester-Pdiesterase
    IPR030395 GP_PDE_dom
    IPR017946 PLC-like_Pdiesterase_TIM-brl
    PANTHERiPTHR23344 PTHR23344, 1 hit
    PfamiView protein in Pfam
    PF03009 GDPD, 1 hit
    SUPFAMiSSF51695 SSF51695, 1 hit
    PROSITEiView protein in PROSITE
    PS51704 GP_PDE, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P10908-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MSNWPYPRIV AHRGGGKLAP ENTLASIDVG AKYGHKMIEF DAKLSKDGEI
    60 70 80 90 100
    FLLHDDNLER TSNGWGVAGE LNWQDLLRVD AGSWYSKMFK GEPLPLLSQV
    110 120 130 140 150
    AERCREHGMM ANIEIKPTTG TGPLTGKMVA LAARELWAGM TPPLLSSFEI
    160 170 180 190 200
    DALEAAQQAA PELPRGLLLD EWRDDWRELT ARLGCVSIHL NHKLLNKARV
    210 220 230 240
    MQLKDAGLRI LVYTVNKPQR AAELLRWGVD CICTDAIDVI GPNFTAQ
    Length:247
    Mass (Da):27,410
    Last modified:July 1, 1989 - v1
    Checksum:iFF5EBFB4C6D7CC0D
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X14437 Genomic DNA Translation: CAA32609.1
    X13141 Genomic DNA Translation: CAA31535.1
    X56908 Genomic DNA Translation: CAA40224.1
    U00039 Genomic DNA Translation: AAB18424.1
    U00096 Genomic DNA Translation: AAC76474.1
    AP009048 Genomic DNA Translation: BAE77844.1
    PIRiJV0024 ESECGD
    RefSeqiNP_417906.1, NC_000913.3
    WP_000073623.1, NZ_LN832404.1

    Genome annotation databases

    EnsemblBacteriaiAAC76474; AAC76474; b3449
    BAE77844; BAE77844; BAE77844
    GeneIDi947955
    KEGGiecj:JW3414
    eco:b3449
    PATRICifig|1411691.4.peg.3278

    Similar proteinsi

    Entry informationi

    Entry nameiUGPQ_ECOLI
    AccessioniPrimary (citable) accession number: P10908
    Secondary accession number(s): P22633, Q2M7B2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: March 28, 2018
    This is version 133 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

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