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Protein

sn-glycerol-3-phosphate transport system permease protein UgpE

Gene

ugpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: EcoCyc
  • glycerophosphodiester transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • glycerol-3-phosphate transport Source: EcoCyc
  • glycerophosphodiester transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:UGPE-MONOMER.
ECOL316407:JW3416-MONOMER.
MetaCyc:UGPE-MONOMER.
BRENDAi3.6.3.20. 2026.

Protein family/group databases

TCDBi3.A.1.1.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
sn-glycerol-3-phosphate transport system permease protein UgpE
Gene namesi
Name:ugpE
Ordered Locus Names:b3451, JW3416
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11049. ugpE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei85 – 105HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei113 – 133HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei202 – 222HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei247 – 267HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Source: EcoCyc
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602331 – 281sn-glycerol-3-phosphate transport system permease protein UgpEAdd BLAST281

Proteomic databases

PaxDbiP10906.
PRIDEiP10906.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).Curated

Protein-protein interaction databases

BioGridi4261664. 218 interactors.
IntActiP10906. 1 interactor.
STRINGi511145.b3451.

Structurei

3D structure databases

ProteinModelPortaliP10906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 268ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST192

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EX2. Bacteria.
COG0395. LUCA.
HOGENOMiHOG000220524.
InParanoidiP10906.
KOiK05815.
OMAiATDWNLL.
PhylomeDBiP10906.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR030165. UgpE.
[Graphical view]
PANTHERiPTHR32243:SF31. PTHR32243:SF31. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENRPWLTI FSHTMLILGI AVILFPLYVA FVAATLDKQA VYAAPMTLIP
60 70 80 90 100
GTHLLENIHN IWVNGVGTNS APFWRMLLNS FVMAFSITLG KITVSMLSAF
110 120 130 140 150
AIVWFRFPLR NLFFWMIFIT LMLPVEVRIF PTVEVIANLQ MLDSYAGLTL
160 170 180 190 200
PLMASATATF LFRQFFMTLP DELVEAARID GASPMRFFCD IVFPLSKTNL
210 220 230 240 250
AALFVITFIY GWNQYLWPLL IITDVDLGTT VAGIKGMIAT GEGTTEWNSV
260 270 280
MVAMLLTLIP PVVIVLVMQR AFVRGLVDSE K
Length:281
Mass (Da):31,500
Last modified:July 1, 1989 - v1
Checksum:i16CEE371D329C10B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13141 Genomic DNA. Translation: CAA31533.1.
U00039 Genomic DNA. Translation: AAB18426.1.
U00096 Genomic DNA. Translation: AAC76476.1.
AP009048 Genomic DNA. Translation: BAE77842.1.
PIRiS03782. MMECUE.
RefSeqiNP_417908.1. NC_000913.3.
WP_000572177.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76476; AAC76476; b3451.
BAE77842; BAE77842; BAE77842.
GeneIDi947959.
KEGGiecj:JW3416.
eco:b3451.
PATRICi32122342. VBIEscCol129921_3548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13141 Genomic DNA. Translation: CAA31533.1.
U00039 Genomic DNA. Translation: AAB18426.1.
U00096 Genomic DNA. Translation: AAC76476.1.
AP009048 Genomic DNA. Translation: BAE77842.1.
PIRiS03782. MMECUE.
RefSeqiNP_417908.1. NC_000913.3.
WP_000572177.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP10906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261664. 218 interactors.
IntActiP10906. 1 interactor.
STRINGi511145.b3451.

Protein family/group databases

TCDBi3.A.1.1.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP10906.
PRIDEiP10906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76476; AAC76476; b3451.
BAE77842; BAE77842; BAE77842.
GeneIDi947959.
KEGGiecj:JW3416.
eco:b3451.
PATRICi32122342. VBIEscCol129921_3548.

Organism-specific databases

EchoBASEiEB1042.
EcoGeneiEG11049. ugpE.

Phylogenomic databases

eggNOGiENOG4105EX2. Bacteria.
COG0395. LUCA.
HOGENOMiHOG000220524.
InParanoidiP10906.
KOiK05815.
OMAiATDWNLL.
PhylomeDBiP10906.

Enzyme and pathway databases

BioCyciEcoCyc:UGPE-MONOMER.
ECOL316407:JW3416-MONOMER.
MetaCyc:UGPE-MONOMER.
BRENDAi3.6.3.20. 2026.

Miscellaneous databases

PROiP10906.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR030165. UgpE.
[Graphical view]
PANTHERiPTHR32243:SF31. PTHR32243:SF31. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUGPE_ECOLI
AccessioniPrimary (citable) accession number: P10906
Secondary accession number(s): Q2M7B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.