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Protein

sn-glycerol-3-phosphate transport system permease protein UgpA

Gene

ugpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: EcoCyc
  • glycerophosphodiester transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • glycerol-3-phosphate transport Source: EcoCyc
  • glycerophosphodiester transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:UGPA-MONOMER.
ECOL316407:JW3417-MONOMER.
MetaCyc:UGPA-MONOMER.
BRENDAi3.6.3.20. 2026.

Protein family/group databases

TCDBi3.A.1.1.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
sn-glycerol-3-phosphate transport system permease protein UgpA
Gene namesi
Name:ugpA
Ordered Locus Names:b3452, JW3417
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11046. ugpA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini33 – 80PeriplasmicSequence analysisAdd BLAST48
Transmembranei81 – 101HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini102 – 109CytoplasmicSequence analysis8
Transmembranei110 – 130HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini131 – 156PeriplasmicSequence analysisAdd BLAST26
Transmembranei157 – 177HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini178 – 207CytoplasmicSequence analysisAdd BLAST30
Transmembranei208 – 228HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini229 – 262PeriplasmicSequence analysisAdd BLAST34
Transmembranei263 – 283HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini284 – 295CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602321 – 295sn-glycerol-3-phosphate transport system permease protein UgpAAdd BLAST295

Proteomic databases

PaxDbiP10905.
PRIDEiP10905.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).Curated

Protein-protein interaction databases

BioGridi4263421. 118 interactors.
DIPiDIP-11077N.
IntActiP10905. 1 interactor.
STRINGi511145.b3452.

Structurei

3D structure databases

ProteinModelPortaliP10905.
SMRiP10905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 284ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E4X. Bacteria.
COG1175. LUCA.
HOGENOMiHOG000220406.
InParanoidiP10905.
KOiK05814.
OMAiFFYTDAF.
PhylomeDBiP10905.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRPVFRS RWLPYLLVAP QLIITVIFFI WPAGEALWYS LQSVDPFGFS
60 70 80 90 100
SQFVGLDNFV TLFHDSYYLD SFWTTIKFST FVTVSGLLVS LFFAALVEYI
110 120 130 140 150
VRGSRFYQTL MLLPYAVAPA VAAVLWIFLF NPGRGLITHF LAEFGYDWNH
160 170 180 190 200
AQNSGQAMFL VVFASVWKQI SYNFLFFYAA LQSIPRSLIE AAAIDGAGPI
210 220 230 240 250
RRFFKIALPL IAPVSFFLLV VNLVYAFFDT FPVIDAATSG GPVQATTTLI
260 270 280 290
YKIYREGFTG LDLASSAAQS VVLMFLVIVL TVVQFRYVES KVRYQ
Length:295
Mass (Da):33,264
Last modified:July 1, 1989 - v1
Checksum:iCC8765DE0FB647A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13141 Genomic DNA. Translation: CAA31532.1.
U00039 Genomic DNA. Translation: AAB18427.1.
U00096 Genomic DNA. Translation: AAC76477.1.
AP009048 Genomic DNA. Translation: BAE77841.1.
PIRiS03781. MMECUA.
RefSeqiNP_417909.1. NC_000913.3.
WP_000099289.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76477; AAC76477; b3452.
BAE77841; BAE77841; BAE77841.
GeneIDi947957.
KEGGiecj:JW3417.
eco:b3452.
PATRICi32122344. VBIEscCol129921_3549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13141 Genomic DNA. Translation: CAA31532.1.
U00039 Genomic DNA. Translation: AAB18427.1.
U00096 Genomic DNA. Translation: AAC76477.1.
AP009048 Genomic DNA. Translation: BAE77841.1.
PIRiS03781. MMECUA.
RefSeqiNP_417909.1. NC_000913.3.
WP_000099289.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP10905.
SMRiP10905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263421. 118 interactors.
DIPiDIP-11077N.
IntActiP10905. 1 interactor.
STRINGi511145.b3452.

Protein family/group databases

TCDBi3.A.1.1.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP10905.
PRIDEiP10905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76477; AAC76477; b3452.
BAE77841; BAE77841; BAE77841.
GeneIDi947957.
KEGGiecj:JW3417.
eco:b3452.
PATRICi32122344. VBIEscCol129921_3549.

Organism-specific databases

EchoBASEiEB1039.
EcoGeneiEG11046. ugpA.

Phylogenomic databases

eggNOGiENOG4105E4X. Bacteria.
COG1175. LUCA.
HOGENOMiHOG000220406.
InParanoidiP10905.
KOiK05814.
OMAiFFYTDAF.
PhylomeDBiP10905.

Enzyme and pathway databases

BioCyciEcoCyc:UGPA-MONOMER.
ECOL316407:JW3417-MONOMER.
MetaCyc:UGPA-MONOMER.
BRENDAi3.6.3.20. 2026.

Miscellaneous databases

PROiP10905.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUGPA_ECOLI
AccessioniPrimary (citable) accession number: P10905
Secondary accession number(s): Q2M7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.