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Protein

Alpha-L-fucosidase

Gene

alfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Miscellaneous

The maximum expression of alpha-L-fucosidase occurs during aggregation stage of dictyostelium discoideum.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei288May be important for catalysis1

GO - Molecular functioni

  • 1,6-alpha-L-fucosidase activity Source: dictyBase
  • alpha-L-fucosidase activity Source: dictyBase

GO - Biological processi

  • fucose metabolic process Source: dictyBase

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51 1939
ReactomeiR-DDI-6798695 Neutrophil degranulation
R-DDI-975578 Reactions specific to the complex N-glycan synthesis pathway

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
Name:alfA
ORF Names:DDB_G0274391
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274391 alfA

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: dictyBase
  • lysosome Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001031719 – 461Alpha-L-fucosidaseAdd BLAST443

Proteomic databases

PaxDbiP10901
PRIDEiP10901

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185016

Structurei

3D structure databases

ProteinModelPortaliP10901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
InParanoidiP10901
KOiK01206
OMAiAPDQYWN
PhylomeDBiP10901

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMIIIFFIL LILNLIKSQQ YGPTWDQINS RPLPGWYDDV KFGIFIHFGI
60 70 80 90 100
YSVPAFANGG YAEWYWWTLK NPSSDGGATQ RYHEKEFGAN FTYQDFVSRF
110 120 130 140 150
DCRLFDANEW ASIIEKSGAK YVVLTSKHHE GYTLWNSEQS WNWNSVETGP
160 170 180 190 200
GIDIVGELTK SVKNMGLHMG LYHSLFEWFN PLYLADAETG KNPTTQVYVD
210 220 230 240 250
EILMKQLKDI VTTYEPELIW ADGDWMQLSN YWKSTEFLSW LYTNSSVKDT
260 270 280 290 300
VIVNDRWGSE CRDKNGGFYT GADHFNPYKL QSHKWENCAT IGYSYGYDEY
310 320 330 340 350
EQATDYQNAT ELIIDLVTTV ACGGNFLLDV GPDAQGTIPN NMVDRLLEIG
360 370 380 390 400
NWLSINSESI YGSSPWRVQN MTFNIWYTTN TTNGNVYAFV FELPDDGVLI
410 420 430 440 450
LSDPIGNNKT EATLLGLKGE KGVEVSLPIE STKPGITLNI PMVAPQDYPP
460
YVYVFRLTDV E
Length:461
Mass (Da):52,647
Last modified:July 1, 1989 - v1
Checksum:iCB33D0771FF4B516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07497 Genomic DNA Translation: CAA68800.1
AAFI02000012 Genomic DNA Translation: EAL70088.1
PIRiA30364
RefSeqiXP_644263.1, XM_639171.1

Genome annotation databases

EnsemblProtistsiEAL70088; EAL70088; DDB_G0274391
GeneIDi8619691
KEGGiddi:DDB_G0274391

Similar proteinsi

Entry informationi

Entry nameiFUCO_DICDI
AccessioniPrimary (citable) accession number: P10901
Secondary accession number(s): Q554R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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