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P10901

- FUCO_DICDI

UniProt

P10901 - FUCO_DICDI

Protein

Alpha-L-fucosidase

Gene

alfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei288 – 2881May be important for catalysis

    GO - Molecular functioni

    1. 1,6-alpha-L-fucosidase activity Source: dictyBase
    2. alpha-L-fucosidase activity Source: dictyBase
    3. fucose binding Source: RefGenome

    GO - Biological processi

    1. fucose metabolic process Source: dictyBase

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.51. 1939.

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase
    Gene namesi
    Name:alfA
    ORF Names:DDB_G0274391
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0274391. alfA.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: dictyBase
    2. lysosome Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 461443Alpha-L-fucosidasePRO_0000010317Add
    BLAST

    Proteomic databases

    PRIDEiP10901.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0185016.

    Structurei

    3D structure databases

    ProteinModelPortaliP10901.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    KOiK01206.
    OMAiVGSICKH.
    PhylomeDBiP10901.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10901-1 [UniParc]FASTAAdd to Basket

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    MKMIIIFFIL LILNLIKSQQ YGPTWDQINS RPLPGWYDDV KFGIFIHFGI    50
    YSVPAFANGG YAEWYWWTLK NPSSDGGATQ RYHEKEFGAN FTYQDFVSRF 100
    DCRLFDANEW ASIIEKSGAK YVVLTSKHHE GYTLWNSEQS WNWNSVETGP 150
    GIDIVGELTK SVKNMGLHMG LYHSLFEWFN PLYLADAETG KNPTTQVYVD 200
    EILMKQLKDI VTTYEPELIW ADGDWMQLSN YWKSTEFLSW LYTNSSVKDT 250
    VIVNDRWGSE CRDKNGGFYT GADHFNPYKL QSHKWENCAT IGYSYGYDEY 300
    EQATDYQNAT ELIIDLVTTV ACGGNFLLDV GPDAQGTIPN NMVDRLLEIG 350
    NWLSINSESI YGSSPWRVQN MTFNIWYTTN TTNGNVYAFV FELPDDGVLI 400
    LSDPIGNNKT EATLLGLKGE KGVEVSLPIE STKPGITLNI PMVAPQDYPP 450
    YVYVFRLTDV E 461
    Length:461
    Mass (Da):52,647
    Last modified:July 1, 1989 - v1
    Checksum:iCB33D0771FF4B516
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07497 Genomic DNA. Translation: CAA68800.1.
    AAFI02000012 Genomic DNA. Translation: EAL70088.1.
    PIRiA30364.
    RefSeqiXP_644263.1. XM_639171.1.

    Genome annotation databases

    EnsemblProtistsiDDB0185016; DDB0185016; DDB_G0274391.
    GeneIDi8619691.
    KEGGiddi:DDB_G0274391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07497 Genomic DNA. Translation: CAA68800.1 .
    AAFI02000012 Genomic DNA. Translation: EAL70088.1 .
    PIRi A30364.
    RefSeqi XP_644263.1. XM_639171.1.

    3D structure databases

    ProteinModelPortali P10901.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0185016.

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Proteomic databases

    PRIDEi P10901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0185016 ; DDB0185016 ; DDB_G0274391 .
    GeneIDi 8619691.
    KEGGi ddi:DDB_G0274391.

    Organism-specific databases

    dictyBasei DDB_G0274391. alfA.

    Phylogenomic databases

    eggNOGi COG3669.
    KOi K01206.
    OMAi VGSICKH.
    PhylomeDBi P10901.

    Enzyme and pathway databases

    BRENDAi 3.2.1.51. 1939.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A developmentally regulated gene product from Dictyostelium discoideum shows high homology to human alpha-L-fucosidase."
      Mueller-Taubenberger A., Westphal M., Noegel A., Gerisch G.
      FEBS Lett. 246:185-192(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX2 and AX3.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiFUCO_DICDI
    AccessioniPrimary (citable) accession number: P10901
    Secondary accession number(s): Q554R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The maximum expression of alpha-L-fucosidase occurs during aggregation stage of dictyostelium discoideum.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3