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Protein

Alpha-L-fucosidase

Gene

alfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei288 – 2881May be important for catalysis

GO - Molecular functioni

  • 1,6-alpha-L-fucosidase activity Source: dictyBase
  • alpha-L-fucosidase activity Source: dictyBase

GO - Biological processi

  • fucose metabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 1939.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
Name:alfA
ORF Names:DDB_G0274391
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274391. alfA.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: dictyBase
  • lysosome Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 461443Alpha-L-fucosidasePRO_0000010317Add
BLAST

Proteomic databases

PRIDEiP10901.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185016.

Structurei

3D structure databases

ProteinModelPortaliP10901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
InParanoidiP10901.
KOiK01206.
OMAiNDWADLF.
PhylomeDBiP10901.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMIIIFFIL LILNLIKSQQ YGPTWDQINS RPLPGWYDDV KFGIFIHFGI
60 70 80 90 100
YSVPAFANGG YAEWYWWTLK NPSSDGGATQ RYHEKEFGAN FTYQDFVSRF
110 120 130 140 150
DCRLFDANEW ASIIEKSGAK YVVLTSKHHE GYTLWNSEQS WNWNSVETGP
160 170 180 190 200
GIDIVGELTK SVKNMGLHMG LYHSLFEWFN PLYLADAETG KNPTTQVYVD
210 220 230 240 250
EILMKQLKDI VTTYEPELIW ADGDWMQLSN YWKSTEFLSW LYTNSSVKDT
260 270 280 290 300
VIVNDRWGSE CRDKNGGFYT GADHFNPYKL QSHKWENCAT IGYSYGYDEY
310 320 330 340 350
EQATDYQNAT ELIIDLVTTV ACGGNFLLDV GPDAQGTIPN NMVDRLLEIG
360 370 380 390 400
NWLSINSESI YGSSPWRVQN MTFNIWYTTN TTNGNVYAFV FELPDDGVLI
410 420 430 440 450
LSDPIGNNKT EATLLGLKGE KGVEVSLPIE STKPGITLNI PMVAPQDYPP
460
YVYVFRLTDV E
Length:461
Mass (Da):52,647
Last modified:July 1, 1989 - v1
Checksum:iCB33D0771FF4B516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07497 Genomic DNA. Translation: CAA68800.1.
AAFI02000012 Genomic DNA. Translation: EAL70088.1.
PIRiA30364.
RefSeqiXP_644263.1. XM_639171.1.

Genome annotation databases

EnsemblProtistsiDDB0185016; DDB0185016; DDB_G0274391.
GeneIDi8619691.
KEGGiddi:DDB_G0274391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07497 Genomic DNA. Translation: CAA68800.1.
AAFI02000012 Genomic DNA. Translation: EAL70088.1.
PIRiA30364.
RefSeqiXP_644263.1. XM_639171.1.

3D structure databases

ProteinModelPortaliP10901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0185016.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PRIDEiP10901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0185016; DDB0185016; DDB_G0274391.
GeneIDi8619691.
KEGGiddi:DDB_G0274391.

Organism-specific databases

dictyBaseiDDB_G0274391. alfA.

Phylogenomic databases

eggNOGiCOG3669.
InParanoidiP10901.
KOiK01206.
OMAiNDWADLF.
PhylomeDBiP10901.

Enzyme and pathway databases

BRENDAi3.2.1.51. 1939.

Miscellaneous databases

PROiP10901.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A developmentally regulated gene product from Dictyostelium discoideum shows high homology to human alpha-L-fucosidase."
    Mueller-Taubenberger A., Westphal M., Noegel A., Gerisch G.
    FEBS Lett. 246:185-192(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX2 and AX3.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiFUCO_DICDI
AccessioniPrimary (citable) accession number: P10901
Secondary accession number(s): Q554R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The maximum expression of alpha-L-fucosidase occurs during aggregation stage of dictyostelium discoideum.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.