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P10901

- FUCO_DICDI

UniProt

P10901 - FUCO_DICDI

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Protein

Alpha-L-fucosidase

Gene
alfA, DDB_G0274391
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei288 – 2881May be important for catalysis

GO - Molecular functioni

  1. 1,6-alpha-L-fucosidase activity Source: dictyBase
  2. alpha-L-fucosidase activity Source: dictyBase
  3. fucose binding Source: RefGenome

GO - Biological processi

  1. fucose metabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 1939.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
Name:alfA
ORF Names:DDB_G0274391
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274391. alfA.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: dictyBase
  2. lysosome Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 461443Alpha-L-fucosidasePRO_0000010317Add
BLAST

Proteomic databases

PRIDEiP10901.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0185016.

Structurei

3D structure databases

ProteinModelPortaliP10901.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
KOiK01206.
OMAiVGSICKH.
PhylomeDBiP10901.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10901-1 [UniParc]FASTAAdd to Basket

« Hide

MKMIIIFFIL LILNLIKSQQ YGPTWDQINS RPLPGWYDDV KFGIFIHFGI    50
YSVPAFANGG YAEWYWWTLK NPSSDGGATQ RYHEKEFGAN FTYQDFVSRF 100
DCRLFDANEW ASIIEKSGAK YVVLTSKHHE GYTLWNSEQS WNWNSVETGP 150
GIDIVGELTK SVKNMGLHMG LYHSLFEWFN PLYLADAETG KNPTTQVYVD 200
EILMKQLKDI VTTYEPELIW ADGDWMQLSN YWKSTEFLSW LYTNSSVKDT 250
VIVNDRWGSE CRDKNGGFYT GADHFNPYKL QSHKWENCAT IGYSYGYDEY 300
EQATDYQNAT ELIIDLVTTV ACGGNFLLDV GPDAQGTIPN NMVDRLLEIG 350
NWLSINSESI YGSSPWRVQN MTFNIWYTTN TTNGNVYAFV FELPDDGVLI 400
LSDPIGNNKT EATLLGLKGE KGVEVSLPIE STKPGITLNI PMVAPQDYPP 450
YVYVFRLTDV E 461
Length:461
Mass (Da):52,647
Last modified:July 1, 1989 - v1
Checksum:iCB33D0771FF4B516
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07497 Genomic DNA. Translation: CAA68800.1.
AAFI02000012 Genomic DNA. Translation: EAL70088.1.
PIRiA30364.
RefSeqiXP_644263.1. XM_639171.1.

Genome annotation databases

EnsemblProtistsiDDB0185016; DDB0185016; DDB_G0274391.
GeneIDi8619691.
KEGGiddi:DDB_G0274391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07497 Genomic DNA. Translation: CAA68800.1 .
AAFI02000012 Genomic DNA. Translation: EAL70088.1 .
PIRi A30364.
RefSeqi XP_644263.1. XM_639171.1.

3D structure databases

ProteinModelPortali P10901.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0185016.

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Proteomic databases

PRIDEi P10901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185016 ; DDB0185016 ; DDB_G0274391 .
GeneIDi 8619691.
KEGGi ddi:DDB_G0274391.

Organism-specific databases

dictyBasei DDB_G0274391. alfA.

Phylogenomic databases

eggNOGi COG3669.
KOi K01206.
OMAi VGSICKH.
PhylomeDBi P10901.

Enzyme and pathway databases

BRENDAi 3.2.1.51. 1939.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A developmentally regulated gene product from Dictyostelium discoideum shows high homology to human alpha-L-fucosidase."
    Mueller-Taubenberger A., Westphal M., Noegel A., Gerisch G.
    FEBS Lett. 246:185-192(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX2 and AX3.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiFUCO_DICDI
AccessioniPrimary (citable) accession number: P10901
Secondary accession number(s): Q554R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The maximum expression of alpha-L-fucosidase occurs during aggregation stage of dictyostelium discoideum.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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