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Protein

Cytochrome b561

Gene

CYB561

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeNote: Binds 2 heme groups non-covalently.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi92Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi110Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi122Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi161Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Protein family/group databases

TCDBi5.B.2.1.1. the eukaryotic cytochrome b561 (cytb561) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 252CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510261 – 252Cytochrome b561Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei248PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10897.
PRIDEiP10897.

Expressioni

Tissue specificityi

Expressed in the adrenal medulla and all brain regions, but not in visceral organs.

Gene expression databases

BgeeiENSBTAG00000020810.
ExpressionAtlasiP10897. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027732.

Structurei

3D structure databases

SMRiP10897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 221Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOGENOMiHOG000231043.
HOVERGENiHBG054164.
InParanoidiP10897.
KOiK08360.
TreeFamiTF314222.

Family and domain databases

InterProiView protein in InterPro
IPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
PANTHERiPTHR10106:SF23. PTHR10106:SF23. 1 hit.
PfamiView protein in Pfam
PF03188. Cytochrom_B561. 1 hit.
SMARTiView protein in SMART
SM00665. B561. 1 hit.
PROSITEiView protein in PROSITE
PS50939. CYTOCHROME_B561. 1 hit.

Sequencei

Sequence statusi: Complete.

P10897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPASPARA PGALPYYVAF SQLLGLIVVA MTGAWLGMYR GGIAWESALQ
60 70 80 90 100
FNVHPLCMII GLVFLQGDAL LVYRVFRNEA KRTTKVLHGL LHVFAFVIAL
110 120 130 140 150
VGLVAVFEHH RKKGYADLYS LHSWCGILVF ALFFAQWLVG FSFFLFPGAS
160 170 180 190 200
FSLRSRYRPQ HVFFGAAIFL LSVATALLGL KEALLFELGT KYSMFEPEGV
210 220 230 240 250
LANVLGLLLA TFATVILYIL TRADWKRPLQ AEEQALSMDF KTLTEGDSPS

SQ
Length:252
Mass (Da):27,904
Last modified:May 30, 2000 - v2
Checksum:iB64599D5C06AF969
GO

Sequence cautioni

The sequence CAA31274 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12783 mRNA. Translation: CAA31274.1. Different initiation.
BC120119 mRNA. Translation: AAI20120.1.
PIRiS01167.
RefSeqiNP_777262.1. NM_174837.2.
XP_005220876.1. XM_005220819.2.
XP_005220878.1. XM_005220821.3.
XP_010814617.1. XM_010816315.2.
UniGeneiBt.4360.

Genome annotation databases

EnsembliENSBTAT00000042727; ENSBTAP00000040358; ENSBTAG00000020810.
GeneIDi317663.
KEGGibta:317663.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCY561_BOVIN
AccessioniPrimary (citable) accession number: P10897
Secondary accession number(s): Q0P5F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 30, 2000
Last modified: July 5, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome