UniProtKB - P10897 (CY561_BOVIN)
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Protein
Cytochrome b561
Gene
CYB561
Organism
Bos taurus (Bovine)
Status
Functioni
Secretory vesicle-specific electron transport protein.
Cofactori
hemeNote: Binds 2 heme groups non-covalently.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 54 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 88 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 92 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 110 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 122 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 161 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ferric-chelate reductase activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- electron transport chain Source: InterPro
- oxidation-reduction process Source: GO_Central
Keywordsi
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Protein family/group databases
TCDBi | 5.B.2.1.1 the eukaryotic cytochrome b561 (cytb561) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b561Alternative name(s): Cytochrome b-561 |
Gene namesi | Name:CYB561 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:50257 CYB561 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 252 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000151026 | 1 – 252 | Cytochrome b561Add BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 250 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P10897 |
PRIDEi | P10897 |
PTM databases
iPTMneti | P10897 |
Expressioni
Tissue specificityi
Expressed in the adrenal medulla and all brain regions, but not in visceral organs.
Gene expression databases
Bgeei | ENSBTAG00000020810 |
ExpressionAtlasi | P10897 baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 221 | Cytochrome b561PROSITE-ProRule annotationAdd BLAST | 202 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1619 Eukaryota ENOG4111FKI LUCA |
GeneTreei | ENSGT00390000010986 |
HOGENOMi | HOG000231043 |
HOVERGENi | HBG054164 |
InParanoidi | P10897 |
KOi | K08360 |
TreeFami | TF314222 |
Family and domain databases
InterProi | View protein in InterPro IPR006593 Cyt_b561/ferric_Rdtase_TM IPR028837 Cytochrome_b561 |
PANTHERi | PTHR10106:SF14 PTHR10106:SF14, 1 hit |
Pfami | View protein in Pfam PF03188 Cytochrom_B561, 1 hit |
SMARTi | View protein in SMART SM00665 B561, 1 hit |
PROSITEi | View protein in PROSITE PS50939 CYTOCHROME_B561, 1 hit |
i Sequence
Sequence statusi: Complete.
P10897-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGPASPARA PGALPYYVAF SQLLGLIVVA MTGAWLGMYR GGIAWESALQ
60 70 80 90 100
FNVHPLCMII GLVFLQGDAL LVYRVFRNEA KRTTKVLHGL LHVFAFVIAL
110 120 130 140 150
VGLVAVFEHH RKKGYADLYS LHSWCGILVF ALFFAQWLVG FSFFLFPGAS
160 170 180 190 200
FSLRSRYRPQ HVFFGAAIFL LSVATALLGL KEALLFELGT KYSMFEPEGV
210 220 230 240 250
LANVLGLLLA TFATVILYIL TRADWKRPLQ AEEQALSMDF KTLTEGDSPS
SQ
Sequence cautioni
The sequence CAA31274 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12783 mRNA Translation: CAA31274.1 Different initiation. BC120119 mRNA Translation: AAI20120.1 |
PIRi | S01167 |
RefSeqi | NP_777262.1, NM_174837.2 XP_005220876.1, XM_005220819.2 XP_005220878.1, XM_005220821.3 XP_010814617.1, XM_010816315.2 |
UniGenei | Bt.4360 |
Genome annotation databases
Ensembli | ENSBTAT00000042727; ENSBTAP00000040358; ENSBTAG00000020810 |
GeneIDi | 317663 |
KEGGi | bta:317663 |
Similar proteinsi
Entry informationi
Entry namei | CY561_BOVIN | |
Accessioni | P10897Primary (citable) accession number: P10897 Secondary accession number(s): Q0P5F5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | May 30, 2000 | |
Last modified: | March 28, 2018 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |