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P10895

- PLCD1_BOVIN

UniProt

P10895 - PLCD1_BOVIN

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Gene
PLCD1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111 By similarity
Metal bindingi312 – 3121Calcium 1; catalytic By similarity
Metal bindingi341 – 3411Calcium 1; catalytic By similarity
Metal bindingi343 – 3431Calcium 1; catalytic By similarity
Active sitei356 – 3561 By similarity
Metal bindingi390 – 3901Calcium 1; catalytic By similarity
Binding sitei438 – 4381Substrate By similarity
Binding sitei440 – 4401Substrate By similarity
Binding sitei522 – 5221Substrate By similarity
Binding sitei549 – 5491Substrate By similarity
Metal bindingi651 – 6511Calcium 2; via carbonyl oxygen By similarity
Metal bindingi653 – 6531Calcium 2 By similarity
Metal bindingi677 – 6771Calcium 2 By similarity
Metal bindingi706 – 7061Calcium 3 By similarity
Metal bindingi707 – 7071Calcium 3; via carbonyl oxygen By similarity
Metal bindingi708 – 7081Calcium 3 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi153 – 164121 Reviewed predictionAdd
BLAST
Calcium bindingi189 – 200122 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. labyrinthine layer blood vessel development Source: Ensembl
  4. lipid catabolic process Source: UniProtKB-KW
  5. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_225102. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-delta-1
Phospholipase C-III
Short name:
PLC-III
Phospholipase C-delta-1
Short name:
PLC-delta-1
Gene namesi
Name:PLCD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7567561-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1PRO_0000088503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911O-linked (GlcNAc) By similarity
Glycosylationi193 – 1931O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP10895.

Structurei

3D structure databases

ProteinModelPortaliP10895.
SMRiP10895. Positions 12-130, 158-756.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 130110PHAdd
BLAST
Domaini140 – 17536EF-hand 1Add
BLAST
Domaini176 – 21136EF-hand 2Add
BLAST
Domaini296 – 440145PI-PLC X-boxAdd
BLAST
Domaini492 – 609118PI-PLC Y-boxAdd
BLAST
Domaini628 – 72093C2Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.
Contains 2 EF-hand domains.
Contains 1 PH domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00740000114979.
HOGENOMiHOG000006871.
HOVERGENiHBG053610.
InParanoidiP10895.
KOiK05857.
OMAiTSGQAFY.
OrthoDBiEOG7V49XT.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028391. PLC-delta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF80. PTHR10336:SF80. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00169. PH. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10895-1 [UniParc]FASTAAdd to Basket

« Hide

MDSGRDFLTL HGLQDDKDLQ ALLKGGQLLK VKSNSWRRER FYKLQEDCKT    50
IWQESRKVMR TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPENRCFSIV 100
FKDQRNTLDL IAPSPADAQH WVQGLGKIIH HSGSMDQQQK LRHWIHSCLR 150
KADKNKDNKM SFKELQNFLK ELNIQVDDSY ARKIFKECDH SQTDSLEDEE 200
IETFYKILTQ RKEIDRTFEE ATGSKETLSV DQLVTFLQHQ QREEEAGPAL 250
ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFDLA HRRVYQDMDQ 300
PLSHYLVSSS HNTYLLEDQL TGPSSTEAYI RALCKGCRCL ELDCWDGPNQ 350
EPIIYHGYTF TSKILFCDVV RAIRDYAFKA SPYPVILSLE NHCSLEQQRV 400
MARHLRTLLG PMLLDRPLDG VVTSLPSPEQ LRGKILLKGK KLGGLFPPGG 450
EGGPEATVVS DEDEAAEMED EAVRSQVQHK SKEDKLRLAK ELSDMVIYCK 500
SVHFRGFPSS GTSGQAFYEM SSFSENRALR LLQESGNSFV RHNVNHLSRI 550
YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGSEMDVYQ GRFLDNGACG 600
YVLKPAFLRD PNSTFNSRAL AHGPWWTPKR LNVRVISGQQ LPKVNKNKNS 650
IVDPKVTVEI HGVSRDVASR QTAVVTNNGF NPWWDTELEF EVAVPELALV 700
RFVVEDYDAS SKNDFIGQST IPLKSLKQGY RHIHLLSKNG DQHPSATLFV 750
KVALQD 756
Length:756
Mass (Da):86,073
Last modified:November 13, 2007 - v2
Checksum:iEBA47E8BAEE2D398
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911H → D in AAA30710. 1 Publication
Sequence conflicti664 – 6652SR → TG in AAA30710. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133304 mRNA. Translation: AAI33305.1.
M20638 mRNA. Translation: AAA30710.1.
PIRiC28821.
RefSeqiNP_001075045.1. NM_001081576.1.
XP_001256610.2. XM_001256609.4.
UniGeneiBt.4877.

Genome annotation databases

EnsembliENSBTAT00000052073; ENSBTAP00000049395; ENSBTAG00000037726.
GeneIDi281986.
790012.
KEGGibta:281986.
bta:790012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133304 mRNA. Translation: AAI33305.1 .
M20638 mRNA. Translation: AAA30710.1 .
PIRi C28821.
RefSeqi NP_001075045.1. NM_001081576.1.
XP_001256610.2. XM_001256609.4.
UniGenei Bt.4877.

3D structure databases

ProteinModelPortali P10895.
SMRi P10895. Positions 12-130, 158-756.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P10895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000052073 ; ENSBTAP00000049395 ; ENSBTAG00000037726 .
GeneIDi 281986.
790012.
KEGGi bta:281986.
bta:790012.

Organism-specific databases

CTDi 5333.

Phylogenomic databases

eggNOGi NOG149692.
GeneTreei ENSGT00740000114979.
HOGENOMi HOG000006871.
HOVERGENi HBG053610.
InParanoidi P10895.
KOi K05857.
OMAi TSGQAFY.
OrthoDBi EOG7V49XT.
TreeFami TF313216.

Enzyme and pathway databases

Reactomei REACT_225102. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi 20805854.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028391. PLC-delta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF80. PTHR10336:SF80. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00169. PH. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.
  2. "Cloning and sequence of multiple forms of phospholipase C."
    Suh P.-G., Ryu S.H., Moon K.H., Suh H.W., Rhee S.G.
    Cell 54:161-169(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 62-756.

Entry informationi

Entry nameiPLCD1_BOVIN
AccessioniPrimary (citable) accession number: P10895
Secondary accession number(s): A2VDM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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