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P10891

- DEFI_PROTE

UniProt

P10891 - DEFI_PROTE

Protein

Phormicin

Gene
N/A
Organism
Protophormia terraenovae (Northern blowfly) (Lucilia terraenovae)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Responsible for the anti Gram-positive activity of immune hemolymph of P.terraenovae.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Keywords - Biological processi

    Immunity, Innate immunity

    Protein family/group databases

    TCDBi1.C.47.1.2. the insect/fungal defensin (insect/fungal defensin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phormicin
    Alternative name(s):
    Insect defensin A/B
    OrganismiProtophormia terraenovae (Northern blowfly) (Lucilia terraenovae)
    Taxonomic identifieri34676 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeChrysomyinaeProtophormia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 54311 PublicationPRO_0000006748Add
    BLAST
    Chaini55 – 9440PhormicinPRO_0000006749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 841 PublicationPROSITE-ProRule annotation
    Disulfide bondi70 ↔ 901 PublicationPROSITE-ProRule annotation
    Disulfide bondi74 ↔ 921 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Structurei

    Secondary structure

    1
    94
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi68 – 7710
    Beta strandi86 – 883

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ICANMR-A55-94[»]
    ProteinModelPortaliP10891.
    SMRiP10891. Positions 55-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10891.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the invertebrate defensin family. Type 1 subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR017982. Defensin_insect.
    IPR001542. Defensin_invertebrate/fungal.
    IPR003614. Scorpion_toxin-like.
    [Graphical view]
    PfamiPF01097. Defensin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00271. DEFENSIN.
    SMARTiSM00505. Knot1. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10891-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFFMVFVVT FCLAVCFVSQ SLAIPADAAN DAHFVDGVQA LKEIEPELHG   50
    RYKRATCDLL SGTGINHSAC AAHCLLRGNR GGYCNGKGVC VCRN 94
    Length:94
    Mass (Da):10,110
    Last modified:November 1, 1991 - v2
    Checksum:iCE24ED83D7CBE6D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861G → R in defensin B.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55546 mRNA. Translation: CAA39152.1.
    PIRiS12558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55546 mRNA. Translation: CAA39152.1 .
    PIRi S12558.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ICA NMR - A 55-94 [» ]
    ProteinModelPortali P10891.
    SMRi P10891. Positions 55-94.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.47.1.2. the insect/fungal defensin (insect/fungal defensin) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P10891.

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR017982. Defensin_insect.
    IPR001542. Defensin_invertebrate/fungal.
    IPR003614. Scorpion_toxin-like.
    [Graphical view ]
    Pfami PF01097. Defensin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00271. DEFENSIN.
    SMARTi SM00505. Knot1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS51378. INVERT_DEFENSINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae."
      Dimarcq J.-L., Zachary D., Hoffmann J.A., Hoffmann D., Reichhart J.-M.
      EMBO J. 9:2507-2515(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides."
      Lambert J., Keppi E., Dimarcq J.-L., Wicker C., Reichhart J.-M., Dunbar B., Lepage P., van Dorsselaer A., Hoffmann J.A., Fothergill J., Hoffmann D.
      Proc. Natl. Acad. Sci. U.S.A. 86:262-266(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 55-94.
      Tissue: Hemolymph.
    3. Cited for: DISULFIDE BONDS.
    4. "Progress in multidimensional NMR investigations of peptide and protein 3-D structures in solution. From structure to functional aspects."
      Bonmatin J.-M., Genest M., Petit M.-C., Gincel E., Simorre J.-P., Cornet B., Gallet X., Caille A., Labbe H., Vovelle F., Ptak M.
      Biochimie 74:825-836(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    5. "Refined three-dimensional solution structure of insect defensin A."
      Cornet B., Bonmatin J.-M., Hetru C., Hoffmann J.A., Ptak M., Vovelle F.
      Structure 3:435-448(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 55-94.

    Entry informationi

    Entry nameiDEFI_PROTE
    AccessioniPrimary (citable) accession number: P10891
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3