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P10891

- DEFI_PROTE

UniProt

P10891 - DEFI_PROTE

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Protein

Phormicin

Gene
N/A
Organism
Protophormia terraenovae (Northern blowfly) (Lucilia terraenovae)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the anti Gram-positive activity of immune hemolymph of P.terraenovae.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.47.1.2. the insect/fungal defensin (insect/fungal defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phormicin
Alternative name(s):
Insect defensin A/B
OrganismiProtophormia terraenovae (Northern blowfly) (Lucilia terraenovae)
Taxonomic identifieri34676 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeChrysomyinaeProtophormia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 54311 PublicationPRO_0000006748Add
BLAST
Chaini55 – 9440PhormicinPRO_0000006749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 841 PublicationPROSITE-ProRule annotation
Disulfide bondi70 ↔ 901 PublicationPROSITE-ProRule annotation
Disulfide bondi74 ↔ 921 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi68 – 7710
Beta strandi86 – 883

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ICANMR-A55-94[»]
ProteinModelPortaliP10891.
SMRiP10891. Positions 55-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10891.

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR017982. Defensin_insect.
IPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
PRINTSiPR00271. DEFENSIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10891 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFFMVFVVT FCLAVCFVSQ SLAIPADAAN DAHFVDGVQA LKEIEPELHG
60 70 80 90
RYKRATCDLL SGTGINHSAC AAHCLLRGNR GGYCNGKGVC VCRN
Length:94
Mass (Da):10,110
Last modified:November 1, 1991 - v2
Checksum:iCE24ED83D7CBE6D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861G → R in defensin B.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55546 mRNA. Translation: CAA39152.1.
PIRiS12558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55546 mRNA. Translation: CAA39152.1 .
PIRi S12558.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ICA NMR - A 55-94 [» ]
ProteinModelPortali P10891.
SMRi P10891. Positions 55-94.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.C.47.1.2. the insect/fungal defensin (insect/fungal defensin) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P10891.

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR017982. Defensin_insect.
IPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view ]
Pfami PF01097. Defensin_2. 1 hit.
[Graphical view ]
PRINTSi PR00271. DEFENSIN.
SMARTi SM00505. Knot1. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae."
    Dimarcq J.-L., Zachary D., Hoffmann J.A., Hoffmann D., Reichhart J.-M.
    EMBO J. 9:2507-2515(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides."
    Lambert J., Keppi E., Dimarcq J.-L., Wicker C., Reichhart J.-M., Dunbar B., Lepage P., van Dorsselaer A., Hoffmann J.A., Fothergill J., Hoffmann D.
    Proc. Natl. Acad. Sci. U.S.A. 86:262-266(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 55-94.
    Tissue: Hemolymph.
  3. Cited for: DISULFIDE BONDS.
  4. "Progress in multidimensional NMR investigations of peptide and protein 3-D structures in solution. From structure to functional aspects."
    Bonmatin J.-M., Genest M., Petit M.-C., Gincel E., Simorre J.-P., Cornet B., Gallet X., Caille A., Labbe H., Vovelle F., Ptak M.
    Biochimie 74:825-836(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "Refined three-dimensional solution structure of insect defensin A."
    Cornet B., Bonmatin J.-M., Hetru C., Hoffmann J.A., Ptak M., Vovelle F.
    Structure 3:435-448(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 55-94.

Entry informationi

Entry nameiDEFI_PROTE
AccessioniPrimary (citable) accession number: P10891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3