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Protein

C-X-C motif chemokine 2

Gene

Cxcl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Macrophage inflammatory protein 2
Short name:
MIP2
Gene namesi
Name:Cxcl2
Synonyms:Mip-2, Mip2, Scyb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1340094. Cxcl2.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000506128 – 100C-X-C motif chemokine 2Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62
Disulfide bondi38 ↔ 78

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10889.
PRIDEiP10889.

Miscellaneous databases

PMAP-CutDBP10889.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058427.
CleanExiMM_CXCL2.
ExpressionAtlasiP10889. baseline and differential.
GenevisibleiP10889. MM.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203135. 1 interactor.
DIPiDIP-61570N.
STRINGi10090.ENSMUSP00000074885.

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 35Combined sources4
Beta strandi37 – 39Combined sources3
Beta strandi42 – 44Combined sources3
Helixi47 – 49Combined sources3
Beta strandi50 – 56Combined sources7
Turni60 – 62Combined sources3
Beta strandi66 – 71Combined sources6
Beta strandi76 – 79Combined sources4
Helixi84 – 94Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI2NMR-A/B28-100[»]
3N52X-ray1.90A/B/C/D28-100[»]
ProteinModelPortaliP10889.
SMRiP10889.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10889.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP10889.
KOiK05505.
OMAiCINTHSK.
OrthoDBiEOG091G14TE.
PhylomeDBiP10889.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLK TLPRVDFKNI
60 70 80 90 100
QSLSVTPPGP HCAQTEVIAT LKGGQKVCLD PEAPLVQKII QKILNKGKAN
Length:100
Mass (Da):10,621
Last modified:February 1, 1991 - v2
Checksum:iB9EF0A3218EE92B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53798 mRNA. Translation: CAA37807.1.
CCDSiCCDS39144.1.
PIRiJH0200.
RefSeqiNP_033166.1. NM_009140.2.
UniGeneiMm.4979.

Genome annotation databases

EnsembliENSMUST00000075433; ENSMUSP00000074885; ENSMUSG00000058427.
GeneIDi20310.
KEGGimmu:20310.
UCSCiuc008ybm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53798 mRNA. Translation: CAA37807.1.
CCDSiCCDS39144.1.
PIRiJH0200.
RefSeqiNP_033166.1. NM_009140.2.
UniGeneiMm.4979.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI2NMR-A/B28-100[»]
3N52X-ray1.90A/B/C/D28-100[»]
ProteinModelPortaliP10889.
SMRiP10889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203135. 1 interactor.
DIPiDIP-61570N.
STRINGi10090.ENSMUSP00000074885.

Proteomic databases

PaxDbiP10889.
PRIDEiP10889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075433; ENSMUSP00000074885; ENSMUSG00000058427.
GeneIDi20310.
KEGGimmu:20310.
UCSCiuc008ybm.1. mouse.

Organism-specific databases

CTDi2920.
MGIiMGI:1340094. Cxcl2.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP10889.
KOiK05505.
OMAiCINTHSK.
OrthoDBiEOG091G14TE.
PhylomeDBiP10889.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP10889.
PMAP-CutDBP10889.
PROiP10889.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058427.
CleanExiMM_CXCL2.
ExpressionAtlasiP10889. baseline and differential.
GenevisibleiP10889. MM.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL2_MOUSE
AccessioniPrimary (citable) accession number: P10889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.