P10888 (COX41_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1

Gene names

Name:	Cox4i1
Synonyms:	Cox4, Cox4a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	response to nutrient Inferred from expression pattern PubMed 18725894. Source: RGD
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion Ref.7
	Chain	23 – 169	147	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Ref.1		PRO_0000006088
Amino acid modifications
	Modified residue	53	1	N6-acetyllysine By similarity
	Modified residue	60	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10888 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: F0187C76B7A1A9FE	FASTA	169	19,515
	10 20 30 40 50 60 MLATRALSLI GKRAISTSVC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA HVKLLSASQK 70 80 90 100 110 120 ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNKGTNEW KTVVGLAMFF IGFTALVLIW 130 140 150 160 EKSYVYGPIP HTFDRDWVAM QTKRMLDMKV NPIQGFSAKW DYNKNEWKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of cDNA for rat brain and liver cytochrome c oxidase subunit IV." Goto Y., Amuro N., Okazaki T. Nucleic Acids Res. 17:2851-2851(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"Nucleotide sequence of cDNA encoding subunit IV of cytochrome c oxidase from fetal rat liver." Gopalan G., Droste M., Kadenbach B. Nucleic Acids Res. 17:4376-4376(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Liver.
[3]	"Structural organization of the rat cytochrome c oxidase subunit IV gene." Yamada M., Amuro N., Goto Y., Okazaki T. J. Biol. Chem. 265:7687-7692(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete nucleotide sequence of the gene encoding rat cytochrome c oxidase subunit IV." Amuro N., Yamada M., Goto Y., Okazaki T. Nucleic Acids Res. 18:3992-3992(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The rat cytochrome c oxidase subunit IV gene family: tissue-specific and hormonal differences in subunit IV and cytochrome c mRNA expression." Virbasius J.V., Scarpulla R.C. Nucleic Acids Res. 18:6581-6586(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform." Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G. Eur. J. Biochem. 230:235-241(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-32. Strain: Wistar. Tissue: Liver.
[8]	Lubec G., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 68-75 AND 150-159, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14209 mRNA. Translation: CAA32426.1. X15029 mRNA. Translation: CAA33133.1. J05425 Genomic DNA. Translation: AAA40949.1. X54081 Genomic DNA. Translation: CAA38018.1. BC084719 mRNA. Translation: AAH84719.1.
IPI	IPI00194222.
PIR	A35209. S65374.
RefSeq	NP_058898.1. NM_017202.1.
UniGene	Rn.2528.
3D structure databases
ProteinModelPortal	P10888.
SMR	P10888. Positions 26-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	P10888. 1 interaction.
STRING	10116.ENSRNOP00000024033.
PTM databases
PhosphoSite	P10888.
Proteomic databases
PaxDb	P10888.
PRIDE	P10888.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000024033; ENSRNOP00000024033; ENSRNOG00000017817.
GeneID	29445.
KEGG	rno:29445.
UCSC	RGD:68374. rat.
Organism-specific databases
CTD	1327.
RGD	68374. Cox4i1.
Phylogenomic databases
eggNOG	NOG276242.
GeneTree	ENSGT00390000002407.
HOGENOM	HOG000231486.
HOVERGEN	HBG051087.
InParanoid	P10888.
KO	K02263.
OrthoDB	EOG48SGV7.
Gene expression databases
Genevestigator	P10888.
GermOnline	ENSRNOG00000017817. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.442.10. 1 hit.
InterPro	IPR013288. Cyt_c_oxidase_su4. IPR004203. Cyt_c_oxidase_su4_fam. [Graphical view]
Pfam	PF02936. COX4. 1 hit. [Graphical view]
PRINTS	PR01873. CYTCOXIDASE4.
SUPFAM	SSF81406. COX4. 1 hit.
ProtoNet	Search...
Other
NextBio	609201.

Entry information

Entry name

COX41_RAT

Accession

Primary (citable) accession number: P10888

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program