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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

Cox4i1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  • response to nutrient Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:Cox4i1
Synonyms:Cox4, Cox4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi68374. Cox4i1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion1 PublicationAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; alternateBy similarity
Modified residuei29 – 291N6-succinyllysine; alternateBy similarity
Modified residuei53 – 531N6-acetyllysineBy similarity
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei58 – 581PhosphoserineCombined sources
Modified residuei60 – 601N6-acetyllysine; alternateBy similarity
Modified residuei60 – 601N6-succinyllysine; alternateBy similarity
Modified residuei67 – 671N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10888.
PRIDEiP10888.

PTM databases

iPTMnetiP10888.
PhosphoSiteiP10888.
SwissPalmiP10888.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017817.
GenevisibleiP10888. RN.

Interactioni

Protein-protein interaction databases

BioGridi248090. 1 interaction.
IntActiP10888. 1 interaction.
MINTiMINT-4587177.
STRINGi10116.ENSRNOP00000024033.

Structurei

3D structure databases

ProteinModelPortaliP10888.
SMRiP10888. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP10888.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
PhylomeDBiP10888.
TreeFamiTF105061.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRALSLI GKRAISTSVC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKLLSASQK ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNKGTNEW
110 120 130 140 150
KTVVGLAMFF IGFTALVLIW EKSYVYGPIP HTFDRDWVAM QTKRMLDMKV
160
NPIQGFSAKW DYNKNEWKK
Length:169
Mass (Da):19,515
Last modified:July 1, 1989 - v1
Checksum:iF0187C76B7A1A9FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14209 mRNA. Translation: CAA32426.1.
X15029 mRNA. Translation: CAA33133.1.
J05425 Genomic DNA. Translation: AAA40949.1.
X54081 Genomic DNA. Translation: CAA38018.1.
BC084719 mRNA. Translation: AAH84719.1.
PIRiA35209.
S65374.
RefSeqiNP_058898.1. NM_017202.1.
UniGeneiRn.2528.

Genome annotation databases

EnsembliENSRNOT00000024033; ENSRNOP00000024033; ENSRNOG00000017817.
GeneIDi29445.
KEGGirno:29445.
UCSCiRGD:68374. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14209 mRNA. Translation: CAA32426.1.
X15029 mRNA. Translation: CAA33133.1.
J05425 Genomic DNA. Translation: AAA40949.1.
X54081 Genomic DNA. Translation: CAA38018.1.
BC084719 mRNA. Translation: AAH84719.1.
PIRiA35209.
S65374.
RefSeqiNP_058898.1. NM_017202.1.
UniGeneiRn.2528.

3D structure databases

ProteinModelPortaliP10888.
SMRiP10888. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248090. 1 interaction.
IntActiP10888. 1 interaction.
MINTiMINT-4587177.
STRINGi10116.ENSRNOP00000024033.

PTM databases

iPTMnetiP10888.
PhosphoSiteiP10888.
SwissPalmiP10888.

Proteomic databases

PaxDbiP10888.
PRIDEiP10888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024033; ENSRNOP00000024033; ENSRNOG00000017817.
GeneIDi29445.
KEGGirno:29445.
UCSCiRGD:68374. rat.

Organism-specific databases

CTDi1327.
RGDi68374. Cox4i1.

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP10888.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
PhylomeDBiP10888.
TreeFamiTF105061.

Miscellaneous databases

PROiP10888.

Gene expression databases

BgeeiENSRNOG00000017817.
GenevisibleiP10888. RN.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX41_RAT
AccessioniPrimary (citable) accession number: P10888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.