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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

Cox4i1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  • response to nutrient Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:Cox4i1
Synonyms:Cox4, Cox4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi68374 Cox4i1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
ChainiPRO_000000608823 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10888
PRIDEiP10888

PTM databases

CarbonylDBiP10888
iPTMnetiP10888
PhosphoSitePlusiP10888
SwissPalmiP10888

Expressioni

Gene expression databases

BgeeiENSRNOG00000017817
GenevisibleiP10888 RN

Interactioni

Protein-protein interaction databases

BioGridi248090, 1 interactor
CORUMiP10888
IntActiP10888, 1 interactor
STRINGi10116.ENSRNOP00000024033

Structurei

3D structure databases

ProteinModelPortaliP10888
SMRiP10888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOGENOMiHOG000231486
HOVERGENiHBG051087
InParanoidiP10888
KOiK02263
OMAiAMQTKRM
OrthoDBiEOG091G0XDH
PhylomeDBiP10888
TreeFamiTF105061

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRALSLI GKRAISTSVC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKLLSASQK ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNKGTNEW
110 120 130 140 150
KTVVGLAMFF IGFTALVLIW EKSYVYGPIP HTFDRDWVAM QTKRMLDMKV
160
NPIQGFSAKW DYNKNEWKK
Length:169
Mass (Da):19,515
Last modified:July 1, 1989 - v1
Checksum:iF0187C76B7A1A9FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14209 mRNA Translation: CAA32426.1
X15029 mRNA Translation: CAA33133.1
J05425 Genomic DNA Translation: AAA40949.1
X54081 Genomic DNA Translation: CAA38018.1
BC084719 mRNA Translation: AAH84719.1
PIRiA35209
S65374
RefSeqiNP_058898.1, NM_017202.1
UniGeneiRn.2528

Genome annotation databases

EnsembliENSRNOT00000024033; ENSRNOP00000024033; ENSRNOG00000017817
GeneIDi29445
KEGGirno:29445
UCSCiRGD:68374 rat

Similar proteinsi

Entry informationi

Entry nameiCOX41_RAT
AccessioniPrimary (citable) accession number: P10888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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