P10881 (LA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lupus La protein homolog

Alternative name(s):
La autoantigen homolog
La ribonucleoprotein

Gene names

Name:

SSB

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subunit structure	Interacts with DDX15. May interact with RUFY1 By similarity.
Subcellular location	Nucleus Probable.
Post-translational modification	Phosphorylated in the C-terminal part of the protein.
Sequence similarities	Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell ribonucleoprotein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Lupus La protein homolog		PRO_0000207598
Regions
	Domain	7 – 99	93	HTH La-type RNA-binding
	Domain	111 – 187	77	RRM
Amino acid modifications
	Modified residue	116	1	N6-acetyllysine By similarity
	Modified residue	128	1	N6-acetyllysine By similarity
	Modified residue	328	1	N6-acetyllysine By similarity
	Modified residue	360	1	N6-acetyllysine By similarity
	Modified residue	366	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	76	1	K → E in CAA31986. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P10881 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: B918FDB174232E06	FASTA	404	46,534
	10 20 30 40 50 60 MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR 70 80 90 100 110 120 LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT 130 140 150 160 170 180 DAALDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFAVFDS IESAKKFVET PGQKYKDTDL 190 200 210 220 230 240 LILFKEDYFT KKNEERKQNK MEAKLRAKQE QEEKQKLAEN AEMKSLEEKI GCLLKFSGDL 250 260 270 280 290 300 DDQTCREDLH TLFSNHGEIK WIHFVRGAKE GIILFKEKAK EALDKAKEAN NGNLQLRNKE 310 320 330 340 350 360 VTWEVLEGDV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQAGS AKGKVQFQGK 370 380 390 400 KTKFDSDDER DENGASRAVK RAREETDKEP PSKQQKTENG AGDQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding." Chan E.K.L., Sullivan K.F., Tan E.M. Nucleic Acids Res. 17:2233-2244(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13698 mRNA. Translation: CAA31986.1. BC103234 mRNA. Translation: AAI03235.1.
IPI	IPI00687044.
PIR	S03849.
RefSeq	NP_788838.1. NM_176665.2.
UniGene	Bt.15513.
3D structure databases
ProteinModelPortal	P10881.
SMR	P10881. Positions 1-202, 225-334.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000011484.
Proteomic databases
PaxDb	P10881.
PRIDE	P10881.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000011484; ENSBTAP00000011484; ENSBTAG00000008716.
GeneID	338071.
KEGG	bta:338071.
Organism-specific databases
CTD	6741.
Phylogenomic databases
eggNOG	COG5193.
GeneTree	ENSGT00530000063464.
HOGENOM	HOG000006947.
HOVERGEN	HBG001407.
KO	K11090.
OMA	ENAEMKS.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.30.70.330. 2 hits.
InterPro	IPR002344. Lupus_La. IPR006630. Lupus_La_RNA-bd. IPR012677. Nucleotide-bd_a/b_plait. IPR014886. RRM_3. IPR000504. RRM_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF05383. La. 1 hit. PF00076. RRM_1. 1 hit. PF08777. RRM_3. 1 hit. [Graphical view]
PRINTS	PR00302. LUPUSLA.
SMART	SM00715. LA. 1 hit. SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20812521.

Entry information

Entry name

LA_BOVIN

Accession

Primary (citable) accession number: P10881
Secondary accession number(s): Q3ZBL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program