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P10881

- LA_BOVIN

UniProt

P10881 - LA_BOVIN

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Protein

Lupus La protein homolog

Gene

SSB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_209748. RNA Polymerase III Abortive And Retractive Initiation.
REACT_224876. RNA Polymerase III Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:SSB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Lupus La protein homologPRO_0000207598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei328 – 3281N6-acetyllysineBy similarity
Modified residuei341 – 3411N6-acetyllysineBy similarity
Modified residuei360 – 3601N6-acetyllysineBy similarity
Modified residuei366 – 3661PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated in the C-terminal part of the protein.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10881.
PRIDEiP10881.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011484.

Structurei

3D structure databases

ProteinModelPortaliP10881.
SMRiP10881. Positions 1-202, 225-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18777RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5193.
GeneTreeiENSGT00760000119379.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP10881.
KOiK11090.
OMAiSHGEIKW.
OrthoDBiEOG7C5M90.
TreeFamiTF314476.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10881-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DAALDDIKEW LEDKGQVLNI QMRRTLHKAF
160 170 180 190 200
KGSIFAVFDS IESAKKFVET PGQKYKDTDL LILFKEDYFT KKNEERKQNK
210 220 230 240 250
MEAKLRAKQE QEEKQKLAEN AEMKSLEEKI GCLLKFSGDL DDQTCREDLH
260 270 280 290 300
TLFSNHGEIK WIHFVRGAKE GIILFKEKAK EALDKAKEAN NGNLQLRNKE
310 320 330 340 350
VTWEVLEGDV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQAGS
360 370 380 390 400
AKGKVQFQGK KTKFDSDDER DENGASRAVK RAREETDKEP PSKQQKTENG

AGDQ
Length:404
Mass (Da):46,534
Last modified:April 3, 2007 - v2
Checksum:iB918FDB174232E06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761K → E in CAA31986. (PubMed:2468131)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13698 mRNA. Translation: CAA31986.1.
BC103234 mRNA. Translation: AAI03235.1.
PIRiS03849.
RefSeqiNP_788838.1. NM_176665.2.
XP_005202366.1. XM_005202309.1.
UniGeneiBt.15513.

Genome annotation databases

EnsembliENSBTAT00000011484; ENSBTAP00000011484; ENSBTAG00000008716.
GeneIDi338071.
KEGGibta:338071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13698 mRNA. Translation: CAA31986.1 .
BC103234 mRNA. Translation: AAI03235.1 .
PIRi S03849.
RefSeqi NP_788838.1. NM_176665.2.
XP_005202366.1. XM_005202309.1.
UniGenei Bt.15513.

3D structure databases

ProteinModelPortali P10881.
SMRi P10881. Positions 1-202, 225-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000011484.

Proteomic databases

PaxDbi P10881.
PRIDEi P10881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011484 ; ENSBTAP00000011484 ; ENSBTAG00000008716 .
GeneIDi 338071.
KEGGi bta:338071.

Organism-specific databases

CTDi 6741.

Phylogenomic databases

eggNOGi COG5193.
GeneTreei ENSGT00760000119379.
HOGENOMi HOG000006947.
HOVERGENi HBG001407.
InParanoidi P10881.
KOi K11090.
OMAi SHGEIKW.
OrthoDBi EOG7C5M90.
TreeFami TF314476.

Enzyme and pathway databases

Reactomei REACT_209748. RNA Polymerase III Abortive And Retractive Initiation.
REACT_224876. RNA Polymerase III Transcription Termination.

Miscellaneous databases

NextBioi 20812521.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProi IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view ]
PRINTSi PR00302. LUPUSLA.
SMARTi SM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding."
    Chan E.K.L., Sullivan K.F., Tan E.M.
    Nucleic Acids Res. 17:2233-2244(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiLA_BOVIN
AccessioniPrimary (citable) accession number: P10881
Secondary accession number(s): Q3ZBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3