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P10881 (LA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene names
Name:SSB
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Subunit structure

Interacts with DDX15. May interact with RUFY1 By similarity.

Subcellular location

Nucleus Probable.

Post-translational modification

Phosphorylated in the C-terminal part of the protein.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandRNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Lupus La protein homolog
PRO_0000207598

Regions

Domain7 – 9993HTH La-type RNA-binding
Domain111 – 18777RRM

Amino acid modifications

Modified residue1161N6-acetyllysine By similarity
Modified residue1281N6-acetyllysine By similarity
Modified residue3281N6-acetyllysine By similarity
Modified residue3411N6-acetyllysine By similarity
Modified residue3601N6-acetyllysine By similarity
Modified residue3661Phosphoserine By similarity

Experimental info

Sequence conflict761K → E in CAA31986. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10881 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: B918FDB174232E06

FASTA40446,534
        10         20         30         40         50         60 
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR 

        70         80         90        100        110        120 
LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT 

       130        140        150        160        170        180 
DAALDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFAVFDS IESAKKFVET PGQKYKDTDL 

       190        200        210        220        230        240 
LILFKEDYFT KKNEERKQNK MEAKLRAKQE QEEKQKLAEN AEMKSLEEKI GCLLKFSGDL 

       250        260        270        280        290        300 
DDQTCREDLH TLFSNHGEIK WIHFVRGAKE GIILFKEKAK EALDKAKEAN NGNLQLRNKE 

       310        320        330        340        350        360 
VTWEVLEGDV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQAGS AKGKVQFQGK 

       370        380        390        400 
KTKFDSDDER DENGASRAVK RAREETDKEP PSKQQKTENG AGDQ 

« Hide

References

« Hide 'large scale' references
[1]"Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding."
Chan E.K.L., Sullivan K.F., Tan E.M.
Nucleic Acids Res. 17:2233-2244(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13698 mRNA. Translation: CAA31986.1.
BC103234 mRNA. Translation: AAI03235.1.
PIRS03849.
RefSeqNP_788838.1. NM_176665.2.
XP_005202366.1. XM_005202309.1.
UniGeneBt.15513.

3D structure databases

ProteinModelPortalP10881.
SMRP10881. Positions 1-202, 225-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011484.

Proteomic databases

PaxDbP10881.
PRIDEP10881.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011484; ENSBTAP00000011484; ENSBTAG00000008716.
GeneID338071.
KEGGbta:338071.

Organism-specific databases

CTD6741.

Phylogenomic databases

eggNOGCOG5193.
GeneTreeENSGT00750000117664.
HOGENOMHOG000006947.
HOVERGENHBG001407.
KOK11090.
OMASHGEIKW.
OrthoDBEOG7C5M90.
TreeFamTF314476.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSPR00302. LUPUSLA.
SMARTSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20812521.

Entry information

Entry nameLA_BOVIN
AccessionPrimary (citable) accession number: P10881
Secondary accession number(s): Q3ZBL2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families