Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10870

- SNF3_YEAST

UniProt

P10870 - SNF3_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

High-affinity glucose transporter SNF3

Gene

SNF3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter. Can function as a negative regulator of glucose transport. SNF3 is involved as well in the transport of mannose and fructose. Serves as a sensor that generates an intracellular signal in the presence of low level of glucose. Inhibition of RGT1 by low levels of glucose, and hence induction of HTX2 and HTX4 expression, requires SNF3.

GO - Molecular functioni

  1. glucose binding Source: SGD
  2. receptor activity Source: SGD
  3. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. detection of glucose Source: SGD
  2. fructose transport Source: SGD
  3. glucose transport Source: SGD
  4. mannose transport Source: SGD
  5. negative regulation of meiosis Source: SGD
  6. signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29579-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter SNF3
Gene namesi
Name:SNF3
Ordered Locus Names:YDL194W
ORF Names:D1234
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL194w.
SGDiS000002353. SNF3.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi112 – 1121G → D in SNF3-142. 1 Publication
Mutagenesisi153 – 1531G → R in SNF3-72. 1 Publication
Mutagenesisi229 – 2291R → K in SNF3-1; constitutively signaling glucose receptor. 1 Publication
Mutagenesisi402 – 4021V → I in SNF3-39. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884High-affinity glucose transporter SNF3PRO_0000050390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Glucose-repressible.

Gene expression databases

GenevestigatoriP10870.

Interactioni

Protein-protein interaction databases

BioGridi31851. 30 interactions.
IntActiP10870. 2 interactions.
STRINGi4932.YDL194W.

Structurei

3D structure databases

ProteinModelPortaliP10870.
SMRiP10870. Positions 100-556.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9797CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini119 – 14325ExtracellularSequence AnalysisAdd
BLAST
Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini200 – 2023ExtracellularSequence Analysis
Topological domaini224 – 2296CytoplasmicSequence Analysis
Topological domaini251 – 26414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini286 – 35873CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini380 – 39112ExtracellularSequence AnalysisAdd
BLAST
Topological domaini413 – 4197CytoplasmicSequence Analysis
Topological domaini441 – 45111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini473 – 48816CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini510 – 52112ExtracellularSequence AnalysisAdd
BLAST
Topological domaini543 – 884342CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei359 – 37921Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei392 – 41221Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei420 – 44021Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei489 – 50921Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei522 – 54221Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

The C-terminal cytoplasmic domain seems to be important for SNF3 regulatory function.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP10870.
KOiK08139.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNSNSSSE TLRQEKQGFL DKALQRVKGI ALRRNNSNKD HTTDDTTGSI
60 70 80 90 100
RTPTSLQRQN SDRQSNMTSV FTDDISTIDD NSILFSEPPQ KQSMMMSICV
110 120 130 140 150
GVFVAVGGFL FGYDTGLINS ITSMNYVKSH VAPNHDSFTA QQMSILVSFL
160 170 180 190 200
SLGTFFGALT APFISDSYGR KPTIIFSTIF IFSIGNSLQV GAGGITLLIV
210 220 230 240 250
GRVISGIGIG AISAVVPLYQ AEATHKSLRG AIISTYQWAI TWGLLVSSAV
260 270 280 290 300
SQGTHARNDA SSYRIPIGLQ YVWSSFLAIG MFFLPESPRY YVLKDKLDEA
310 320 330 340 350
AKSLSFLRGV PVHDSGLLEE LVEIKATYDY EASFGSSNFI DCFISSKSRP
360 370 380 390 400
KQTLRMFTGI ALQAFQQFSG INFIFYYGVN FFNKTGVSNS YLVSFITYAV
410 420 430 440 450
NVVFNVPGLF FVEFFGRRKV LVVGGVIMTI ANFIVAIVGC SLKTVAAAKV
460 470 480 490 500
MIAFICLFIA AFSATWGGVV WVISAELYPL GVRSKCTAIC AAANWLVNFI
510 520 530 540 550
CALITPYIVD TGSHTSSLGA KIFFIWGSLN AMGVIVVYLT VYETKGLTLE
560 570 580 590 600
EIDELYIKSS TGVVSPKFNK DIRERALKFQ YDPLQRLEDG KNTFVAKRNN
610 620 630 640 650
FDDETPRNDF RNTISGEIDH SPNQKEVHSI PERVDIPTST EILESPNKSS
660 670 680 690 700
GMTVPVSPSL QDVPIPQTTE PAEIRTKYVD LGNGLGLNTY NRGPPSLSSD
710 720 730 740 750
SSEDYTEDEI GGPSSQGDQS NRSTMNDIND YMARLIHSTS TASNTTDKFS
760 770 780 790 800
GNQSTLRYHT ASSHSDTTEE DSNLMDLGNG LALNAYNRGP PSILMNSSDE
810 820 830 840 850
EANGGETSDN LNTAQDLAGM KERMAQFAQS YIDKRGGLEP ETQSNILSTS
860 870 880
LSVMADTNEH NNEILHSSEE NATNQPVNEN NDLK
Length:884
Mass (Da):96,719
Last modified:October 3, 2006 - v3
Checksum:i8E2A5A1A7739344F
GO

Sequence cautioni

The sequence CAA58253.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03246 Genomic DNA. Translation: AAA35060.1.
X83276 Genomic DNA. Translation: CAA58253.1. Different initiation.
Z74242 Genomic DNA. Translation: CAA98771.1.
BK006938 Genomic DNA. Translation: DAA11669.1.
PIRiA31928.
RefSeqiNP_010087.1. NM_001180254.1.

Genome annotation databases

EnsemblFungiiYDL194W; YDL194W; YDL194W.
GeneIDi851333.
KEGGisce:YDL194W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03246 Genomic DNA. Translation: AAA35060.1 .
X83276 Genomic DNA. Translation: CAA58253.1 . Different initiation.
Z74242 Genomic DNA. Translation: CAA98771.1 .
BK006938 Genomic DNA. Translation: DAA11669.1 .
PIRi A31928.
RefSeqi NP_010087.1. NM_001180254.1.

3D structure databases

ProteinModelPortali P10870.
SMRi P10870. Positions 100-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31851. 30 interactions.
IntActi P10870. 2 interactions.
STRINGi 4932.YDL194W.

Protein family/group databases

TCDBi 2.A.1.1.17. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL194W ; YDL194W ; YDL194W .
GeneIDi 851333.
KEGGi sce:YDL194W.

Organism-specific databases

CYGDi YDL194w.
SGDi S000002353. SNF3.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00720000108754.
HOGENOMi HOG000202870.
InParanoidi P10870.
KOi K08139.
OrthoDBi EOG73JM4H.

Enzyme and pathway databases

BioCyci YEAST:G3O-29579-MONOMER.

Miscellaneous databases

NextBioi 968396.

Gene expression databases

Genevestigatori P10870.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein."
    Celenza J.L., Marshall-Carlson L., Carlson M.
    Proc. Natl. Acad. Sci. U.S.A. 85:2130-2134(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. "The sequence of 23 kb surrounding the SNF3 locus on the left arm of yeast chromosome IV reveals the location of five known genes and characterizes at least six new open reading frames including putative genes for ribosomal protein L35 and a sugar transport protein."
    Verhasselt P., Voet M., Mathys J., Volckaert G.
    Yeast 12:1065-1070(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiae."
    Marshall-Carlson L., Celenza J.L., Laurent B.C., Carlson M.
    Mol. Cell. Biol. 10:1105-1115(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF GLY-112; GLY-153; ARG-229 AND VAL-402.
  6. "The C-terminal domain of Snf3p is sufficient to complement the growth defect of snf3 null mutations in Saccharomyces cerevisiae: SNF3 functions in glucose recognition."
    Coons D.M., Vagnoli P., Bisson L.F.
    Yeast 13:9-20(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNF3_YEAST
AccessioniPrimary (citable) accession number: P10870
Secondary accession number(s): D6VRF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3