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P10866

- HN_MUMPR

UniProt

P10866 - HN_MUMPR

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Mumps virus (strain RW) (MuV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiMumps virus (strain RW) (MuV)
Taxonomic identifieri11172 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Hemagglutinin-neuraminidasePRO_0000142604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi329 – 3291N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi507 – 5071N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP10866.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434IntravirionSequence AnalysisAdd
BLAST
Topological domaini56 – 582527Virion surfaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P10866-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSKLFTIS DNATFAPGPV NNAADKKTFR TCFRILVLSV QAVTLILVIV
60 70 80 90 100
TLGELVRMIN DQGLSNQLSS ITDKIRESAT MIASAVGVMN QVIHGVTVSL
110 120 130 140 150
PLQIEGNQNQ LLSTLATICT SKKQISNCST NIPLVNDLRF INGINKFIIE
160 170 180 190 200
DYANHDFSIG HPLNMPSFIP TATSPNGCTR IPSFSLGKTH WCYTHNVINA
210 220 230 240 250
NCKDHTSSNQ YVSMGILVQT ASGYPMFKTL KIQYLSDGLN RKSCSIATVP
260 270 280 290 300
DGCAMYCYVS TQLETDDYAG SSPPTQKLTL LFYNDTVTER TISPSGLEGN
310 320 330 340 350
WATLVPGVGS GIYFENKLIF PAYGGVLPNS TLGVKLAREF FRPVNPYNPC
360 370 380 390 400
SGPQQDLDQR ALRSYFPSYL SNRRVQSAFL VCAWNQILVT NCELVVPSNN
410 420 430 440 450
QTLMGAEGRV LLINNRLLYY QRSTSWWPYE LLYEISFTFT NSGQSSVNMS
460 470 480 490 500
WIPIYSFTRP GSGKCSGENV CPIACVSGVY LDPWPLTPYS HQSGINRNFY
510 520 530 540 550
FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGTQGLSASY TTTTCFQDTG
560 570 580
DASVYCVYIM ELASNIVGEF QILPVLTRLT IT
Length:582
Mass (Da):64,045
Last modified:July 1, 1989 - v1
Checksum:i6BCCB6990E65F869
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19933 mRNA. Translation: AAA46609.1.
PIRiA28917. HNNZMP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19933 mRNA. Translation: AAA46609.1 .
PIRi A28917. HNNZMP.

3D structure databases

ProteinModelPortali P10866.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHN_MUMPR
AccessioniPrimary (citable) accession number: P10866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3