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P10866

- HN_MUMPR

UniProt

P10866 - HN_MUMPR

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Mumps virus (strain RW) (MuV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiMumps virus (strain RW) (MuV)
    Taxonomic identifieri11172 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Hemagglutinin-neuraminidasePRO_0000142604Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi507 – 5071N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP10866.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini56 – 582527Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P10866-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPSKLFTIS DNATFAPGPV NNAADKKTFR TCFRILVLSV QAVTLILVIV    50
    TLGELVRMIN DQGLSNQLSS ITDKIRESAT MIASAVGVMN QVIHGVTVSL 100
    PLQIEGNQNQ LLSTLATICT SKKQISNCST NIPLVNDLRF INGINKFIIE 150
    DYANHDFSIG HPLNMPSFIP TATSPNGCTR IPSFSLGKTH WCYTHNVINA 200
    NCKDHTSSNQ YVSMGILVQT ASGYPMFKTL KIQYLSDGLN RKSCSIATVP 250
    DGCAMYCYVS TQLETDDYAG SSPPTQKLTL LFYNDTVTER TISPSGLEGN 300
    WATLVPGVGS GIYFENKLIF PAYGGVLPNS TLGVKLAREF FRPVNPYNPC 350
    SGPQQDLDQR ALRSYFPSYL SNRRVQSAFL VCAWNQILVT NCELVVPSNN 400
    QTLMGAEGRV LLINNRLLYY QRSTSWWPYE LLYEISFTFT NSGQSSVNMS 450
    WIPIYSFTRP GSGKCSGENV CPIACVSGVY LDPWPLTPYS HQSGINRNFY 500
    FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGTQGLSASY TTTTCFQDTG 550
    DASVYCVYIM ELASNIVGEF QILPVLTRLT IT 582
    Length:582
    Mass (Da):64,045
    Last modified:July 1, 1989 - v1
    Checksum:i6BCCB6990E65F869
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19933 mRNA. Translation: AAA46609.1.
    PIRiA28917. HNNZMP.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19933 mRNA. Translation: AAA46609.1 .
    PIRi A28917. HNNZMP.

    3D structure databases

    ProteinModelPortali P10866.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHN_MUMPR
    AccessioniPrimary (citable) accession number: P10866
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3