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P10866

- HN_MUMPR

UniProt

P10866 - HN_MUMPR

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Mumps virus (strain RW) (MuV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiMumps virus (strain RW) (MuV)
Taxonomic identifieri11172 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Intravirion Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini56 – 582527Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Hemagglutinin-neuraminidase
PRO_0000142604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi507 – 5071N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP10866.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P10866-1 [UniParc]FASTAAdd to Basket

« Hide

MEPSKLFTIS DNATFAPGPV NNAADKKTFR TCFRILVLSV QAVTLILVIV    50
TLGELVRMIN DQGLSNQLSS ITDKIRESAT MIASAVGVMN QVIHGVTVSL 100
PLQIEGNQNQ LLSTLATICT SKKQISNCST NIPLVNDLRF INGINKFIIE 150
DYANHDFSIG HPLNMPSFIP TATSPNGCTR IPSFSLGKTH WCYTHNVINA 200
NCKDHTSSNQ YVSMGILVQT ASGYPMFKTL KIQYLSDGLN RKSCSIATVP 250
DGCAMYCYVS TQLETDDYAG SSPPTQKLTL LFYNDTVTER TISPSGLEGN 300
WATLVPGVGS GIYFENKLIF PAYGGVLPNS TLGVKLAREF FRPVNPYNPC 350
SGPQQDLDQR ALRSYFPSYL SNRRVQSAFL VCAWNQILVT NCELVVPSNN 400
QTLMGAEGRV LLINNRLLYY QRSTSWWPYE LLYEISFTFT NSGQSSVNMS 450
WIPIYSFTRP GSGKCSGENV CPIACVSGVY LDPWPLTPYS HQSGINRNFY 500
FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGTQGLSASY TTTTCFQDTG 550
DASVYCVYIM ELASNIVGEF QILPVLTRLT IT 582
Length:582
Mass (Da):64,045
Last modified:July 1, 1989 - v1
Checksum:i6BCCB6990E65F869
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19933 mRNA. Translation: AAA46609.1.
PIRiA28917. HNNZMP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19933 mRNA. Translation: AAA46609.1 .
PIRi A28917. HNNZMP.

3D structure databases

ProteinModelPortali P10866.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHN_MUMPR
AccessioniPrimary (citable) accession number: P10866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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