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Protein

Hyaluronan and proteoglycan link protein 1

Gene

HAPLN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 1
Alternative name(s):
Cartilage-linking protein 1
Short name:
Cartilage-link protein
Proteoglycan link protein
Gene namesi
Name:HAPLN1
Synonyms:CRTL1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99PRO_0000013181
Chaini10 – 354345Hyaluronan and proteoglycan link protein 1PRO_0000013182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi61 ↔ 139By similarity
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi205 ↔ 226By similarity
Disulfide bondi279 ↔ 349By similarity
Disulfide bondi304 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10859.
PeptideAtlasiP10859.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015032.

Structurei

3D structure databases

ProteinModelPortaliP10859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 152115Ig-like V-typeAdd
BLAST
Domaini159 – 25496Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini259 – 35193Link 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF28. Eukaryota.
ENOG410XRS8. LUCA.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiP10859.
KOiK06848.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLLLVLI SVCWADHLSN NYTLDHDRVI HIQAENGPRL LVEAEQAKVF
60 70 80 90 100
SHRGGNVTLP CKFFRDPTAF GSGTHKIRIK WTKLTSDYLK EVDVFVSMGY
110 120 130 140 150
HKKTYGGYHG RVFLKGGSDN DASLVITDLT LEDYGRYKCE VIEGLEDDTA
160 170 180 190 200
VVALDLEGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG
210 220 230 240 250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV
260 270 280 290 300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKLLG
310 320 330 340 350
YDRCDAGWLA DGSVRYPISR PRRRCRPNEA AVRFVGFPDK KHKLYGVYCF

RAYN
Length:354
Mass (Da):40,261
Last modified:July 1, 1989 - v1
Checksum:i68FFFB9DE51ABCC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00165 mRNA. Translation: CAA68358.1.
PIRiS04243.
RefSeqiNP_001004028.1. NM_001004028.1.
UniGeneiSsc.16229.

Genome annotation databases

GeneIDi445513.
KEGGissc:445513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00165 mRNA. Translation: CAA68358.1.
PIRiS04243.
RefSeqiNP_001004028.1. NM_001004028.1.
UniGeneiSsc.16229.

3D structure databases

ProteinModelPortaliP10859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015032.

Proteomic databases

PaxDbiP10859.
PeptideAtlasiP10859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445513.
KEGGissc:445513.

Organism-specific databases

CTDi1404.

Phylogenomic databases

eggNOGiENOG410IF28. Eukaryota.
ENOG410XRS8. LUCA.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiP10859.
KOiK06848.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein."
    Perkins S.J., Nealis A.S., Dudhia J., Hardingham T.E.
    J. Mol. Biol. 206:737-753(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Laryngeal cartilage chondrocyte.

Entry informationi

Entry nameiHPLN1_PIG
AccessioniPrimary (citable) accession number: P10859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.