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Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:Tnp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98784. Tnp1.

Subcellular locationi

GO - Cellular componenti

  • male germ cell nucleus Source: MGI
  • nucleosome Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 5554Spermatid nuclear transition protein 1PRO_0000191418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10856.
PRIDEiP10856.

PTM databases

iPTMnetiP10856.
PhosphoSiteiP10856.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiP10856.
CleanExiMM_TNP1.
ExpressionAtlasiP10856. baseline and differential.
GenevisibleiP10856. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027374.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
HOGENOMiHOG000136637.
HOVERGENiHBG094887.
InParanoidiP10856.
OMAiKRCDDAN.
OrthoDBiEOG7MSMS7.
PhylomeDBiP10856.
TreeFamiTF338391.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSVLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,407
Last modified:January 23, 2007 - v2
Checksum:iC3715E99698A7B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12521 mRNA. Translation: CAA31039.1.
S80846 Genomic DNA. Translation: AAB21244.2.
BC048494 mRNA. Translation: AAH48494.1.
BC061170 mRNA. Translation: AAH61170.1.
CCDSiCCDS35611.1.
PIRiA40561. BGMS.
RefSeqiNP_033433.1. NM_009407.2.
UniGeneiMm.425024.

Genome annotation databases

EnsembliENSMUST00000027374; ENSMUSP00000027374; ENSMUSG00000026182.
GeneIDi21958.
KEGGimmu:21958.
UCSCiuc007bkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12521 mRNA. Translation: CAA31039.1.
S80846 Genomic DNA. Translation: AAB21244.2.
BC048494 mRNA. Translation: AAH48494.1.
BC061170 mRNA. Translation: AAH61170.1.
CCDSiCCDS35611.1.
PIRiA40561. BGMS.
RefSeqiNP_033433.1. NM_009407.2.
UniGeneiMm.425024.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027374.

PTM databases

iPTMnetiP10856.
PhosphoSiteiP10856.

Proteomic databases

PaxDbiP10856.
PRIDEiP10856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027374; ENSMUSP00000027374; ENSMUSG00000026182.
GeneIDi21958.
KEGGimmu:21958.
UCSCiuc007bkz.2. mouse.

Organism-specific databases

CTDi7141.
MGIiMGI:98784. Tnp1.

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
HOGENOMiHOG000136637.
HOVERGENiHBG094887.
InParanoidiP10856.
OMAiKRCDDAN.
OrthoDBiEOG7MSMS7.
PhylomeDBiP10856.
TreeFamiTF338391.

Miscellaneous databases

ChiTaRSiTnp1. mouse.
NextBioi301644.
PROiP10856.
SOURCEiSearch...

Gene expression databases

BgeeiP10856.
CleanExiMM_TNP1.
ExpressionAtlasiP10856. baseline and differential.
GenevisibleiP10856. MM.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1."
    Kleene K.C., Borzorgzadeh A., Flynn J.F., Yelick P.C., Hecht N.B.
    Biochim. Biophys. Acta 950:215-220(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The mouse transition protein 1 gene contains a B1 repetitive element and is located on chromosome 1."
    Yelick P.C., Kozak C., Kwon Y.K., Seldin M.F., Hecht N.B.
    Genomics 11:687-694(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSTP1_MOUSE
AccessioniPrimary (citable) accession number: P10856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.