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Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AFB1-HIST1H2BA/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643).5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:Tnp1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98784. Tnp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced fertility in males (PubMed:10781074). Testis weights and sperm production are normal but sperm motility is severely reduced (PubMed:10781074). A significant proportion of Prm2 remains unprocessed (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521). Male mice lacking both Tnp1 and Tnp2 are completely infertile, but protamine alone are capable of histone eviction (PubMed:15163613, PubMed:15189834, PubMed:15083521). Chromatin in mature spermatozoa shows defects in density (PubMed:15189834, PubMed:15083521).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914181 – 55Spermatid nuclear transition protein 1Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10856.
PRIDEiP10856.

PTM databases

iPTMnetiP10856.
PhosphoSitePlusiP10856.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

Appears in elongating/condensing spermatids when histones are still detectable (PubMed:15163613). Coexpressed with H2afb1 during late spermiogenesis (PubMed:28366643).2 Publications

Gene expression databases

BgeeiENSMUSG00000026182.
CleanExiMM_TNP1.
ExpressionAtlasiP10856. baseline and differential.
GenevisibleiP10856. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027374.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
GeneTreeiENSGT00390000000539.
HOGENOMiHOG000136637.
HOVERGENiHBG094887.
InParanoidiP10856.
OMAiKRCDDAN.
PhylomeDBiP10856.
TreeFamiTF338391.

Family and domain databases

InterProiView protein in InterPro
IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiView protein in Pfam
PF02079. TP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292. TP1. 1 hit.
PROSITEiView protein in PROSITE
PS00541. TP1. 1 hit.

Sequencei

Sequence statusi: Complete.

P10856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSVLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,407
Last modified:January 23, 2007 - v2
Checksum:iC3715E99698A7B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12521 mRNA. Translation: CAA31039.1.
S80846 Genomic DNA. Translation: AAB21244.2.
BC048494 mRNA. Translation: AAH48494.1.
BC061170 mRNA. Translation: AAH61170.1.
CCDSiCCDS35611.1.
PIRiA40561. BGMS.
RefSeqiNP_033433.1. NM_009407.2.
UniGeneiMm.425024.

Genome annotation databases

EnsembliENSMUST00000027374; ENSMUSP00000027374; ENSMUSG00000026182.
GeneIDi21958.
KEGGimmu:21958.
UCSCiuc007bkz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSTP1_MOUSE
AccessioniPrimary (citable) accession number: P10856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families