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Protein

C-C motif chemokine 3

Gene

Ccl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Heparin-binding chemotaxis protein
L2G25B
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
SIS-alpha
Small-inducible cytokine A3
TY-5
Gene namesi
Name:Ccl3
Synonyms:Mip1a, Scya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98260. Ccl3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular space Source: MGI
  • intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9269C-C motif chemokine 3PRO_0000005158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 57By similarity
Disulfide bondi35 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP10855.

Expressioni

Tissue specificityi

Expressed in lung, spleen, and pancreas.

Gene expression databases

BgeeiP10855.
CleanExiMM_CCL3.
ExpressionAtlasiP10855. baseline and differential.
GenevestigatoriP10855.

Interactioni

Protein-protein interaction databases

BioGridi203127. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP10855.
SMRiP10855. Positions 28-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42742.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP10855.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP10855.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY
60 70 80 90
FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA
Length:92
Mass (Da):10,345
Last modified:April 1, 1990 - v2
Checksum:i8BFF2DE7C6DEDD38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221F → L in AAA40146 (PubMed:2521353).Curated
Sequence conflicti62 – 621V → A in AAA40146 (PubMed:2521353).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA. Translation: AAA40146.1.
X12531 mRNA. Translation: CAA31047.1.
X53372 Genomic DNA. Translation: CAA37452.1.
J04491 mRNA. Translation: AAA40304.1.
M73061 Genomic DNA. Translation: AAA39707.1.
AF065939 mRNA. Translation: AAC17506.1.
AF065940 mRNA. Translation: AAC17507.1.
AF065941 mRNA. Translation: AAC17508.1.
AF065942 mRNA. Translation: AAC17509.1.
AF065943 mRNA. Translation: AAC17510.1.
CCDSiCCDS36255.1.
PIRiS11685. A32393.
RefSeqiNP_035467.1. NM_011337.2.
UniGeneiMm.1282.

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982.
GeneIDi20302.
KEGGimmu:20302.
UCSCiuc007kpn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA. Translation: AAA40146.1.
X12531 mRNA. Translation: CAA31047.1.
X53372 Genomic DNA. Translation: CAA37452.1.
J04491 mRNA. Translation: AAA40304.1.
M73061 Genomic DNA. Translation: AAA39707.1.
AF065939 mRNA. Translation: AAC17506.1.
AF065940 mRNA. Translation: AAC17507.1.
AF065941 mRNA. Translation: AAC17508.1.
AF065942 mRNA. Translation: AAC17509.1.
AF065943 mRNA. Translation: AAC17510.1.
CCDSiCCDS36255.1.
PIRiS11685. A32393.
RefSeqiNP_035467.1. NM_011337.2.
UniGeneiMm.1282.

3D structure databases

ProteinModelPortaliP10855.
SMRiP10855. Positions 28-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203127. 1 interaction.

Proteomic databases

PRIDEiP10855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982.
GeneIDi20302.
KEGGimmu:20302.
UCSCiuc007kpn.1. mouse.

Organism-specific databases

CTDi6348.
MGIiMGI:98260. Ccl3.

Phylogenomic databases

eggNOGiNOG42742.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP10855.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP10855.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi298047.
PROiP10855.
SOURCEiSearch...

Gene expression databases

BgeeiP10855.
CleanExiMM_CCL3.
ExpressionAtlasiP10855. baseline and differential.
GenevestigatoriP10855.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties."
    Davatelis G., Tekamp-Olson P., Wolpe S.D., Hermsen K., Luedke C., Gallegos C., Coit D., Merryweather J., Cerami A.
    J. Exp. Med. 167:1939-1944(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: SEQUENCE REVISION.
  3. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene."
    Grove M., Lowe S., Graham G., Pragnell I., Plumb M.
    Nucleic Acids Res. 18:5561-5561(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78."
    Widmer U., Yang Z., van Deventer S., Manogue K.R., Sherry B., Cerami A.
    J. Immunol. 146:4031-4040(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  8. "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties."
    Wolpe S.D., Davatelis G., Sherry B., Beutler B., Hesse D.G., Nguyen H.T., Moldawer L.L., Nathan C.F., Lowry S.F., Cerami A.
    J. Exp. Med. 167:570-581(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-42.

Entry informationi

Entry nameiCCL3_MOUSE
AccessioniPrimary (citable) accession number: P10855
Secondary accession number(s): P14096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: April 1, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.