Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10855

- CCL3_MOUSE

UniProt

P10855 - CCL3_MOUSE

Protein

C-C motif chemokine 3

Gene

Ccl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

    GO - Molecular functioni

    1. calcium-dependent protein kinase C activity Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. chemokine activity Source: MGI
    4. kinase activity Source: UniProtKB
    5. phospholipase activator activity Source: UniProtKB
    6. protein binding Source: MGI
    7. protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. astrocyte cell migration Source: UniProtKB
    2. behavior Source: UniProtKB
    3. calcium ion transport Source: UniProtKB
    4. calcium-mediated signaling Source: UniProtKB
    5. cell activation Source: UniProtKB
    6. cell-cell signaling Source: UniProtKB
    7. cellular calcium ion homeostasis Source: UniProtKB
    8. cellular response to organic cyclic compound Source: UniProtKB
    9. chemotaxis Source: UniProtKB
    10. cytoskeleton organization Source: UniProtKB
    11. eosinophil chemotaxis Source: UniProtKB
    12. eosinophil degranulation Source: UniProtKB
    13. exocytosis Source: UniProtKB
    14. granulocyte chemotaxis Source: UniProtKB
    15. inflammatory response Source: UniProtKB
    16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    17. lymphocyte chemotaxis Source: UniProtKB
    18. macrophage chemotaxis Source: UniProtKB
    19. MAPK cascade Source: UniProtKB
    20. monocyte chemotaxis Source: UniProtKB
    21. negative regulation by host of viral transcription Source: UniProtKB
    22. negative regulation of gene expression Source: UniProtKB
    23. negative regulation of osteoclast differentiation Source: UniProtKB
    24. neutrophil chemotaxis Source: UniProtKB
    25. osteoblast differentiation Source: UniProtKB
    26. positive chemotaxis Source: GOC
    27. positive regulation of calcium ion transport Source: UniProtKB
    28. positive regulation of calcium-mediated signaling Source: UniProtKB
    29. positive regulation of catalytic activity Source: GOC
    30. positive regulation of cell migration Source: UniProtKB
    31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    32. positive regulation of gene expression Source: UniProtKB
    33. positive regulation of inflammatory response Source: UniProtKB
    34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
    35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
    36. positive regulation of neuron apoptotic process Source: UniProtKB
    37. positive regulation of osteoclast differentiation Source: Ensembl
    38. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    39. positive regulation of tumor necrosis factor production Source: UniProtKB
    40. protein kinase B signaling Source: UniProtKB
    41. protein phosphorylation Source: UniProtKB
    42. regulation of cell shape Source: UniProtKB
    43. regulation of sensory perception of pain Source: UniProtKB
    44. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
    45. response to cholesterol Source: UniProtKB
    46. response to drug Source: Ensembl
    47. response to toxic substance Source: UniProtKB
    48. signaling Source: UniProtKB
    49. T cell chemotaxis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 3
    Alternative name(s):
    Heparin-binding chemotaxis protein
    L2G25B
    Macrophage inflammatory protein 1-alpha
    Short name:
    MIP-1-alpha
    SIS-alpha
    Small-inducible cytokine A3
    TY-5
    Gene namesi
    Name:Ccl3
    Synonyms:Mip1a, Scya3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98260. Ccl3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular space Source: MGI
    4. intracellular Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 3PRO_0000005158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 57By similarity
    Disulfide bondi35 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP10855.

    Expressioni

    Tissue specificityi

    Expressed in lung, spleen, and pancreas.

    Gene expression databases

    ArrayExpressiP10855.
    BgeeiP10855.
    CleanExiMM_CCL3.
    GenevestigatoriP10855.

    Interactioni

    Protein-protein interaction databases

    BioGridi203127. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP10855.
    SMRiP10855. Positions 28-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42742.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP10855.
    KOiK05408.
    OMAiSKETWVQ.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiP10855.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY   50
    FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA 92
    Length:92
    Mass (Da):10,345
    Last modified:April 1, 1990 - v2
    Checksum:i8BFF2DE7C6DEDD38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221F → L in AAA40146. (PubMed:2521353)Curated
    Sequence conflicti62 – 621V → A in AAA40146. (PubMed:2521353)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23447 mRNA. Translation: AAA40146.1.
    X12531 mRNA. Translation: CAA31047.1.
    X53372 Genomic DNA. Translation: CAA37452.1.
    J04491 mRNA. Translation: AAA40304.1.
    M73061 Genomic DNA. Translation: AAA39707.1.
    AF065939 mRNA. Translation: AAC17506.1.
    AF065940 mRNA. Translation: AAC17507.1.
    AF065941 mRNA. Translation: AAC17508.1.
    AF065942 mRNA. Translation: AAC17509.1.
    AF065943 mRNA. Translation: AAC17510.1.
    CCDSiCCDS36255.1.
    PIRiS11685. A32393.
    RefSeqiNP_035467.1. NM_011337.2.
    UniGeneiMm.1282.

    Genome annotation databases

    EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982.
    GeneIDi20302.
    KEGGimmu:20302.
    UCSCiuc007kpn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23447 mRNA. Translation: AAA40146.1 .
    X12531 mRNA. Translation: CAA31047.1 .
    X53372 Genomic DNA. Translation: CAA37452.1 .
    J04491 mRNA. Translation: AAA40304.1 .
    M73061 Genomic DNA. Translation: AAA39707.1 .
    AF065939 mRNA. Translation: AAC17506.1 .
    AF065940 mRNA. Translation: AAC17507.1 .
    AF065941 mRNA. Translation: AAC17508.1 .
    AF065942 mRNA. Translation: AAC17509.1 .
    AF065943 mRNA. Translation: AAC17510.1 .
    CCDSi CCDS36255.1.
    PIRi S11685. A32393.
    RefSeqi NP_035467.1. NM_011337.2.
    UniGenei Mm.1282.

    3D structure databases

    ProteinModelPortali P10855.
    SMRi P10855. Positions 28-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203127. 1 interaction.

    Proteomic databases

    PRIDEi P10855.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001008 ; ENSMUSP00000001008 ; ENSMUSG00000000982 .
    GeneIDi 20302.
    KEGGi mmu:20302.
    UCSCi uc007kpn.1. mouse.

    Organism-specific databases

    CTDi 6348.
    MGIi MGI:98260. Ccl3.

    Phylogenomic databases

    eggNOGi NOG42742.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P10855.
    KOi K05408.
    OMAi SKETWVQ.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi P10855.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298047.
    PROi P10855.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10855.
    Bgeei P10855.
    CleanExi MM_CCL3.
    Genevestigatori P10855.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties."
      Davatelis G., Tekamp-Olson P., Wolpe S.D., Hermsen K., Luedke C., Gallegos C., Coit D., Merryweather J., Cerami A.
      J. Exp. Med. 167:1939-1944(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: SEQUENCE REVISION.
    3. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
      Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
      J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene."
      Grove M., Lowe S., Graham G., Pragnell I., Plumb M.
      Nucleic Acids Res. 18:5561-5561(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78."
      Widmer U., Yang Z., van Deventer S., Manogue K.R., Sherry B., Cerami A.
      J. Immunol. 146:4031-4040(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    8. "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties."
      Wolpe S.D., Davatelis G., Sherry B., Beutler B., Hesse D.G., Nguyen H.T., Moldawer L.L., Nathan C.F., Lowry S.F., Cerami A.
      J. Exp. Med. 167:570-581(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-42.

    Entry informationi

    Entry nameiCCL3_MOUSE
    AccessioniPrimary (citable) accession number: P10855
    Secondary accession number(s): P14096
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3