Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 3

Gene

Ccl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Heparin-binding chemotaxis protein
L2G25B
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
SIS-alpha
Small-inducible cytokine A3
TY-5
Gene namesi
Name:Ccl3
Synonyms:Mip1a, Scya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98260. Ccl3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular space Source: MGI
  • intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000515824 – 92C-C motif chemokine 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 57By similarity
Disulfide bondi35 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10855.
PeptideAtlasiP10855.
PRIDEiP10855.

Expressioni

Tissue specificityi

Expressed in lung, spleen, and pancreas.

Gene expression databases

BgeeiENSMUSG00000000982.
CleanExiMM_CCL3.
ExpressionAtlasiP10855. baseline and differential.
GenevisibleiP10855. MM.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI

Protein-protein interaction databases

BioGridi203127. 1 interactor.
DIPiDIP-61916N.
STRINGi10090.ENSMUSP00000001008.

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 37Combined sources4
Helixi44 – 46Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi57 – 59Combined sources3
Beta strandi61 – 66Combined sources6
Beta strandi71 – 75Combined sources5
Helixi79 – 89Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZLTX-ray3.00F/L24-92[»]
ProteinModelPortaliP10855.
SMRiP10855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP10855.
KOiK05408.
OMAiMALCNQV.
OrthoDBiEOG091G14Y2.
PhylomeDBiP10855.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY
60 70 80 90
FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA
Length:92
Mass (Da):10,345
Last modified:April 1, 1990 - v2
Checksum:i8BFF2DE7C6DEDD38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22F → L in AAA40146 (PubMed:2521353).Curated1
Sequence conflicti62V → A in AAA40146 (PubMed:2521353).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA. Translation: AAA40146.1.
X12531 mRNA. Translation: CAA31047.1.
X53372 Genomic DNA. Translation: CAA37452.1.
J04491 mRNA. Translation: AAA40304.1.
M73061 Genomic DNA. Translation: AAA39707.1.
AF065939 mRNA. Translation: AAC17506.1.
AF065940 mRNA. Translation: AAC17507.1.
AF065941 mRNA. Translation: AAC17508.1.
AF065942 mRNA. Translation: AAC17509.1.
AF065943 mRNA. Translation: AAC17510.1.
CCDSiCCDS36255.1.
PIRiS11685. A32393.
RefSeqiNP_035467.1. NM_011337.2.
UniGeneiMm.1282.

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982.
GeneIDi20302.
KEGGimmu:20302.
UCSCiuc007kpn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA. Translation: AAA40146.1.
X12531 mRNA. Translation: CAA31047.1.
X53372 Genomic DNA. Translation: CAA37452.1.
J04491 mRNA. Translation: AAA40304.1.
M73061 Genomic DNA. Translation: AAA39707.1.
AF065939 mRNA. Translation: AAC17506.1.
AF065940 mRNA. Translation: AAC17507.1.
AF065941 mRNA. Translation: AAC17508.1.
AF065942 mRNA. Translation: AAC17509.1.
AF065943 mRNA. Translation: AAC17510.1.
CCDSiCCDS36255.1.
PIRiS11685. A32393.
RefSeqiNP_035467.1. NM_011337.2.
UniGeneiMm.1282.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZLTX-ray3.00F/L24-92[»]
ProteinModelPortaliP10855.
SMRiP10855.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203127. 1 interactor.
DIPiDIP-61916N.
STRINGi10090.ENSMUSP00000001008.

Proteomic databases

PaxDbiP10855.
PeptideAtlasiP10855.
PRIDEiP10855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982.
GeneIDi20302.
KEGGimmu:20302.
UCSCiuc007kpn.1. mouse.

Organism-specific databases

CTDi6348.
MGIiMGI:98260. Ccl3.

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP10855.
KOiK05408.
OMAiMALCNQV.
OrthoDBiEOG091G14Y2.
PhylomeDBiP10855.
TreeFamiTF334888.

Miscellaneous databases

PROiP10855.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000982.
CleanExiMM_CCL3.
ExpressionAtlasiP10855. baseline and differential.
GenevisibleiP10855. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL3_MOUSE
AccessioniPrimary (citable) accession number: P10855
Secondary accession number(s): P14096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.