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Protein

C-C motif chemokine 3

Gene

Ccl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Heparin-binding chemotaxis protein
L2G25B
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
SIS-alpha
Small-inducible cytokine A3
TY-5
Gene namesi
Name:Ccl3
Synonyms:Mip1a, Scya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98260 Ccl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000515824 – 92C-C motif chemokine 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 57By similarity
Disulfide bondi35 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10855
PeptideAtlasiP10855
PRIDEiP10855

Expressioni

Tissue specificityi

Expressed in lung, spleen, and pancreas.

Gene expression databases

BgeeiENSMUSG00000000982
CleanExiMM_CCL3
ExpressionAtlasiP10855 baseline and differential
GenevisibleiP10855 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHVP.R17E9M5R04EBI-16188162,EBI-16188152From Cricetid gammaherpesvirus 2.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemoattractant activity Source: UniProtKB
  • chemokine activity Source: MGI

Protein-protein interaction databases

BioGridi203127, 1 interactor
DIPiDIP-61916N
IntActiP10855, 1 interactor
STRINGi10090.ENSMUSP00000001008

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 37Combined sources4
Helixi44 – 46Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi57 – 59Combined sources3
Beta strandi61 – 66Combined sources6
Beta strandi71 – 75Combined sources5
Helixi79 – 89Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZLTX-ray3.00F/L24-92[»]
ProteinModelPortaliP10855
SMRiP10855
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP10855
KOiK05408
OMAiMALCNQV
OrthoDBiEOG091G14Y2
PhylomeDBiP10855
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY
60 70 80 90
FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA
Length:92
Mass (Da):10,345
Last modified:April 1, 1990 - v2
Checksum:i8BFF2DE7C6DEDD38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22F → L in AAA40146 (PubMed:2521353).Curated1
Sequence conflicti62V → A in AAA40146 (PubMed:2521353).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA Translation: AAA40146.1
X12531 mRNA Translation: CAA31047.1
X53372 Genomic DNA Translation: CAA37452.1
J04491 mRNA Translation: AAA40304.1
M73061 Genomic DNA Translation: AAA39707.1
AF065939 mRNA Translation: AAC17506.1
AF065940 mRNA Translation: AAC17507.1
AF065941 mRNA Translation: AAC17508.1
AF065942 mRNA Translation: AAC17509.1
AF065943 mRNA Translation: AAC17510.1
CCDSiCCDS36255.1
PIRiS11685 A32393
RefSeqiNP_035467.1, NM_011337.2
UniGeneiMm.1282

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982
GeneIDi20302
KEGGimmu:20302
UCSCiuc007kpn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCL3_MOUSE
AccessioniPrimary (citable) accession number: P10855
Secondary accession number(s): P14096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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