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P10852

- 4F2_MOUSE

UniProt

P10852 - 4F2_MOUSE

Protein

4F2 cell-surface antigen heavy chain

Gene

Slc3a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.3 Publications

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. cation binding Source: InterPro
    3. double-stranded RNA binding Source: MGI
    4. neutral amino acid transmembrane transporter activity Source: UniProtKB
    5. protein binding Source: MGI

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. leucine import Source: UniProtKB
    3. response to exogenous dsRNA Source: MGI
    4. tryptophan transport Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4F2 cell-surface antigen heavy chain
    Short name:
    4F2hc
    Alternative name(s):
    Solute carrier family 3 member 2
    CD_antigen: CD98
    Gene namesi
    Name:Slc3a2
    Synonyms:Mdu1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:96955. Slc3a2.

    Subcellular locationi

    Apical cell membrane; Single-pass type II membrane protein. Melanosome By similarity
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV By similarity. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8 By similarity. Localized to the placental apical membrane By similarity. Located selectively at cell-cell adhesion sites. Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi103 – 1031C → S: No effect on guidance of LAT1 to the plasma membrane. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5265264F2 cell-surface antigen heavy chainPRO_0000064384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21PhosphoserineBy similarity
    Cross-linki42 – 42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei58 – 581Phosphoserine1 Publication
    Disulfide bondi103 – 103Interchain (with light chain)Curated
    Glycosylationi160 – 1601N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi166 – 1661N-linked (GlcNAc...)2 Publications
    Glycosylationi249 – 2491N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi259 – 2591N-linked (GlcNAc...)2 Publications
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi385 – 3851N-linked (GlcNAc...)2 Publications
    Glycosylationi399 – 3991N-linked (GlcNAc...)2 Publications
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation on Ser-300 or Ser-302 and on Ser-420 by ecto-protein kinases favors heterotypic cell-cell interactions.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP10852.
    PaxDbiP10852.
    PRIDEiP10852.

    PTM databases

    PhosphoSiteiP10852.

    Expressioni

    Tissue specificityi

    Observed in all adult tissues tested with strongest expression in kidney, small intestine, spleen, thymus and liver. Moderate expression in brain, stomach, heart, testis, lung, skin, pancreas and skeletal muscle. Expressed on the surface of epithelial cells of most embryonic tissues including epidermis, choroid plexus in the brain, retina, as well as intestinal, renal, and thymic epithelium. In brain expressed on capillary endothelia in cerebral cortex.3 Publications

    Developmental stagei

    Strong expression in the liver of 14 dpc embryo and in brain, spleen, liver, kidney and intestine of an 18 dpc embryo.1 Publication

    Inductioni

    Expression induced by concanavilin-A stimulation. Induced during cell activation but is subsequently maintained at constant levels throughout the cell cycle in exponentially growing cells.2 Publications

    Gene expression databases

    ArrayExpressiP10852.
    BgeeiP10852.
    GenevestigatoriP10852.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins By similarity. Interacts with FAM57A/CT120 and ICAM1 By similarity. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP10852. 4 interactions.
    MINTiMINT-4996392.

    Structurei

    3D structure databases

    ProteinModelPortaliP10852.
    SMRiP10852. Positions 105-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 526427ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9924Helical; Signal-anchor for type II membrane proteinAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC3A transporter family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0366.
    GeneTreeiENSGT00530000063127.
    HOVERGENiHBG000023.
    InParanoidiP10852.
    KOiK06519.
    OMAiNMTVKGQ.
    OrthoDBiEOG7ZSHSV.
    PhylomeDBiP10852.
    TreeFamiTF314498.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P10852-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQDTEVDMK DVELNELEPE KQPMNAADGA AAGEKNGLVK IKVAEDETEA    50
    GVKFTGLSKE ELLKVAGSPG WVRTRWALLL LFWLGWLGML AGAVVIIVRA 100
    PRCRELPVQR WWHKGALYRI GDLQAFVGRD AGGIAGLKSH LEYLSTLKVK 150
    GLVLGPIHKN QKDEINETDL KQINPTLGSQ EDFKDLLQSA KKKSIHIILD 200
    LTPNYQGQNA WFLPAQADIV ATKMKEALSS WLQDGVDGFQ FRDVGKLMNA 250
    PLYLAEWQNI TKNLSEDRLL IAGTESSDLQ QIVNILESTS DLLLTSSYLS 300
    NSTFTGERTE SLVTRFLNAT GSQWCSWSVS QAGLLADFIP DHLLRLYQLL 350
    LFTLPGTPVF SYGDELGLQG ALPGQPAKAP LMPWNESSIF HIPRPVSLNM 400
    TVKGQNEDPG SLLTQFRRLS DLRGKERSLL HGDFHALSSS PDLFSYIRHW 450
    DQNERYLVVL NFRDSGRSAR LGASNLPAGI SLPASAKLLL STDSARQSRE 500
    EDTSLKLENL SLNPYEGLLL QFPFVA 526
    Length:526
    Mass (Da):58,337
    Last modified:July 1, 1989 - v1
    Checksum:iAE6261F11C7D9468
    GO
    Isoform 2 (identifier: P10852-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MDPEPTEHSTDGVSVPRQPPSAQTGLDVQVVSAAGDSGTM

    Note: No experimental confirmation available.

    Show »
    Length:565
    Mass (Da):62,240
    Checksum:i7CF0572C4E948451
    GO

    Sequence cautioni

    The sequence BAE36291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MDPEPTEHSTDGVSVPRQPP SAQTGLDVQVVSAAGDSGTM in isoform 2. 1 PublicationVSP_054953

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14309 mRNA. Translation: CAA32490.1.
    AB023408 mRNA. Translation: BAA90555.1.
    AK161280 mRNA. Translation: BAE36291.1. Different initiation.
    AK165417 mRNA. Translation: BAE38172.1.
    AC025794 Genomic DNA. No translation available.
    CH466612 Genomic DNA. Translation: EDL33352.1.
    BC065173 mRNA. Translation: AAH65173.1.
    CCDSiCCDS29540.1. [P10852-1]
    CCDS50381.1. [P10852-2]
    PIRiS03600.
    RefSeqiNP_001154885.1. NM_001161413.1. [P10852-2]
    NP_032603.3. NM_008577.4. [P10852-1]
    XP_006526794.1. XM_006526731.1. [P10852-1]
    XP_006526795.1. XM_006526732.1. [P10852-1]
    UniGeneiMm.4114.

    Genome annotation databases

    EnsembliENSMUST00000010239; ENSMUSP00000010239; ENSMUSG00000010095. [P10852-1]
    ENSMUST00000170157; ENSMUSP00000130194; ENSMUSG00000010095. [P10852-2]
    GeneIDi17254.
    KEGGimmu:17254.
    UCSCiuc008gmi.2. mouse.
    uc012bib.1. mouse. [P10852-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14309 mRNA. Translation: CAA32490.1 .
    AB023408 mRNA. Translation: BAA90555.1 .
    AK161280 mRNA. Translation: BAE36291.1 . Different initiation.
    AK165417 mRNA. Translation: BAE38172.1 .
    AC025794 Genomic DNA. No translation available.
    CH466612 Genomic DNA. Translation: EDL33352.1 .
    BC065173 mRNA. Translation: AAH65173.1 .
    CCDSi CCDS29540.1. [P10852-1 ]
    CCDS50381.1. [P10852-2 ]
    PIRi S03600.
    RefSeqi NP_001154885.1. NM_001161413.1. [P10852-2 ]
    NP_032603.3. NM_008577.4. [P10852-1 ]
    XP_006526794.1. XM_006526731.1. [P10852-1 ]
    XP_006526795.1. XM_006526732.1. [P10852-1 ]
    UniGenei Mm.4114.

    3D structure databases

    ProteinModelPortali P10852.
    SMRi P10852. Positions 105-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10852. 4 interactions.
    MINTi MINT-4996392.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    PTM databases

    PhosphoSitei P10852.

    Proteomic databases

    MaxQBi P10852.
    PaxDbi P10852.
    PRIDEi P10852.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000010239 ; ENSMUSP00000010239 ; ENSMUSG00000010095 . [P10852-1 ]
    ENSMUST00000170157 ; ENSMUSP00000130194 ; ENSMUSG00000010095 . [P10852-2 ]
    GeneIDi 17254.
    KEGGi mmu:17254.
    UCSCi uc008gmi.2. mouse.
    uc012bib.1. mouse. [P10852-1 ]

    Organism-specific databases

    CTDi 6520.
    MGIi MGI:96955. Slc3a2.

    Phylogenomic databases

    eggNOGi COG0366.
    GeneTreei ENSGT00530000063127.
    HOVERGENi HBG000023.
    InParanoidi P10852.
    KOi K06519.
    OMAi NMTVKGQ.
    OrthoDBi EOG7ZSHSV.
    PhylomeDBi P10852.
    TreeFami TF314498.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    NextBioi 291726.
    PROi P10852.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10852.
    Bgeei P10852.
    Genevestigatori P10852.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression and regulation of the murine 4F2 heavy chain."
      Parmacek M.S., Karpinski B.A., Gottsdiener K.M., Thompson C.B., Leiden J.M.
      Nucleic Acids Res. 17:1915-1931(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
      Strain: C57BL/6 X DBA/2 and ICR.
      Tissue: Macrophage and Pre-B cell.
    2. "Localization of expression of system L neutral amino acid transporter LAT1 in brain."
      Kanai Y., Watanabe M., Endou H.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: ICR.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Kidney and Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    7. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 43-53; 163-171; 456-463 AND 488-496, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    8. "4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer."
      Nakamura E., Sato M., Yang H., Miyagawa F., Harasaki M., Tomita K., Matsuoka S., Noma A., Iwai K., Minato N.
      J. Biol. Chem. 274:3009-3016(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, MUTAGENESIS OF CYS-103.
      Strain: BALB/c.
    9. "Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids."
      Pineda M., Fernandez E., Torrents D., Estevez R., Lopez C., Camps M., Lloberas J., Zorzano A., Palacin M.
      J. Biol. Chem. 274:19738-19744(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    10. "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine."
      Rossier G., Meier C., Bauch C., Summa V., Sordat B., Verrey F., Kuehn L.C.
      J. Biol. Chem. 274:34948-34954(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. Cited for: FUNCTION.
    12. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160; ASN-166; ASN-249; ASN-259; ASN-385 AND ASN-399.
      Tissue: Myoblast.
    14. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-166; ASN-259; ASN-385 AND ASN-399.

    Entry informationi

    Entry namei4F2_MOUSE
    AccessioniPrimary (citable) accession number: P10852
    Secondary accession number(s): G3UWA6, Q54AH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Leucine uptake was inhibited by ileum, valine histidine and phenylalanine as well as by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) (a specific inhibitor of system L transport).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3