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Protein

Alcohol dehydrogenase 3

Gene

ADH3

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH3
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607011 – 379Alcohol dehydrogenase 3Add BLAST379

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi4513.MLOC_59323.1.

Structurei

3D structure databases

ProteinModelPortaliP10848.
SMRiP10848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P10848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRILGHE AGGIVESVGE GVTELVPGDH VLPVFTGECK
110 120 130 140 150
DCAHCKSEES NLCDLLRINV DRGVMIGDGQ SRFTINGKPI FHFVGTSTFS
160 170 180 190 200
EYTVIHVGCL AKINPEAPLD KVCVLSCGLS TGLGATLNVA KPKKGSTVAI
210 220 230 240 250
FGLGAVGLAA MEGARMAGAS RIIGVDLNPA KYEQAKKFGC TDFVNPKDHT
260 270 280 290 300
KPVQEVLVEM TNGGVDRAVE CTGHIDAMIA TFECVHDGWG VAVLVGVPHK
310 320 330 340 350
EAVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPEVVEMYMR KELDLEKFIT
360 370
HSVPFSQINT AFDLMLKGEG LRCITRTDQ
Length:379
Mass (Da):41,011
Last modified:July 1, 1989 - v1
Checksum:iA97E94A74A68A05A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12734 Genomic DNA. Translation: CAA31231.1.
PIRiS04040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12734 Genomic DNA. Translation: CAA31231.1.
PIRiS04040.

3D structure databases

ProteinModelPortaliP10848.
SMRiP10848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4513.MLOC_59323.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_HORVU
AccessioniPrimary (citable) accession number: P10848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.