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P10848 (ADH3_HORVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 3
EC=1.1.1.1
Gene names
Name:ADH3
OrganismHordeum vulgare (Barley)
Taxonomic identifier4513 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Pooideae › Triticeae › Hordeum

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Alcohol dehydrogenase 3
PRO_0000160701

Regions

Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding295 – 2973NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Binding site2261NAD By similarity
Binding site2311NAD By similarity
Binding site3721NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P10848 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: A97E94A74A68A05A

FASTA37941,011
        10         20         30         40         50         60 
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PVFPRILGHE AGGIVESVGE GVTELVPGDH VLPVFTGECK DCAHCKSEES NLCDLLRINV 

       130        140        150        160        170        180 
DRGVMIGDGQ SRFTINGKPI FHFVGTSTFS EYTVIHVGCL AKINPEAPLD KVCVLSCGLS 

       190        200        210        220        230        240 
TGLGATLNVA KPKKGSTVAI FGLGAVGLAA MEGARMAGAS RIIGVDLNPA KYEQAKKFGC 

       250        260        270        280        290        300 
TDFVNPKDHT KPVQEVLVEM TNGGVDRAVE CTGHIDAMIA TFECVHDGWG VAVLVGVPHK 

       310        320        330        340        350        360 
EAVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPEVVEMYMR KELDLEKFIT HSVPFSQINT 

       370 
AFDLMLKGEG LRCITRTDQ

« Hide

References

[1]"Molecular analysis of the alcohol dehydrogenase gene family of barley."
Trick M., Dennis E.S., Edwards K.J.R., Peacock W.J.
Plant Mol. Biol. 11:147-160(1988) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Proctor.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X12734 Genomic DNA. Translation: CAA31231.1.
PIRS04040.

3D structure databases

ProteinModelPortalP10848.
SMRP10848. Positions 4-374.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP10848.

Gene expression databases

GenevestigatorP10848.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH3_HORVU
AccessionPrimary (citable) accession number: P10848
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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