ID   ADH2_HORVU              Reviewed;         373 AA.
AC   P10847;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Alcohol dehydrogenase 2;
DE            EC=1.1.1.1;
GN   Name=ADH2;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Pooideae; Triticeae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Proctor;
RX   AGRICOLA=IND92000066; DOI=10.1007/BF00015667;
RA   Trick M., Dennis E.S., Edwards K.J.R., Peacock W.J.;
RT   "Molecular analysis of the alcohol dehydrogenase gene family of
RT   barley.";
RL   Plant Mol. Biol. 11:147-160(1988).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X12733; CAA31230.1; -; Genomic_DNA.
DR   PIR; S04039; S04039.
DR   HSSP; P11766; 1M6H.
DR   Gramene; P10847; -.
DR   BRENDA; 1.1.1.1; 283.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   CHAIN         1    373       Alcohol dehydrogenase 2.
FT                                /FTId=PRO_0000160700.
FT   NP_BIND     202    207       NAD (By similarity).
FT   NP_BIND     295    297       NAD (By similarity).
FT   METAL        47     47       Zinc 1; catalytic (By similarity).
FT   METAL        69     69       Zinc 1; catalytic (By similarity).
FT   METAL        99     99       Zinc 2 (By similarity).
FT   METAL       102    102       Zinc 2 (By similarity).
FT   METAL       105    105       Zinc 2 (By similarity).
FT   METAL       113    113       Zinc 2 (By similarity).
FT   METAL       177    177       Zinc 1; catalytic (By similarity).
FT   BINDING     226    226       NAD (By similarity).
FT   BINDING     231    231       NAD (By similarity).
FT   BINDING     366    366       NAD (By similarity).
SQ   SEQUENCE   373 AA;  40512 MW;  97EA42A3EA3937E9 CRC64;
     MATAGKVIKC KAAVAWEAGK PLSMEEVEDA PPQAMEVRDK ILYTALCHTD VYFWEANGQT
     PVFPRILGHE AGGIVESVGE GVTELVPGDH VLPVFTGECK ECAHCMSEES NLCDLLRINV
     DRGVMIDDGQ SRFTIDGKPI FHFLGTSTFS EYTVIHVGCV AKIDPEAPLD KVCLLSCGIS
     TGLGATLNVT KPKKGMTVAI FGLGAVGLAA MEGARMSGAS RIIGVDLNPA KHEQAKKFGC
     TDFVNPKDHT KPVQEVIVEM TDGGVNRAVE CTGNADAMIS AFECVHDGWG VAHKEAVFKT
     HPMNFLNERT LRGTFFGNYK PRTGLPGVVD MYMRKELELD KFITHSLPFS QINTAFDLML
     RGEGLRCVIR SEE
//