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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei316NAD; via amide nitrogenBy similarity1
Binding sitei366NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607001 – 373Alcohol dehydrogenase 2Add BLAST373

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP10847. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP10847.
SMRiP10847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P10847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSMEEVEDA PPQAMEVRDK ILYTALCHTD
60 70 80 90 100
VYFWEANGQT PVFPRILGHE AGGIVESVGE GVTELVPGDH VLPVFTGECK
110 120 130 140 150
ECAHCMSEES NLCDLLRINV DRGVMIDDGQ SRFTIDGKPI FHFLGTSTFS
160 170 180 190 200
EYTVIHVGCV AKIDPEAPLD KVCLLSCGIS TGLGATLNVT KPKKGMTVAI
210 220 230 240 250
FGLGAVGLAA MEGARMSGAS RIIGVDLNPA KHEQAKKFGC TDFVNPKDHT
260 270 280 290 300
KPVQEVIVEM TDGGVNRAVE CTGNADAMIS AFECVHDGWG VAHKEAVFKT
310 320 330 340 350
HPMNFLNERT LRGTFFGNYK PRTGLPGVVD MYMRKELELD KFITHSLPFS
360 370
QINTAFDLML RGEGLRCVIR SEE
Length:373
Mass (Da):40,512
Last modified:July 1, 1989 - v1
Checksum:i97EA42A3EA3937E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12733 Genomic DNA. Translation: CAA31230.1.
PIRiS04039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12733 Genomic DNA. Translation: CAA31230.1.
PIRiS04039.

3D structure databases

ProteinModelPortaliP10847.
SMRiP10847.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10847. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_HORVU
AccessioniPrimary (citable) accession number: P10847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.