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P10835 (MTC3_PBCVC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Modification methylase CviBIII

Short name=M.CviBIII
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase CviBIII
Gene names
Name:CVIBIIIM
OrganismParamecium bursaria Chlorella virus NC1A (PBCV-NC1A)
Taxonomic identifier46020 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostChlorella [TaxID: 3071]

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Modification methylase CviBIII
PRO_0000087948

Sequences

Sequence LengthMass (Da)Tools
P10835 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: B22D471367D61BBC

FASTA37742,895
        10         20         30         40         50         60 
MNVEQYTQVT TDFEKTLTKE KKSKQGIFFT PKTVREKLFG FTEHFQNTPG FSILEPSCGT 

        70         80         90        100        110        120 
GEIISECVER FPLASIKGVE LDNDMSTICS KKYAEYNVDI VNEDFLLWKG GKFDFIVGNP 

       130        140        150        160        170        180 
PYVVRPSGYK NDNRIAKGRS NLYVEFLYKC ITEHLKEDGI LAFIIPSTIG NSSFYEPIRK 

       190        200        210        220        230        240 
LIITLDILSF EILDKHDFCD TNTRLCSIVI KNSPGTGKYT YRDYICDKDI PHHGNSYIGS 

       250        260        270        280        290        300 
LDLKFKTGFA WANVNKFFTD KSEIPFFTSS NIKLNEIHIG DKMKYLTQDT TKFFTGKALL 

       310        320        330        340        350        360 
IKTASAGKRG GRFEFGFSLY ENDKWAVDND IIVIQGPDTV LSIVQDVLMK DVTNEFINIL 

       370 
VNNGHISMKL LKSIPLF 

« Hide

References

[1]"Molecular cloning and characterization of the gene encoding the DNA methyltransferase, M.CviBIII, from Chlorella virus NC-1A."
Narva K.E., Wendell D.L., Skrdla M.P., van Etten J.L.
Nucleic Acids Res. 15:9807-9823(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06618 Genomic DNA. Translation: CAA29835.1.

3D structure databases

ProteinModelPortalP10835.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE752. M.CviBIII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTC3_PBCVC
AccessionPrimary (citable) accession number: P10835
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries