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P10835

- MTC3_PBCVC

UniProt

P10835 - MTC3_PBCVC

Protein

Modification methylase CviBIII

Gene

CVIBIIIM

Organism
Paramecium bursaria Chlorella virus NC1A (PBCV-NC1A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi752. M.CviBIII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase CviBIII (EC:2.1.1.72)
    Short name:
    M.CviBIII
    Alternative name(s):
    Adenine-specific methyltransferase CviBIII
    Gene namesi
    Name:CVIBIIIM
    OrganismiParamecium bursaria Chlorella virus NC1A (PBCV-NC1A)
    Taxonomic identifieri46020 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
    Virus hostiChlorella [TaxID: 3071]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Modification methylase CviBIIIPRO_0000087948Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP10835.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10835-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVEQYTQVT TDFEKTLTKE KKSKQGIFFT PKTVREKLFG FTEHFQNTPG    50
    FSILEPSCGT GEIISECVER FPLASIKGVE LDNDMSTICS KKYAEYNVDI 100
    VNEDFLLWKG GKFDFIVGNP PYVVRPSGYK NDNRIAKGRS NLYVEFLYKC 150
    ITEHLKEDGI LAFIIPSTIG NSSFYEPIRK LIITLDILSF EILDKHDFCD 200
    TNTRLCSIVI KNSPGTGKYT YRDYICDKDI PHHGNSYIGS LDLKFKTGFA 250
    WANVNKFFTD KSEIPFFTSS NIKLNEIHIG DKMKYLTQDT TKFFTGKALL 300
    IKTASAGKRG GRFEFGFSLY ENDKWAVDND IIVIQGPDTV LSIVQDVLMK 350
    DVTNEFINIL VNNGHISMKL LKSIPLF 377
    Length:377
    Mass (Da):42,895
    Last modified:July 1, 1989 - v1
    Checksum:iB22D471367D61BBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06618 Genomic DNA. Translation: CAA29835.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06618 Genomic DNA. Translation: CAA29835.1 .

    3D structure databases

    ProteinModelPortali P10835.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 752. M.CviBIII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the gene encoding the DNA methyltransferase, M.CviBIII, from Chlorella virus NC-1A."
      Narva K.E., Wendell D.L., Skrdla M.P., van Etten J.L.
      Nucleic Acids Res. 15:9807-9823(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTC3_PBCVC
    AccessioniPrimary (citable) accession number: P10835
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3