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Protein

Modification methylase CviBIII

Gene

CVIBIIIM

Organism
Paramecium bursaria Chlorella virus NC1A (PBCV-NC1A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi752. M.CviBIII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CviBIII (EC:2.1.1.72)
Short name:
M.CviBIII
Alternative name(s):
Adenine-specific methyltransferase CviBIII
Gene namesi
Name:CVIBIIIM
OrganismiParamecium bursaria Chlorella virus NC1A (PBCV-NC1A)
Taxonomic identifieri46020 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 3071]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Modification methylase CviBIIIPRO_0000087948Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVEQYTQVT TDFEKTLTKE KKSKQGIFFT PKTVREKLFG FTEHFQNTPG
60 70 80 90 100
FSILEPSCGT GEIISECVER FPLASIKGVE LDNDMSTICS KKYAEYNVDI
110 120 130 140 150
VNEDFLLWKG GKFDFIVGNP PYVVRPSGYK NDNRIAKGRS NLYVEFLYKC
160 170 180 190 200
ITEHLKEDGI LAFIIPSTIG NSSFYEPIRK LIITLDILSF EILDKHDFCD
210 220 230 240 250
TNTRLCSIVI KNSPGTGKYT YRDYICDKDI PHHGNSYIGS LDLKFKTGFA
260 270 280 290 300
WANVNKFFTD KSEIPFFTSS NIKLNEIHIG DKMKYLTQDT TKFFTGKALL
310 320 330 340 350
IKTASAGKRG GRFEFGFSLY ENDKWAVDND IIVIQGPDTV LSIVQDVLMK
360 370
DVTNEFINIL VNNGHISMKL LKSIPLF
Length:377
Mass (Da):42,895
Last modified:July 1, 1989 - v1
Checksum:iB22D471367D61BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06618 Genomic DNA. Translation: CAA29835.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06618 Genomic DNA. Translation: CAA29835.1.

3D structure databases

ProteinModelPortaliP10835.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi752. M.CviBIII.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of the gene encoding the DNA methyltransferase, M.CviBIII, from Chlorella virus NC-1A."
    Narva K.E., Wendell D.L., Skrdla M.P., van Etten J.L.
    Nucleic Acids Res. 15:9807-9823(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTC3_PBCVC
AccessioniPrimary (citable) accession number: P10835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.