Rras

Functionⁱ

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	36 – 44	GTPBy similarity	9
Nucleotide bindingⁱ	83 – 87	GTPBy similarity	5
Nucleotide bindingⁱ	142 – 145	GTPBy similarity	4
Nucleotide bindingⁱ	172 – 174	GTPBy similarity	3

GO - Molecular functionⁱ

GDP binding Source: UniProtKB
GTPase activity Source: UniProtKB
GTP binding Source: UniProtKB-KW
protein complex binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23209302

Complete GO annotation...

GO - Biological processⁱ

face morphogenesis Source: MGI
leukocyte differentiation Source: MGI
negative regulation of cell migration
Source: MGI
Inferred from genetic interactionⁱ
- 14724565
positive regulation of angiogenesis Source: UniProtKB
regulation of ERK1 and ERK2 cascade Source: MGI
regulation of protein kinase B signaling Source: MGI
signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion. R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration. R-MMU-442742. CREB phosphorylation through the activation of Ras.

Reactomeⁱ

R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-442742. CREB phosphorylation through the activation of Ras.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein R-Ras Alternative name(s): p23
Gene namesⁱ	Name:Rras
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:98179. Rras.

Subcellular locationⁱ

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

Note:

Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

GO - Cellular componentⁱ

cytosol Source: Reactome
extracellular exosome Source: MGI
focal adhesion Source: MGI
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082651	1 – 215	Ras-related protein R-RasAdd BLAST		215
PropeptideⁱPRO_0000281301	216 – 218	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	215	Cysteine methyl esterBy similarity		1
Lipidationⁱ	215	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P10833.
PaxDbⁱ	P10833.
PeptideAtlas More...PeptideAtlasⁱ	P10833.
PRIDEⁱ	P10833.

PTM databases

iPTMnetⁱ	P10833.
PhosphoSitePlusⁱ	P10833.
SwissPalmⁱ	P10833.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000038387.
CleanExⁱ	MM_RRAS.
ExpressionAtlasⁱ	P10833. baseline and differential.
Genevisibleⁱ	P10833. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14. Interacts with OSBPL3.By similarity

GO - Molecular functionⁱ

protein complex binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23209302

Complete GO annotation...

Protein-protein interaction databases

IntActⁱ	P10833. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4133129.
STRINGⁱ	10090.ENSMUSP00000042150.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10833.
SMRⁱ	P10833.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	58 – 66	Effector region		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672.
HOGENOMⁱ	HOG000233973.
HOVERGENⁱ	HBG009351.
InParanoidⁱ	P10833.
KEGG Orthology (KO) More...KOⁱ	K07829.
OMAⁱ	RSEASTF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU.
PhylomeDBⁱ	P10833.
TreeFamⁱ	TF312796.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10833-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI 
        60         70         80         90        100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA 
       110        120        130        140        150
GNGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPIVLV GNKADLENQR 
       160        170        180        190        200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP 
       210 
SPPSAPRKKD GGCPCVLL

Length:218

Mass (Da):23,764

Last modified:July 1, 1989 - v1

Checksum:ⁱC1D32CE7904322E5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21019 mRNA. Translation: AAA40038.1. BC009105 mRNA. Translation: AAH09105.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21226.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033127.1. NM_009101.2.
UniGeneⁱ	Mm.389894.

Genome annotation databases

Ensemblⁱ	ENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387.
GeneIDⁱ	20130.
KEGGⁱ	mmu:20130.
UCSC genome browser More...UCSCⁱ	uc009gss.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21019 mRNA. Translation: AAA40038.1. BC009105 mRNA. Translation: AAH09105.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21226.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033127.1. NM_009101.2.
UniGeneⁱ	Mm.389894.

3D structure databases

ProteinModelPortalⁱ	P10833.
SMRⁱ	P10833.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P10833. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4133129.
STRINGⁱ	10090.ENSMUSP00000042150.

PTM databases

iPTMnetⁱ	P10833.
PhosphoSitePlusⁱ	P10833.
SwissPalmⁱ	P10833.

Proteomic databases

EPDⁱ	P10833.
PaxDbⁱ	P10833.
PeptideAtlas More...PeptideAtlasⁱ	P10833.
PRIDEⁱ	P10833.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387.
GeneIDⁱ	20130.
KEGGⁱ	mmu:20130.
UCSC genome browser More...UCSCⁱ	uc009gss.1. mouse.

Organism-specific databases

CTDⁱ	6237.
MGIⁱ	MGI:98179. Rras.

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672.
HOGENOMⁱ	HOG000233973.
HOVERGENⁱ	HBG009351.
InParanoidⁱ	P10833.
KEGG Orthology (KO) More...KOⁱ	K07829.
OMAⁱ	RSEASTF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU.
PhylomeDBⁱ	P10833.
TreeFamⁱ	TF312796.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion. R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration. R-MMU-442742. CREB phosphorylation through the activation of Ras.

Reactomeⁱ

R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-442742. CREB phosphorylation through the activation of Ras.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10833.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038387.
CleanExⁱ	MM_RRAS.
ExpressionAtlasⁱ	P10833. baseline and differential.
Genevisibleⁱ	P10833. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRAS_MOUSE
Accessionⁱ	P10833Primary (citable) accession number: P10833
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	May 10, 2017
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10833 (RRAS_MOUSE)

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Ras-related protein R-Ras

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ