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Protein

Ras-related protein R-Ras

Gene

Rras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 449GTPBy similarity
Nucleotide bindingi83 – 875GTPBy similarity
Nucleotide bindingi142 – 1454GTPBy similarity
Nucleotide bindingi172 – 1743GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-442742. CREB phosphorylation through the activation of Ras.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:Rras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98179. Rras.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Ras-related protein R-RasPRO_0000082651Add
BLAST
Propeptidei216 – 2183Removed in mature formBy similarityPRO_0000281301

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei215 – 2151Cysteine methyl esterBy similarity
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP10833.
PaxDbiP10833.
PRIDEiP10833.

PTM databases

iPTMnetiP10833.
PhosphoSiteiP10833.
SwissPalmiP10833.

Expressioni

Gene expression databases

BgeeiP10833.
CleanExiMM_RRAS.
ExpressionAtlasiP10833. baseline and differential.
GenevisibleiP10833. MM.

Interactioni

Subunit structurei

Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14. Interacts with OSBPL3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP10833. 1 interaction.
MINTiMINT-4133129.
STRINGi10090.ENSMUSP00000042150.

Structurei

3D structure databases

ProteinModelPortaliP10833.
SMRiP10833. Positions 24-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 669Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP10833.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG7QVM41.
PhylomeDBiP10833.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPIVLV GNKADLENQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKD GGCPCVLL
Length:218
Mass (Da):23,764
Last modified:July 1, 1989 - v1
Checksum:iC1D32CE7904322E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21019 mRNA. Translation: AAA40038.1.
BC009105 mRNA. Translation: AAH09105.1.
CCDSiCCDS21226.1.
RefSeqiNP_033127.1. NM_009101.2.
UniGeneiMm.389894.

Genome annotation databases

EnsembliENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387.
GeneIDi20130.
KEGGimmu:20130.
UCSCiuc009gss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21019 mRNA. Translation: AAA40038.1.
BC009105 mRNA. Translation: AAH09105.1.
CCDSiCCDS21226.1.
RefSeqiNP_033127.1. NM_009101.2.
UniGeneiMm.389894.

3D structure databases

ProteinModelPortaliP10833.
SMRiP10833. Positions 24-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10833. 1 interaction.
MINTiMINT-4133129.
STRINGi10090.ENSMUSP00000042150.

PTM databases

iPTMnetiP10833.
PhosphoSiteiP10833.
SwissPalmiP10833.

Proteomic databases

EPDiP10833.
PaxDbiP10833.
PRIDEiP10833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387.
GeneIDi20130.
KEGGimmu:20130.
UCSCiuc009gss.1. mouse.

Organism-specific databases

CTDi6237.
MGIiMGI:98179. Rras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP10833.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG7QVM41.
PhylomeDBiP10833.
TreeFamiTF312796.

Enzyme and pathway databases

ReactomeiR-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-442742. CREB phosphorylation through the activation of Ras.

Miscellaneous databases

NextBioi297635.
PROiP10833.
SOURCEiSearch...

Gene expression databases

BgeeiP10833.
CleanExiMM_RRAS.
ExpressionAtlasiP10833. baseline and differential.
GenevisibleiP10833. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes."
    Lowe D.G., Capon D.J., Delwart E., Sakaguchi A.Y., Naylor S.L., Goeddel D.V.
    Cell 48:137-146(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRRAS_MOUSE
AccessioniPrimary (citable) accession number: P10833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.