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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei282Thyroid hormone1
Binding sitei320Thyroid hormone1
Binding sitei331Thyroid hormone; via amide nitrogen1
Binding sitei435Thyroid hormone1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • chromatin DNA binding Source: Ensembl
  • DNA binding Source: ProtInc
  • enzyme binding Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • thyroid hormone binding Source: UniProtKB
  • thyroid hormone receptor activity Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151090-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10828.
SIGNORiP10828.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:THRB
Synonyms:ERBA2, NR1A2, THR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11799. THRB.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nuclear chromatin Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Generalized thyroid hormone resistance (GTHR)17 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
See also OMIM:188570
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant rs121918694dbSNPEnsembl.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant rs121918707dbSNPEnsembl.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant rs121918690dbSNPEnsembl.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant rs121918696dbSNPEnsembl.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant rs121918693dbSNPEnsembl.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant rs28999969dbSNPEnsembl.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant rs121918697dbSNPEnsembl.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant rs121918688dbSNPEnsembl.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant rs121918686dbSNPEnsembl.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant rs121918686dbSNPEnsembl.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant rs28999970dbSNPEnsembl.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant rs28999971dbSNPEnsembl.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant rs121918698dbSNPEnsembl.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant rs121918691dbSNPEnsembl.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant rs121918692dbSNPEnsembl.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant rs121918703dbSNPEnsembl.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant rs121918687dbSNPEnsembl.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 Publication1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant rs28933408dbSNPEnsembl.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant rs121918702dbSNPEnsembl.1
Generalized thyroid hormone resistance autosomal recessive (GTHRAR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone.
See also OMIM:274300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Selective pituitary thyroid hormone resistance (PRTH)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionVariant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
See also OMIM:145650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant rs121918695dbSNPEnsembl.1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207 – 208SI → AA: Modestly inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi207 – 208SI → KK: Inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi243R → Q: Impairs hormone binding and ligand-dependent conformational changes. 1 Publication1
Mutagenesisi331N → S: No effect on thyroid hormone binding. 2 Publications1
Mutagenesisi355D → R: Stabilizes homodimer. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNETi7068.
MalaCardsiTHRB.
MIMi145650. phenotype.
188570. phenotype.
274300. phenotype.
OpenTargetsiENSG00000151090.
Orphaneti3221. Generalized resistance to thyroid hormone.
97927. Peripheral resistance to thyroid hormones.
165994. Selective pituitary resistance to thyroid hormone.
PharmGKBiPA36508.

Chemistry databases

ChEMBLiCHEMBL1947.
DrugBankiDB00509. Dextrothyroxine.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
GuidetoPHARMACOLOGYi589.

Polymorphism and mutation databases

BioMutaiTHRB.
DMDMi586092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534461 – 461Thyroid hormone receptor betaAdd BLAST461

Proteomic databases

MaxQBiP10828.
PaxDbiP10828.
PeptideAtlasiP10828.
PRIDEiP10828.

PTM databases

iPTMnetiP10828.
PhosphoSitePlusiP10828.

Expressioni

Gene expression databases

BgeeiENSG00000151090.
CleanExiHS_THRB.
ExpressionAtlasiP10828. baseline and differential.
GenevisibleiP10828. HS.

Organism-specific databases

HPAiCAB002008.
CAB002009.
HPA061035.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRA. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP.By similarity11 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112924. 55 interactors.
DIPiDIP-5991N.
IntActiP10828. 11 interactors.
MINTiMINT-1508903.
STRINGi9606.ENSP00000348827.

Chemistry databases

BindingDBiP10828.

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni108 – 110Combined sources3
Beta strandi116 – 118Combined sources3
Helixi125 – 136Combined sources12
Helixi140 – 142Combined sources3
Turni155 – 159Combined sources5
Helixi162 – 171Combined sources10
Helixi176 – 178Combined sources3
Helixi182 – 195Combined sources14
Helixi198 – 204Combined sources7
Helixi205 – 208Combined sources4
Helixi216 – 230Combined sources15
Turni234 – 237Combined sources4
Helixi239 – 242Combined sources4
Turni248 – 251Combined sources4
Beta strandi260 – 263Combined sources4
Helixi266 – 273Combined sources8
Helixi276 – 288Combined sources13
Helixi293 – 295Combined sources3
Helixi298 – 319Combined sources22
Turni323 – 326Combined sources4
Beta strandi327 – 330Combined sources4
Turni331 – 333Combined sources3
Beta strandi334 – 336Combined sources3
Helixi338 – 343Combined sources6
Turni344 – 348Combined sources5
Helixi349 – 360Combined sources12
Helixi361 – 363Combined sources3
Helixi367 – 378Combined sources12
Helixi389 – 410Combined sources22
Beta strandi413 – 416Combined sources4
Helixi417 – 445Combined sources29
Helixi448 – 450Combined sources3
Helixi453 – 459Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSXX-ray3.70A/B202-461[»]
1N46X-ray2.20A/B204-461[»]
1NAXX-ray2.70A209-460[»]
1NQ0X-ray2.40A202-461[»]
1NQ1X-ray2.90A202-461[»]
1NQ2X-ray2.40A202-461[»]
1NUOX-ray3.10A202-461[»]
1Q4XX-ray2.80A209-461[»]
1R6GX-ray3.00A203-461[»]
1XZXX-ray2.50X202-461[»]
1Y0XX-ray3.10X202-461[»]
2J4AX-ray2.20A209-461[»]
2NLLX-ray1.90B104-204[»]
2PINX-ray2.30A/B209-461[»]
3D57X-ray2.20A/B209-460[»]
3GWSX-ray2.20X202-460[»]
3IMYX-ray2.55A202-461[»]
3JZCX-ray2.50A202-461[»]
4ZO1X-ray3.22X210-461[»]
ProteinModelPortaliP10828.
SMRiP10828.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10828.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106ModulatingAdd BLAST106
Regioni244 – 461Interaction with NR2F61 PublicationAdd BLAST218
Regioni244 – 461Ligand-bindingAdd BLAST218

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP10828.
KOiK08362.
OMAiWELIKIV.
OrthoDBiEOG091G0GC1.
PhylomeDBiP10828.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta-1 (identifier: P10828-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,788
Last modified:October 1, 1994 - v2
Checksum:i6770BB0D372A7CAA
GO
Isoform Beta-2 (identifier: P10828-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMQEIYE...QVQSPSYSQK

Show »
Length:476
Mass (Da):54,449
Checksum:i21755292507335D8
GO

Sequence cautioni

The sequence AAA35677 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA28412 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243R → P in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti243R → P in CAA28412 (PubMed:2879243).Curated1
Sequence conflicti451F → L in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti451F → L in CAA28412 (PubMed:2879243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050577216D → G.Corresponds to variant rs9865746dbSNPEnsembl.1
Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant rs121918694dbSNPEnsembl.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant rs121918707dbSNPEnsembl.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant rs121918695dbSNPEnsembl.1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant rs121918690dbSNPEnsembl.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant rs121918696dbSNPEnsembl.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant rs121918693dbSNPEnsembl.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant rs28999969dbSNPEnsembl.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_011784337T → I.2 PublicationsCorresponds to variant rs1054624dbSNPEnsembl.1
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant rs121918697dbSNPEnsembl.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant rs121918688dbSNPEnsembl.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant rs121918686dbSNPEnsembl.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant rs121918686dbSNPEnsembl.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant rs28999970dbSNPEnsembl.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant rs28999971dbSNPEnsembl.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant rs121918698dbSNPEnsembl.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant rs121918691dbSNPEnsembl.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant rs121918692dbSNPEnsembl.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant rs121918703dbSNPEnsembl.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant rs121918687dbSNPEnsembl.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 Publication1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant rs28933408dbSNPEnsembl.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant rs121918702dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310771 – 93MTPNS…EEKKC → MNYCMQEIYEVHPAAGSNCY MQSTDYYAYFEDSPGYSGCD AQAVPSNNIYMEQAWAVNQP YTCSYPGNMFKSKDSDLDMA LNQYSQPEYFTEEKPTFSQV QSPSYSQK in isoform Beta-2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26747 mRNA. Translation: AAA35677.1. Different initiation.
X04707 mRNA. Translation: CAA28412.1. Different initiation.
AK096628 mRNA. Translation: BAG53341.1.
AC012087 Genomic DNA. No translation available.
AC093927 Genomic DNA. No translation available.
AC098971 Genomic DNA. No translation available.
AC099054 Genomic DNA. No translation available.
AC112217 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64345.1.
BC106929 mRNA. Translation: AAI06930.1.
BC106930 mRNA. Translation: AAI06931.1.
AY286465 mRNA. Translation: AAQ23704.1.
AY286466 mRNA. Translation: AAQ23705.1.
AY286467 mRNA. Translation: AAQ23706.1.
AY286468 mRNA. Translation: AAQ23707.1.
AY286469 mRNA. Translation: AAQ23708.1.
AY286470 mRNA. Translation: AAQ23709.1.
AY286471 mRNA. Translation: AAQ23710.1.
X74497 mRNA. Translation: CAA52606.1.
CCDSiCCDS2641.1. [P10828-1]
PIRiA25237. TVHUAR.
S40152.
RefSeqiNP_000452.2. NM_000461.4. [P10828-1]
NP_001121648.1. NM_001128176.2. [P10828-1]
NP_001121649.1. NM_001128177.1. [P10828-1]
NP_001239563.1. NM_001252634.1. [P10828-1]
XP_005265478.1. XM_005265421.4. [P10828-1]
XP_005265480.1. XM_005265423.4. [P10828-1]
XP_005265481.1. XM_005265424.3. [P10828-1]
XP_006713380.1. XM_006713317.3. [P10828-1]
XP_006713381.1. XM_006713318.3. [P10828-1]
XP_011532348.1. XM_011534046.2. [P10828-1]
XP_011532349.1. XM_011534047.2. [P10828-1]
XP_011532350.1. XM_011534048.2. [P10828-1]
XP_011532351.1. XM_011534049.2. [P10828-1]
XP_011532352.1. XM_011534050.2. [P10828-1]
XP_011532353.1. XM_011534051.2. [P10828-1]
XP_011532354.1. XM_011534052.2. [P10828-1]
XP_016862597.1. XM_017007108.1. [P10828-1]
XP_016862598.1. XM_017007109.1. [P10828-1]
XP_016862599.1. XM_017007110.1. [P10828-1]
XP_016862600.1. XM_017007111.1. [P10828-1]
XP_016862601.1. XM_017007112.1. [P10828-1]
UniGeneiHs.187861.
Hs.713754.

Genome annotation databases

EnsembliENST00000280696; ENSP00000280696; ENSG00000151090. [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090. [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090. [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090. [P10828-1]
GeneIDi7068.
KEGGihsa:7068.
UCSCiuc003ccx.5. human. [P10828-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26747 mRNA. Translation: AAA35677.1. Different initiation.
X04707 mRNA. Translation: CAA28412.1. Different initiation.
AK096628 mRNA. Translation: BAG53341.1.
AC012087 Genomic DNA. No translation available.
AC093927 Genomic DNA. No translation available.
AC098971 Genomic DNA. No translation available.
AC099054 Genomic DNA. No translation available.
AC112217 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64345.1.
BC106929 mRNA. Translation: AAI06930.1.
BC106930 mRNA. Translation: AAI06931.1.
AY286465 mRNA. Translation: AAQ23704.1.
AY286466 mRNA. Translation: AAQ23705.1.
AY286467 mRNA. Translation: AAQ23706.1.
AY286468 mRNA. Translation: AAQ23707.1.
AY286469 mRNA. Translation: AAQ23708.1.
AY286470 mRNA. Translation: AAQ23709.1.
AY286471 mRNA. Translation: AAQ23710.1.
X74497 mRNA. Translation: CAA52606.1.
CCDSiCCDS2641.1. [P10828-1]
PIRiA25237. TVHUAR.
S40152.
RefSeqiNP_000452.2. NM_000461.4. [P10828-1]
NP_001121648.1. NM_001128176.2. [P10828-1]
NP_001121649.1. NM_001128177.1. [P10828-1]
NP_001239563.1. NM_001252634.1. [P10828-1]
XP_005265478.1. XM_005265421.4. [P10828-1]
XP_005265480.1. XM_005265423.4. [P10828-1]
XP_005265481.1. XM_005265424.3. [P10828-1]
XP_006713380.1. XM_006713317.3. [P10828-1]
XP_006713381.1. XM_006713318.3. [P10828-1]
XP_011532348.1. XM_011534046.2. [P10828-1]
XP_011532349.1. XM_011534047.2. [P10828-1]
XP_011532350.1. XM_011534048.2. [P10828-1]
XP_011532351.1. XM_011534049.2. [P10828-1]
XP_011532352.1. XM_011534050.2. [P10828-1]
XP_011532353.1. XM_011534051.2. [P10828-1]
XP_011532354.1. XM_011534052.2. [P10828-1]
XP_016862597.1. XM_017007108.1. [P10828-1]
XP_016862598.1. XM_017007109.1. [P10828-1]
XP_016862599.1. XM_017007110.1. [P10828-1]
XP_016862600.1. XM_017007111.1. [P10828-1]
XP_016862601.1. XM_017007112.1. [P10828-1]
UniGeneiHs.187861.
Hs.713754.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSXX-ray3.70A/B202-461[»]
1N46X-ray2.20A/B204-461[»]
1NAXX-ray2.70A209-460[»]
1NQ0X-ray2.40A202-461[»]
1NQ1X-ray2.90A202-461[»]
1NQ2X-ray2.40A202-461[»]
1NUOX-ray3.10A202-461[»]
1Q4XX-ray2.80A209-461[»]
1R6GX-ray3.00A203-461[»]
1XZXX-ray2.50X202-461[»]
1Y0XX-ray3.10X202-461[»]
2J4AX-ray2.20A209-461[»]
2NLLX-ray1.90B104-204[»]
2PINX-ray2.30A/B209-461[»]
3D57X-ray2.20A/B209-460[»]
3GWSX-ray2.20X202-460[»]
3IMYX-ray2.55A202-461[»]
3JZCX-ray2.50A202-461[»]
4ZO1X-ray3.22X210-461[»]
ProteinModelPortaliP10828.
SMRiP10828.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112924. 55 interactors.
DIPiDIP-5991N.
IntActiP10828. 11 interactors.
MINTiMINT-1508903.
STRINGi9606.ENSP00000348827.

Chemistry databases

BindingDBiP10828.
ChEMBLiCHEMBL1947.
DrugBankiDB00509. Dextrothyroxine.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
GuidetoPHARMACOLOGYi589.

PTM databases

iPTMnetiP10828.
PhosphoSitePlusiP10828.

Polymorphism and mutation databases

BioMutaiTHRB.
DMDMi586092.

Proteomic databases

MaxQBiP10828.
PaxDbiP10828.
PeptideAtlasiP10828.
PRIDEiP10828.

Protocols and materials databases

DNASUi7068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280696; ENSP00000280696; ENSG00000151090. [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090. [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090. [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090. [P10828-1]
GeneIDi7068.
KEGGihsa:7068.
UCSCiuc003ccx.5. human. [P10828-1]

Organism-specific databases

CTDi7068.
DisGeNETi7068.
GeneCardsiTHRB.
HGNCiHGNC:11799. THRB.
HPAiCAB002008.
CAB002009.
HPA061035.
MalaCardsiTHRB.
MIMi145650. phenotype.
188570. phenotype.
190160. gene.
274300. phenotype.
neXtProtiNX_P10828.
OpenTargetsiENSG00000151090.
Orphaneti3221. Generalized resistance to thyroid hormone.
97927. Peripheral resistance to thyroid hormones.
165994. Selective pituitary resistance to thyroid hormone.
PharmGKBiPA36508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP10828.
KOiK08362.
OMAiWELIKIV.
OrthoDBiEOG091G0GC1.
PhylomeDBiP10828.
TreeFamiTF328382.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151090-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10828.
SIGNORiP10828.

Miscellaneous databases

ChiTaRSiTHRB. human.
EvolutionaryTraceiP10828.
GeneWikiiThyroid_hormone_receptor_beta.
GenomeRNAii7068.
PROiP10828.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151090.
CleanExiHS_THRB.
ExpressionAtlasiP10828. baseline and differential.
GenevisibleiP10828. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHB_HUMAN
AccessioniPrimary (citable) accession number: P10828
Secondary accession number(s): B3KU79
, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 208 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.