UniProtKB - P10827 (THA_HUMAN)
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Thyroid hormone receptor alpha
THRA
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 228 | Thyroid hormone | 1 | |
Binding sitei | 277 | Thyroid hormone; via amide nitrogen | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 53 – 127 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 53 – 73 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 91 – 115 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- chromatin DNA binding Source: Ensembl
- DNA binding transcription factor activity Source: UniProtKB
- protein complex binding Source: Ensembl
- protein domain specific binding Source: UniProtKB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- steroid hormone receptor activity Source: InterPro
- steroid receptor RNA activator RNA binding Source: Ensembl
- TBP-class protein binding Source: UniProtKB
- thyroid hormone binding Source: UniProtKB
- thyroid hormone receptor activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
- transcription regulatory region DNA binding Source: BHF-UCL
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- cartilage condensation Source: Ensembl
- cytoplasmic sequestering of transcription factor Source: Ensembl
- erythrocyte differentiation Source: Ensembl
- female courtship behavior Source: Ensembl
- hormone-mediated signaling pathway Source: BHF-UCL
- learning or memory Source: Ensembl
- negative regulation of DNA-templated transcription, initiation Source: UniProtKB
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- ossification Source: Ensembl
- positive regulation of female receptivity Source: Ensembl
- positive regulation of myotube differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of heart contraction Source: Ensembl
- regulation of lipid catabolic process Source: Ensembl
- regulation of myeloid cell apoptotic process Source: Ensembl
- regulation of thyroid hormone mediated signaling pathway Source: Ensembl
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- response to cold Source: Ensembl
- thyroid gland development Source: Ensembl
- transcription by RNA polymerase II Source: UniProtKB
- transcription initiation from RNA polymerase II promoter Source: Reactome
- Type I pneumocyte differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-383280. Nuclear Receptor transcription pathway. |
SignaLinki | P10827. |
SIGNORi | P10827. |
Names & Taxonomyi
Protein namesi | Recommended name: Thyroid hormone receptor alphaAlternative name(s): Nuclear receptor subfamily 1 group A member 1 V-erbA-related protein 7 Short name: EAR-7 c-erbA-1 c-erbA-alpha |
Gene namesi | Name:THRA Synonyms:EAR7, ERBA1, NR1A1, THRA1, THRA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126351.12. |
HGNCi | HGNC:11796. THRA. |
MIMi | 190120. gene. |
neXtProti | NX_P10827. |
Pathology & Biotechi
Involvement in diseasei
Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_074559 | 263 | A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 Publication | 1 | ||
Natural variantiVAR_074560 | 359 | N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication | 1 | ||
Isoform Alpha-1 (identifier: P10827-2) | |||||
Natural varianti | 263 | A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.23. 3 Publications | 1 | ||
Natural varianti | 359 | N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.24. 3 Publications | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 277 | S → N: No effect on thyroid hormone binding. 2 Publications | 1 |
Keywords - Diseasei
Congenital hypothyroidism, Disease mutationOrganism-specific databases
DisGeNETi | 7067. |
MalaCardsi | THRA. |
MIMi | 614450. phenotype. |
OpenTargetsi | ENSG00000126351. |
Orphaneti | 97927. Peripheral resistance to thyroid hormones. |
PharmGKBi | PA36507. |
Chemistry databases
ChEMBLi | CHEMBL1860. |
DrugBanki | DB00509. Dextrothyroxine. DB05035. KB2115. DB00451. Levothyroxine. DB00279. Liothyronine. DB01583. Liotrix. DB05235. NRP409. |
GuidetoPHARMACOLOGYi | 588. |
Polymorphism and mutation databases
BioMutai | THRA. |
DMDMi | 135705. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053424 | 1 – 490 | Thyroid hormone receptor alphaAdd BLAST | 490 |
Proteomic databases
MaxQBi | P10827. |
PaxDbi | P10827. |
PeptideAtlasi | P10827. |
PRIDEi | P10827. |
PTM databases
iPTMneti | P10827. |
PhosphoSitePlusi | P10827. |
Expressioni
Gene expression databases
Bgeei | ENSG00000126351. |
CleanExi | HS_THRA. |
ExpressionAtlasi | P10827. baseline and differential. |
Genevisiblei | P10827. HS. |
Organism-specific databases
HPAi | CAB023349. HPA009654. |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- protein complex binding Source: Ensembl
- protein domain specific binding Source: UniProtKB
- TBP-class protein binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 112923. 79 interactors. |
CORUMi | P10827. |
DIPi | DIP-31452N. |
IntActi | P10827. 27 interactors. |
MINTi | P10827. |
STRINGi | 9606.ENSP00000264637. |
Chemistry databases
BindingDBi | P10827. |
Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 148 – 151 | Combined sources | 4 | |
Turni | 152 – 154 | Combined sources | 3 | |
Helixi | 162 – 176 | Combined sources | 15 | |
Turni | 180 – 184 | Combined sources | 5 | |
Turni | 186 – 188 | Combined sources | 3 | |
Beta strandi | 189 – 191 | Combined sources | 3 | |
Beta strandi | 196 – 198 | Combined sources | 3 | |
Helixi | 212 – 234 | Combined sources | 23 | |
Helixi | 237 – 240 | Combined sources | 4 | |
Helixi | 244 – 264 | Combined sources | 21 | |
Turni | 269 – 272 | Combined sources | 4 | |
Beta strandi | 273 – 276 | Combined sources | 4 | |
Turni | 277 – 279 | Combined sources | 3 | |
Beta strandi | 280 – 282 | Combined sources | 3 | |
Helixi | 284 – 289 | Combined sources | 6 | |
Turni | 290 – 293 | Combined sources | 4 | |
Helixi | 294 – 306 | Combined sources | 13 | |
Helixi | 307 – 309 | Combined sources | 3 | |
Helixi | 313 – 324 | Combined sources | 12 | |
Beta strandi | 329 – 331 | Combined sources | 3 | |
Helixi | 335 – 356 | Combined sources | 22 | |
Helixi | 363 – 370 | Combined sources | 8 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NAV | X-ray | 2.50 | A | 148-370 | [»] | |
2H77 | X-ray | 2.33 | A | 148-370 | [»] | |
2H79 | X-ray | 1.87 | A | 148-370 | [»] | |
3HZF | X-ray | 2.50 | A | 148-370 | [»] | |
3ILZ | X-ray | 1.85 | A | 148-370 | [»] | |
3JZB | X-ray | 2.01 | A | 148-370 | [»] | |
4LNW | X-ray | 1.90 | A | 148-370 | [»] | |
4LNX | X-ray | 2.05 | A | 148-370 | [»] | |
ProteinModelPortali | P10827. | |||||
SMRi | P10827. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10827. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 407 | NR LBDPROSITE-ProRule annotationAdd BLAST | 245 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | ModulatingAdd BLAST | 52 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 53 – 73 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 91 – 115 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575. Eukaryota. ENOG410XRZC. LUCA. |
GeneTreei | ENSGT00870000136372. |
HOGENOMi | HOG000010313. |
HOVERGENi | HBG005606. |
InParanoidi | P10827. |
KOi | K05547. |
OMAi | WLNGPKR. |
OrthoDBi | EOG091G0GC1. |
PhylomeDBi | P10827. |
TreeFami | TF328382. |
Family and domain databases
Gene3Di | 3.30.50.10. 1 hit. |
InterProi | View protein in InterPro IPR035500. NHR_like_dom_sf. IPR000536. Nucl_hrmn_rcpt_lig-bd. IPR001723. Nuclear_hrmn_rcpt. IPR001728. ThyrH_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. |
Pfami | View protein in Pfam PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. |
PRINTSi | PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00546. THYROIDHORMR. |
SMARTi | View protein in SMART SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. |
SUPFAMi | SSF48508. SSF48508. 1 hit. |
PROSITEi | View protein in PROSITE PS51843. NR_LBD. 1 hit. PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
The sequence of this isoform differs from the canonical sequence as follows:
371-490: EREVQSSILY...EDLAGNAASP → VTDLRMIGAC...FLEVFEDQEV
The sequence of this isoform differs from the canonical sequence as follows:
371-409: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
371-412: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | T → S in CAA68539 (PubMed:3684612).Curated | 1 | |
Sequence conflicti | 119 | G → A in CAA68539 (PubMed:3684612).Curated | 1 | |
Sequence conflicti | 285 | E → A in CAB57886 (PubMed:1850510).Curated | 1 | |
Sequence conflicti | 285 | E → A in CAA38899 (PubMed:1850510).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_074559 | 263 | A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 Publication | 1 | ||
Natural variantiVAR_074560 | 359 | N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication | 1 | ||
Isoform Alpha-1 (identifier: P10827-2) | |||||
Natural varianti | 263 | A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.23. 3 Publications | 1 | ||
Natural varianti | 359 | N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.24. 3 Publications | 1 | ||
Natural varianti | 398 | P → R in CHNG6) (Ref.25. 3 Publications | 1 | ||
Natural varianti | 403 | E → Q in CHNG6) (Ref.25. 3 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003621 | 371 – 490 | EREVQ…NAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1. 2 PublicationsAdd BLAST | 120 | |
Alternative sequenceiVSP_003623 | 371 – 412 | Missing in isoform Alpha-4. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_003622 | 371 – 409 | Missing in isoform Alpha-3. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55074 X55066 Genomic DNA. Translation: CAB57886.1. X55005 mRNA. Translation: CAA38749.1. X55074 X55068 Genomic DNA. Translation: CAA38899.1. M24899 mRNA. Translation: AAA35783.1. M24900 mRNA. Translation: AAA52333.1. J03239 mRNA. Translation: AAA61176.1. Y00479 mRNA. Translation: CAA68539.1. M24748 Genomic DNA. Translation: AAA66021.1. AK290530 mRNA. Translation: BAF83219.1. CH471152 Genomic DNA. Translation: EAW60632.1. BC000261 mRNA. Translation: AAH00261.1. BC002728 mRNA. Translation: AAH02728.1. BC035137 mRNA. Translation: AAH35137.1. AF522368 mRNA. Translation: AAM77692.1. |
CCDSi | CCDS11360.1. [P10827-1] CCDS42316.1. [P10827-2] CCDS58546.1. [P10827-3] |
PIRi | A30893. A40917. S06163. |
RefSeqi | NP_001177847.1. NM_001190918.1. [P10827-3] NP_001177848.1. NM_001190919.1. [P10827-1] NP_003241.2. NM_003250.5. [P10827-1] NP_955366.1. NM_199334.3. [P10827-2] |
UniGenei | Hs.724. |
Genome annotation databases
Ensembli | ENST00000264637; ENSP00000264637; ENSG00000126351. [P10827-1] ENST00000394121; ENSP00000377679; ENSG00000126351. [P10827-1] ENST00000450525; ENSP00000395641; ENSG00000126351. [P10827-2] ENST00000546243; ENSP00000443972; ENSG00000126351. [P10827-2] ENST00000584985; ENSP00000463466; ENSG00000126351. [P10827-3] |
GeneIDi | 7067. |
KEGGi | hsa:7067. |
UCSCi | uc002htw.4. human. [P10827-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | THA_HUMAN | |
Accessioni | P10827Primary (citable) accession number: P10827 Secondary accession number(s): A8K3B5 Q96H73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | March 28, 2018 | |
This is version 218 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |