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Protein

Thyroid hormone receptor alpha

Gene

THRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.4 Publications
Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228Thyroid hormone1
Binding sitei277Thyroid hormone; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 127Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • chromatin DNA binding Source: Ensembl
  • protein domain specific binding Source: UniProtKB
  • steroid hormone receptor activity Source: InterPro
  • steroid receptor RNA activator RNA binding Source: Ensembl
  • TBP-class protein binding Source: UniProtKB
  • thyroid hormone binding Source: UniProtKB
  • thyroid hormone receptor activity Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: BHF-UCL
  • transcription regulatory region sequence-specific DNA binding Source: Ensembl
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126351-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10827.
SIGNORiP10827.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
V-erbA-related protein 7
Short name:
EAR-7
c-erbA-1
c-erbA-alpha
Gene namesi
Name:THRA
Synonyms:EAR7, ERBA1, NR1A1, THRA1, THRA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11796. THRA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.
See also OMIM:614450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074559263A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 Publication1
Natural variantiVAR_074560359N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication1
Isoform Alpha-1 (identifier: P10827-2)
Natural varianti263A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.23. 3 Publications1
Natural varianti359N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.24. 3 Publications1
Natural varianti398P → R in CHNG6) (Ref.25. 3 Publications1
Natural varianti403E → Q in CHNG6) (Ref.25. 3 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi277S → N: No effect on thyroid hormone binding. 2 Publications1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi7067.
MalaCardsiTHRA.
MIMi614450. phenotype.
OpenTargetsiENSG00000126351.
Orphaneti97927. Peripheral resistance to thyroid hormones.
PharmGKBiPA36507.

Chemistry databases

ChEMBLiCHEMBL1860.
DrugBankiDB00509. Dextrothyroxine.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
GuidetoPHARMACOLOGYi588.

Polymorphism and mutation databases

BioMutaiTHRA.
DMDMi135705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534241 – 490Thyroid hormone receptor alphaAdd BLAST490

Proteomic databases

MaxQBiP10827.
PaxDbiP10827.
PeptideAtlasiP10827.
PRIDEiP10827.

PTM databases

iPTMnetiP10827.
PhosphoSitePlusiP10827.

Expressioni

Gene expression databases

BgeeiENSG00000126351.
CleanExiHS_THRA.
ExpressionAtlasiP10827. baseline and differential.
GenevisibleiP10827. HS.

Organism-specific databases

HPAiCAB023349.
HPA009654.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-286285,EBI-10187270
CEP76Q8TAP63EBI-286285,EBI-742887
L3MBTL3Q96JM73EBI-286285,EBI-2686809
MED1Q156485EBI-286285,EBI-394459
Ncoa6Q9JLI42EBI-286285,EBI-286271From a different organism.

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • TBP-class protein binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112923. 77 interactors.
DIPiDIP-31452N.
IntActiP10827. 25 interactors.
MINTiMINT-267914.
STRINGi9606.ENSP00000264637.

Chemistry databases

BindingDBiP10827.

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi148 – 151Combined sources4
Turni152 – 154Combined sources3
Helixi162 – 176Combined sources15
Turni180 – 184Combined sources5
Turni186 – 188Combined sources3
Beta strandi189 – 191Combined sources3
Beta strandi196 – 198Combined sources3
Helixi212 – 234Combined sources23
Helixi237 – 240Combined sources4
Helixi244 – 264Combined sources21
Turni269 – 272Combined sources4
Beta strandi273 – 276Combined sources4
Turni277 – 279Combined sources3
Beta strandi280 – 282Combined sources3
Helixi284 – 289Combined sources6
Turni290 – 293Combined sources4
Helixi294 – 306Combined sources13
Helixi307 – 309Combined sources3
Helixi313 – 324Combined sources12
Beta strandi329 – 331Combined sources3
Helixi335 – 356Combined sources22
Helixi363 – 370Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NAVX-ray2.50A148-370[»]
2H77X-ray2.33A148-370[»]
2H79X-ray1.87A148-370[»]
3HZFX-ray2.50A148-370[»]
3ILZX-ray1.85A148-370[»]
3JZBX-ray2.01A148-370[»]
4LNWX-ray1.90A148-370[»]
4LNXX-ray2.05A148-370[»]
ProteinModelPortaliP10827.
SMRiP10827.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10827.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 52ModulatingAdd BLAST52
Regioni190 – 370Ligand-bindingAdd BLAST181

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP10827.
KOiK05547.
OMAiMEHMPKE.
OrthoDBiEOG091G0GC1.
PhylomeDBiP10827.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha-2 (identifier: P10827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
Length:490
Mass (Da):54,816
Last modified:July 1, 1989 - v1
Checksum:iC87C7D2F67B1AE49
GO
Isoform Alpha-1 (identifier: P10827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-490: EREVQSSILY...EDLAGNAASP → VTDLRMIGAC...FLEVFEDQEV

Show »
Length:410
Mass (Da):46,813
Checksum:iB9FD7BFAC16D6882
GO
Isoform Alpha-3 (identifier: P10827-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-409: Missing.

Show »
Length:451
Mass (Da):50,747
Checksum:i1495A3F2EE6601DD
GO
Isoform Alpha-4 (identifier: P10827-4) [UniParc]FASTAAdd to basket
Also known as: Alpha3

The sequence of this isoform differs from the canonical sequence as follows:
     371-412: Missing.

Show »
Length:448
Mass (Da):50,465
Checksum:i15FD778790B4D26B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37T → S in CAA68539 (PubMed:3684612).Curated1
Sequence conflicti119G → A in CAA68539 (PubMed:3684612).Curated1
Sequence conflicti285E → A in CAB57886 (PubMed:1850510).Curated1
Sequence conflicti285E → A in CAA38899 (PubMed:1850510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074559263A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 Publication1
Natural variantiVAR_074560359N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication1
Isoform Alpha-1 (identifier: P10827-2)
Natural varianti263A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.23. 3 Publications1
Natural varianti359N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.24. 3 Publications1
Natural varianti398P → R in CHNG6) (Ref.25. 3 Publications1
Natural varianti403E → Q in CHNG6) (Ref.25. 3 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003621371 – 490EREVQ…NAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1. 2 PublicationsAdd BLAST120
Alternative sequenceiVSP_003623371 – 412Missing in isoform Alpha-4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_003622371 – 409Missing in isoform Alpha-3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55074
, X55073, X55070, X55071, X55004, X55069, X55068, X55066 Genomic DNA. Translation: CAB57886.1.
X55005 mRNA. Translation: CAA38749.1.
X55074
, X55073, X55070, X55071, X55004, X55069, X55068 Genomic DNA. Translation: CAA38899.1.
M24899 mRNA. Translation: AAA35783.1.
M24900 mRNA. Translation: AAA52333.1.
J03239 mRNA. Translation: AAA61176.1.
Y00479 mRNA. Translation: CAA68539.1.
M24748 Genomic DNA. Translation: AAA66021.1.
AK290530 mRNA. Translation: BAF83219.1.
CH471152 Genomic DNA. Translation: EAW60632.1.
BC000261 mRNA. Translation: AAH00261.1.
BC002728 mRNA. Translation: AAH02728.1.
BC035137 mRNA. Translation: AAH35137.1.
AF522368 mRNA. Translation: AAM77692.1.
CCDSiCCDS11360.1. [P10827-1]
CCDS42316.1. [P10827-2]
CCDS58546.1. [P10827-3]
PIRiA30893.
A40917.
S06163.
RefSeqiNP_001177847.1. NM_001190918.1. [P10827-3]
NP_001177848.1. NM_001190919.1. [P10827-1]
NP_003241.2. NM_003250.5. [P10827-1]
NP_955366.1. NM_199334.3. [P10827-2]
UniGeneiHs.724.

Genome annotation databases

EnsembliENST00000264637; ENSP00000264637; ENSG00000126351. [P10827-1]
ENST00000394121; ENSP00000377679; ENSG00000126351. [P10827-1]
ENST00000450525; ENSP00000395641; ENSG00000126351. [P10827-2]
ENST00000546243; ENSP00000443972; ENSG00000126351. [P10827-2]
ENST00000584985; ENSP00000463466; ENSG00000126351. [P10827-3]
GeneIDi7067.
KEGGihsa:7067.
UCSCiuc002htw.4. human. [P10827-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55074
, X55073, X55070, X55071, X55004, X55069, X55068, X55066 Genomic DNA. Translation: CAB57886.1.
X55005 mRNA. Translation: CAA38749.1.
X55074
, X55073, X55070, X55071, X55004, X55069, X55068 Genomic DNA. Translation: CAA38899.1.
M24899 mRNA. Translation: AAA35783.1.
M24900 mRNA. Translation: AAA52333.1.
J03239 mRNA. Translation: AAA61176.1.
Y00479 mRNA. Translation: CAA68539.1.
M24748 Genomic DNA. Translation: AAA66021.1.
AK290530 mRNA. Translation: BAF83219.1.
CH471152 Genomic DNA. Translation: EAW60632.1.
BC000261 mRNA. Translation: AAH00261.1.
BC002728 mRNA. Translation: AAH02728.1.
BC035137 mRNA. Translation: AAH35137.1.
AF522368 mRNA. Translation: AAM77692.1.
CCDSiCCDS11360.1. [P10827-1]
CCDS42316.1. [P10827-2]
CCDS58546.1. [P10827-3]
PIRiA30893.
A40917.
S06163.
RefSeqiNP_001177847.1. NM_001190918.1. [P10827-3]
NP_001177848.1. NM_001190919.1. [P10827-1]
NP_003241.2. NM_003250.5. [P10827-1]
NP_955366.1. NM_199334.3. [P10827-2]
UniGeneiHs.724.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NAVX-ray2.50A148-370[»]
2H77X-ray2.33A148-370[»]
2H79X-ray1.87A148-370[»]
3HZFX-ray2.50A148-370[»]
3ILZX-ray1.85A148-370[»]
3JZBX-ray2.01A148-370[»]
4LNWX-ray1.90A148-370[»]
4LNXX-ray2.05A148-370[»]
ProteinModelPortaliP10827.
SMRiP10827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112923. 77 interactors.
DIPiDIP-31452N.
IntActiP10827. 25 interactors.
MINTiMINT-267914.
STRINGi9606.ENSP00000264637.

Chemistry databases

BindingDBiP10827.
ChEMBLiCHEMBL1860.
DrugBankiDB00509. Dextrothyroxine.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
GuidetoPHARMACOLOGYi588.

PTM databases

iPTMnetiP10827.
PhosphoSitePlusiP10827.

Polymorphism and mutation databases

BioMutaiTHRA.
DMDMi135705.

Proteomic databases

MaxQBiP10827.
PaxDbiP10827.
PeptideAtlasiP10827.
PRIDEiP10827.

Protocols and materials databases

DNASUi7067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264637; ENSP00000264637; ENSG00000126351. [P10827-1]
ENST00000394121; ENSP00000377679; ENSG00000126351. [P10827-1]
ENST00000450525; ENSP00000395641; ENSG00000126351. [P10827-2]
ENST00000546243; ENSP00000443972; ENSG00000126351. [P10827-2]
ENST00000584985; ENSP00000463466; ENSG00000126351. [P10827-3]
GeneIDi7067.
KEGGihsa:7067.
UCSCiuc002htw.4. human. [P10827-1]

Organism-specific databases

CTDi7067.
DisGeNETi7067.
GeneCardsiTHRA.
HGNCiHGNC:11796. THRA.
HPAiCAB023349.
HPA009654.
MalaCardsiTHRA.
MIMi190120. gene.
614450. phenotype.
neXtProtiNX_P10827.
OpenTargetsiENSG00000126351.
Orphaneti97927. Peripheral resistance to thyroid hormones.
PharmGKBiPA36507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP10827.
KOiK05547.
OMAiMEHMPKE.
OrthoDBiEOG091G0GC1.
PhylomeDBiP10827.
TreeFamiTF328382.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126351-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10827.
SIGNORiP10827.

Miscellaneous databases

ChiTaRSiTHRA. human.
EvolutionaryTraceiP10827.
GeneWikiiThyroid_hormone_receptor_alpha.
GenomeRNAii7067.
PROiP10827.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126351.
CleanExiHS_THRA.
ExpressionAtlasiP10827. baseline and differential.
GenevisibleiP10827. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHA_HUMAN
AccessioniPrimary (citable) accession number: P10827
Secondary accession number(s): A8K3B5
, P21205, Q8N6A1, Q96H73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 207 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.