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Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

Cox6a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Gene namesi
Name:Cox6a1
Synonyms:Cox6al
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2384. Cox6a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion2 PublicationsAdd
BLAST
Chaini27 – 11185Cytochrome c oxidase subunit 6A1, mitochondrialPRO_0000006122Add
BLAST

Proteomic databases

PaxDbiP10818.
PRIDEiP10818.

Expressioni

Gene expression databases

GenevisibleiP10818. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001545.

Structurei

3D structure databases

ProteinModelPortaliP10818.
SMRiP10818. Positions 27-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP10818.
KOiK02266.
OMAiGYEGHDE.
OrthoDBiEOG757D0Z.
PhylomeDBiP10818.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVLSASR VSGLLGRALP RVGRPMSSGA HGEEGSARIW KALTYFVALP
60 70 80 90 100
GVGVSMLNVF LKSRHEEHER PEFVAYPHLR IRTKPFPWGD GNHTLFHNPH
110
MNPLPTGYED E
Length:111
Mass (Da):12,301
Last modified:February 1, 1996 - v2
Checksum:i71EA06E23ED7546D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72757 Genomic DNA. Translation: CAA51286.1. Sequence problems.
X12553 mRNA. Translation: CAA31067.1.
PIRiS01156.
S65379.
RefSeqiNP_036946.1. NM_012814.1.
UniGeneiRn.880.

Genome annotation databases

EnsembliENSRNOT00000001545; ENSRNOP00000001545; ENSRNOG00000001170.
GeneIDi25282.
KEGGirno:25282.
UCSCiRGD:2384. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72757 Genomic DNA. Translation: CAA51286.1. Sequence problems.
X12553 mRNA. Translation: CAA31067.1.
PIRiS01156.
S65379.
RefSeqiNP_036946.1. NM_012814.1.
UniGeneiRn.880.

3D structure databases

ProteinModelPortaliP10818.
SMRiP10818. Positions 27-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001545.

Proteomic databases

PaxDbiP10818.
PRIDEiP10818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001545; ENSRNOP00000001545; ENSRNOG00000001170.
GeneIDi25282.
KEGGirno:25282.
UCSCiRGD:2384. rat.

Organism-specific databases

CTDi1337.
RGDi2384. Cox6a1.

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP10818.
KOiK02266.
OMAiGYEGHDE.
OrthoDBiEOG757D0Z.
PhylomeDBiP10818.
TreeFamiTF105064.

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi606005.
PROiP10818.

Gene expression databases

GenevisibleiP10818. RN.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural organisation of the rat genes encoding liver- and heart-type of cytochrome c oxidase subunit VIa and a pseudogene related to the COXVIa-L cDNA."
    Mell O.C., Seibel P., Kadenbach B.
    Gene 140:179-186(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Fischer.
    Tissue: Liver.
  2. "Characterization of two different genes (cDNA) for cytochrome c oxidase subunit VIa from heart and liver of the rat."
    Schlerf A., Droste M., Winter M., Kadenbach B.
    EMBO J. 7:2387-2391(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 27-111.
    Tissue: Liver.
  3. "Tissue- and species-specific expression of cytochrome c oxidase isozymes in vertebrates."
    Kadenbach B., Stroh A., Becker A., Eckersorn C., Lottspeich F.
    Biochim. Biophys. Acta 1015:368-372(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-48.
    Tissue: Brown adipose tissue and Liver.
  4. "Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform."
    Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G.
    Eur. J. Biochem. 230:235-241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-49.
    Strain: Wistar.
    Tissue: Liver.
  5. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 65-80, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiCX6A1_RAT
AccessioniPrimary (citable) accession number: P10818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: November 11, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.