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Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

Cox6a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Gene namesi
Name:Cox6a1
Synonyms:Cox6al
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2384. Cox6a1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26Mitochondrion2 PublicationsAdd BLAST26
ChainiPRO_000000612227 – 111Cytochrome c oxidase subunit 6A1, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiP10818.
PRIDEiP10818.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001170.
GenevisibleiP10818. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001545.

Structurei

3D structure databases

ProteinModelPortaliP10818.
SMRiP10818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP10818.
KOiK02266.
OMAiHEEHERP.
OrthoDBiEOG091G0C5F.
PhylomeDBiP10818.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiView protein in InterPro
IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiView protein in Pfam
PF02046. COX6A. 1 hit.
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036. Cyt_c_oxidase_su6a. 1 hit.
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiView protein in PROSITE
PS01329. COX6A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVLSASR VSGLLGRALP RVGRPMSSGA HGEEGSARIW KALTYFVALP
60 70 80 90 100
GVGVSMLNVF LKSRHEEHER PEFVAYPHLR IRTKPFPWGD GNHTLFHNPH
110
MNPLPTGYED E
Length:111
Mass (Da):12,301
Last modified:February 1, 1996 - v2
Checksum:i71EA06E23ED7546D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72757 Genomic DNA. Translation: CAA51286.1. Sequence problems.
X12553 mRNA. Translation: CAA31067.1.
PIRiS01156.
S65379.
RefSeqiNP_036946.1. NM_012814.1.
UniGeneiRn.880.

Genome annotation databases

EnsembliENSRNOT00000001545; ENSRNOP00000001545; ENSRNOG00000001170.
GeneIDi25282.
KEGGirno:25282.
UCSCiRGD:2384. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCX6A1_RAT
AccessioniPrimary (citable) accession number: P10818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: June 7, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families