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Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

Cox6a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Gene namesi
Name:Cox6a1
Synonyms:Cox6al
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2384. Cox6a1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26Mitochondrion2 PublicationsAdd BLAST26
ChainiPRO_000000612227 – 111Cytochrome c oxidase subunit 6A1, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiP10818.
PRIDEiP10818.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001170.
GenevisibleiP10818. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001545.

Structurei

3D structure databases

ProteinModelPortaliP10818.
SMRiP10818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP10818.
KOiK02266.
OMAiGYEGHDE.
OrthoDBiEOG091G0C5F.
PhylomeDBiP10818.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiView protein in InterPro
IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiView protein in Pfam
PF02046. COX6A. 1 hit.
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036. Cyt_c_oxidase_su6a. 1 hit.
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiView protein in PROSITE
PS01329. COX6A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVLSASR VSGLLGRALP RVGRPMSSGA HGEEGSARIW KALTYFVALP
60 70 80 90 100
GVGVSMLNVF LKSRHEEHER PEFVAYPHLR IRTKPFPWGD GNHTLFHNPH
110
MNPLPTGYED E
Length:111
Mass (Da):12,301
Last modified:February 1, 1996 - v2
Checksum:i71EA06E23ED7546D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72757 Genomic DNA. Translation: CAA51286.1. Sequence problems.
X12553 mRNA. Translation: CAA31067.1.
PIRiS01156.
S65379.
RefSeqiNP_036946.1. NM_012814.1.
UniGeneiRn.880.

Genome annotation databases

EnsembliENSRNOT00000001545; ENSRNOP00000001545; ENSRNOG00000001170.
GeneIDi25282.
KEGGirno:25282.
UCSCiRGD:2384. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72757 Genomic DNA. Translation: CAA51286.1. Sequence problems.
X12553 mRNA. Translation: CAA31067.1.
PIRiS01156.
S65379.
RefSeqiNP_036946.1. NM_012814.1.
UniGeneiRn.880.

3D structure databases

ProteinModelPortaliP10818.
SMRiP10818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001545.

Proteomic databases

PaxDbiP10818.
PRIDEiP10818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001545; ENSRNOP00000001545; ENSRNOG00000001170.
GeneIDi25282.
KEGGirno:25282.
UCSCiRGD:2384. rat.

Organism-specific databases

CTDi1337.
RGDi2384. Cox6a1.

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP10818.
KOiK02266.
OMAiGYEGHDE.
OrthoDBiEOG091G0C5F.
PhylomeDBiP10818.
TreeFamiTF105064.

Miscellaneous databases

PROiPR:P10818.

Gene expression databases

BgeeiENSRNOG00000001170.
GenevisibleiP10818. RN.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiView protein in InterPro
IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiView protein in Pfam
PF02046. COX6A. 1 hit.
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036. Cyt_c_oxidase_su6a. 1 hit.
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiView protein in PROSITE
PS01329. COX6A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX6A1_RAT
AccessioniPrimary (citable) accession number: P10818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.