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P10815 (CG23_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G2/mitotic-specific cyclin cdc13
Gene names
Name:cdc13
ORF Names:SPBC582.03
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1. Ref.1 Ref.2 Ref.7 Ref.8 Ref.10

Subunit structure

Interacts with cdc2 and rum1. Associates with microtubules. Also interacts with cdc11. Ref.8 Ref.10 Ref.11 Ref.12 Ref.13

Subcellular location

Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centerspindle pole body Ref.4 Ref.7 Ref.14.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Contains 1 cyclin N-terminal domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Molecular functionCyclin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from direct assay PubMed 958201. Source: PomBase

cellular protein localization

Inferred from mutant phenotype PubMed 16824200. Source: PomBase

cellular response to nitrogen starvation

Inferred from mutant phenotype PubMed 19366728. Source: PomBase

microtubule cytoskeleton organization

Inferred from mutant phenotype PubMed 3428262. Source: PomBase

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of G0 to G1 transition

Inferred from mutant phenotype PubMed 19366728. Source: PomBase

negative regulation of induction of conjugation with cellular fusion

Inferred from mutant phenotype PubMed 18059475. Source: PomBase

positive regulation of protein localization to nucleus

Inferred from mutant phenotype PubMed 2569363. Source: PomBase

regulation of G2/M transition of mitotic cell cycle

Inferred from mutant phenotype Ref.2. Source: PomBase

regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from direct assay Ref.7. Source: PomBase

signal transduction

Non-traceable author statement. Source: PomBase

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

mitotic spindle pole body

Inferred from direct assay Ref.14. Source: PomBase

nucleus

Inferred from direct assay Ref.14Ref.7PubMed 2569363. Source: PomBase

spindle

Inferred from direct assay Ref.14. Source: PomBase

   Molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity

Non-traceable author statement. Source: PomBase

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

rum1P403805EBI-1187843,EBI-1187892

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482G2/mitotic-specific cyclin cdc13
PRO_0000080402

Regions

Domain206 – 332127Cyclin N-terminal

Experimental info

Sequence conflict4791D → H no nucleotide entry Ref.2

Sequences

Sequence LengthMass (Da)Tools
P10815 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: B2C267CF57F5FD36

FASTA48255,609
        10         20         30         40         50         60 
MTTRRLTRQH LLANTLGNND ENHPSNHIAR AKSSLHSSEN SLVNGKKATV SSTNVPKKRH 

        70         80         90        100        110        120 
ALDDVSNFHN KEGVPLASKN TNVRHTTASV STRRALEEKS IIPATDDEPA SKKRRQPSVF 

       130        140        150        160        170        180 
NSSVPSLPQH LSTKSHSVST HGVDAFHKDQ ATIPKKLKKD VDERVVSKDI PKLHRDSVES 

       190        200        210        220        230        240 
PESQDWDDLD AEDWADPLMV SEYVVDIFEY LNELEIETMP SPTYMDRQKE LAWKMRGILT 

       250        260        270        280        290        300 
DWLIEVHSRF RLLPETLFLA VNIIDRFLSL RVCSLNKLQL VGIAALFIAS KYEEVMCPSV 

       310        320        330        340        350        360 
QNFVYMADGG YDEEEILQAE RYILRVLEFN LAYPNPMNFL RRISKADFYD IQTRTVAKYL 

       370        380        390        400        410        420 
VEIGLLDHKL LPYPPSQQCA AAMYLAREML GRGPWNRNLV HYSGYEEYQL ISVVKKMINY 

       430        440        450        460        470        480 
LQKPVQHEAF FKKYASKKFM KASLFVRDWI KKNSIPLGDD ADEDYTFHKQ KRIQHDMKDE 


EW 

« Hide

References

« Hide 'large scale' references
[1]"Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules."
Booher R., Beach D.
EMBO J. 7:2321-2327(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ASSOCIATION WITH MICROTUBULES.
[2]"Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis."
Hagan I., Hayles J., Nurse P.
J. Cell Sci. 91:587-595(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[4]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 22-226, SUBCELLULAR LOCATION.
Strain: ATCC 38364 / 968.
[5]"Cyclin in fission yeast."
Solomon M., Booher R., Kirschner M., Beach B.
Cell 54:738-739(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: SIMILARITY TO THE CYCLIN FAMILY.
[6]"Cyclin in fission yeast."
Goebl M., Bryers B.
Cell 54:739-740(1988)
Cited for: SIMILARITY TO THE CYCLIN FAMILY.
[7]"Fission yeast cyclin: subcellular localisation and cell cycle regulation."
Alfa C.E., Booher R., Beach D., Hyams J.S.
J. Cell Sci. Suppl. 12:9-19(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis."
Bueno A., Russell P.
Mol. Cell. Biol. 13:2286-2297(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CDC2.
Strain: 972 / ATCC 24843.
[9]"A quantitative model for the cdc2 control of S phase and mitosis in fission yeast."
Stern B., Nurse P.
Trends Genet. 12:345-350(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON ASSOCIATION WITH CDC2.
[10]"p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle."
Correa-Bordes J., Gulli M.P., Nurse P.
EMBO J. 16:4657-4664(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RUM1.
[11]"The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast."
Sanchez-Diaz A., Gonzalez I., Arellano M., Moreno S.
J. Cell Sci. 111:843-851(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RUM1.
[12]"Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast."
Stern B., Nurse P.
Mol. Biol. Cell 9:1309-1321(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RUM1.
[13]"Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB."
Morrell J.L., Tomlin G.C., Rajagopalan S., Venkatram S., Feoktistova A.S., Tasto J.J., Mehta S., Jennings J.L., Link A., Balasubramanian M.K., Gould K.L.
Curr. Biol. 14:579-584(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDC11.
[14]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12557 Genomic DNA. Translation: CAA31070.1.
CU329671 Genomic DNA. Translation: CAB46666.1.
AB027869 Genomic DNA. Translation: BAA87173.1.
PIRA34948.
S01153.
RefSeqNP_595171.1. NM_001021079.2.

3D structure databases

ProteinModelPortalP10815.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277397. 61 interactions.
DIPDIP-620N.
IntActP10815. 4 interactions.
MINTMINT-4687197.
STRING4896.SPBC582.03-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC582.03.1; SPBC582.03.1:pep; SPBC582.03.
GeneID2540880.
KEGGspo:SPBC582.03.

Organism-specific databases

PomBaseSPBC582.03.

Phylogenomic databases

eggNOGCOG5024.
HOGENOMHOG000167672.
KOK02220.
OMAARYILEC.
OrthoDBEOG7FNCJX.
PhylomeDBP10815.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801996.

Entry information

Entry nameCG23_SCHPO
AccessionPrimary (citable) accession number: P10815
Secondary accession number(s): Q9UU16
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names