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P10815

- CG23_SCHPO

UniProt

P10815 - CG23_SCHPO

Protein

G2/mitotic-specific cyclin cdc13

Gene

cdc13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1.5 Publications

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: PomBase
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to nitrogen starvation Source: PomBase
    2. microtubule cytoskeleton organization Source: PomBase
    3. mitotic nuclear division Source: UniProtKB-KW
    4. negative regulation of G0 to G1 transition Source: PomBase
    5. negative regulation of induction of conjugation with cellular fusion Source: PomBase
    6. positive regulation of protein localization to nucleus Source: PomBase
    7. regulation of cyclin-dependent protein serine/threonine kinase activity Source: PomBase
    8. regulation of G2/M transition of mitotic cell cycle Source: PomBase
    9. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_188254. Condensation of Prometaphase Chromosomes.
    REACT_188278. MASTL Facilitates Mitotic Progression.
    REACT_199398. Cyclin A/B1 associated events during G2/M transition.
    REACT_219807. Resolution of Sister Chromatid Cohesion.
    REACT_219991. Cyclin B2 mediated events.
    REACT_221258. Depolymerisation of the Nuclear Lamina.
    REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin cdc13
    Gene namesi
    Name:cdc13
    ORF Names:SPBC582.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC582.03.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. mitotic spindle pole body Source: PomBase
    3. nucleus Source: PomBase
    4. spindle Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482G2/mitotic-specific cyclin cdc13PRO_0000080402Add
    BLAST

    Proteomic databases

    MaxQBiP10815.

    Interactioni

    Subunit structurei

    Interacts with cdc2 and rum1. Associates with microtubules. Also interacts with cdc11.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    rum1P403805EBI-1187843,EBI-1187892

    Protein-protein interaction databases

    BioGridi277397. 61 interactions.
    DIPiDIP-620N.
    IntActiP10815. 4 interactions.
    MINTiMINT-4687197.
    STRINGi4896.SPBC582.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP10815.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini206 – 332127Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000167672.
    KOiK02220.
    OMAiARYILEC.
    OrthoDBiEOG7FNCJX.
    PhylomeDBiP10815.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10815-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTRRLTRQH LLANTLGNND ENHPSNHIAR AKSSLHSSEN SLVNGKKATV    50
    SSTNVPKKRH ALDDVSNFHN KEGVPLASKN TNVRHTTASV STRRALEEKS 100
    IIPATDDEPA SKKRRQPSVF NSSVPSLPQH LSTKSHSVST HGVDAFHKDQ 150
    ATIPKKLKKD VDERVVSKDI PKLHRDSVES PESQDWDDLD AEDWADPLMV 200
    SEYVVDIFEY LNELEIETMP SPTYMDRQKE LAWKMRGILT DWLIEVHSRF 250
    RLLPETLFLA VNIIDRFLSL RVCSLNKLQL VGIAALFIAS KYEEVMCPSV 300
    QNFVYMADGG YDEEEILQAE RYILRVLEFN LAYPNPMNFL RRISKADFYD 350
    IQTRTVAKYL VEIGLLDHKL LPYPPSQQCA AAMYLAREML GRGPWNRNLV 400
    HYSGYEEYQL ISVVKKMINY LQKPVQHEAF FKKYASKKFM KASLFVRDWI 450
    KKNSIPLGDD ADEDYTFHKQ KRIQHDMKDE EW 482
    Length:482
    Mass (Da):55,609
    Last modified:July 1, 1989 - v1
    Checksum:iB2C267CF57F5FD36
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti479 – 4791D → H no nucleotide entry (PubMed:2908246)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12557 Genomic DNA. Translation: CAA31070.1.
    CU329671 Genomic DNA. Translation: CAB46666.1.
    AB027869 Genomic DNA. Translation: BAA87173.1.
    PIRiA34948.
    S01153.
    RefSeqiNP_595171.1. NM_001021079.2.

    Genome annotation databases

    EnsemblFungiiSPBC582.03.1; SPBC582.03.1:pep; SPBC582.03.
    GeneIDi2540880.
    KEGGispo:SPBC582.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12557 Genomic DNA. Translation: CAA31070.1 .
    CU329671 Genomic DNA. Translation: CAB46666.1 .
    AB027869 Genomic DNA. Translation: BAA87173.1 .
    PIRi A34948.
    S01153.
    RefSeqi NP_595171.1. NM_001021079.2.

    3D structure databases

    ProteinModelPortali P10815.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277397. 61 interactions.
    DIPi DIP-620N.
    IntActi P10815. 4 interactions.
    MINTi MINT-4687197.
    STRINGi 4896.SPBC582.03-1.

    Proteomic databases

    MaxQBi P10815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC582.03.1 ; SPBC582.03.1:pep ; SPBC582.03 .
    GeneIDi 2540880.
    KEGGi spo:SPBC582.03.

    Organism-specific databases

    PomBasei SPBC582.03.

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000167672.
    KOi K02220.
    OMAi ARYILEC.
    OrthoDBi EOG7FNCJX.
    PhylomeDBi P10815.

    Enzyme and pathway databases

    Reactomei REACT_188254. Condensation of Prometaphase Chromosomes.
    REACT_188278. MASTL Facilitates Mitotic Progression.
    REACT_199398. Cyclin A/B1 associated events during G2/M transition.
    REACT_219807. Resolution of Sister Chromatid Cohesion.
    REACT_219991. Cyclin B2 mediated events.
    REACT_221258. Depolymerisation of the Nuclear Lamina.
    REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

    Miscellaneous databases

    NextBioi 20801996.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules."
      Booher R., Beach D.
      EMBO J. 7:2321-2327(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ASSOCIATION WITH MICROTUBULES.
    2. "Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis."
      Hagan I., Hayles J., Nurse P.
      J. Cell Sci. 91:587-595(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    4. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 22-226, SUBCELLULAR LOCATION.
      Strain: ATCC 38364 / 968.
    5. "Cyclin in fission yeast."
      Solomon M., Booher R., Kirschner M., Beach B.
      Cell 54:738-739(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIMILARITY TO THE CYCLIN FAMILY.
    6. "Cyclin in fission yeast."
      Goebl M., Bryers B.
      Cell 54:739-740(1988)
      Cited for: SIMILARITY TO THE CYCLIN FAMILY.
    7. "Fission yeast cyclin: subcellular localisation and cell cycle regulation."
      Alfa C.E., Booher R., Beach D., Hyams J.S.
      J. Cell Sci. Suppl. 12:9-19(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis."
      Bueno A., Russell P.
      Mol. Cell. Biol. 13:2286-2297(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDC2.
      Strain: 972 / ATCC 24843.
    9. "A quantitative model for the cdc2 control of S phase and mitosis in fission yeast."
      Stern B., Nurse P.
      Trends Genet. 12:345-350(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON ASSOCIATION WITH CDC2.
    10. "p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle."
      Correa-Bordes J., Gulli M.P., Nurse P.
      EMBO J. 16:4657-4664(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RUM1.
    11. "The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast."
      Sanchez-Diaz A., Gonzalez I., Arellano M., Moreno S.
      J. Cell Sci. 111:843-851(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RUM1.
    12. "Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast."
      Stern B., Nurse P.
      Mol. Biol. Cell 9:1309-1321(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RUM1.
    13. "Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB."
      Morrell J.L., Tomlin G.C., Rajagopalan S., Venkatram S., Feoktistova A.S., Tasto J.J., Mehta S., Jennings J.L., Link A., Balasubramanian M.K., Gould K.L.
      Curr. Biol. 14:579-584(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDC11.
    14. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCG23_SCHPO
    AccessioniPrimary (citable) accession number: P10815
    Secondary accession number(s): Q9UU16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3