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Protein

G2/mitotic-specific cyclin cdc13

Gene

cdc13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1.5 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activator activity Source: PomBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • correction of merotelic kinetochore attachment Source: PomBase
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of G0 to G1 transition Source: PomBase
  • positive regulation of protein localization to nucleus Source: PomBase
  • positive regulation of protein serine/threonine kinase activity Source: GOC
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: PomBase
  • regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_281737. Depolymerisation of the Nuclear Lamina.
REACT_284579. Cyclin B2 mediated events.
REACT_291429. Cyclin A/B1 associated events during G2/M transition.
REACT_297137. G2/M DNA replication checkpoint.
REACT_317100. Regulation of APC/C activators between G1/S and early anaphase.
REACT_321583. E2F-enabled inhibition of pre-replication complex formation.
REACT_322081. Condensation of Prometaphase Chromosomes.
REACT_346337. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin cdc13
Gene namesi
Name:cdc13
ORF Names:SPBC582.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC582.03.
PomBaseiSPBC582.03. cdc13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • mitotic spindle Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nuclear envelope lumen Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482G2/mitotic-specific cyclin cdc13PRO_0000080402Add
BLAST

Proteomic databases

MaxQBiP10815.

Interactioni

Subunit structurei

Interacts with cdc2 and rum1. Associates with microtubules. Also interacts with cdc11.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
rum1P403805EBI-1187843,EBI-1187892

Protein-protein interaction databases

BioGridi277397. 54 interactions.
DIPiDIP-620N.
IntActiP10815. 4 interactions.
MINTiMINT-4687197.

Structurei

3D structure databases

ProteinModelPortaliP10815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 332127Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000167672.
InParanoidiP10815.
KOiK02220.
OMAiRESEFRI.
OrthoDBiEOG7FNCJX.
PhylomeDBiP10815.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRRLTRQH LLANTLGNND ENHPSNHIAR AKSSLHSSEN SLVNGKKATV
60 70 80 90 100
SSTNVPKKRH ALDDVSNFHN KEGVPLASKN TNVRHTTASV STRRALEEKS
110 120 130 140 150
IIPATDDEPA SKKRRQPSVF NSSVPSLPQH LSTKSHSVST HGVDAFHKDQ
160 170 180 190 200
ATIPKKLKKD VDERVVSKDI PKLHRDSVES PESQDWDDLD AEDWADPLMV
210 220 230 240 250
SEYVVDIFEY LNELEIETMP SPTYMDRQKE LAWKMRGILT DWLIEVHSRF
260 270 280 290 300
RLLPETLFLA VNIIDRFLSL RVCSLNKLQL VGIAALFIAS KYEEVMCPSV
310 320 330 340 350
QNFVYMADGG YDEEEILQAE RYILRVLEFN LAYPNPMNFL RRISKADFYD
360 370 380 390 400
IQTRTVAKYL VEIGLLDHKL LPYPPSQQCA AAMYLAREML GRGPWNRNLV
410 420 430 440 450
HYSGYEEYQL ISVVKKMINY LQKPVQHEAF FKKYASKKFM KASLFVRDWI
460 470 480
KKNSIPLGDD ADEDYTFHKQ KRIQHDMKDE EW
Length:482
Mass (Da):55,609
Last modified:July 1, 1989 - v1
Checksum:iB2C267CF57F5FD36
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti479 – 4791D → H no nucleotide entry (PubMed:2908246).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12557 Genomic DNA. Translation: CAA31070.1.
CU329671 Genomic DNA. Translation: CAB46666.1.
AB027869 Genomic DNA. Translation: BAA87173.1.
PIRiA34948.
S01153.
RefSeqiNP_595171.1. NM_001021079.2.

Genome annotation databases

EnsemblFungiiSPBC582.03.1; SPBC582.03.1:pep; SPBC582.03.
GeneIDi2540880.
KEGGispo:SPBC582.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12557 Genomic DNA. Translation: CAA31070.1.
CU329671 Genomic DNA. Translation: CAB46666.1.
AB027869 Genomic DNA. Translation: BAA87173.1.
PIRiA34948.
S01153.
RefSeqiNP_595171.1. NM_001021079.2.

3D structure databases

ProteinModelPortaliP10815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277397. 54 interactions.
DIPiDIP-620N.
IntActiP10815. 4 interactions.
MINTiMINT-4687197.

Proteomic databases

MaxQBiP10815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC582.03.1; SPBC582.03.1:pep; SPBC582.03.
GeneIDi2540880.
KEGGispo:SPBC582.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC582.03.
PomBaseiSPBC582.03. cdc13.

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000167672.
InParanoidiP10815.
KOiK02220.
OMAiRESEFRI.
OrthoDBiEOG7FNCJX.
PhylomeDBiP10815.

Enzyme and pathway databases

ReactomeiREACT_281737. Depolymerisation of the Nuclear Lamina.
REACT_284579. Cyclin B2 mediated events.
REACT_291429. Cyclin A/B1 associated events during G2/M transition.
REACT_297137. G2/M DNA replication checkpoint.
REACT_317100. Regulation of APC/C activators between G1/S and early anaphase.
REACT_321583. E2F-enabled inhibition of pre-replication complex formation.
REACT_322081. Condensation of Prometaphase Chromosomes.
REACT_346337. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

NextBioi20801996.
PROiP10815.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules."
    Booher R., Beach D.
    EMBO J. 7:2321-2327(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ASSOCIATION WITH MICROTUBULES.
  2. "Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis."
    Hagan I., Hayles J., Nurse P.
    J. Cell Sci. 91:587-595(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 22-226, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  5. "Cyclin in fission yeast."
    Solomon M., Booher R., Kirschner M., Beach B.
    Cell 54:738-739(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO THE CYCLIN FAMILY.
  6. "Cyclin in fission yeast."
    Goebl M., Bryers B.
    Cell 54:739-740(1988)
    Cited for: SIMILARITY TO THE CYCLIN FAMILY.
  7. "Fission yeast cyclin: subcellular localisation and cell cycle regulation."
    Alfa C.E., Booher R., Beach D., Hyams J.S.
    J. Cell Sci. Suppl. 12:9-19(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis."
    Bueno A., Russell P.
    Mol. Cell. Biol. 13:2286-2297(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDC2.
    Strain: 972 / ATCC 24843.
  9. "A quantitative model for the cdc2 control of S phase and mitosis in fission yeast."
    Stern B., Nurse P.
    Trends Genet. 12:345-350(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON ASSOCIATION WITH CDC2.
  10. "p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle."
    Correa-Bordes J., Gulli M.P., Nurse P.
    EMBO J. 16:4657-4664(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RUM1.
  11. "The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast."
    Sanchez-Diaz A., Gonzalez I., Arellano M., Moreno S.
    J. Cell Sci. 111:843-851(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUM1.
  12. "Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast."
    Stern B., Nurse P.
    Mol. Biol. Cell 9:1309-1321(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUM1.
  13. "Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB."
    Morrell J.L., Tomlin G.C., Rajagopalan S., Venkatram S., Feoktistova A.S., Tasto J.J., Mehta S., Jennings J.L., Link A., Balasubramanian M.K., Gould K.L.
    Curr. Biol. 14:579-584(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC11.
  14. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCG23_SCHPO
AccessioniPrimary (citable) accession number: P10815
Secondary accession number(s): Q9UU16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 22, 2015
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.