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P10810

- CD14_MOUSE

UniProt

P10810 - CD14_MOUSE

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Protein

Monocyte differentiation antigen CD14

Gene

Cd14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).By similarity

GO - Molecular functioni

  1. lipopolysaccharide binding Source: Ensembl
  2. lipoteichoic acid binding Source: Ensembl

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. cellular response to lipoteichoic acid Source: Ensembl
  3. inflammatory response Source: UniProtKB-KW
  4. innate immune response Source: UniProtKB-KW
  5. positive regulation of cytokine secretion Source: Ensembl
  6. positive regulation of endocytosis Source: UniProtKB
  7. positive regulation of tumor necrosis factor production Source: Ensembl
  8. response to ethanol Source: Ensembl
  9. response to heat Source: Ensembl
  10. response to magnesium ion Source: Ensembl
  11. response to molecule of bacterial origin Source: UniProtKB
  12. response to tumor necrosis factor Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_196636. TRIF-mediated programmed cell death.
REACT_198539. TRAF6 mediated induction of TAK1 complex.
REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_226192. IKK complex recruitment mediated by RIP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte differentiation antigen CD14
Alternative name(s):
Myeloid cell-specific leucine-rich glycoprotein
CD_antigen: CD14
Gene namesi
Name:Cd14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88318. Cd14.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. membrane raft Source: UniProtKB
  6. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Chaini16 – 336321Monocyte differentiation antigen CD14PRO_0000020887Add
BLAST
Propeptidei337 – 36630Removed in mature formSequence AnalysisPRO_0000020888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 321 Publication
Disulfide bondi30 ↔ 471 Publication
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)1 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication
Disulfide bondi183 ↔ 2131 Publication
Disulfide bondi237 ↔ 2661 Publication
Glycosylationi276 – 2761N-linked (GlcNAc...)1 Publication
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Lipidationi336 – 3361GPI-anchor amidated asparagineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP10810.
PaxDbiP10810.
PRIDEiP10810.

PTM databases

PhosphoSiteiP10810.

Miscellaneous databases

PMAP-CutDBP10810.

Expressioni

Gene expression databases

BgeeiP10810.
CleanExiMM_CD14.
ExpressionAtlasiP10810. baseline and differential.
GenevestigatoriP10810.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.By similarity

Protein-protein interaction databases

BioGridi198573. 1 interaction.

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 383
Helixi41 – 466
Beta strandi47 – 493
Beta strandi51 – 6111
Helixi65 – 684
Helixi76 – 849
Beta strandi89 – 968
Helixi99 – 10911
Beta strandi116 – 1238
Beta strandi132 – 1343
Beta strandi141 – 1477
Beta strandi151 – 1555
Helixi156 – 1616
Beta strandi170 – 1756
Turni183 – 1853
Beta strandi194 – 1963
Helixi204 – 2118
Beta strandi222 – 2243
Helixi233 – 24210
Beta strandi248 – 2514
Beta strandi274 – 2763
Beta strandi291 – 2977
Turni309 – 3113
Beta strandi314 – 3196
Turni324 – 3263

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WWLX-ray2.50A/B20-329[»]
ProteinModelPortaliP10810.
SMRiP10810. Positions 22-329.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10810.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 7829LRR 1Add
BLAST
Repeati79 – 11436LRR 2Add
BLAST
Repeati115 – 14026LRR 3Add
BLAST
Repeati141 – 16828LRR 4Add
BLAST
Repeati169 – 19224LRR 5Add
BLAST
Repeati193 – 22028LRR 6Add
BLAST
Repeati221 – 24727LRR 7Add
BLAST
Repeati248 – 27225LRR 8Add
BLAST
Repeati273 – 29321LRR 9Add
BLAST
Repeati294 – 31522LRR 10Add
BLAST
Repeati316 – 34025LRR 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 8267LPS-bindingAdd
BLAST
Regioni38 – 7841Ligand-binding pocket rimAdd
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG86091.
HOGENOMiHOG000237268.
HOVERGENiHBG005269.
InParanoidiP10810.
KOiK04391.
OMAiWATGGAW.
OrthoDBiEOG751NFQ.
PhylomeDBiP10810.
TreeFamiTF338550.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR016337. Monocyte_diff_Ag_CD14.
[Graphical view]
PIRSFiPIRSF002017. CD14. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10810-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERVLGLLLL LLVHASPAPP EPCELDEESC SCNFSDPKPD WSSAFNCLGA
60 70 80 90 100
ADVELYGGGR SLEYLLKRVD TEADLGQFTD IIKSLSLKRL TVRAARIPSR
110 120 130 140 150
ILFGALRVLG ISGLQELTLE NLEVTGTAPP PLLEATGPDL NILNLRNVSW
160 170 180 190 200
ATRDAWLAEL QQWLKPGLKV LSIAQAHSLN FSCEQVRVFP ALSTLDLSDN
210 220 230 240 250
PELGERGLIS ALCPLKFPTL QVLALRNAGM ETPSGVCSAL AAARVQLQGL
260 270 280 290 300
DLSHNSLRDA AGAPSCDWPS QLNSLNLSFT GLKQVPKGLP AKLSVLDLSY
310 320 330 340 350
NRLDRNPSPD ELPQVGNLSL KGNPFLDSES HSEKFNSGVV TAGAPSSQAV
360
ALSGTLALLL GDRLFV
Length:366
Mass (Da):39,204
Last modified:July 1, 1989 - v1
Checksum:i57C4492EC7EA3AA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13987 Genomic DNA. Translation: CAA32166.1.
X13333 mRNA. Translation: CAA31710.1.
M34510 Genomic DNA. Translation: AAA37387.1.
BC057889 mRNA. Translation: AAH57889.1.
CCDSiCCDS29159.1.
PIRiS03605. TDMSM4.
RefSeqiNP_033971.1. NM_009841.4.
UniGeneiMm.3460.

Genome annotation databases

EnsembliENSMUST00000061829; ENSMUSP00000056669; ENSMUSG00000051439.
GeneIDi12475.
KEGGimmu:12475.
UCSCiuc008eof.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13987 Genomic DNA. Translation: CAA32166.1 .
X13333 mRNA. Translation: CAA31710.1 .
M34510 Genomic DNA. Translation: AAA37387.1 .
BC057889 mRNA. Translation: AAH57889.1 .
CCDSi CCDS29159.1.
PIRi S03605. TDMSM4.
RefSeqi NP_033971.1. NM_009841.4.
UniGenei Mm.3460.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WWL X-ray 2.50 A/B 20-329 [» ]
ProteinModelPortali P10810.
SMRi P10810. Positions 22-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198573. 1 interaction.

Chemistry

ChEMBLi CHEMBL3038514.

PTM databases

PhosphoSitei P10810.

Proteomic databases

MaxQBi P10810.
PaxDbi P10810.
PRIDEi P10810.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061829 ; ENSMUSP00000056669 ; ENSMUSG00000051439 .
GeneIDi 12475.
KEGGi mmu:12475.
UCSCi uc008eof.1. mouse.

Organism-specific databases

CTDi 929.
MGIi MGI:88318. Cd14.

Phylogenomic databases

eggNOGi NOG86091.
HOGENOMi HOG000237268.
HOVERGENi HBG005269.
InParanoidi P10810.
KOi K04391.
OMAi WATGGAW.
OrthoDBi EOG751NFQ.
PhylomeDBi P10810.
TreeFami TF338550.

Enzyme and pathway databases

Reactomei REACT_196636. TRIF-mediated programmed cell death.
REACT_198539. TRAF6 mediated induction of TAK1 complex.
REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_226192. IKK complex recruitment mediated by RIP1.

Miscellaneous databases

EvolutionaryTracei P10810.
NextBioi 281354.
PMAP-CutDB P10810.
PROi P10810.
SOURCEi Search...

Gene expression databases

Bgeei P10810.
CleanExi MM_CD14.
ExpressionAtlasi P10810. baseline and differential.
Genevestigatori P10810.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR016337. Monocyte_diff_Ag_CD14.
[Graphical view ]
PIRSFi PIRSF002017. CD14. 1 hit.
PROSITEi PS51450. LRR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones."
    Setoguchi M., Nasu N., Yoshida S., Higuchi Y., Akizuki S., Yamamoto S.
    Biochim. Biophys. Acta 1008:213-222(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Macrophage.
  3. "CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes."
    Ferrero E., Hsieh C.L., Francke U., Goyert S.M.
    J. Immunol. 145:331-336(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary gland.
  5. "Crystal structure of CD14 and its implications for lipopolysaccharide signaling."
    Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., Lee J.O.
    J. Biol. Chem. 280:11347-11351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 20-329, DISULFIDE BONDS, GLYCOSYLATION AT ASN-147; ASN-180 AND ASN-276, DOMAINS LEUCINE-RICH REPEATS.

Entry informationi

Entry nameiCD14_MOUSE
AccessioniPrimary (citable) accession number: P10810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3