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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Substrate
Active sitei151 – 1511Proton acceptor

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3324NAD1 PublicationAdd
BLAST

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP10807.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Taxonomic identifieri7225 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeScaptodrosophila

Organism-specific databases

FlyBaseiFBgn0012438. Dleb\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Alcohol dehydrogenasePRO_0000054471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7944097,EBI-7944097

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-8383791.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Turni12 – 143Combined sources
Helixi16 – 2712Combined sources
Beta strandi31 – 399Combined sources
Helixi42 – 5110Combined sources
Beta strandi55 – 617Combined sources
Helixi68 – 8215Combined sources
Beta strandi87 – 904Combined sources
Helixi100 – 1078Combined sources
Helixi109 – 12214Combined sources
Helixi124 – 1263Combined sources
Beta strandi131 – 1366Combined sources
Helixi139 – 1413Combined sources
Helixi149 – 17224Combined sources
Beta strandi173 – 1819Combined sources
Beta strandi183 – 1864Combined sources
Helixi187 – 1904Combined sources
Helixi195 – 1973Combined sources
Helixi202 – 2065Combined sources
Helixi214 – 22714Combined sources
Beta strandi233 – 2375Combined sources
Beta strandi240 – 2434Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4UX-ray1.92A/B1-254[»]
1B14X-ray2.40A/B1-254[»]
1B15X-ray2.20A/B1-254[»]
1B16X-ray1.40A/B1-254[»]
1B2LX-ray1.60A1-254[»]
1SBYX-ray1.10A/B1-254[»]
3RJ5X-ray1.45A/B1-254[»]
3RJ9X-ray1.98A/B/C/D/E/F1-254[»]
ProteinModelPortaliP10807.
SMRiP10807. Positions 1-254.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10807.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTNKNVIF VAALGGIGLD TSRELVKRNL KNFVILDRVE NPTALAELKA
60 70 80 90 100
INPKVNITFH TYDVTVPVAE SKKLLKKIFD QLKTVDILIN GAGILDDHQI
110 120 130 140 150
ERTIAINFTG LVNTTTAILD FWDKRKGGPG GIIANICSVT GFNAIHQVPV
160 170 180 190 200
YSASKAAVVS FTNSLAKLAP ITGVTAYSIN PGITRTPLVH TFNSWLDVEP
210 220 230 240 250
RVAELLLSHP TQTSEQCGQN FVKAIEANKN GAIWKLDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,792
Last modified:July 1, 1989 - v1
Checksum:i56DA3644E6B9CDCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA. Translation: CAA37520.1. Sequence problems.
X54814 Genomic DNA. Translation: CAA38583.1.
M97637 Genomic DNA. Translation: AAA28355.1.
PIRiS12695. DEFFRL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA. Translation: CAA37520.1. Sequence problems.
X54814 Genomic DNA. Translation: CAA38583.1.
M97637 Genomic DNA. Translation: AAA28355.1.
PIRiS12695. DEFFRL.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4UX-ray1.92A/B1-254[»]
1B14X-ray2.40A/B1-254[»]
1B15X-ray2.20A/B1-254[»]
1B16X-ray1.40A/B1-254[»]
1B2LX-ray1.60A1-254[»]
1SBYX-ray1.10A/B1-254[»]
3RJ5X-ray1.45A/B1-254[»]
3RJ9X-ray1.98A/B/C/D/E/F1-254[»]
ProteinModelPortaliP10807.
SMRiP10807. Positions 1-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8383791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012438. Dleb\Adh.

Enzyme and pathway databases

SABIO-RKP10807.

Miscellaneous databases

EvolutionaryTraceiP10807.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROLE
AccessioniPrimary (citable) accession number: P10807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.