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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138Substrate1
Active sitei151Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NAD1 PublicationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP10807.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Taxonomic identifieri7225 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeScaptodrosophila

Organism-specific databases

FlyBaseiFBgn0012438. Dleb\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544711 – 254Alcohol dehydrogenaseAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7944097,EBI-7944097

Protein-protein interaction databases

MINTiMINT-8383791.

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Turni12 – 14Combined sources3
Helixi16 – 27Combined sources12
Beta strandi31 – 39Combined sources9
Helixi42 – 51Combined sources10
Beta strandi55 – 61Combined sources7
Helixi68 – 82Combined sources15
Beta strandi87 – 90Combined sources4
Helixi100 – 107Combined sources8
Helixi109 – 122Combined sources14
Helixi124 – 126Combined sources3
Beta strandi131 – 136Combined sources6
Helixi139 – 141Combined sources3
Helixi149 – 172Combined sources24
Beta strandi173 – 181Combined sources9
Beta strandi183 – 186Combined sources4
Helixi187 – 190Combined sources4
Helixi195 – 197Combined sources3
Helixi202 – 206Combined sources5
Helixi214 – 227Combined sources14
Beta strandi233 – 237Combined sources5
Beta strandi240 – 243Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4UX-ray1.92A/B1-254[»]
1B14X-ray2.40A/B1-254[»]
1B15X-ray2.20A/B1-254[»]
1B16X-ray1.40A/B1-254[»]
1B2LX-ray1.60A1-254[»]
1SBYX-ray1.10A/B1-254[»]
3RJ5X-ray1.45A/B1-254[»]
3RJ9X-ray1.98A/B/C/D/E/F1-254[»]
ProteinModelPortaliP10807.
SMRiP10807.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10807.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTNKNVIF VAALGGIGLD TSRELVKRNL KNFVILDRVE NPTALAELKA
60 70 80 90 100
INPKVNITFH TYDVTVPVAE SKKLLKKIFD QLKTVDILIN GAGILDDHQI
110 120 130 140 150
ERTIAINFTG LVNTTTAILD FWDKRKGGPG GIIANICSVT GFNAIHQVPV
160 170 180 190 200
YSASKAAVVS FTNSLAKLAP ITGVTAYSIN PGITRTPLVH TFNSWLDVEP
210 220 230 240 250
RVAELLLSHP TQTSEQCGQN FVKAIEANKN GAIWKLDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,792
Last modified:July 1, 1989 - v1
Checksum:i56DA3644E6B9CDCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA. Translation: CAA37520.1. Sequence problems.
X54814 Genomic DNA. Translation: CAA38583.1.
M97637 Genomic DNA. Translation: AAA28355.1.
PIRiS12695. DEFFRL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA. Translation: CAA37520.1. Sequence problems.
X54814 Genomic DNA. Translation: CAA38583.1.
M97637 Genomic DNA. Translation: AAA28355.1.
PIRiS12695. DEFFRL.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4UX-ray1.92A/B1-254[»]
1B14X-ray2.40A/B1-254[»]
1B15X-ray2.20A/B1-254[»]
1B16X-ray1.40A/B1-254[»]
1B2LX-ray1.60A1-254[»]
1SBYX-ray1.10A/B1-254[»]
3RJ5X-ray1.45A/B1-254[»]
3RJ9X-ray1.98A/B/C/D/E/F1-254[»]
ProteinModelPortaliP10807.
SMRiP10807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8383791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012438. Dleb\Adh.

Enzyme and pathway databases

SABIO-RKP10807.

Miscellaneous databases

EvolutionaryTraceiP10807.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROLE
AccessioniPrimary (citable) accession number: P10807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.