ID   ODP1_AZOVI              Reviewed;          45 AA.
AC   P10801;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   05-MAY-2009, entry version 45.
DE   RecName: Full=Pyruvate dehydrogenase E1 component;
DE            EC=1.2.4.1;
DE   Flags: Fragment;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 478 / NRS 16 / DSM 2289 / VKM B-1617;
RX   MEDLINE=88271330; PubMed=3292237;
RX   DOI=10.1111/j.1432-1033.1988.tb14140.x;
RA   Hanemaaijer R., Janssen A., de Kok A., Veeger C.;
RT   "The dihydrolipoyltransacetylase component of the pyruvate
RT   dehydrogenase complex from Azotobacter vinelandii. Molecular cloning
RT   and sequence analysis.";
RL   Eur. J. Biochem. 174:593-599(1988).
CC   -!- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall
CC       conversion of pyruvate to acetyl-CoA and CO(2). It contains
CC       multiple copies of three enzymatic components: pyruvate
CC       dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and
CC       lipoamide dehydrogenase (E3).
CC   -!- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue
CC       acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue
CC       acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Thiamine pyrophosphate.
CC   -!- SUBUNIT: Homodimer.
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DR   EMBL; X12455; CAA30986.1; -; Genomic_DNA.
DR   PIR; S12208; S12208.
DR   HSSP; P06958; 1L8A.
DR   BRENDA; 1.2.4.1; 883.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring...; IEA:EC.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR015941; Transketolase_C-like.
DR   Gene3D; G3DSA:3.40.50.920; Transketo_C_like; 1.
PE   4: Predicted;
KW   Glycolysis; Oxidoreductase; Pyruvate; Thiamine pyrophosphate.
FT   CHAIN        <1     45       Pyruvate dehydrogenase E1 component.
FT                                /FTId=PRO_0000162239.
FT   NON_TER       1      1
SQ   SEQUENCE   45 AA;  4957 MW;  C2929BB637D1B032 CRC64;
     EVDRYWVVLA ALEALADRGD IEAKVVAEAI AKFGIDPDKR NPLDC
//