Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate dehydrogenase E1 component

Gene
N/A
Organism
Azotobacter vinelandii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
OrganismiAzotobacter vinelandii
Taxonomic identifieri354 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000162239‹1 – 45Pyruvate dehydrogenase E1 componentAdd BLAST›45

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi322710.Avin_44900.

Structurei

3D structure databases

ProteinModelPortaliP10801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ. Bacteria.
COG2609. LUCA.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiIPR009014. Transketo_C/PFOR_II.
[Graphical view]
SUPFAMiSSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Fragment.

P10801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
EVDRYWVVLA ALEALADRGD IEAKVVAEAI AKFGIDPDKR NPLDC
Length:45
Mass (Da):4,957
Last modified:July 1, 1989 - v1
Checksum:iC2929BB637D1B032
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12455 Genomic DNA. Translation: CAA30986.1.
PIRiS12208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12455 Genomic DNA. Translation: CAA30986.1.
PIRiS12208.

3D structure databases

ProteinModelPortaliP10801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_44900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DAQ. Bacteria.
COG2609. LUCA.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiIPR009014. Transketo_C/PFOR_II.
[Graphical view]
SUPFAMiSSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiODP1_AZOVI
AccessioniPrimary (citable) accession number: P10801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.