Reviewed, UniProtKB/Swiss-Prot P10801 (ODP1_AZOVI)

Names and origin

Protein names	Recommended name:     Pyruvate dehydrogenase E1 component     EC=1.2.4.1
Organism	Azotobacter vinelandii
Taxonomic identifier	354 [NCBI]
Taxonomic lineage	Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Azotobacter

Protein attributes

Sequence length	45 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate.
Subunit structure	Homodimer.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Pyruvate Thiamine pyrophosphate
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 45	›45	Pyruvate dehydrogenase E1 component		PRO_0000162239
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P10801-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: C2929BB637D1B032	FASTA	45	4,957
	10 20 30 40 EVDRYWVVLA ALEALADRGD IEAKVVAEAI AKFGIDPDKR NPLDC

References

[1]

"The dihydrolipoyltransacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii. Molecular cloning and sequence analysis." Hanemaaijer R., Janssen A., de Kok A., Veeger C. Eur. J. Biochem. 174:593-599(1988) [PubMed: 3292237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 478 / NRS 16 / DSM 2289 / VKM B-1617.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X12455 Genomic DNA. Translation: CAA30986.1.
PIR	S12208.
3D structure databases
HSSP	HSSP built from PDB template 1L8A based on UniProtKB P06958.
ModBase	Search...
Family and domain databases
InterPro	IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODP1_AZOVI

Accession

Primary (citable) accession number: P10801

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 4, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)