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Protein

Pyruvate dehydrogenase E1 component

Gene
N/A
Organism
Azotobacter vinelandii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
OrganismiAzotobacter vinelandii
Taxonomic identifieri354 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 45›45Pyruvate dehydrogenase E1 componentPRO_0000162239Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP10801.
SMRiP10801. Positions 1-42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiIPR009014. Transketo_C/Pyr-ferredox_oxred.
[Graphical view]
SUPFAMiSSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Fragment.

P10801-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40 
EVDRYWVVLA ALEALADRGD IEAKVVAEAI AKFGIDPDKR NPLDC
Length:45
Mass (Da):4,957
Last modified:July 1, 1989 - v1
Checksum:iC2929BB637D1B032
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12455 Genomic DNA. Translation: CAA30986.1.
PIRiS12208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12455 Genomic DNA. Translation: CAA30986.1.
PIRiS12208.

3D structure databases

ProteinModelPortaliP10801.
SMRiP10801. Positions 1-42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiIPR009014. Transketo_C/Pyr-ferredox_oxred.
[Graphical view]
SUPFAMiSSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The dihydrolipoyltransacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii. Molecular cloning and sequence analysis."
    Hanemaaijer R., Janssen A., de Kok A., Veeger C.
    Eur. J. Biochem. 174:593-599(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 478 / NRS 16 / DSM 2289 / VKM B-1617.

Entry informationi

Entry nameiODP1_AZOVI
AccessioniPrimary (citable) accession number: P10801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.