P10791 (SODC_DROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:	Sod
ORF Names:	GJ11304

Organism

Drosophila virilis (Fruit fly) [Complete proteome]

Taxonomic identifier

7244 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Drosophila › virilis group

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit. Binds 1 zinc ion per subunit.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 153	152	Superoxide dismutase [Cu-Zn]		PRO_0000164098
Sites
	Metal binding	45	1	Copper; catalytic
	Metal binding	47	1	Copper; catalytic
	Metal binding	62	1	Copper; catalytic
	Metal binding	62	1	Zinc; structural
	Metal binding	70	1	Zinc; structural
	Metal binding	79	1	Zinc; structural
	Metal binding	82	1	Zinc; structural
	Metal binding	119	1	Copper; catalytic
Amino acid modifications
	Disulfide bond	56 ↔ 145		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10791 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 26E121BBF6B7A25C	FASTA	153	15,770
	10 20 30 40 50 60 MVVKAVCVIN GDAKGTVFFE QEGEGCPVKV TGEVTGLAKG QHGFHVHEFG DNTNGCMSSG 70 80 90 100 110 120 PHFNPYQKEH GAPTDENRHL GDLGNIIANG DGPTPVNICD CKITLLGANS IIGRTVVVHA 130 140 150 DPDDLGKGGH ELSKTTGNAG ARIGCGVIGI AKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drosophila virilis Cu-Zn superoxide dismutase gene sequence." Kwiatowski J., Ayala F.J. Nucleic Acids Res. 17:2133-2133(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15010-1051.87.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13831 Genomic DNA. Translation: CAA32060.1. CH940647 Genomic DNA. Translation: EDW70874.1.
PIR	S03606.
RefSeq	XP_002048532.1. XM_002048496.1.
3D structure databases
ProteinModelPortal	P10791.
SMR	P10791. Positions 4-152.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0227229; FBpp0225721; FBgn0013096.
GeneID	6624514.
KEGG	dvi:Dvir_GJ11304.
Organism-specific databases
FlyBase	FBgn0013096. Dvir\Sod.
Phylogenomic databases
eggNOG	COG2032.
InParanoid	P10791.
KO	K04565.
OMA	APRFESS.
OrthoDB	EOG43TXBZ.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_DROVI

Accession

Primary (citable) accession number: P10791
Secondary accession number(s): B4LC46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project