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Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
MDGI reversibly inhibits proliferation of mammary carcinoma cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:FABP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000673202 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvaline1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10790.
PeptideAtlasiP10790.
PRIDEiP10790.

Expressioni

Tissue specificityi

Mammary epithelial cells of developing lobuloalveolar structures and heart.

Gene expression databases

BgeeiENSBTAG00000016819.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022375.

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 5Combined sources3
Beta strandi7 – 14Combined sources8
Helixi17 – 24Combined sources8
Turni28 – 30Combined sources3
Helixi31 – 34Combined sources4
Beta strandi40 – 46Combined sources7
Beta strandi49 – 54Combined sources6
Beta strandi61 – 65Combined sources5
Beta strandi69 – 75Combined sources7
Turni76 – 78Combined sources3
Beta strandi79 – 88Combined sources10
Beta strandi91 – 97Combined sources7
Beta strandi102 – 110Combined sources9
Beta strandi113 – 122Combined sources10
Beta strandi124 – 133Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BWYNMR-A2-133[»]
ProteinModelPortaliP10790.
SMRiP10790.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10790.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 20Fatty acid binding4

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP10790.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVGNMTKPT TIIEVNGDTV
60 70 80 90 100
IIKTQSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHVQKWNG
110 120 130
QETSLVREMV DGKLILTLTH GTAVCTRTYE KQA
Length:133
Mass (Da):14,779
Last modified:January 23, 2007 - v2
Checksum:iC620160BFF167BC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 15DSK → SSE AA sequence (PubMed:3667628).Curated3
Sequence conflicti41T → L AA sequence (PubMed:3667628).Curated1
Sequence conflicti44E → S AA sequence (PubMed:3667628).Curated1
Sequence conflicti94H → Q AA sequence (PubMed:3667628).Curated1
Sequence conflicti128T → V AA sequence (PubMed:3667628).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti99N → D.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12710 mRNA. Translation: CAA31212.1.
X51933 mRNA. Translation: CAA36199.1.
DQ174319 Genomic DNA. Translation: AAZ99892.1.
BC102153 mRNA. Translation: AAI02154.1.
PIRiA34676.
RefSeqiNP_776738.1. NM_174313.2.
UniGeneiBt.4758.

Genome annotation databases

EnsembliENSBTAT00000022375; ENSBTAP00000022375; ENSBTAG00000016819.
GeneIDi281758.
KEGGibta:281758.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12710 mRNA. Translation: CAA31212.1.
X51933 mRNA. Translation: CAA36199.1.
DQ174319 Genomic DNA. Translation: AAZ99892.1.
BC102153 mRNA. Translation: AAI02154.1.
PIRiA34676.
RefSeqiNP_776738.1. NM_174313.2.
UniGeneiBt.4758.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BWYNMR-A2-133[»]
ProteinModelPortaliP10790.
SMRiP10790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022375.

Proteomic databases

PaxDbiP10790.
PeptideAtlasiP10790.
PRIDEiP10790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022375; ENSBTAP00000022375; ENSBTAG00000016819.
GeneIDi281758.
KEGGibta:281758.

Organism-specific databases

CTDi2170.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP10790.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

EvolutionaryTraceiP10790.

Gene expression databases

BgeeiENSBTAG00000016819.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABPH_BOVIN
AccessioniPrimary (citable) accession number: P10790
Secondary accession number(s): P12103, Q3T125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.