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Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
MDGI reversibly inhibits proliferation of mammary carcinoma cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:FABP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:28697 FABP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000673202 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvaline1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10790
PeptideAtlasiP10790
PRIDEiP10790

PTM databases

iPTMnetiP10790

Expressioni

Tissue specificityi

Mammary epithelial cells of developing lobuloalveolar structures and heart.

Gene expression databases

BgeeiENSBTAG00000016819

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022375

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 5Combined sources3
Beta strandi7 – 14Combined sources8
Helixi17 – 24Combined sources8
Turni28 – 30Combined sources3
Helixi31 – 34Combined sources4
Beta strandi40 – 46Combined sources7
Beta strandi49 – 54Combined sources6
Beta strandi61 – 65Combined sources5
Beta strandi69 – 75Combined sources7
Turni76 – 78Combined sources3
Beta strandi79 – 88Combined sources10
Beta strandi91 – 97Combined sources7
Beta strandi102 – 110Combined sources9
Beta strandi113 – 122Combined sources10
Beta strandi124 – 133Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BWYNMR-A2-133[»]
ProteinModelPortaliP10790
SMRiP10790
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10790

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 20Fatty acid binding4

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP10790
KOiK08752
OMAiTWNLKES
OrthoDBiEOG091G0QSV
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVGNMTKPT TIIEVNGDTV
60 70 80 90 100
IIKTQSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHVQKWNG
110 120 130
QETSLVREMV DGKLILTLTH GTAVCTRTYE KQA
Length:133
Mass (Da):14,779
Last modified:January 23, 2007 - v2
Checksum:iC620160BFF167BC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 15DSK → SSE AA sequence (PubMed:3667628).Curated3
Sequence conflicti41T → L AA sequence (PubMed:3667628).Curated1
Sequence conflicti44E → S AA sequence (PubMed:3667628).Curated1
Sequence conflicti94H → Q AA sequence (PubMed:3667628).Curated1
Sequence conflicti128T → V AA sequence (PubMed:3667628).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti99N → D1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12710 mRNA Translation: CAA31212.1
X51933 mRNA Translation: CAA36199.1
DQ174319 Genomic DNA Translation: AAZ99892.1
BC102153 mRNA Translation: AAI02154.1
PIRiA34676
RefSeqiNP_776738.1, NM_174313.2
UniGeneiBt.4758

Genome annotation databases

EnsembliENSBTAT00000022375; ENSBTAP00000022375; ENSBTAG00000016819
GeneIDi281758
KEGGibta:281758

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFABPH_BOVIN
AccessioniPrimary (citable) accession number: P10790
Secondary accession number(s): P12103, Q3T125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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