Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
MDGI reversibly inhibits proliferation of mammary carcinoma cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271Fatty acidBy similarity
Binding sitei129 – 1291Fatty acidBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:FABP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 133132Fatty acid-binding protein, heartPRO_0000067320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvaline1 Publication
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei20 – 201Phosphotyrosine; by Tyr-kinasesBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei30 – 301PhosphothreonineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10790.
PeptideAtlasiP10790.
PRIDEiP10790.

Expressioni

Tissue specificityi

Mammary epithelial cells of developing lobuloalveolar structures and heart.

Gene expression databases

BgeeiENSBTAG00000016819.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022375.

Structurei

Secondary structure

1
133
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 53Combined sources
Beta strandi7 – 148Combined sources
Helixi17 – 248Combined sources
Turni28 – 303Combined sources
Helixi31 – 344Combined sources
Beta strandi40 – 467Combined sources
Beta strandi49 – 546Combined sources
Beta strandi61 – 655Combined sources
Beta strandi69 – 757Combined sources
Turni76 – 783Combined sources
Beta strandi79 – 8810Combined sources
Beta strandi91 – 977Combined sources
Beta strandi102 – 1109Combined sources
Beta strandi113 – 12210Combined sources
Beta strandi124 – 13310Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BWYNMR-A2-133[»]
ProteinModelPortaliP10790.
SMRiP10790. Positions 2-133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10790.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 204Fatty acid binding

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP10790.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVGNMTKPT TIIEVNGDTV
60 70 80 90 100
IIKTQSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHVQKWNG
110 120 130
QETSLVREMV DGKLILTLTH GTAVCTRTYE KQA
Length:133
Mass (Da):14,779
Last modified:January 23, 2007 - v2
Checksum:iC620160BFF167BC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 153DSK → SSE AA sequence (PubMed:3667628).Curated
Sequence conflicti41 – 411T → L AA sequence (PubMed:3667628).Curated
Sequence conflicti44 – 441E → S AA sequence (PubMed:3667628).Curated
Sequence conflicti94 – 941H → Q AA sequence (PubMed:3667628).Curated
Sequence conflicti128 – 1281T → V AA sequence (PubMed:3667628).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991N → D.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12710 mRNA. Translation: CAA31212.1.
X51933 mRNA. Translation: CAA36199.1.
DQ174319 Genomic DNA. Translation: AAZ99892.1.
BC102153 mRNA. Translation: AAI02154.1.
PIRiA34676.
RefSeqiNP_776738.1. NM_174313.2.
UniGeneiBt.4758.

Genome annotation databases

EnsembliENSBTAT00000022375; ENSBTAP00000022375; ENSBTAG00000016819.
GeneIDi281758.
KEGGibta:281758.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12710 mRNA. Translation: CAA31212.1.
X51933 mRNA. Translation: CAA36199.1.
DQ174319 Genomic DNA. Translation: AAZ99892.1.
BC102153 mRNA. Translation: AAI02154.1.
PIRiA34676.
RefSeqiNP_776738.1. NM_174313.2.
UniGeneiBt.4758.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BWYNMR-A2-133[»]
ProteinModelPortaliP10790.
SMRiP10790. Positions 2-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022375.

Proteomic databases

PaxDbiP10790.
PeptideAtlasiP10790.
PRIDEiP10790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022375; ENSBTAP00000022375; ENSBTAG00000016819.
GeneIDi281758.
KEGGibta:281758.

Organism-specific databases

CTDi2170.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP10790.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-BTA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

EvolutionaryTraceiP10790.

Gene expression databases

BgeeiENSBTAG00000016819.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABPH_BOVIN
AccessioniPrimary (citable) accession number: P10790
Secondary accession number(s): P12103, Q3T125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.