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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Phalacrocorax carbo (Great cormorant) (Pelecanus carbo)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)
Metal bindingi87 – 871Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiPhalacrocorax carbo (Great cormorant) (Pelecanus carbo)
Taxonomic identifieri9209 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePelecaniformesPhalacrocoracidaePhalacrocorax

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin subunit alpha-APRO_0000052726Add
BLAST

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714Combined sources
Helixi18 – 203Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 426Combined sources
Helixi53 – 6917Combined sources
Helixi73 – 753Combined sources
Helixi76 – 794Combined sources
Helixi81 – 899Combined sources
Helixi95 – 11218Combined sources
Turni114 – 1163Combined sources
Helixi119 – 13517Combined sources
Turni136 – 1405Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WR1X-ray3.50A1-141[»]
ProteinModelPortaliP10780.
SMRiP10780. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSASDKTNV KGVFAKVGGS AEAYGAETLE RMFTAYPQTK TYFPHFDLHH
60 70 80 90 100
GSAQIKAHGK KVAAALVEAA NHIDDIAGAL SKLSDLHAQK LRVDPVNFKL
110 120 130 140
LGHCFLVVVA IHHPTLLTPE VHASLDKFMC AVAKELTAKY R
Length:141
Mass (Da):15,275
Last modified:July 1, 1989 - v1
Checksum:iC4F1F3967F88F49B
GO

Sequence databases

PIRiS01804. HACOAG.

Cross-referencesi

Sequence databases

PIRiS01804. HACOAG.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WR1X-ray3.50A1-141[»]
ProteinModelPortaliP10780.
SMRiP10780. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The primary structure of the hemoglobin of the Cormorant (Phalacrocorax carbo, Pelecaniformes)."
    Huber K., Braunitzer G., Schneeganss D., Kosters J., Grimm F.
    Biol. Chem. Hoppe-Seyler 369:1251-1258(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiHBA_PHACA
AccessioniPrimary (citable) accession number: P10780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 14, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.