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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Phalacrocorax carbo (Great cormorant) (Pelecanus carbo)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiPhalacrocorax carbo (Great cormorant) (Pelecanus carbo)
Taxonomic identifieri9209 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePelecaniformesPhalacrocoracidaePhalacrocorax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000527261 – 141Hemoglobin subunit alpha-AAdd BLAST141

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Helixi18 – 20Combined sources3
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi53 – 69Combined sources17
Helixi73 – 75Combined sources3
Helixi76 – 79Combined sources4
Helixi81 – 89Combined sources9
Helixi95 – 112Combined sources18
Turni114 – 116Combined sources3
Helixi119 – 135Combined sources17
Turni136 – 140Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WR1X-ray3.50A1-141[»]
ProteinModelPortaliP10780
SMRiP10780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P10780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSASDKTNV KGVFAKVGGS AEAYGAETLE RMFTAYPQTK TYFPHFDLHH
60 70 80 90 100
GSAQIKAHGK KVAAALVEAA NHIDDIAGAL SKLSDLHAQK LRVDPVNFKL
110 120 130 140
LGHCFLVVVA IHHPTLLTPE VHASLDKFMC AVAKELTAKY R
Length:141
Mass (Da):15,275
Last modified:July 1, 1989 - v1
Checksum:iC4F1F3967F88F49B
GO

Sequence databases

PIRiS01804 HACOAG

Similar proteinsi

Entry informationi

Entry nameiHBA_PHACA
AccessioniPrimary (citable) accession number: P10780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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