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Protein

Ribonuclease inhibitor

Gene

RNH1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease inhibitor
Alternative name(s):
Ribonuclease/angiogenin inhibitor 1
Gene namesi
Name:RNH1
Synonyms:RI, RNH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Ribonuclease inhibitorPRO_0000097346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei86 – 861PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiP10775.
PRIDEiP10775.

Interactioni

Subunit structurei

Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.1 Publication

Protein-protein interaction databases

IntActiP10775. 1 interaction.
MINTiMINT-1510428.

Structurei

Secondary structure

1
456
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73Combined sources
Helixi12 – 2211Combined sources
Beta strandi26 – 316Combined sources
Helixi37 – 4711Combined sources
Beta strandi55 – 573Combined sources
Helixi64 – 7512Combined sources
Beta strandi84 – 863Combined sources
Helixi94 – 985Combined sources
Helixi100 – 1067Combined sources
Beta strandi112 – 1143Combined sources
Helixi121 – 13313Combined sources
Beta strandi141 – 1433Combined sources
Helixi151 – 16313Combined sources
Beta strandi169 – 1713Combined sources
Helixi178 – 19013Combined sources
Beta strandi198 – 2003Combined sources
Helixi208 – 22013Combined sources
Beta strandi226 – 2283Combined sources
Helixi235 – 24612Combined sources
Beta strandi255 – 2573Combined sources
Helixi265 – 27713Combined sources
Beta strandi283 – 2853Combined sources
Helixi292 – 30312Combined sources
Beta strandi312 – 3143Combined sources
Helixi322 – 3243Combined sources
Helixi325 – 33410Combined sources
Beta strandi340 – 3423Combined sources
Beta strandi345 – 3473Combined sources
Helixi349 – 35911Combined sources
Beta strandi362 – 3643Combined sources
Beta strandi369 – 3713Combined sources
Helixi379 – 39113Combined sources
Beta strandi397 – 3993Combined sources
Beta strandi402 – 4043Combined sources
Helixi407 – 41711Combined sources
Beta strandi419 – 4213Combined sources
Beta strandi426 – 4283Combined sources
Helixi436 – 44813Combined sources
Beta strandi453 – 4553Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DFJX-ray2.50I1-456[»]
2BNHX-ray2.30A1-456[»]
ProteinModelPortaliP10775.
SMRiP10775. Positions 1-456.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10775.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 4329LRR 1Add
BLAST
Repeati44 – 7128LRR 2Add
BLAST
Repeati72 – 10029LRR 3Add
BLAST
Repeati101 – 12828LRR 4Add
BLAST
Repeati129 – 15729LRR 5Add
BLAST
Repeati158 – 18528LRR 6Add
BLAST
Repeati186 – 21429LRR 7Add
BLAST
Repeati215 – 24228LRR 8Add
BLAST
Repeati243 – 27129LRR 9Add
BLAST
Repeati272 – 29928LRR 10Add
BLAST
Repeati300 – 32829LRR 11Add
BLAST
Repeati329 – 35628LRR 12Add
BLAST
Repeati357 – 38529LRR 13Add
BLAST
Repeati386 – 41328LRR 14Add
BLAST
Repeati414 – 44229LRR 15Add
BLAST

Domaini

The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.By similarity

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG001059.
InParanoidiP10775.
KOiK16634.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 8 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLDIHCEQL SDARWTELLP LLQQYEVVRL DDCGLTEEHC KDIGSALRAN
60 70 80 90 100
PSLTELCLRT NELGDAGVHL VLQGLQSPTC KIQKLSLQNC SLTEAGCGVL
110 120 130 140 150
PSTLRSLPTL RELHLSDNPL GDAGLRLLCE GLLDPQCHLE KLQLEYCRLT
160 170 180 190 200
AASCEPLASV LRATRALKEL TVSNNDIGEA GARVLGQGLA DSACQLETLR
210 220 230 240 250
LENCGLTPAN CKDLCGIVAS QASLRELDLG SNGLGDAGIA ELCPGLLSPA
260 270 280 290 300
SRLKTLWLWE CDITASGCRD LCRVLQAKET LKELSLAGNK LGDEGARLLC
310 320 330 340 350
ESLLQPGCQL ESLWVKSCSL TAACCQHVSL MLTQNKHLLE LQLSSNKLGD
360 370 380 390 400
SGIQELCQAL SQPGTTLRVL CLGDCEVTNS GCSSLASLLL ANRSLRELDL
410 420 430 440 450
SNNCVGDPGV LQLLGSLEQP GCALEQLVLY DTYWTEEVED RLQALEGSKP

GLRVIS
Length:456
Mass (Da):49,023
Last modified:July 1, 1989 - v1
Checksum:i01DA0A529CDC763E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58700 mRNA. Translation: AAA63448.1.
PIRiA31857.
RefSeqiXP_013847653.1. XM_013992199.1.
UniGeneiSsc.6413.

Genome annotation databases

GeneIDi445517.
KEGGissc:445517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58700 mRNA. Translation: AAA63448.1.
PIRiA31857.
RefSeqiXP_013847653.1. XM_013992199.1.
UniGeneiSsc.6413.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DFJX-ray2.50I1-456[»]
2BNHX-ray2.30A1-456[»]
ProteinModelPortaliP10775.
SMRiP10775. Positions 1-456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10775. 1 interaction.
MINTiMINT-1510428.

Proteomic databases

PeptideAtlasiP10775.
PRIDEiP10775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445517.
KEGGissc:445517.

Organism-specific databases

CTDi6050.

Phylogenomic databases

HOVERGENiHBG001059.
InParanoidiP10775.
KOiK16634.

Miscellaneous databases

EvolutionaryTraceiP10775.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 8 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRINI_PIG
AccessioniPrimary (citable) accession number: P10775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.