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Protein

B-enzyme

Gene

lyzB

Organism
Bacillus subtilis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Sequence Analysis

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
B-enzyme
Alternative name(s):
Lysozyme (EC:3.2.1.17)
Gene namesi
Name:lyzB
OrganismiBacillus subtilis
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117B-enzymePRO_0000057725Add
BLAST

Sequencei

Sequence statusi: Complete.

P10773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ISPLGSVTKK NQDSTAYNWT GNKTANGNWP VLGICAVHRK KDIGGSGNSP
60 70 80 90 100
VIPFGTTLKT DKDIWLPDGV GYKSSFNVDD TGSGPKKTDY WIDIYYSKDT
110
KAAINYGVVK LSYTYST
Length:117
Mass (Da):12,732
Last modified:July 1, 1989 - v1
Checksum:i322C5FD7C5EB3762
GO

Sequence databases

PIRiJX0053.

Cross-referencesi

Sequence databases

PIRiJX0053.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Amino acid sequence of a lysozyme (B-enzyme) from Bacillus subtilis YT-25."
    Kamei K., Hara S., Ikenaka T., Murao S.
    J. Biochem. 104:832-836(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: YT-25.

Entry informationi

Entry nameiLYB_BACIU
AccessioniPrimary (citable) accession number: P10773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Usually lysozymes have a catalytic site with Asp and Glu, but B-enzyme has no Glu (two Asp for catalytic site).

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.