P10773 (LYB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-enzyme

Alternative name(s):
Lysozyme
EC=3.2.1.17

Gene names

Name:

lyzB

Organism

Bacillus subtilis

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Miscellaneous	Usually lysozymes have a catalytic site with Asp and Glu, but B-enzyme has no Glu (two Asp for catalytic site).

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	B-enzyme		PRO_0000057725
Sites
	Active site	89	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	P10773 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 322C5FD7C5EB3762	FASTA	117	12,732
	10 20 30 40 50 60 ISPLGSVTKK NQDSTAYNWT GNKTANGNWP VLGICAVHRK KDIGGSGNSP VIPFGTTLKT 70 80 90 100 110 DKDIWLPDGV GYKSSFNVDD TGSGPKKTDY WIDIYYSKDT KAAINYGVVK LSYTYST

References

[1]	"Amino acid sequence of a lysozyme (B-enzyme) from Bacillus subtilis YT-25." Kamei K., Hara S., Ikenaka T., Murao S. J. Biochem. 104:832-836(1988) [PubMed: 3148618] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: YT-25.

Cross-references

Sequence databases
PIR	JX0053.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

LYB_BACSU

Accession

Primary (citable) accession number: P10773

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 31, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program