Reviewed, UniProtKB/Swiss-Prot P10767 (FGF6_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 6
      Short name=FGF-6
Alternative name(s):
    Heparin-binding growth factor 6
      Short name=HBGF-6
    HST-2

Gene names

Name:	FGF6
Synonyms:	HST2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.
Subcellular location	Secreted › extracellular space.
Tissue specificity	Leukemia cell lines with platelet/ megakaryocytic differentiation potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.5 Traceable author statement. Source: ProtInc cell-cell signaling Ref.5 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	growth factor activity Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 208	171	Fibroblast growth factor 6		PRO_0000008961
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Disulfide bond	90 ↔ 157		Potential
Natural variations
	Natural variant	36	1	V → A: dbSNP rs11613495. Ref.2		VAR_018882
	Natural variant	63	1	A → V: dbSNP rs17183529. Ref.2		VAR_018883
	Natural variant	174	1	D → V: dbSNP rs7961645. Ref.2		VAR_018884
	Natural variant	191	1	R → W: dbSNP rs17183778. Ref.2		VAR_018885
Experimental info
	Sequence conflict	100	1	V → G in CAB37648. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P10767-1 [UniParc]. Last modified November 1, 1995. Version 4. Checksum: 79EF44685B324322	FASTA	208	22,905
	10 20 30 40 50 60 MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 70 80 90 100 110 120 SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 130 140 150 160 170 180 STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 190 200 IALSKYGRVK RGSKVSPIMT VTHFLPRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative structure of the FGF6 gene product and role of the signal peptide." Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D. Oncogene 6:1437-1444(1991) [PubMed: 1886714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	NIEHS SNPs program Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization." Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M. Oncogene 7:303-309(1992) [PubMed: 1549352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]	"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family." Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D. Oncogene 4:335-340(1989) [PubMed: 2649847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	X57075 Genomic DNA. Translation: CAA40358.1. X57075 Genomic DNA. Translation: CAA40359.1. Different initiation. X57075 Genomic DNA. Translation: CAA40360.1. Different initiation. AY581424 Genomic DNA. Translation: AAS79318.1. BC121097 mRNA. Translation: AAI21098.1. BC121098 mRNA. Translation: AAI21099.1. X63454 mRNA. Translation: CAA45054.1. X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
IPI	IPI00022396.
PIR	S20102.
RefSeq	NP_066276.2.
UniGene	Hs.166015
3D structure databases
HSSP	HSSP built from PDB template 1IJT based on UniProtKB P08620.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6035N.
Proteomic databases
PRIDE	P10767.
Genome annotation databases
Ensembl	ENSG00000111241. Homo sapiens. [Contig view]
GeneID	2251.
KEGG	hsa:2251.
NMPDR	fig|9606.3.peg.6985.
Organism-specific databases
GeneCards	GC12M004413.
H-InvDB	HIX0036856.
HGNC	HGNC:3684. FGF6.
MIM	134921. gene.
PharmGKB	PA28123.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P10767.
HOVERGEN	P10767.
OMA	P10767. GEIAGVN.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway. syndecan_4_pathway. Syndecan-4-mediated signaling events.
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	P10767.
Bgee	P10767.
CleanEx	HS_FGF6.
GermOnline	ENSG00000111241. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9113.
SOURCE	Search...

Entry information

Entry name

FGF6_HUMAN

Accession

Primary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 90 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)