P10767 (FGF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 6
Short name=FGF-6

Alternative name(s):
Heparin secretory-transforming protein 2
Short name=HST-2
Short name=HSTF-2
Heparin-binding growth factor 6
Short name=HBGF-6

Gene names

Name:	FGF6
Synonyms:	HST2, HSTF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Ref.6
Subunit structure	Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.6
Subcellular location	Secreted › extracellular space.
Tissue specificity	Leukemia cell lines with platelet/ megakaryocytic differentiation potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.
Sequence caution	The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cartilage condensation Inferred from electronic annotation. Source: Compara cell proliferation Traceable author statement Ref.5. Source: ProtInc cell-cell signaling Traceable author statement Ref.5. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from genetic interaction Ref.6. Source: MGI insulin receptor signaling pathway Traceable author statement. Source: Reactome myoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from genetic interaction Ref.6. Source: MGI
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell sarcolemma Inferred from electronic annotation. Source: Compara
Molecular_function	growth factor activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 208	171	Fibroblast growth factor 6		PRO_0000008961
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Disulfide bond	90 ↔ 157		Potential
Natural variations
	Natural variant	36	1	V → A. Ref.2 Corresponds to variant rs11613495 [ dbSNP | Ensembl ].		VAR_018882
	Natural variant	63	1	A → V. Ref.2 Corresponds to variant rs17183529 [ dbSNP | Ensembl ].		VAR_018883
	Natural variant	174	1	D → V. Ref.2 Corresponds to variant rs7961645 [ dbSNP | Ensembl ].		VAR_018884
	Natural variant	191	1	R → W. Ref.2 Corresponds to variant rs17183778 [ dbSNP | Ensembl ].		VAR_018885
Experimental info
	Sequence conflict	100	1	V → G in CAB37648. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P10767 [UniParc]. Last modified November 1, 1995. Version 4. Checksum: 79EF44685B324322	FASTA	208	22,905
	10 20 30 40 50 60 MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 70 80 90 100 110 120 SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 130 140 150 160 170 180 STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 190 200 IALSKYGRVK RGSKVSPIMT VTHFLPRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative structure of the FGF6 gene product and role of the signal peptide." Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D. Oncogene 6:1437-1444(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	NIEHS SNPs program Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization." Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M. Oncogene 7:303-309(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]	"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family." Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D. Oncogene 4:335-340(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
[6]	"Receptor specificity of the fibroblast growth factor family." Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR1; FGFR2 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[7]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57075 Genomic DNA. Translation: CAA40358.1. X57075 Genomic DNA. Translation: CAA40359.1. Different initiation. X57075 Genomic DNA. Translation: CAA40360.1. Different initiation. AY581424 Genomic DNA. Translation: AAS79318.1. BC121097 mRNA. Translation: AAI21098.1. BC121098 mRNA. Translation: AAI21099.1. X63454 mRNA. Translation: CAA45054.1. X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
IPI	IPI00022396.
PIR	S20102.
RefSeq	NP_066276.2. NM_020996.1.
UniGene	Hs.166015.
3D structure databases
ProteinModelPortal	P10767.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6035N.
STRING	9606.ENSP00000228837.
PTM databases
PhosphoSite	P10767.
Polymorphism databases
DMDM	1169676.
Proteomic databases
PaxDb	P10767.
PRIDE	P10767.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000228837; ENSP00000228837; ENSG00000111241.
GeneID	2251.
KEGG	hsa:2251.
UCSC	uc001qmr.1. human.
Organism-specific databases
CTD	2251.
GeneCards	GC12M004543.
HGNC	HGNC:3684. FGF6.
MIM	134921. gene.
neXtProt	NX_P10767.
PharmGKB	PA28123.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320285.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P10767.
KO	K04358.
OMA	EIAGVNW.
OrthoDB	EOG4N8R5V.
PhylomeDB	P10767.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway. syndecan_4_pathway. Syndecan-4-mediated signaling events.
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P10767.
Bgee	P10767.
CleanEx	HS_FGF6.
Genevestigator	P10767.
GermOnline	ENSG00000111241. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2251.
NextBio	9113.
SOURCE	Search...

Entry information

Entry name

FGF6_HUMAN

Accession

Primary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 128 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.