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P10767

- FGF6_HUMAN

UniProt

P10767 - FGF6_HUMAN

Protein

Fibroblast growth factor 6

Gene

FGF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 4 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.1 Publication

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cartilage condensation Source: Ensembl
    3. cell-cell signaling Source: ProtInc
    4. cell proliferation Source: ProtInc
    5. epidermal growth factor receptor signaling pathway Source: Reactome
    6. Fc-epsilon receptor signaling pathway Source: Reactome
    7. fibroblast growth factor receptor signaling pathway Source: MGI
    8. innate immune response Source: Reactome
    9. insulin receptor signaling pathway Source: Reactome
    10. myoblast differentiation Source: Ensembl
    11. neurotrophin TRK receptor signaling pathway Source: Reactome
    12. phosphatidylinositol-mediated signaling Source: Reactome
    13. positive regulation of cell division Source: UniProtKB-KW
    14. positive regulation of cell proliferation Source: MGI
    15. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiP10767.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 6
    Short name:
    FGF-6
    Alternative name(s):
    Heparin secretory-transforming protein 2
    Short name:
    HST-2
    Short name:
    HSTF-2
    Heparin-binding growth factor 6
    Short name:
    HBGF-6
    Gene namesi
    Name:FGF6
    Synonyms:HST2, HSTF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:3684. FGF6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-SubCell
    3. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA28123.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 208171Fibroblast growth factor 6PRO_0000008961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 ↔ 157Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP10767.
    PRIDEiP10767.

    PTM databases

    PhosphoSiteiP10767.

    Expressioni

    Tissue specificityi

    Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

    Gene expression databases

    ArrayExpressiP10767.
    BgeeiP10767.
    CleanExiHS_FGF6.
    GenevestigatoriP10767.

    Interactioni

    Subunit structurei

    Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

    Protein-protein interaction databases

    DIPiDIP-6035N.
    STRINGi9606.ENSP00000228837.

    Structurei

    3D structure databases

    ProteinModelPortaliP10767.
    SMRiP10767. Positions 81-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320285.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP10767.
    KOiK04358.
    OMAiEIAGVNW.
    PhylomeDBiP10767.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028242. FGF6.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF25. PTHR11486:SF25. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10767-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD    50
    SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV 100
    LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT 150
    PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT 200
    VTHFLPRI 208
    Length:208
    Mass (Da):22,905
    Last modified:November 1, 1995 - v4
    Checksum:i79EF44685B324322
    GO

    Sequence cautioni

    The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001V → G in CAB37648. (PubMed:2649847)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361V → A.1 Publication
    Corresponds to variant rs11613495 [ dbSNP | Ensembl ].
    VAR_018882
    Natural varianti63 – 631A → V.1 Publication
    Corresponds to variant rs17183529 [ dbSNP | Ensembl ].
    VAR_018883
    Natural varianti174 – 1741D → V.1 Publication
    Corresponds to variant rs7961645 [ dbSNP | Ensembl ].
    VAR_018884
    Natural varianti191 – 1911R → W.1 Publication
    Corresponds to variant rs17183778 [ dbSNP | Ensembl ].
    VAR_018885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57075 Genomic DNA. Translation: CAA40358.1.
    X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
    X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
    AY581424 Genomic DNA. Translation: AAS79318.1.
    BC121097 mRNA. Translation: AAI21098.1.
    BC121098 mRNA. Translation: AAI21099.1.
    X63454 mRNA. Translation: CAA45054.1.
    X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
    CCDSiCCDS8527.1.
    PIRiS20102.
    RefSeqiNP_066276.2. NM_020996.1.
    UniGeneiHs.166015.

    Genome annotation databases

    EnsembliENST00000228837; ENSP00000228837; ENSG00000111241.
    GeneIDi2251.
    KEGGihsa:2251.
    UCSCiuc001qmr.1. human.

    Polymorphism databases

    DMDMi1169676.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57075 Genomic DNA. Translation: CAA40358.1 .
    X57075 Genomic DNA. Translation: CAA40359.1 . Different initiation.
    X57075 Genomic DNA. Translation: CAA40360.1 . Different initiation.
    AY581424 Genomic DNA. Translation: AAS79318.1 .
    BC121097 mRNA. Translation: AAI21098.1 .
    BC121098 mRNA. Translation: AAI21099.1 .
    X63454 mRNA. Translation: CAA45054.1 .
    X14071 , X14072 , X14073 Genomic DNA. Translation: CAB37648.2 .
    CCDSi CCDS8527.1.
    PIRi S20102.
    RefSeqi NP_066276.2. NM_020996.1.
    UniGenei Hs.166015.

    3D structure databases

    ProteinModelPortali P10767.
    SMRi P10767. Positions 81-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6035N.
    STRINGi 9606.ENSP00000228837.

    PTM databases

    PhosphoSitei P10767.

    Polymorphism databases

    DMDMi 1169676.

    Proteomic databases

    PaxDbi P10767.
    PRIDEi P10767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228837 ; ENSP00000228837 ; ENSG00000111241 .
    GeneIDi 2251.
    KEGGi hsa:2251.
    UCSCi uc001qmr.1. human.

    Organism-specific databases

    CTDi 2251.
    GeneCardsi GC12M004543.
    HGNCi HGNC:3684. FGF6.
    MIMi 134921. gene.
    neXtProti NX_P10767.
    PharmGKBi PA28123.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320285.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P10767.
    KOi K04358.
    OMAi EIAGVNW.
    PhylomeDBi P10767.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki P10767.

    Miscellaneous databases

    GeneWikii FGF6.
    GenomeRNAii 2251.
    NextBioi 9113.
    PROi P10767.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10767.
    Bgeei P10767.
    CleanExi HS_FGF6.
    Genevestigatori P10767.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028242. FGF6.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF25. PTHR11486:SF25. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Putative structure of the FGF6 gene product and role of the signal peptide."
      Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.
      Oncogene 6:1437-1444(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. NIEHS SNPs program
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
      Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.
      Oncogene 7:303-309(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
    5. "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
      Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.
      Oncogene 4:335-340(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
    6. Cited for: INTERACTION WITH FGFR1; FGFR2 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
    7. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF6_HUMAN
    AccessioniPrimary (citable) accession number: P10767
    Secondary accession number(s): Q0VAE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 140 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3