Fibroblast growth factor 6 precursor

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P10767 (FGF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 6
Short name=FGF-6

Alternative name(s):
Heparin secretory-transforming protein 2
Short name=HST-2
Short name=HSTF-2
Heparin-binding growth factor 6
Short name=HBGF-6

Gene names

Name:	FGF6
Synonyms:	HST2, HSTF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Ref.6
Subunit structure	Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.6
Subcellular location	Secreted › extracellular space.
Tissue specificity	Leukemia cell lines with platelet/ megakaryocytic differentiation potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.
Sequence caution	The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement. Source: ProtInc cell-cell signaling Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from genetic interaction Ref.6. Source: MGI insulin receptor signaling pathway Traceable author statement. Source: Reactome positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from genetic interaction Ref.6. Source: MGI
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	growth factor activity Traceable author statement. Source: ProtInc protein tyrosine kinase activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 37

Potential

Chain

38 – 208

171

Fibroblast growth factor 6

PRO_0000008961

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

90 ↔ 157

Potential

Natural variations

Natural variant

V → A. Ref.2
Corresponds to variant rs11613495 [ dbSNP | Ensembl ].

VAR_018882

Natural variant

A → V. Ref.2
Corresponds to variant rs17183529 [ dbSNP | Ensembl ].

VAR_018883

Natural variant

174

D → V. Ref.2
Corresponds to variant rs7961645 [ dbSNP | Ensembl ].

VAR_018884

Natural variant

191

R → W. Ref.2
Corresponds to variant rs17183778 [ dbSNP | Ensembl ].

VAR_018885

Experimental info

Sequence conflict

100

V → G in CAB37648. Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

P10767 [UniParc].

Last modified November 1, 1995. Version 4.
Checksum: 79EF44685B324322
Show »

FASTA

208

22,905

        10         20         30         40         50         60 
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative structure of the FGF6 gene product and role of the signal peptide." Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D. Oncogene 6:1437-1444(1991) [PubMed: 1886714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	NIEHS SNPs program Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization." Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M. Oncogene 7:303-309(1992) [PubMed: 1549352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]	"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family." Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D. Oncogene 4:335-340(1989) [PubMed: 2649847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
[6]	"Receptor specificity of the fibroblast growth factor family." Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. J. Biol. Chem. 271:15292-15297(1996) [PubMed: 8663044] [Abstract] Cited for: INTERACTION WITH FGFR1; FGFR2 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[7]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed: 20094046] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57075 Genomic DNA. Translation: CAA40358.1. X57075 Genomic DNA. Translation: CAA40359.1. Different initiation. X57075 Genomic DNA. Translation: CAA40360.1. Different initiation. AY581424 Genomic DNA. Translation: AAS79318.1. BC121097 mRNA. Translation: AAI21098.1. BC121098 mRNA. Translation: AAI21099.1. X63454 mRNA. Translation: CAA45054.1. X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
IPI	IPI00022396.
PIR	S20102.
RefSeq	NP_066276.2. NM_020996.1.
UniGene	Hs.166015.
3D structure databases
ProteinModelPortal	P10767.
SMR	P10767. Positions 81-208.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6035N.
STRING	P10767.
Polymorphism databases
DMDM	1169676.
Proteomic databases
PRIDE	P10767.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000228837; ENSP00000228837; ENSG00000111241.
GeneID	2251.
KEGG	hsa:2251.
NMPDR	fig\|9606.3.peg.6985.
UCSC	uc001qmr.1. human.
Organism-specific databases
CTD	2251.
GeneCards	GC12M004543.
H-InvDB	HIX0201928.
HGNC	HGNC:3684. FGF6.
MIM	134921. gene.
neXtProt	NX_P10767.
PharmGKB	PA28123.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11077.
GeneTree	ENSGT00590000082822.
HOGENOM	HBG715603.
HOVERGEN	HBG007580.
InParanoid	P10767.
OMA	FITMSRG.
OrthoDB	EOG4N8R5V.
PhylomeDB	P10767.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway. syndecan_4_pathway. Syndecan-4-mediated signaling events.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P10767.
Bgee	P10767.
CleanEx	HS_FGF6.
Genevestigator	P10767.
GermOnline	ENSG00000111241. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
KO	K04358.
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	9113.
SOURCE	Search...

Entry information

Entry name

FGF6_HUMAN

Accession

Primary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 115 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents