Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10767

- FGF6_HUMAN

UniProt

P10767 - FGF6_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fibroblast growth factor 6

Gene

FGF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.1 Publication

GO - Molecular functioni

  1. growth factor activity Source: ProtInc

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cartilage condensation Source: Ensembl
  3. cell-cell signaling Source: ProtInc
  4. cell proliferation Source: ProtInc
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. Fc-epsilon receptor signaling pathway Source: Reactome
  7. fibroblast growth factor receptor signaling pathway Source: MGI
  8. innate immune response Source: Reactome
  9. insulin receptor signaling pathway Source: Reactome
  10. myoblast differentiation Source: Ensembl
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. phosphatidylinositol-mediated signaling Source: Reactome
  13. positive regulation of cell division Source: UniProtKB-KW
  14. positive regulation of cell proliferation Source: MGI
  15. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP10767.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:FGF6
Synonyms:HST2, HSTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:3684. FGF6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA28123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 208171Fibroblast growth factor 6PRO_0000008961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 ↔ 157Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10767.
PRIDEiP10767.

PTM databases

PhosphoSiteiP10767.

Expressioni

Tissue specificityi

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Gene expression databases

BgeeiP10767.
CleanExiHS_FGF6.
ExpressionAtlasiP10767. baseline.
GenevestigatoriP10767.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

Protein-protein interaction databases

DIPiDIP-6035N.
STRINGi9606.ENSP00000228837.

Structurei

3D structure databases

ProteinModelPortaliP10767.
SMRiP10767. Positions 81-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320285.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP10767.
KOiK04358.
OMAiEIAGVNW.
PhylomeDBiP10767.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10767-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT
160 170 180 190 200
PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,905
Last modified:November 1, 1995 - v4
Checksum:i79EF44685B324322
GO

Sequence cautioni

The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001V → G in CAB37648. (PubMed:2649847)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → A.1 Publication
Corresponds to variant rs11613495 [ dbSNP | Ensembl ].
VAR_018882
Natural varianti63 – 631A → V.1 Publication
Corresponds to variant rs17183529 [ dbSNP | Ensembl ].
VAR_018883
Natural varianti174 – 1741D → V.1 Publication
Corresponds to variant rs7961645 [ dbSNP | Ensembl ].
VAR_018884
Natural varianti191 – 1911R → W.1 Publication
Corresponds to variant rs17183778 [ dbSNP | Ensembl ].
VAR_018885

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
CCDSiCCDS8527.1.
PIRiS20102.
RefSeqiNP_066276.2. NM_020996.1.
UniGeneiHs.166015.

Genome annotation databases

EnsembliENST00000228837; ENSP00000228837; ENSG00000111241.
GeneIDi2251.
KEGGihsa:2251.
UCSCiuc001qmr.1. human.

Polymorphism databases

DMDMi1169676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA. Translation: CAA40358.1 .
X57075 Genomic DNA. Translation: CAA40359.1 . Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1 . Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1 .
BC121097 mRNA. Translation: AAI21098.1 .
BC121098 mRNA. Translation: AAI21099.1 .
X63454 mRNA. Translation: CAA45054.1 .
X14071 , X14072 , X14073 Genomic DNA. Translation: CAB37648.2 .
CCDSi CCDS8527.1.
PIRi S20102.
RefSeqi NP_066276.2. NM_020996.1.
UniGenei Hs.166015.

3D structure databases

ProteinModelPortali P10767.
SMRi P10767. Positions 81-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6035N.
STRINGi 9606.ENSP00000228837.

PTM databases

PhosphoSitei P10767.

Polymorphism databases

DMDMi 1169676.

Proteomic databases

PaxDbi P10767.
PRIDEi P10767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228837 ; ENSP00000228837 ; ENSG00000111241 .
GeneIDi 2251.
KEGGi hsa:2251.
UCSCi uc001qmr.1. human.

Organism-specific databases

CTDi 2251.
GeneCardsi GC12M004543.
HGNCi HGNC:3684. FGF6.
MIMi 134921. gene.
neXtProti NX_P10767.
PharmGKBi PA28123.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320285.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P10767.
KOi K04358.
OMAi EIAGVNW.
PhylomeDBi P10767.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinki P10767.

Miscellaneous databases

GeneWikii FGF6.
GenomeRNAii 2251.
NextBioi 9113.
PROi P10767.
SOURCEi Search...

Gene expression databases

Bgeei P10767.
CleanExi HS_FGF6.
ExpressionAtlasi P10767. baseline.
Genevestigatori P10767.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Putative structure of the FGF6 gene product and role of the signal peptide."
    Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.
    Oncogene 6:1437-1444(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. NIEHS SNPs program
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
    Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.
    Oncogene 7:303-309(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
  5. "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
    Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.
    Oncogene 4:335-340(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
  6. Cited for: INTERACTION WITH FGFR1; FGFR2 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
  7. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF6_HUMAN
AccessioniPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3