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P10767 (FGF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 6

Short name=FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name=HST-2
Short name=HSTF-2
Heparin-binding growth factor 6
Short name=HBGF-6
Gene names
Name:FGF6
Synonyms:HST2, HSTF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Ref.6

Subunit structure

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.6

Subcellular location

Secretedextracellular space.

Tissue specificity

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence caution

The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseProto-oncogene
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

angiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

cartilage condensation

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Traceable author statement Ref.5. Source: ProtInc

cell-cell signaling

Traceable author statement Ref.5. Source: ProtInc

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction Ref.6. Source: MGI

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from genetic interaction Ref.6. Source: MGI

signal transduction

Traceable author statement Ref.5. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

sarcolemma

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiongrowth factor activity

Traceable author statement Ref.5. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 208171Fibroblast growth factor 6
PRO_0000008961

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 157 Potential

Natural variations

Natural variant361V → A. Ref.2
Corresponds to variant rs11613495 [ dbSNP | Ensembl ].
VAR_018882
Natural variant631A → V. Ref.2
Corresponds to variant rs17183529 [ dbSNP | Ensembl ].
VAR_018883
Natural variant1741D → V. Ref.2
Corresponds to variant rs7961645 [ dbSNP | Ensembl ].
VAR_018884
Natural variant1911R → W. Ref.2
Corresponds to variant rs17183778 [ dbSNP | Ensembl ].
VAR_018885

Experimental info

Sequence conflict1001V → G in CAB37648. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P10767 [UniParc].

Last modified November 1, 1995. Version 4.
Checksum: 79EF44685B324322

FASTA20822,905
        10         20         30         40         50         60 
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI 

« Hide

References

« Hide 'large scale' references
[1]"Putative structure of the FGF6 gene product and role of the signal peptide."
Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.
Oncogene 6:1437-1444(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]NIEHS SNPs program
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.
Oncogene 7:303-309(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.
Oncogene 4:335-340(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
[6]"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1; FGFR2 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[7]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
CCDSCCDS8527.1.
PIRS20102.
RefSeqNP_066276.2. NM_020996.1.
UniGeneHs.166015.

3D structure databases

ProteinModelPortalP10767.
SMRP10767. Positions 81-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6035N.
STRING9606.ENSP00000228837.

PTM databases

PhosphoSiteP10767.

Polymorphism databases

DMDM1169676.

Proteomic databases

PaxDbP10767.
PRIDEP10767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000228837; ENSP00000228837; ENSG00000111241.
GeneID2251.
KEGGhsa:2251.
UCSCuc001qmr.1. human.

Organism-specific databases

CTD2251.
GeneCardsGC12M004543.
HGNCHGNC:3684. FGF6.
MIM134921. gene.
neXtProtNX_P10767.
PharmGKBPA28123.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320285.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP10767.
KOK04358.
OMAEIAGVNW.
PhylomeDBP10767.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkP10767.

Gene expression databases

ArrayExpressP10767.
BgeeP10767.
CleanExHS_FGF6.
GenevestigatorP10767.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGF6.
GenomeRNAi2251.
NextBio9113.
PROP10767.
SOURCESearch...

Entry information

Entry nameFGF6_HUMAN
AccessionPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM