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Reviewed, UniProtKB/Swiss-Prot P10767 (FGF6_HUMAN)

Last modified July 22, 2008. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fibroblast growth factor 6
      Short name=FGF-6
Alternative name(s):
    Heparin-binding growth factor 6
      Short name=HBGF-6
    HST-2
Gene names
Name: FGF6
Synonyms: HST2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.

Subcellular location

Secretedextracellular space.

Tissue specificity

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords

   Biological processAngiogenesis
Differentiation
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseProto-oncogene
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processcell proliferation Ref.5

Traceable author statement. Source: ProtInc

cell-cell signaling Ref.5

Traceable author statement. Source: ProtInc

fibroblast growth factor receptor signaling pathway

Inferred from Experiment. Source: Reactome

   Cellular componentextracellular region Ref.5

Traceable author statement. Source: ProtInc

   Molecular functiongrowth factor activity Ref.5

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 208171Fibroblast growth factor 6

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 157 Potential

Natural variations

Natural variant361V → A: dbSNP rs11613495.
Natural variant631A → V: dbSNP rs17183529.
Natural variant1741D → V: dbSNP rs7961645.
Natural variant1911R → W: dbSNP rs17183778.

Experimental info

Sequence conflict1001V → G in CAB37648. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P10767-1 [UniParc].

Last modified November 1, 1995. Version 4.
Checksum: 79EF44685B324322

FASTA20822,905
        10         20         30         40         50         60 
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI 

« Hide

References

« Hide 'large scale' references
[1]"Putative structure of the FGF6 gene product and role of the signal peptide."
Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.
Oncogene 6:1437-1444(1991) [PubMed: 1886714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."
Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.
Oncogene 7:303-309(1992) [PubMed: 1549352] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.
Oncogene 4:335-340(1989) [PubMed: 2649847] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
PIRS20102.
RefSeqNP_066276.2.
UniGeneHs.166015

3D structure databases

HSSPHSSP built from PDB template 1IJT based on UniProtKB P08620.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6035N.

Polymorphism databases

NIEHS-SNPsSearch...

Genome annotation databases

EnsemblENSG00000111241. Homo sapiens. [Contig view]
GeneID2251.
KEGGhsa:2251.
NMPDRfig|9606.3.peg.6985.

Organism-specific databases

H-InvDBHIX0036856.
HGNCHGNC:3684. FGF6.
MIM134921. gene.
PharmGKBPA28123.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP10767.
HOVERGENP10767.

Enzyme and pathway databases

ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressP10767.
CleanExHS_FGF6.
GermOnlineENSG00000111241. Homo sapiens.

Family and domain databases

InterProIPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameFGF6_HUMAN
AccessionPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: July 22, 2008
This is version 83 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents