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Reviewed, UniProtKB/Swiss-Prot P10767 (FGF6_HUMAN)

Last modified March 2, 2010. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 6

Short name=FGF-6
Alternative name(s):
Heparin-binding growth factor 6
Short name=HBGF-6
Heparin secretory-transforming protein 2
Short name=HSTF-2
Short name=HST-2
Gene names
Name:FGF6
Synonyms:HST2, HSTF2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.

Subcellular location

Secretedextracellular space.

Tissue specificity

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 208171Fibroblast growth factor 6
PRO_0000008961

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 157 Potential

Natural variations

Natural variant361V → A: dbSNP rs11613495. Ref.2
VAR_018882
Natural variant631A → V: dbSNP rs17183529. Ref.2
VAR_018883
Natural variant1741D → V: dbSNP rs7961645. Ref.2
VAR_018884
Natural variant1911R → W: dbSNP rs17183778. Ref.2
VAR_018885

Experimental info

Sequence conflict1001V → G in CAB37648. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P10767-1 [UniParc].

Last modified November 1, 1995. Version 4.
Checksum: 79EF44685B324322

FASTA20822,905
        10         20         30         40         50         60 
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI 

« Hide

References

« Hide 'large scale' references
[1]"Putative structure of the FGF6 gene product and role of the signal peptide."
Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.
Oncogene 6:1437-1444(1991) [PubMed: 1886714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]NIEHS SNPs program
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.
Oncogene 7:303-309(1992) [PubMed: 1549352] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-208.
[5]"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.
Oncogene 4:335-340(1989) [PubMed: 2649847] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
IPIIPI00022396.
PIRS20102.
RefSeqNP_066276.2.
UniGeneHs.166015

3D structure databases

SMRP10767. Positions 81-208.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6035N.
STRINGP10767.

Proteomic databases

PRIDEP10767.

Genome annotation databases

EnsemblENST00000228837; ENSP00000228837; ENSG00000111241; Homo sapiens. [Genome view]
GeneID2251.
KEGGhsa:2251.
NMPDRfig|9606.3.peg.6985.
UCSCuc001qmr.1. human.

Organism-specific databases

CTD2251.
GeneCardsGC12M004413.
H-InvDBHIX0036856.
HGNCHGNC:3684. FGF6.
MIM134921. gene.
PharmGKBPA28123.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11077.
HOGENOMHBG715603.
HOVERGENHBG007580.
InParanoidP10767.
OMAFITMSRG.
OrthoDBEOG9PK4TV.
PhylomeDBP10767.

Enzyme and pathway databases

Pathway_Interaction_DBfgf_pathway. FGF signaling pathway.
syndecan_4_pathway. Syndecan-4-mediated signaling events.
ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressP10767.
BgeeP10767.
CleanExHS_FGF6.
GenevestigatorP10767.
GermOnlineENSG00000111241. Homo sapiens.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. Cytok_IL1_like. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio9113.
SOURCESearch...

Entry information

Entry nameFGF6_HUMAN
AccessionPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: March 2, 2010
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents