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Protein

Fibroblast growth factor 6

Gene

FGF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.1 Publication

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cartilage condensation Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • MAPK cascade Source: Reactome
  • myoblast differentiation Source: Ensembl
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111241-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1839122. Signaling by activated point mutants of FGFR1.
R-HSA-190322. FGFR4 ligand binding and activation.
R-HSA-190373. FGFR1c ligand binding and activation.
R-HSA-190375. FGFR2c ligand binding and activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5654720. PI-3K cascade:FGFR4.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5654733. Negative regulation of FGFR4 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiP10767.
SIGNORiP10767.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:FGF6
Synonyms:HST2, HSTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:3684. FGF6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2251.
OpenTargetsiENSG00000111241.
PharmGKBiPA28123.

Polymorphism and mutation databases

BioMutaiFGF6.
DMDMi1169676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000896138 – 208Fibroblast growth factor 6Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi90 ↔ 157Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10767.
PeptideAtlasiP10767.
PRIDEiP10767.

PTM databases

PhosphoSitePlusiP10767.

Expressioni

Tissue specificityi

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Gene expression databases

BgeeiENSG00000111241.
CleanExiHS_FGF6.
ExpressionAtlasiP10767. baseline and differential.
GenevisibleiP10767. HS.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

  • growth factor activity Source: ProtInc

Protein-protein interaction databases

DIPiDIP-6035N.
STRINGi9606.ENSP00000228837.

Structurei

3D structure databases

ProteinModelPortaliP10767.
SMRiP10767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP10767.
KOiK04358.
OMAiHEENPYS.
OrthoDBiEOG091G0NAY.
PhylomeDBiP10767.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT
160 170 180 190 200
PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,905
Last modified:November 1, 1995 - v4
Checksum:i79EF44685B324322
GO

Sequence cautioni

The sequence CAA40359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA40360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100V → G in CAB37648 (PubMed:2649847).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01888236V → A.1 PublicationCorresponds to variant rs11613495dbSNPEnsembl.1
Natural variantiVAR_01888363A → V.1 PublicationCorresponds to variant rs17183529dbSNPEnsembl.1
Natural variantiVAR_018884174D → V.1 PublicationCorresponds to variant rs7961645dbSNPEnsembl.1
Natural variantiVAR_018885191R → W.1 PublicationCorresponds to variant rs17183778dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
CCDSiCCDS8527.1.
PIRiS20102.
RefSeqiNP_066276.2. NM_020996.2.
UniGeneiHs.166015.

Genome annotation databases

EnsembliENST00000228837; ENSP00000228837; ENSG00000111241.
GeneIDi2251.
KEGGihsa:2251.
UCSCiuc001qmr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA. Translation: CAA40358.1.
X57075 Genomic DNA. Translation: CAA40359.1. Different initiation.
X57075 Genomic DNA. Translation: CAA40360.1. Different initiation.
AY581424 Genomic DNA. Translation: AAS79318.1.
BC121097 mRNA. Translation: AAI21098.1.
BC121098 mRNA. Translation: AAI21099.1.
X63454 mRNA. Translation: CAA45054.1.
X14071, X14072, X14073 Genomic DNA. Translation: CAB37648.2.
CCDSiCCDS8527.1.
PIRiS20102.
RefSeqiNP_066276.2. NM_020996.2.
UniGeneiHs.166015.

3D structure databases

ProteinModelPortaliP10767.
SMRiP10767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6035N.
STRINGi9606.ENSP00000228837.

PTM databases

PhosphoSitePlusiP10767.

Polymorphism and mutation databases

BioMutaiFGF6.
DMDMi1169676.

Proteomic databases

PaxDbiP10767.
PeptideAtlasiP10767.
PRIDEiP10767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228837; ENSP00000228837; ENSG00000111241.
GeneIDi2251.
KEGGihsa:2251.
UCSCiuc001qmr.2. human.

Organism-specific databases

CTDi2251.
DisGeNETi2251.
GeneCardsiFGF6.
HGNCiHGNC:3684. FGF6.
MIMi134921. gene.
neXtProtiNX_P10767.
OpenTargetsiENSG00000111241.
PharmGKBiPA28123.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP10767.
KOiK04358.
OMAiHEENPYS.
OrthoDBiEOG091G0NAY.
PhylomeDBiP10767.
TreeFamiTF317805.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111241-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1839122. Signaling by activated point mutants of FGFR1.
R-HSA-190322. FGFR4 ligand binding and activation.
R-HSA-190373. FGFR1c ligand binding and activation.
R-HSA-190375. FGFR2c ligand binding and activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5654720. PI-3K cascade:FGFR4.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5654733. Negative regulation of FGFR4 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiP10767.
SIGNORiP10767.

Miscellaneous databases

GeneWikiiFGF6.
GenomeRNAii2251.
PROiP10767.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111241.
CleanExiHS_FGF6.
ExpressionAtlasiP10767. baseline and differential.
GenevisibleiP10767. HS.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF6_HUMAN
AccessioniPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 158 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.