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P10764

- IGF2_SHEEP

UniProt

P10764 - IGF2_SHEEP

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

    GO - Molecular functioni

    1. protein serine/threonine kinase activator activity Source: Ensembl
    2. receptor activator activity Source: Ensembl

    GO - Biological processi

    1. exocrine pancreas development Source: Ensembl
    2. glucose metabolic process Source: UniProtKB-KW
    3. insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
    4. organ morphogenesis Source: Ensembl
    5. osteoblast differentiation Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of cell division Source: UniProtKB-KW
    8. positive regulation of glycogen (starch) synthase activity Source: Ensembl
    9. positive regulation of glycogen biosynthetic process Source: Ensembl
    10. positive regulation of insulin receptor signaling pathway Source: Ensembl
    11. positive regulation of MAPK cascade Source: Ensembl
    12. positive regulation of mitosis Source: Ensembl
    13. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    14. positive regulation of protein kinase B signaling Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. striated muscle cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Hormone, Mitogen

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Cleaved into the following 2 chains:
    Gene namesi
    Name:IGF2
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24242 PublicationsAdd
    BLAST
    Chaini25 – 9167Insulin-like growth factor IIPRO_0000015731Add
    BLAST
    Propeptidei92 – 17988E peptidePRO_0000015732Add
    BLAST
    Peptidei93 – 12634PreptinPRO_0000370381Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 71By similarity
    Disulfide bondi45 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP10764.

    Structurei

    3D structure databases

    ProteinModelPortaliP10764.
    SMRiP10764. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5228BAdd
    BLAST
    Regioni53 – 6412CAdd
    BLAST
    Regioni65 – 8521AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGITAGKSML ALLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF    50
    YFSRPSSRIN RRSRGIVEEC CFRSCDLALL ETYCAAPAKS ERDVSASTTV 100
    LPDDFTAYPV GKFFQSDTWK QSTQRLRRGL PAFLRARRGR TLAKELEALR 150
    EAKSHRPLIA LPTQDPATHG GASSEASSD 179
    Length:179
    Mass (Da):19,616
    Last modified:October 1, 1989 - v2
    Checksum:i7B369AE57F2E4378
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 472GD → DG AA sequence (PubMed:2537174)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00668, U00666, U00667 Genomic DNA. Translation: AAB60626.1.
    X15248 mRNA. Translation: CAA33324.1.
    X53554 mRNA. Translation: CAA37621.1.
    M89788 mRNA. Translation: AAA31548.1.
    M89789 mRNA. Translation: AAA31549.1.
    X55638 mRNA. Translation: CAA39163.1.
    PIRiS04858.
    RefSeqiNP_001009311.1. NM_001009311.1.
    UniGeneiOar.376.

    Genome annotation databases

    GeneIDi443325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00668 , U00666 , U00667 Genomic DNA. Translation: AAB60626.1 .
    X15248 mRNA. Translation: CAA33324.1 .
    X53554 mRNA. Translation: CAA37621.1 .
    M89788 mRNA. Translation: AAA31548.1 .
    M89789 mRNA. Translation: AAA31549.1 .
    X55638 mRNA. Translation: CAA39163.1 .
    PIRi S04858.
    RefSeqi NP_001009311.1. NM_001009311.1.
    UniGenei Oar.376.

    3D structure databases

    ProteinModelPortali P10764.
    SMRi P10764. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P10764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443325.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    HOVERGENi HBG006137.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of an ovine insulin-like growth factor-II cDNA."
      O'Mahoney J.V., Adams T.E.
      Nucleic Acids Res. 17:5392-5392(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The nucleotide and deduced amino acid sequences of insulin-like growth factor II cDNAs from adult bovine and fetal sheep liver."
      Brown W.M., Dziegielewska K.M., Foreman R.C., Saunders N.R.
      Nucleic Acids Res. 18:4614-4614(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Characterization of two sheep insulin-like growth factor II cDNAs with different 5'-untranslated regions."
      Demmer J., Hill D.F., Petersen G.B.
      Biochim. Biophys. Acta 1173:79-80(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Coopworth.
      Tissue: Liver.
    4. Ohlsen S.M., Wong E.A.
      Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver.
    5. "Sheep insulin-like growth factors I and II: sequences, activities and assays."
      Francis G.L., McNeil K.A., Wallace J.C., Ballard F.J., Owens P.C.
      Endocrinology 124:1173-1183(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-91.
    6. "Simultaneous isolation of insulin-like growth factors I and II from adult sheep serum."
      Hey A.W., Browne C.A., Simpson R.J., Thorburn G.D.
      Biochim. Biophys. Acta 997:27-35(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-58.

    Entry informationi

    Entry nameiIGF2_SHEEP
    AccessioniPrimary (citable) accession number: P10764
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3