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P10764

- IGF2_SHEEP

UniProt

P10764 - IGF2_SHEEP

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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 (By similarity).By similarity

GO - Molecular functioni

  1. protein serine/threonine kinase activator activity Source: Ensembl
  2. receptor activator activity Source: Ensembl

GO - Biological processi

  1. exocrine pancreas development Source: Ensembl
  2. glucose metabolic process Source: UniProtKB-KW
  3. insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
  4. organ morphogenesis Source: Ensembl
  5. osteoblast differentiation Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of cell division Source: UniProtKB-KW
  8. positive regulation of glycogen (starch) synthase activity Source: Ensembl
  9. positive regulation of glycogen biosynthetic process Source: Ensembl
  10. positive regulation of insulin receptor signaling pathway Source: Ensembl
  11. positive regulation of MAPK cascade Source: Ensembl
  12. positive regulation of mitosis Source: Ensembl
  13. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  14. positive regulation of protein kinase B signaling Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone, Mitogen

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24242 PublicationsAdd
BLAST
Chaini25 – 9167Insulin-like growth factor IIPRO_0000015731Add
BLAST
Propeptidei92 – 17988E peptidePRO_0000015732Add
BLAST
Peptidei93 – 12634PreptinPRO_0000370381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP10764.

Structurei

3D structure databases

ProteinModelPortaliP10764.
SMRiP10764. Positions 25-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 5228BAdd
BLAST
Regioni53 – 6412CAdd
BLAST
Regioni65 – 8521AAdd
BLAST
Regioni86 – 916D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10764-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGITAGKSML ALLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPSSRIN RRSRGIVEEC CFRSCDLALL ETYCAAPAKS ERDVSASTTV
110 120 130 140 150
LPDDFTAYPV GKFFQSDTWK QSTQRLRRGL PAFLRARRGR TLAKELEALR
160 170
EAKSHRPLIA LPTQDPATHG GASSEASSD
Length:179
Mass (Da):19,616
Last modified:October 1, 1989 - v2
Checksum:i7B369AE57F2E4378
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 472GD → DG AA sequence (PubMed:2537174)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00668, U00666, U00667 Genomic DNA. Translation: AAB60626.1.
X15248 mRNA. Translation: CAA33324.1.
X53554 mRNA. Translation: CAA37621.1.
M89788 mRNA. Translation: AAA31548.1.
M89789 mRNA. Translation: AAA31549.1.
X55638 mRNA. Translation: CAA39163.1.
PIRiS04858.
RefSeqiNP_001009311.1. NM_001009311.1.
UniGeneiOar.376.

Genome annotation databases

GeneIDi443325.
KEGGioas:443325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00668 , U00666 , U00667 Genomic DNA. Translation: AAB60626.1 .
X15248 mRNA. Translation: CAA33324.1 .
X53554 mRNA. Translation: CAA37621.1 .
M89788 mRNA. Translation: AAA31548.1 .
M89789 mRNA. Translation: AAA31549.1 .
X55638 mRNA. Translation: CAA39163.1 .
PIRi S04858.
RefSeqi NP_001009311.1. NM_001009311.1.
UniGenei Oar.376.

3D structure databases

ProteinModelPortali P10764.
SMRi P10764. Positions 25-91.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P10764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443325.
KEGGi oas:443325.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of an ovine insulin-like growth factor-II cDNA."
    O'Mahoney J.V., Adams T.E.
    Nucleic Acids Res. 17:5392-5392(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The nucleotide and deduced amino acid sequences of insulin-like growth factor II cDNAs from adult bovine and fetal sheep liver."
    Brown W.M., Dziegielewska K.M., Foreman R.C., Saunders N.R.
    Nucleic Acids Res. 18:4614-4614(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Characterization of two sheep insulin-like growth factor II cDNAs with different 5'-untranslated regions."
    Demmer J., Hill D.F., Petersen G.B.
    Biochim. Biophys. Acta 1173:79-80(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Coopworth.
    Tissue: Liver.
  4. Ohlsen S.M., Wong E.A.
    Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  5. "Sheep insulin-like growth factors I and II: sequences, activities and assays."
    Francis G.L., McNeil K.A., Wallace J.C., Ballard F.J., Owens P.C.
    Endocrinology 124:1173-1183(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-91.
  6. "Simultaneous isolation of insulin-like growth factors I and II from adult sheep serum."
    Hey A.W., Browne C.A., Simpson R.J., Thorburn G.D.
    Biochim. Biophys. Acta 997:27-35(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-58.

Entry informationi

Entry nameiIGF2_SHEEP
AccessioniPrimary (citable) accession number: P10764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3