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Protein

Lithostathine

Gene

Reg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • growth factor activity Source: MGI
  • identical protein binding Source: RGD
  • phosphatase binding Source: RGD
  • protein homodimerization activity Source: RGD
  • protein phosphatase binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • calcium ion homeostasis Source: RGD
  • cellular response to chemokine Source: RGD
  • cellular response to gastrin Source: RGD
  • liver regeneration Source: RGD
  • midgut development Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • pancreas regeneration Source: RGD
  • positive regulation of acinar cell proliferation Source: RGD
  • positive regulation of dendrite extension Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of type B pancreatic cell proliferation Source: RGD
  • protein homooligomerization Source: RGD
  • protein homotetramerization Source: RGD
  • response to acetylsalicylate Source: RGD
  • response to gastrin Source: RGD
  • response to growth hormone-releasing hormone Source: RGD
  • response to hypoxia Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to water-immersion restraint stress Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine
Alternative name(s):
Islet cells regeneration factor
Short name:
ICRF
Islet of Langerhans regenerating protein
Short name:
REG
Pancreatic stone protein
Short name:
PSP
Pancreatic thread protein
Short name:
PTP
Gene namesi
Name:Reg1
Synonyms:Reg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3552. Reg1.

Subcellular locationi

GO - Cellular componenti

  • basal part of cell Source: RGD
  • cytosol Source: RGD
  • dendrite membrane Source: RGD
  • extracellular space Source: RGD
  • growth cone Source: RGD
  • neuronal cell body membrane Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • protein complex Source: RGD
  • zymogen granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 165144LithostathinePRO_0000017428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acidBy similarity
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Disulfide bondi63 ↔ 161PROSITE-ProRule annotation
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi136 ↔ 153PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP10758.

Expressioni

Tissue specificityi

Expressed only in regenerating islets, but not in normal pancreatic islets, insulinomas or regenerating liver.

Gene expression databases

GenevisibleiP10758. RN.

Interactioni

GO - Molecular functioni

  • growth factor activity Source: MGI
  • identical protein binding Source: RGD
  • phosphatase binding Source: RGD
  • protein homodimerization activity Source: RGD
  • protein phosphatase binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054678.

Structurei

3D structure databases

ProteinModelPortaliP10758.
SMRiP10758. Positions 22-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 163131C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KDDW. Eukaryota.
ENOG410ZSJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP10758.
OMAiKSWGIGA.
OrthoDBiEOG79KPH7.
PhylomeDBiP10758.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRNKYFILL SCLMVLSPSQ GQEAEEDLPS ARITCPEGSN AYSSYCYYFM
60 70 80 90 100
EDHLSWAEAD LFCQNMNSGY LVSVLSQAEG NFLASLIKES GTTAANVWIG
110 120 130 140 150
LHDPKNNRRW HWSSGSLFLY KSWDTGYPNN SNRGYCVSVT SNSGYKKWRD
160
NSCDAQLSFV CKFKA
Length:165
Mass (Da):18,672
Last modified:July 1, 1989 - v1
Checksum:i9B61EB236B82CF8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07512 Genomic DNA. Translation: AAA41533.1.
M62930 mRNA. Translation: AAA41974.1.
M18962 mRNA. Translation: AAA42028.1.
D26164 Genomic DNA. Translation: BAA05149.1.
PIRiA28351.
RefSeqiNP_036773.1. NM_012641.1.
UniGeneiRn.11332.

Genome annotation databases

EnsembliENSRNOT00000057869; ENSRNOP00000054678; ENSRNOG00000006486.
GeneIDi24714.
KEGGirno:24714.
UCSCiRGD:3552. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07512 Genomic DNA. Translation: AAA41533.1.
M62930 mRNA. Translation: AAA41974.1.
M18962 mRNA. Translation: AAA42028.1.
D26164 Genomic DNA. Translation: BAA05149.1.
PIRiA28351.
RefSeqiNP_036773.1. NM_012641.1.
UniGeneiRn.11332.

3D structure databases

ProteinModelPortaliP10758.
SMRiP10758. Positions 22-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054678.

Protein family/group databases

MEROPSiI63.002.

Proteomic databases

PaxDbiP10758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057869; ENSRNOP00000054678; ENSRNOG00000006486.
GeneIDi24714.
KEGGirno:24714.
UCSCiRGD:3552. rat.

Organism-specific databases

CTDi5967.
RGDi3552. Reg1.

Phylogenomic databases

eggNOGiENOG410KDDW. Eukaryota.
ENOG410ZSJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP10758.
OMAiKSWGIGA.
OrthoDBiEOG79KPH7.
PhylomeDBiP10758.

Miscellaneous databases

PROiP10758.

Gene expression databases

GenevisibleiP10758. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat pancreatic stone protein messenger RNA. Abundant expression in mature exocrine cells, regulation by food content, and sequence identity with the endocrine reg transcript."
    Rouquier S., Verdier J.-M., Iovanna J., Dagorn J.-C., Giorgi D.
    J. Biol. Chem. 266:786-791(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene activated in regenerating islets."
    Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., Okamoto H.
    J. Biol. Chem. 263:2111-2114(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Rapid PCR cloning and sequence determination of the rat lithostathine gene."
    Dusetti N.J., Frigerio J.-M., Dagorn J.-C., Iovanna J.L.
    Biochim. Biophys. Acta 1174:99-102(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Structure and characterization of rat Reg I gene."
    Miyashita H., Suzuki Y., Watanabe T., Unno M., Moriizumi S., Yonekura H., Okamoto H.
    Seikagaku 65:1082-1082(1993)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wistar.
  5. "Characterization in rat pancreatic juice of a protein homologous to the human pancreatic stone protein."
    Adrich Z., de Caro A.M., Guidoni A.A., Woudstra M.E., Rovery M.
    Comp. Biochem. Physiol. 93B:793-797(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-69.
    Tissue: Pancreas.

Entry informationi

Entry nameiLITH_RAT
AccessioniPrimary (citable) accession number: P10758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.