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P10749 (IL1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-1 beta

Short name=IL-1 beta
Gene names
Name:Il1b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit structure

Monomer. Interacts with MEFV By similarity.

Subcellular location

Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Domain

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentSecreted
   Molecular functionCytokine
Mitogen
Pyrogen
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

activation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from sequence orthology PubMed 19158679. Source: MGI

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to organic substance

Inferred from sequence orthology PubMed 19158679. Source: MGI

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

ectopic germ cell programmed cell death

Inferred from genetic interaction PubMed 11536012. Source: MGI

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 11536012. Source: MGI

fever generation

Inferred from electronic annotation. Source: UniProtKB-KW

hyaluronan biosynthetic process

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

interleukin-1 beta production

Inferred from genetic interaction PubMed 19158679. Source: MGI

leukocyte migration

Inferred from direct assay PubMed 15034066. Source: MGI

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

monocyte aggregation

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAP kinase activity

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

negative regulation of adiponectin secretion

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of glucose transport

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

negative regulation of insulin receptor signaling pathway

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

negative regulation of lipid catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipid metabolic process

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

neutrophil chemotaxis

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay PubMed 16260493. Source: MGI

positive regulation of JNK cascade

Inferred from direct assay PubMed 16260493. Source: MGI

positive regulation of NF-kappaB import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of chemokine biosynthetic process

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of fever generation

Inferred from direct assay PubMed 19940926. Source: BHF-UCL

positive regulation of gene expression

Inferred from direct assay PubMed 19666510. Source: MGI

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-2 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of interleukin-6 production

Inferred from direct assay PubMed 15292196PubMed 19734906. Source: MGI

positive regulation of interleukin-8 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of lipid catabolic process

Inferred from direct assay PubMed 16865359. Source: BHF-UCL

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of monocyte chemotactic protein-1 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of myosin light chain kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin secretion

Inferred from direct assay PubMed 19940926. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19734906. Source: MGI

positive regulation vascular endothelial growth factor production

Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

response to ATP

Inferred from direct assay PubMed 15905573PubMed 16301672PubMed 18490713. Source: MGI

response to carbohydrate

Inferred from direct assay PubMed 16301672. Source: MGI

response to lipopolysaccharide

Inferred from direct assay PubMed 16423834PubMed 18490713. Source: MGI

sequestering of triglyceride

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from direct assay PubMed 11016935PubMed 11168643PubMed 15905573PubMed 16423834PubMed 23892723. Source: MGI

secretory granule

Inferred from direct assay PubMed 16423834. Source: MGI

vesicle

Inferred from direct assay PubMed 15905573. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 12925700PubMed 15292196. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 117117
PRO_0000015311
Chain118 – 269152Interleukin-1 beta
PRO_0000015312

Secondary structure

.................................. 269
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P10749 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 734FA17B02ED87EE

FASTA26930,931
        10         20         30         40         50         60 
MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF 

        70         80         90        100        110        120 
RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI 

       130        140        150        160        170        180 
RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK 

       190        200        210        220        230        240 
GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS 

       250        260 
TSQAEHKPVF LGNNSGQDII DFTMESVSS 

« Hide

References

« Hide 'large scale' references
[1]"Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta."
Gray P.W., Glaister D., Chen E., Goeddel D.V., Pennica D.
J. Immunol. 137:3644-3648(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The murine interleukin 1 beta gene: structure and evolution."
Telford J.L., Macchia G., Massone A., Carinci V., Palla E., Melli M.
Nucleic Acids Res. 14:9955-9963(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
Farber C.R., Corva P.M., Medrano J.F.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CAST/EiJ.
Tissue: Spleen.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[6]"Characterization of murine IL-1 beta. Isolation, expression, and purification."
Huang J.J., Newton R.C., Rutledge S.J., Horuk R., Matthew J.B., Covington M., Lin Y.
J. Immunol. 140:3838-3843(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 118-139.
[7]"The structure of murine interleukin-1 beta at 2.8-A resolution."
van Oostrum J., Priestle J.P., Gruetter M.G., Schmitz A.
J. Struct. Biol. 107:189-195(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15131 mRNA. Translation: AAA39276.1.
X04964 Genomic DNA. Translation: CAA28637.1.
AY902319 Genomic DNA. Translation: AAX90604.1.
CH466519 Genomic DNA. Translation: EDL28238.1.
BC011437 mRNA. Translation: AAH11437.1.
CCDSCCDS16726.1.
PIRI55969.
RefSeqNP_032387.1. NM_008361.3.
UniGeneMm.222830.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIBX-ray2.84A118-269[»]
8I1BX-ray2.40A118-269[»]
ProteinModelPortalP10749.
SMRP10749. Positions 122-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200624. 1 interaction.
IntActP10749. 1 interaction.
STRING10090.ENSMUSP00000028881.

Proteomic databases

PRIDEP10749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
GeneID16176.
KEGGmmu:16176.
UCSCuc008mht.1. mouse.

Organism-specific databases

CTD3553.
MGIMGI:96543. Il1b.

Phylogenomic databases

eggNOGNOG40099.
GeneTreeENSGT00510000048687.
HOGENOMHOG000246399.
HOVERGENHBG007328.
InParanoidP10749.
KOK04519.
OMASNDKIPV.
OrthoDBEOG71P2BQ.
PhylomeDBP10749.
TreeFamTF300203.

Gene expression databases

BgeeP10749.
CleanExMM_IL1B.
GenevestigatorP10749.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP10749.
NextBio289037.
PMAP-CutDBP10749.
PROP10749.
SOURCESearch...

Entry information

Entry nameIL1B_MOUSE
AccessionPrimary (citable) accession number: P10749
Secondary accession number(s): Q2M4J6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot