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P10749

- IL1B_MOUSE

UniProt

P10749 - IL1B_MOUSE

Protein

Interleukin-1 beta

Gene

Il1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. cellular response to drug Source: MGI
    3. cellular response to mechanical stimulus Source: Ensembl
    4. cellular response to organic cyclic compound Source: Ensembl
    5. cellular response to organic substance Source: MGI
    6. cytokine-mediated signaling pathway Source: Ensembl
    7. ectopic germ cell programmed cell death Source: MGI
    8. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    9. fever generation Source: UniProtKB-KW
    10. hyaluronan biosynthetic process Source: Ensembl
    11. immune response Source: InterPro
    12. interleukin-1 beta production Source: MGI
    13. leukocyte migration Source: MGI
    14. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    15. MAPK cascade Source: Ensembl
    16. monocyte aggregation Source: Ensembl
    17. negative regulation of adiponectin secretion Source: BHF-UCL
    18. negative regulation of cell proliferation Source: Ensembl
    19. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    20. negative regulation of glucose transport Source: BHF-UCL
    21. negative regulation of insulin receptor signaling pathway Source: BHF-UCL
    22. negative regulation of lipid catabolic process Source: Ensembl
    23. negative regulation of lipid metabolic process Source: BHF-UCL
    24. negative regulation of MAP kinase activity Source: BHF-UCL
    25. neutrophil chemotaxis Source: MGI
    26. positive regulation of angiogenesis Source: BHF-UCL
    27. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    28. positive regulation of cell division Source: UniProtKB-KW
    29. positive regulation of chemokine biosynthetic process Source: MGI
    30. positive regulation of fever generation Source: BHF-UCL
    31. positive regulation of gene expression Source: MGI
    32. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
    33. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
    34. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    35. positive regulation of interferon-gamma production Source: Ensembl
    36. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
    37. positive regulation of interleukin-6 biosynthetic process Source: MGI
    38. positive regulation of interleukin-6 production Source: MGI
    39. positive regulation of interleukin-8 production Source: Ensembl
    40. positive regulation of JNK cascade Source: MGI
    41. positive regulation of lipid catabolic process Source: BHF-UCL
    42. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    43. positive regulation of mitosis Source: Ensembl
    44. positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
    45. positive regulation of myosin light chain kinase activity Source: Ensembl
    46. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    47. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    48. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    49. positive regulation of prostaglandin secretion Source: BHF-UCL
    50. positive regulation of T cell proliferation Source: Ensembl
    51. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    52. positive regulation vascular endothelial growth factor production Source: BHF-UCL
    53. protein kinase B signaling Source: Ensembl
    54. regulation of insulin secretion Source: Ensembl
    55. response to ATP Source: MGI
    56. response to carbohydrate Source: MGI
    57. response to lipopolysaccharide Source: MGI
    58. sequestering of triglyceride Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Mitogen, Pyrogen

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_198700. Interleukin-1 processing.
    REACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 beta
    Short name:
    IL-1 beta
    Gene namesi
    Name:Il1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96543. Il1b.

    Subcellular locationi

    Secreted
    Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. secretory granule Source: MGI
    3. vesicle Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1171171 PublicationPRO_0000015311Add
    BLAST
    Chaini118 – 269152Interleukin-1 betaPRO_0000015312Add
    BLAST

    Proteomic databases

    PRIDEiP10749.

    Miscellaneous databases

    PMAP-CutDBP10749.

    Expressioni

    Gene expression databases

    BgeeiP10749.
    CleanExiMM_IL1B.
    GenevestigatoriP10749.

    Interactioni

    Subunit structurei

    Monomer. Interacts with MEFV By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200624. 1 interaction.
    IntActiP10749. 1 interaction.
    STRINGi10090.ENSMUSP00000028881.

    Structurei

    Secondary structure

    1
    269
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi123 – 1297
    Beta strandi134 – 1385
    Turni139 – 1413
    Beta strandi142 – 1465
    Helixi150 – 1534
    Beta strandi159 – 1635
    Beta strandi170 – 17910
    Beta strandi182 – 19110
    Beta strandi194 – 2018
    Turni204 – 2063
    Helixi214 – 2163
    Beta strandi217 – 2237
    Beta strandi226 – 2349
    Beta strandi238 – 2414
    Beta strandi243 – 2486
    Beta strandi250 – 2523
    Beta strandi256 – 2594
    Beta strandi262 – 2665

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MIBX-ray2.84A118-269[»]
    8I1BX-ray2.40A118-269[»]
    ProteinModelPortaliP10749.
    SMRiP10749. Positions 122-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10749.

    Family & Domainsi

    Domaini

    The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG40099.
    GeneTreeiENSGT00510000048687.
    HOGENOMiHOG000246399.
    HOVERGENiHBG007328.
    InParanoidiP10749.
    KOiK04519.
    OMAiSNDKIPV.
    OrthoDBiEOG71P2BQ.
    PhylomeDBiP10749.
    TreeFamiTF300203.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR003294. IL-1_alpha/beta.
    IPR003296. IL-1_beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR028142. IL-1_fam/FGF_fam.
    IPR003502. IL-1_propep.
    [Graphical view]
    PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view]
    PRINTSiPR00262. IL1HBGF.
    PR00264. INTERLEUKIN1.
    PR01357. INTRLEUKN1AB.
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ    50
    ISQQHINKSF RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE 100
    PILCDSWDDD DNLLVCDVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG 150
    QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE 200
    SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF 250
    LGNNSGQDII DFTMESVSS 269
    Length:269
    Mass (Da):30,931
    Last modified:July 1, 1989 - v1
    Checksum:i734FA17B02ED87EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15131 mRNA. Translation: AAA39276.1.
    X04964 Genomic DNA. Translation: CAA28637.1.
    AY902319 Genomic DNA. Translation: AAX90604.1.
    CH466519 Genomic DNA. Translation: EDL28238.1.
    BC011437 mRNA. Translation: AAH11437.1.
    CCDSiCCDS16726.1.
    PIRiI55969.
    RefSeqiNP_032387.1. NM_008361.3.
    UniGeneiMm.222830.

    Genome annotation databases

    EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
    GeneIDi16176.
    KEGGimmu:16176.
    UCSCiuc008mht.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15131 mRNA. Translation: AAA39276.1 .
    X04964 Genomic DNA. Translation: CAA28637.1 .
    AY902319 Genomic DNA. Translation: AAX90604.1 .
    CH466519 Genomic DNA. Translation: EDL28238.1 .
    BC011437 mRNA. Translation: AAH11437.1 .
    CCDSi CCDS16726.1.
    PIRi I55969.
    RefSeqi NP_032387.1. NM_008361.3.
    UniGenei Mm.222830.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MIB X-ray 2.84 A 118-269 [» ]
    8I1B X-ray 2.40 A 118-269 [» ]
    ProteinModelPortali P10749.
    SMRi P10749. Positions 122-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200624. 1 interaction.
    IntActi P10749. 1 interaction.
    STRINGi 10090.ENSMUSP00000028881.

    Proteomic databases

    PRIDEi P10749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028881 ; ENSMUSP00000028881 ; ENSMUSG00000027398 .
    GeneIDi 16176.
    KEGGi mmu:16176.
    UCSCi uc008mht.1. mouse.

    Organism-specific databases

    CTDi 3553.
    MGIi MGI:96543. Il1b.

    Phylogenomic databases

    eggNOGi NOG40099.
    GeneTreei ENSGT00510000048687.
    HOGENOMi HOG000246399.
    HOVERGENi HBG007328.
    InParanoidi P10749.
    KOi K04519.
    OMAi SNDKIPV.
    OrthoDBi EOG71P2BQ.
    PhylomeDBi P10749.
    TreeFami TF300203.

    Enzyme and pathway databases

    Reactomei REACT_198700. Interleukin-1 processing.
    REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    EvolutionaryTracei P10749.
    NextBioi 289037.
    PMAP-CutDB P10749.
    PROi P10749.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10749.
    CleanExi MM_IL1B.
    Genevestigatori P10749.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR003294. IL-1_alpha/beta.
    IPR003296. IL-1_beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR028142. IL-1_fam/FGF_fam.
    IPR003502. IL-1_propep.
    [Graphical view ]
    PANTHERi PTHR10078:SF20. PTHR10078:SF20. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view ]
    PRINTSi PR00262. IL1HBGF.
    PR00264. INTERLEUKIN1.
    PR01357. INTRLEUKN1AB.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta."
      Gray P.W., Glaister D., Chen E., Goeddel D.V., Pennica D.
      J. Immunol. 137:3644-3648(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The murine interleukin 1 beta gene: structure and evolution."
      Telford J.L., Macchia G., Massone A., Carinci V., Palla E., Melli M.
      Nucleic Acids Res. 14:9955-9963(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
      Farber C.R., Corva P.M., Medrano J.F.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CAST/EiJ.
      Tissue: Spleen.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    6. "Characterization of murine IL-1 beta. Isolation, expression, and purification."
      Huang J.J., Newton R.C., Rutledge S.J., Horuk R., Matthew J.B., Covington M., Lin Y.
      J. Immunol. 140:3838-3843(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 118-139.
    7. "The structure of murine interleukin-1 beta at 2.8-A resolution."
      van Oostrum J., Priestle J.P., Gruetter M.G., Schmitz A.
      J. Struct. Biol. 107:189-195(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiIL1B_MOUSE
    AccessioniPrimary (citable) accession number: P10749
    Secondary accession number(s): Q2M4J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3