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P10749

- IL1B_MOUSE

UniProt

P10749 - IL1B_MOUSE

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Protein

Interleukin-1 beta

Gene

Il1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. cellular response to drug Source: MGI
  3. cellular response to mechanical stimulus Source: Ensembl
  4. cellular response to organic cyclic compound Source: Ensembl
  5. cellular response to organic substance Source: MGI
  6. cytokine-mediated signaling pathway Source: Ensembl
  7. ectopic germ cell programmed cell death Source: MGI
  8. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  9. fever generation Source: UniProtKB-KW
  10. hyaluronan biosynthetic process Source: Ensembl
  11. immune response Source: InterPro
  12. interleukin-1 beta production Source: MGI
  13. leukocyte migration Source: MGI
  14. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  15. MAPK cascade Source: Ensembl
  16. monocyte aggregation Source: Ensembl
  17. negative regulation of adiponectin secretion Source: BHF-UCL
  18. negative regulation of cell proliferation Source: Ensembl
  19. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  20. negative regulation of glucose transport Source: BHF-UCL
  21. negative regulation of insulin receptor signaling pathway Source: BHF-UCL
  22. negative regulation of lipid catabolic process Source: Ensembl
  23. negative regulation of lipid metabolic process Source: BHF-UCL
  24. negative regulation of MAP kinase activity Source: BHF-UCL
  25. neutrophil chemotaxis Source: MGI
  26. positive regulation of angiogenesis Source: BHF-UCL
  27. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  28. positive regulation of cell division Source: UniProtKB-KW
  29. positive regulation of chemokine biosynthetic process Source: MGI
  30. positive regulation of fever generation Source: BHF-UCL
  31. positive regulation of gene expression Source: MGI
  32. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
  33. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
  34. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  35. positive regulation of interferon-gamma production Source: Ensembl
  36. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
  37. positive regulation of interleukin-6 biosynthetic process Source: MGI
  38. positive regulation of interleukin-6 production Source: MGI
  39. positive regulation of interleukin-8 production Source: Ensembl
  40. positive regulation of JNK cascade Source: MGI
  41. positive regulation of lipid catabolic process Source: BHF-UCL
  42. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  43. positive regulation of mitosis Source: Ensembl
  44. positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
  45. positive regulation of myosin light chain kinase activity Source: Ensembl
  46. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  47. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  48. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  49. positive regulation of prostaglandin secretion Source: BHF-UCL
  50. positive regulation of T cell proliferation Source: Ensembl
  51. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  52. positive regulation vascular endothelial growth factor production Source: BHF-UCL
  53. protein kinase B signaling Source: Ensembl
  54. regulation of insulin secretion Source: Ensembl
  55. response to ATP Source: MGI
  56. response to carbohydrate Source: MGI
  57. response to lipopolysaccharide Source: MGI
  58. sequestering of triglyceride Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_198700. Interleukin-1 processing.
REACT_224208. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:Il1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96543. Il1b.

Subcellular locationi

Secreted
Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. secretory granule Source: MGI
  3. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1171171 PublicationPRO_0000015311Add
BLAST
Chaini118 – 269152Interleukin-1 betaPRO_0000015312Add
BLAST

Proteomic databases

PRIDEiP10749.

Miscellaneous databases

PMAP-CutDBP10749.

Expressioni

Gene expression databases

BgeeiP10749.
CleanExiMM_IL1B.
ExpressionAtlasiP10749. baseline and differential.
GenevestigatoriP10749.

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

Protein-protein interaction databases

BioGridi200624. 1 interaction.
IntActiP10749. 1 interaction.
STRINGi10090.ENSMUSP00000028881.

Structurei

Secondary structure

1
269
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi123 – 1297Combined sources
Beta strandi134 – 1385Combined sources
Turni139 – 1413Combined sources
Beta strandi142 – 1465Combined sources
Helixi150 – 1534Combined sources
Beta strandi159 – 1635Combined sources
Beta strandi170 – 17910Combined sources
Beta strandi182 – 19110Combined sources
Beta strandi194 – 2018Combined sources
Turni204 – 2063Combined sources
Helixi214 – 2163Combined sources
Beta strandi217 – 2237Combined sources
Beta strandi226 – 2349Combined sources
Beta strandi238 – 2414Combined sources
Beta strandi243 – 2486Combined sources
Beta strandi250 – 2523Combined sources
Beta strandi256 – 2594Combined sources
Beta strandi262 – 2665Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIBX-ray2.84A118-269[»]
8I1BX-ray2.40A118-269[»]
ProteinModelPortaliP10749.
SMRiP10749. Positions 122-267.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10749.

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiNOG40099.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiP10749.
KOiK04519.
OMAiSNDKIPV.
OrthoDBiEOG71P2BQ.
PhylomeDBiP10749.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ
60 70 80 90 100
ISQQHINKSF RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE
110 120 130 140 150
PILCDSWDDD DNLLVCDVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG
160 170 180 190 200
QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE
210 220 230 240 250
SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF
260
LGNNSGQDII DFTMESVSS
Length:269
Mass (Da):30,931
Last modified:July 1, 1989 - v1
Checksum:i734FA17B02ED87EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA. Translation: AAA39276.1.
X04964 Genomic DNA. Translation: CAA28637.1.
AY902319 Genomic DNA. Translation: AAX90604.1.
CH466519 Genomic DNA. Translation: EDL28238.1.
BC011437 mRNA. Translation: AAH11437.1.
CCDSiCCDS16726.1.
PIRiI55969.
RefSeqiNP_032387.1. NM_008361.3.
UniGeneiMm.222830.

Genome annotation databases

EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
GeneIDi16176.
KEGGimmu:16176.
UCSCiuc008mht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA. Translation: AAA39276.1 .
X04964 Genomic DNA. Translation: CAA28637.1 .
AY902319 Genomic DNA. Translation: AAX90604.1 .
CH466519 Genomic DNA. Translation: EDL28238.1 .
BC011437 mRNA. Translation: AAH11437.1 .
CCDSi CCDS16726.1.
PIRi I55969.
RefSeqi NP_032387.1. NM_008361.3.
UniGenei Mm.222830.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MIB X-ray 2.84 A 118-269 [» ]
8I1B X-ray 2.40 A 118-269 [» ]
ProteinModelPortali P10749.
SMRi P10749. Positions 122-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200624. 1 interaction.
IntActi P10749. 1 interaction.
STRINGi 10090.ENSMUSP00000028881.

Proteomic databases

PRIDEi P10749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028881 ; ENSMUSP00000028881 ; ENSMUSG00000027398 .
GeneIDi 16176.
KEGGi mmu:16176.
UCSCi uc008mht.1. mouse.

Organism-specific databases

CTDi 3553.
MGIi MGI:96543. Il1b.

Phylogenomic databases

eggNOGi NOG40099.
GeneTreei ENSGT00510000048687.
HOGENOMi HOG000246399.
HOVERGENi HBG007328.
InParanoidi P10749.
KOi K04519.
OMAi SNDKIPV.
OrthoDBi EOG71P2BQ.
PhylomeDBi P10749.
TreeFami TF300203.

Enzyme and pathway databases

Reactomei REACT_198700. Interleukin-1 processing.
REACT_224208. Interleukin-1 signaling.

Miscellaneous databases

EvolutionaryTracei P10749.
NextBioi 289037.
PMAP-CutDB P10749.
PROi P10749.
SOURCEi Search...

Gene expression databases

Bgeei P10749.
CleanExi MM_IL1B.
ExpressionAtlasi P10749. baseline and differential.
Genevestigatori P10749.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view ]
PANTHERi PTHR10078:SF20. PTHR10078:SF20. 1 hit.
Pfami PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view ]
PRINTSi PR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta."
    Gray P.W., Glaister D., Chen E., Goeddel D.V., Pennica D.
    J. Immunol. 137:3644-3648(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine interleukin 1 beta gene: structure and evolution."
    Telford J.L., Macchia G., Massone A., Carinci V., Palla E., Melli M.
    Nucleic Acids Res. 14:9955-9963(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
    Farber C.R., Corva P.M., Medrano J.F.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CAST/EiJ.
    Tissue: Spleen.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  6. "Characterization of murine IL-1 beta. Isolation, expression, and purification."
    Huang J.J., Newton R.C., Rutledge S.J., Horuk R., Matthew J.B., Covington M., Lin Y.
    J. Immunol. 140:3838-3843(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 118-139.
  7. "The structure of murine interleukin-1 beta at 2.8-A resolution."
    van Oostrum J., Priestle J.P., Gruetter M.G., Schmitz A.
    J. Struct. Biol. 107:189-195(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiIL1B_MOUSE
AccessioniPrimary (citable) accession number: P10749
Secondary accession number(s): Q2M4J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3