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Protein

Interleukin-1 beta

Gene

Il1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_319181. Interleukin-1 processing.
REACT_337033. Interleukin-1 signaling.
REACT_358772. CLEC7A/inflammasome pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:Il1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96543. Il1b.

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • secretory granule Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1171171 PublicationPRO_0000015311Add
BLAST
Chaini118 – 269152Interleukin-1 betaPRO_0000015312Add
BLAST

Proteomic databases

PRIDEiP10749.

Miscellaneous databases

PMAP-CutDBP10749.

Expressioni

Gene expression databases

BgeeiP10749.
CleanExiMM_IL1B.
ExpressionAtlasiP10749. baseline and differential.
GenevisibleiP10749. MM.

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

Protein-protein interaction databases

BioGridi200624. 1 interaction.
IntActiP10749. 1 interaction.
STRINGi10090.ENSMUSP00000028881.

Structurei

Secondary structure

1
269
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi123 – 1297Combined sources
Beta strandi134 – 1385Combined sources
Turni139 – 1413Combined sources
Beta strandi142 – 1465Combined sources
Helixi150 – 1534Combined sources
Beta strandi159 – 1635Combined sources
Beta strandi170 – 17910Combined sources
Beta strandi182 – 19110Combined sources
Beta strandi194 – 2018Combined sources
Turni204 – 2063Combined sources
Helixi214 – 2163Combined sources
Beta strandi217 – 2237Combined sources
Beta strandi226 – 2349Combined sources
Beta strandi238 – 2414Combined sources
Beta strandi243 – 2486Combined sources
Beta strandi250 – 2523Combined sources
Beta strandi256 – 2594Combined sources
Beta strandi262 – 2665Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIBX-ray2.84A118-269[»]
8I1BX-ray2.40A118-269[»]
ProteinModelPortaliP10749.
SMRiP10749. Positions 122-267.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10749.

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiNOG40099.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiP10749.
KOiK04519.
OMAiSNDKIPV.
OrthoDBiEOG71P2BQ.
PhylomeDBiP10749.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ
60 70 80 90 100
ISQQHINKSF RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE
110 120 130 140 150
PILCDSWDDD DNLLVCDVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG
160 170 180 190 200
QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE
210 220 230 240 250
SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF
260
LGNNSGQDII DFTMESVSS
Length:269
Mass (Da):30,931
Last modified:July 1, 1989 - v1
Checksum:i734FA17B02ED87EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA. Translation: AAA39276.1.
X04964 Genomic DNA. Translation: CAA28637.1.
AY902319 Genomic DNA. Translation: AAX90604.1.
CH466519 Genomic DNA. Translation: EDL28238.1.
BC011437 mRNA. Translation: AAH11437.1.
CCDSiCCDS16726.1.
PIRiI55969.
RefSeqiNP_032387.1. NM_008361.3.
UniGeneiMm.222830.

Genome annotation databases

EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
GeneIDi16176.
KEGGimmu:16176.
UCSCiuc008mht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA. Translation: AAA39276.1.
X04964 Genomic DNA. Translation: CAA28637.1.
AY902319 Genomic DNA. Translation: AAX90604.1.
CH466519 Genomic DNA. Translation: EDL28238.1.
BC011437 mRNA. Translation: AAH11437.1.
CCDSiCCDS16726.1.
PIRiI55969.
RefSeqiNP_032387.1. NM_008361.3.
UniGeneiMm.222830.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIBX-ray2.84A118-269[»]
8I1BX-ray2.40A118-269[»]
ProteinModelPortaliP10749.
SMRiP10749. Positions 122-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200624. 1 interaction.
IntActiP10749. 1 interaction.
STRINGi10090.ENSMUSP00000028881.

Proteomic databases

PRIDEiP10749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
GeneIDi16176.
KEGGimmu:16176.
UCSCiuc008mht.1. mouse.

Organism-specific databases

CTDi3553.
MGIiMGI:96543. Il1b.

Phylogenomic databases

eggNOGiNOG40099.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiP10749.
KOiK04519.
OMAiSNDKIPV.
OrthoDBiEOG71P2BQ.
PhylomeDBiP10749.
TreeFamiTF300203.

Enzyme and pathway databases

ReactomeiREACT_319181. Interleukin-1 processing.
REACT_337033. Interleukin-1 signaling.
REACT_358772. CLEC7A/inflammasome pathway.

Miscellaneous databases

EvolutionaryTraceiP10749.
NextBioi289037.
PMAP-CutDBP10749.
PROiP10749.
SOURCEiSearch...

Gene expression databases

BgeeiP10749.
CleanExiMM_IL1B.
ExpressionAtlasiP10749. baseline and differential.
GenevisibleiP10749. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR028142. IL-1_fam/FGF_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
PR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta."
    Gray P.W., Glaister D., Chen E., Goeddel D.V., Pennica D.
    J. Immunol. 137:3644-3648(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine interleukin 1 beta gene: structure and evolution."
    Telford J.L., Macchia G., Massone A., Carinci V., Palla E., Melli M.
    Nucleic Acids Res. 14:9955-9963(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
    Farber C.R., Corva P.M., Medrano J.F.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CAST/EiJ.
    Tissue: Spleen.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  6. "Characterization of murine IL-1 beta. Isolation, expression, and purification."
    Huang J.J., Newton R.C., Rutledge S.J., Horuk R., Matthew J.B., Covington M., Lin Y.
    J. Immunol. 140:3838-3843(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 118-139.
  7. "The structure of murine interleukin-1 beta at 2.8-A resolution."
    van Oostrum J., Priestle J.P., Gruetter M.G., Schmitz A.
    J. Struct. Biol. 107:189-195(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiIL1B_MOUSE
AccessioniPrimary (citable) accession number: P10749
Secondary accession number(s): Q2M4J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.