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P10736

- VA52_DOLMA

UniProt

P10736 - VA52_DOLMA

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Protein

Venom allergen 5.01

Gene
N/A
Organism
Dolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5.01
Alternative name(s):
Allergen Dol m V-A
Antigen 5 form 2
Short name:
Ag5-2
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Dol m 5.01
OrganismiDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Taxonomic identifieri7441 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1656. Dol m 5.0101.
330. Dol m 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 227204Venom allergen 5.01PRO_0000006294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 391 Publication
Disulfide bondi31 ↔ 1241 Publication
Disulfide bondi49 ↔ 1171 Publication
Disulfide bondi193 ↔ 2101 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP10736.
SMRiP10736. Positions 21-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 212145SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10736-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIGGLVYLI LIITIINLSF GETNNYCKIK CRKGIHTLCK FGTSMKPNCG
60 70 80 90 100
RNVVKAYGLT NDEKNEILKR HNDFRQNVAK GLETRGKPGP QPPAKNMNVL
110 120 130 140 150
VWNDELAKIA QTWANQCDFN HDDCRNTAKY QVGQNIAISS TTATQFDRPS
160 170 180 190 200
KLIKQWEDEV TEFNYKVGLQ NSNFRKVGHY TQMVWGKTKE IGCGSIKYIE
210 220
DNWYTHYLVC NYGPGGNDFN QPIYERK
Length:227
Mass (Da):26,000
Last modified:July 1, 1989 - v1
Checksum:i4F0ED10D58C44502
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541V → A.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03601 mRNA. Translation: AAA28301.1.
PIRiA31085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03601 mRNA. Translation: AAA28301.1 .
PIRi A31085.

3D structure databases

ProteinModelPortali P10736.
SMRi P10736. Positions 21-227.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 1656. Dol m 5.0101.
330. Dol m 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and primary structure of a white-face hornet venom allergen, antigen 5."
    Fang K.S.Y., Vitale M., Fehlner P., King T.P.
    Proc. Natl. Acad. Sci. U.S.A. 85:895-899(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Venom and Venom gland.
  2. "Structural studies of a hornet venom allergen antigen 5, Dol m V and its sequence similarity with other proteins."
    King T.P., Moran D., Wang D.F., Kochoumian L., Chait B.T.
    Protein Seq. Data Anal. 3:263-266(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
    Tissue: Venom.

Entry informationi

Entry nameiVA52_DOLMA
AccessioniPrimary (citable) accession number: P10736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3