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P10736 (VA52_DOLMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom allergen 5.01
Alternative name(s):
Allergen Dol m V-A
Antigen 5 form 2
Short name=Ag5-2
Cysteine-rich venom protein
Short name=CRVP
Allergen=Dol m 5.01
OrganismDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Taxonomic identifier7441 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 227204Venom allergen 5.01
PRO_0000006294

Regions

Domain68 – 212145SCP

Amino acid modifications

Disulfide bond27 ↔ 39 Ref.2
Disulfide bond31 ↔ 124 Ref.2
Disulfide bond49 ↔ 117 Ref.2
Disulfide bond193 ↔ 210 Ref.2

Natural variations

Natural variant541V → A.

Sequences

Sequence LengthMass (Da)Tools
P10736 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 4F0ED10D58C44502

FASTA22726,000
        10         20         30         40         50         60 
MEIGGLVYLI LIITIINLSF GETNNYCKIK CRKGIHTLCK FGTSMKPNCG RNVVKAYGLT 

        70         80         90        100        110        120 
NDEKNEILKR HNDFRQNVAK GLETRGKPGP QPPAKNMNVL VWNDELAKIA QTWANQCDFN 

       130        140        150        160        170        180 
HDDCRNTAKY QVGQNIAISS TTATQFDRPS KLIKQWEDEV TEFNYKVGLQ NSNFRKVGHY 

       190        200        210        220 
TQMVWGKTKE IGCGSIKYIE DNWYTHYLVC NYGPGGNDFN QPIYERK 

« Hide

References

[1]"cDNA cloning and primary structure of a white-face hornet venom allergen, antigen 5."
Fang K.S.Y., Vitale M., Fehlner P., King T.P.
Proc. Natl. Acad. Sci. U.S.A. 85:895-899(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Venom and Venom gland.
[2]"Structural studies of a hornet venom allergen antigen 5, Dol m V and its sequence similarity with other proteins."
King T.P., Moran D., Wang D.F., Kochoumian L., Chait B.T.
Protein Seq. Data Anal. 3:263-266(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03601 mRNA. Translation: AAA28301.1.
PIRA31085.

3D structure databases

ProteinModelPortalP10736.
SMRP10736. Positions 21-227.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome1656. Dol m 5.0101.
330. Dol m 5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVA52_DOLMA
AccessionPrimary (citable) accession number: P10736
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries