Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10736

- VA52_DOLMA

UniProt

P10736 - VA52_DOLMA

Protein

Venom allergen 5.01

Gene
N/A
Organism
Dolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Venom allergen 5.01
    Alternative name(s):
    Allergen Dol m V-A
    Antigen 5 form 2
    Short name:
    Ag5-2
    Cysteine-rich venom protein
    Short name:
    CRVP
    Allergen: Dol m 5.01
    OrganismiDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
    Taxonomic identifieri7441 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei1656. Dol m 5.0101.
    330. Dol m 5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 227204Venom allergen 5.01PRO_0000006294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 391 Publication
    Disulfide bondi31 ↔ 1241 Publication
    Disulfide bondi49 ↔ 1171 Publication
    Disulfide bondi193 ↔ 2101 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP10736.
    SMRiP10736. Positions 21-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 212145SCPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10736-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIGGLVYLI LIITIINLSF GETNNYCKIK CRKGIHTLCK FGTSMKPNCG    50
    RNVVKAYGLT NDEKNEILKR HNDFRQNVAK GLETRGKPGP QPPAKNMNVL 100
    VWNDELAKIA QTWANQCDFN HDDCRNTAKY QVGQNIAISS TTATQFDRPS 150
    KLIKQWEDEV TEFNYKVGLQ NSNFRKVGHY TQMVWGKTKE IGCGSIKYIE 200
    DNWYTHYLVC NYGPGGNDFN QPIYERK 227
    Length:227
    Mass (Da):26,000
    Last modified:July 1, 1989 - v1
    Checksum:i4F0ED10D58C44502
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541V → A.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03601 mRNA. Translation: AAA28301.1.
    PIRiA31085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03601 mRNA. Translation: AAA28301.1 .
    PIRi A31085.

    3D structure databases

    ProteinModelPortali P10736.
    SMRi P10736. Positions 21-227.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1656. Dol m 5.0101.
    330. Dol m 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and primary structure of a white-face hornet venom allergen, antigen 5."
      Fang K.S.Y., Vitale M., Fehlner P., King T.P.
      Proc. Natl. Acad. Sci. U.S.A. 85:895-899(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Venom and Venom gland.
    2. "Structural studies of a hornet venom allergen antigen 5, Dol m V and its sequence similarity with other proteins."
      King T.P., Moran D., Wang D.F., Kochoumian L., Chait B.T.
      Protein Seq. Data Anal. 3:263-266(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
      Tissue: Venom.

    Entry informationi

    Entry nameiVA52_DOLMA
    AccessioniPrimary (citable) accession number: P10736
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3