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P10736

- VA52_DOLMA

UniProt

P10736 - VA52_DOLMA

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Protein
Venom allergen 5.01
Gene
N/A
Organism
Dolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5.01
Alternative name(s):
Allergen Dol m V-A
Antigen 5 form 2
Short name:
Ag5-2
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Dol m 5.01
OrganismiDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Taxonomic identifieri7441 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1656. Dol m 5.0101.
330. Dol m 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323
Add
BLAST
Chaini24 – 227204Venom allergen 5.01
PRO_0000006294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 391 Publication
Disulfide bondi31 ↔ 1241 Publication
Disulfide bondi49 ↔ 1171 Publication
Disulfide bondi193 ↔ 2101 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP10736.
SMRiP10736. Positions 21-227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 212145SCP
Add
BLAST

Sequence similaritiesi

Belongs to the CRISP family.
Contains 1 SCP domain.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10736-1 [UniParc]FASTAAdd to Basket

« Hide

MEIGGLVYLI LIITIINLSF GETNNYCKIK CRKGIHTLCK FGTSMKPNCG    50
RNVVKAYGLT NDEKNEILKR HNDFRQNVAK GLETRGKPGP QPPAKNMNVL 100
VWNDELAKIA QTWANQCDFN HDDCRNTAKY QVGQNIAISS TTATQFDRPS 150
KLIKQWEDEV TEFNYKVGLQ NSNFRKVGHY TQMVWGKTKE IGCGSIKYIE 200
DNWYTHYLVC NYGPGGNDFN QPIYERK 227
Length:227
Mass (Da):26,000
Last modified:July 1, 1989 - v1
Checksum:i4F0ED10D58C44502
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541V → A.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03601 mRNA. Translation: AAA28301.1.
PIRiA31085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03601 mRNA. Translation: AAA28301.1 .
PIRi A31085.

3D structure databases

ProteinModelPortali P10736.
SMRi P10736. Positions 21-227.
ModBasei Search...

Protein family/group databases

Allergomei 1656. Dol m 5.0101.
330. Dol m 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and primary structure of a white-face hornet venom allergen, antigen 5."
    Fang K.S.Y., Vitale M., Fehlner P., King T.P.
    Proc. Natl. Acad. Sci. U.S.A. 85:895-899(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Venom and Venom gland.
  2. "Structural studies of a hornet venom allergen antigen 5, Dol m V and its sequence similarity with other proteins."
    King T.P., Moran D., Wang D.F., Kochoumian L., Chait B.T.
    Protein Seq. Data Anal. 3:263-266(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
    Tissue: Venom.

Entry informationi

Entry nameiVA52_DOLMA
AccessioniPrimary (citable) accession number: P10736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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