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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processSporulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU23460-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factor (EC:2.7.11.1)
Alternative name(s):
Stage II sporulation protein AB
Gene namesi
Name:spoIIAB
Ordered Locus Names:BSU23460
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035611 – 146Anti-sigma F factorAdd BLAST146

Proteomic databases

PaxDbiP10728
PRIDEiP10728

Expressioni

Developmental stagei

Interaction with SpoIIAB inhibits sigma F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ybdMO314352EBI-9344705,EBI-5255200

Protein-protein interaction databases

IntActiP10728, 5 interactors
STRINGi224308.Bsubs1_010100012876

Structurei

3D structure databases

ProteinModelPortaliP10728
SMRiP10728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.Curated

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
HOGENOMiHOG000269931
InParanoidiP10728
KOiK06379
OMAiHAYEDKI
PhylomeDBiP10728

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00637 Anti_sigma_F, 1 hit
InterProiView protein in InterPro
IPR010194 Anti-sigma_F
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
PANTHERiPTHR35526:SF2 PTHR35526:SF2, 1 hit
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01925 spIIAB, 1 hit

Sequencei

Sequence statusi: Complete.

P10728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNEMHLEFS ALSQNESFAR VTVASFIAQL DPTMDELTEI KTVVSEAVTN
60 70 80 90 100
AIIHGYEENC EGKVYISVTL EDHVVYMTIR DEGLGITDLE EARQPLFTTK
110 120 130 140
PELERSGMGF TIMENFMDDV SIDSSPEMGT TIRLTKHLSK SKALCN
Length:146
Mass (Da):16,356
Last modified:February 1, 1991 - v1
Checksum:i141A28D41EDEC997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17643 Genomic DNA Translation: AAA22790.1
D84432 Genomic DNA Translation: BAA12654.1
AL009126 Genomic DNA Translation: CAB14278.1
PIRiB55646
RefSeqiNP_390227.1, NC_000964.3
WP_003230452.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14278; CAB14278; BSU23460
GeneIDi938930
KEGGibsu:BSU23460
PATRICifig|224308.179.peg.2556

Similar proteinsi

Entry informationi

Entry nameiSP2AB_BACSU
AccessioniPrimary (citable) accession number: P10728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

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