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P10727

- SP2AA_BACSU

UniProt

P10727 - SP2AA_BACSU

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Protein

Anti-sigma F factor antagonist

Gene
spoIIAA, BSU23470
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.1 Publication

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
  2. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU23470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factor antagonist
Alternative name(s):
Stage II sporulation protein AA
Gene namesi
Name:spoIIAA
Ordered Locus Names:BSU23470
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU23470. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 117116Anti-sigma F factor antagonistPRO_0000194204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by SpoIIAB on a serine residue.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10727.

PTM databases

PhosSiteiP010322.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU23470.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 104
Beta strandi13 – 164
Helixi26 – 3813
Beta strandi45 – 495
Helixi60 – 7415
Turni85 – 884
Helixi89 – 946
Helixi97 – 993
Helixi106 – 1083
Helixi110 – 1123

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AUZNMR-A2-117[»]
1BUZNMR-A2-117[»]
ProteinModelPortaliP10727.
SMRiP10727. Positions 2-117.

Miscellaneous databases

EvolutionaryTraceiP10727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 113111STASAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Phylogenomic databases

eggNOGiCOG1366.
HOGENOMiHOG000270156.
KOiK06378.
OMAiHLEVKRD.
OrthoDBiEOG6J48NK.
PhylomeDBiP10727.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR003658. Anti-sigma_ant.
IPR014237. Anti-sigma_F_ant.
IPR002645. STAS_dom.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
TIGRFAMsiTIGR00377. ant_ant_sig. 1 hit.
TIGR02886. spore_II_AA. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10727-1 [UniParc]FASTAAdd to Basket

« Hide

MSLGIDMNVK ESVLCIRLTG ELDHHTAETL KQKVTQSLEK DDIRHIVLNL    50
EDLSFMDSSG LGVILGRYKQ IKQIGGEMVV CAISPAVKRL FDMSGLFKII 100
RFEQSEQQAL LTLGVAS 117
Length:117
Mass (Da):12,990
Last modified:January 23, 2007 - v3
Checksum:i2333E74207568AC2
GO

Sequence cautioni

The sequence AAA22789.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17643 Genomic DNA. Translation: AAA22789.1. Different initiation.
D84432 Genomic DNA. Translation: BAA12653.1.
AL009126 Genomic DNA. Translation: CAB14279.1.
PIRiA55646.
RefSeqiNP_390228.1. NC_000964.3.
WP_004398633.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB14279; CAB14279; BSU23470.
GeneIDi938730.
KEGGibsu:BSU23470.
PATRICi18976513. VBIBacSub10457_2447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17643 Genomic DNA. Translation: AAA22789.1 . Different initiation.
D84432 Genomic DNA. Translation: BAA12653.1 .
AL009126 Genomic DNA. Translation: CAB14279.1 .
PIRi A55646.
RefSeqi NP_390228.1. NC_000964.3.
WP_004398633.1. NZ_CM000487.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AUZ NMR - A 2-117 [» ]
1BUZ NMR - A 2-117 [» ]
ProteinModelPortali P10727.
SMRi P10727. Positions 2-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU23470.

PTM databases

PhosSitei P010322.

Proteomic databases

PaxDbi P10727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14279 ; CAB14279 ; BSU23470 .
GeneIDi 938730.
KEGGi bsu:BSU23470.
PATRICi 18976513. VBIBacSub10457_2447.

Organism-specific databases

GenoListi BSU23470. [Micado ]

Phylogenomic databases

eggNOGi COG1366.
HOGENOMi HOG000270156.
KOi K06378.
OMAi HLEVKRD.
OrthoDBi EOG6J48NK.
PhylomeDBi P10727.

Enzyme and pathway databases

BioCyci BSUB:BSU23470-MONOMER.

Miscellaneous databases

EvolutionaryTracei P10727.

Family and domain databases

Gene3Di 3.30.750.24. 1 hit.
InterProi IPR003658. Anti-sigma_ant.
IPR014237. Anti-sigma_F_ant.
IPR002645. STAS_dom.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 1 hit.
TIGRFAMsi TIGR00377. ant_ant_sig. 1 hit.
TIGR02886. spore_II_AA. 1 hit.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of sporulation locus spoIIA in Bacillus subtilis."
    Fort P., Piggot P.J.
    J. Gen. Microbiol. 130:2147-2153(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CU267.
  2. "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
    Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
    Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Characterization of a Bacillus subtilis sporulation operon that includes genes for an RNA polymerase sigma factor and for a putative DD-carboxypeptidase."
    Wu J.-J., Schuch R., Piggot P.J.
    J. Bacteriol. 174:4885-4892(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-4.
  5. "Sigma F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-sigma factor that is also a protein kinase."
    Min K.-T., Hilditch C.M., Diederich B., Errington J., Yudkin M.D.
    Cell 74:735-742(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PROTEIN SEQUENCE OF 2-14.
  6. "Site of phosphorylation of SpoIIAA, the anti-anti-sigma factor for sporulation-specific sigma F of Bacillus subtilis."
    Najafi S.M.A., Willis A.C., Yudkin M.D.
    J. Bacteriol. 177:2912-2913(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-58, PROTEIN SEQUENCE OF 52-67.
  7. "Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis."
    Kovacs H., Comfort D., Lord M., Campbell I.D., Yudkin M.D.
    Proc. Natl. Acad. Sci. U.S.A. 95:5067-5071(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiSP2AA_BACSU
AccessioniPrimary (citable) accession number: P10727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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