P10720A1L4S0PF4V_HUMANPlatelet factor 4 variantC-X-C motif chemokine 4 variantCXCL4L1PF4altPF4var1Platelet factor 4 variant(4-74)Platelet factor 4 variant(5-74)Platelet factor 4 variant(6-74)PF4V1CXCL4V1SCYB4V1Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoIdentification and characterization of PF4var1, a human gene variant of platelet factor 4.NUCLEOTIDE SEQUENCE [GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Structural and functional comparison of the genes for human platelet factor 4 and PF4alt.NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-104Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.PROTEIN SEQUENCE OF 31-54FUNCTIONMASS SPECTROMETRYAlternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1.X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 35-104DISULFIDE BONDSHEPARIN-BINDING REGIONSUBUNITInhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).Homotetramer.P10720O00585false2P10720O15444false2P10720O14625false2P10720P48061false4P10720P47992false2SecretedThe N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).Platelet factor 4 variantPlatelet factor 4 variant.Platelet factor 4 variant(4-74)Platelet factor 4 variant(4-74).Platelet factor 4 variant(5-74)Platelet factor 4 variant(5-74).Platelet factor 4 variant(6-74)Platelet factor 4 variant(6-74).Binding to heparin is much weaker than in the close homolog PF4/CXCL4.Belongs to the intercrine alpha (chemokine CxC) family.3D-structureCytokineDirect protein sequencingDisulfide bondGlycoproteinHeparin-bindingProteoglycanReference proteomeSecretedSignalheparinASMSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES
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