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Protein

Platelet factor 4 variant

Gene

PF4V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).1 Publication

Miscellaneous

Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding

Enzyme and pathway databases

ReactomeiR-HSA-140875. Common Pathway of Fibrin Clot Formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet factor 4 variant
Alternative name(s):
C-X-C motif chemokine 4 variant
CXCL4L1
PF4alt
PF4var1
Cleaved into the following 3 chains:
Gene namesi
Name:PF4V1
Synonyms:CXCL4V1, SCYB4V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109272.3.
HGNCiHGNC:8862. PF4V1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5197.
OpenTargetsiENSG00000109272.
PharmGKBiPA33204.

Polymorphism and mutation databases

BioMutaiPF4V1.
DMDMi130306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000000507131 – 104Platelet factor 4 variantAdd BLAST74
ChainiPRO_000000507234 – 104Platelet factor 4 variant(4-74)Add BLAST71
ChainiPRO_000000507335 – 104Platelet factor 4 variant(5-74)Add BLAST70
ChainiPRO_000000507436 – 104Platelet factor 4 variant(6-74)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 701 Publication
Disulfide bondi46 ↔ 861 Publication

Post-translational modificationi

The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP10720.
PeptideAtlasiP10720.
PRIDEiP10720.
TopDownProteomicsiP10720.

PTM databases

iPTMnetiP10720.
PhosphoSitePlusiP10720.

Expressioni

Gene expression databases

BgeeiENSG00000109272.
CleanExiHS_PF4V1.

Organism-specific databases

HPAiHPA052485.

Interactioni

Subunit structurei

Homotetramer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111220. 4 interactors.
IntActiP10720. 1 interactor.
STRINGi9606.ENSP00000226524.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 47Combined sources3
Turni55 – 57Combined sources3
Beta strandi58 – 64Combined sources7
Beta strandi70 – 72Combined sources3
Beta strandi74 – 79Combined sources6
Beta strandi84 – 87Combined sources4
Helixi89 – 96Combined sources8
Helixi98 – 101Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HSVX-ray2.08A/B/C/D35-104[»]
ProteinModelPortaliP10720.
SMRiP10720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 101Heparin-binding7

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J314. Eukaryota.
ENOG4111556. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP10720.
KOiK05407.
OMAiRNGRKIC.
OrthoDBiEOG091G14JD.
PhylomeDBiP10720.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027222. PF4.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF53. PTHR10179:SF53. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT
60 70 80 90 100
SQVRPRHITS LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE

HLES
Length:104
Mass (Da):11,553
Last modified:July 1, 1989 - v1
Checksum:i786FE2B288532E28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77A → S no nucleotide entry (PubMed:1695112).Curated1

Mass spectrometryi

Molecular mass is 8250.9 Da from positions 31 - 104. Determined by ESI. Platelet factor 4 variant.1 Publication
Molecular mass is 7877.7 Da from positions 34 - 104. Determined by ESI. Platelet factor 4 variant(4-74).1 Publication
Molecular mass is 7805.8 Da from positions 35 - 104. Determined by ESI. Platelet factor 4 variant(5-74).1 Publication
Molecular mass is 7678.6 Da from positions 36 - 104. Determined by ESI. Platelet factor 4 variant(6-74).1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26167 Genomic DNA. Translation: AAA60067.1.
CH471057 Genomic DNA. Translation: EAX05692.1.
BC130653 mRNA. Translation: AAI30654.1.
BC130657 mRNA. Translation: AAI30658.1.
CCDSiCCDS3561.1.
PIRiA31941. PFHU4A.
RefSeqiNP_002611.1. NM_002620.3.
UniGeneiHs.72933.

Genome annotation databases

EnsembliENST00000226524; ENSP00000226524; ENSG00000109272.
GeneIDi5197.
KEGGihsa:5197.
UCSCiuc003hhg.2. human.

Similar proteinsi

Entry informationi

Entry nameiPF4V_HUMAN
AccessioniPrimary (citable) accession number: P10720
Secondary accession number(s): A1L4S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 27, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families