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Protein

C-type lectin domain family 4 member F

Gene

Clec4f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member F
Alternative name(s):
C-type lectin superfamily member 13
Short name:
C-type lectin 13
Kupffer cell receptor
Gene namesi
Name:Clec4f
Synonyms:Clecsf13, Kclr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621062. Clec4f.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6927Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini70 – 550481ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550C-type lectin domain family 4 member FPRO_0000046624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi440 ↔ 536PROSITE-ProRule annotation
Disulfide bondi516 ↔ 528PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10716.
PRIDEiP10716.

Expressioni

Tissue specificityi

Kupffer cells.

Gene expression databases

GenevisibleiP10716. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017643.

Structurei

3D structure databases

ProteinModelPortaliP10716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 538101C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3X. Eukaryota.
ENOG41123NI. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000264252.
HOVERGENiHBG081248.
InParanoidiP10716.
KOiK10060.
OMAiGDNITGH.
OrthoDBiEOG7HXCVB.
PhylomeDBiP10716.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEAELNRDV AKFCTDNQCV ILQPQGLGPK SAAPMAPRTL RHVQAIVALV
60 70 80 90 100
VVTVFFSLLA LFVVVLQPWR QKQNEDHPVK AGLHGGNYSG SDNCSQFVRR
110 120 130 140 150
AEMQEAIQSL RASGNSSSCH KEIQTLKYQM DNVSSQVQLL GGHLEEANAD
160 170 180 190 200
IQQAKDVLKG TGALASETQA LRSSLEVASA DIHSLRGDLE KANAMTSQTQ
210 220 230 240 250
GLLKSSTDNT SAELHVLGRG LEEAQSEIQA LRGSLQSSND LGSRTQNFLQ
260 270 280 290 300
HSMDNISAEI QAMRDGMQRA GEEMTSLKKD LETLTAQIQN ANGHLEQTDT
310 320 330 340 350
QIQGLKAQLK STSSLNSQIE VVNGKLKDSS RELQTLRRDL SDVSALKSNV
360 370 380 390 400
QMLQSNLQKA KAEVQSLKTG LEATKTLAAK IQGQQSDLEA LQKAVAAHTQ
410 420 430 440 450
GQKTQNQVLQ LIMQDWKYFN GKFYYFSRDK KSWHEAENFC VSQGAHLASV
460 470 480 490 500
TSQEEQAFLV QITNAVDHWI GLTDQGTEGN WRWVDGTPFD YVQSRRFWRK
510 520 530 540 550
GQPDNWRHGN GEREDCVHLQ RMWNDMACGT AYNWVCKKST DWSVARTDQS
Length:550
Mass (Da):61,104
Last modified:April 1, 1990 - v1
Checksum:i9358A6CF4C306270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03734 mRNA. Translation: AAA41472.1.
M55532 Genomic DNA. Translation: AAA40892.1.
BC098661 mRNA. Translation: AAH98661.1.
PIRiA38674. A28166.
RefSeqiNP_446205.1. NM_053753.1.
UniGeneiRn.9886.

Genome annotation databases

EnsembliENSRNOT00000017643; ENSRNOP00000017643; ENSRNOG00000013137.
GeneIDi114598.
KEGGirno:114598.
UCSCiRGD:621062. rat.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Kupffer cell receptor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03734 mRNA. Translation: AAA41472.1.
M55532 Genomic DNA. Translation: AAA40892.1.
BC098661 mRNA. Translation: AAH98661.1.
PIRiA38674. A28166.
RefSeqiNP_446205.1. NM_053753.1.
UniGeneiRn.9886.

3D structure databases

ProteinModelPortaliP10716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017643.

Proteomic databases

PaxDbiP10716.
PRIDEiP10716.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017643; ENSRNOP00000017643; ENSRNOG00000013137.
GeneIDi114598.
KEGGirno:114598.
UCSCiRGD:621062. rat.

Organism-specific databases

CTDi165530.
RGDi621062. Clec4f.

Phylogenomic databases

eggNOGiENOG410IS3X. Eukaryota.
ENOG41123NI. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000264252.
HOVERGENiHBG081248.
InParanoidiP10716.
KOiK10060.
OMAiGDNITGH.
OrthoDBiEOG7HXCVB.
PhylomeDBiP10716.
TreeFamiTF333341.

Miscellaneous databases

PROiP10716.

Gene expression databases

GenevisibleiP10716. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of a cDNA for a carbohydrate binding receptor unique to rat Kupffer cells."
    Hoyle G.W., Hill R.L.
    J. Biol. Chem. 263:7487-7492(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 83-104.
  2. "Structure of the gene for a carbohydrate-binding receptor unique to rat Kupffer cells."
    Hoyle G.W., Hill R.L.
    J. Biol. Chem. 266:1850-1857(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiCLC4F_RAT
AccessioniPrimary (citable) accession number: P10716
Secondary accession number(s): Q4KMB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.